Impact of physical activity on the risk of cardiovascular disease in middle-aged and older adults: EPIC Norfolk prospective population study.

Abstract:

:Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity also translates into cardiovascular health benefits in older adults. Therefore, we aimed to compare the association between different levels of physical activity and the risk of cardiovascular disease (CVD) in elderly to middle-aged individuals. Methods We analysed data from the EPIC Norfolk prospective population study. Cox proportional hazards models were used to analyse the association between physical activity levels and time to CVD events in three age categories (<55, 55-65 and >65 years). Interaction between age categories and physical activity levels was assessed. Results Analyses were based on 24,502 study participants aged 39-79 years. A total of 5240 CVD events occurred during 412,954 person-years follow-up (median follow-up was 18.0 years). Among individuals aged over 65 years, hazard ratios for CVD were 0.86 (95% confidence interval (CI) 0.78-0.96), 0.87 (95% CI 0.77-0.99) and 0.88 (95% CI 0.77-1.02) in moderately inactive, moderately active and active people, respectively, compared to inactive people. Among people aged 55-65 and less than 55 years, the associations were directionally similar, but not statistically significant. The interaction term between physical activity levels and age categories was not significant ( P = 0.38). Conclusion The inverse association between physical activity and the risk of CVD was significant in elderly and comparable with middle-aged individuals. In addition, we observed that modest levels of physical activity confer benefits in terms of CVD risk, compared to being completely inactive.

journal_name

Eur J Prev Cardiol

authors

Lachman S,Boekholdt SM,Luben RN,Sharp SJ,Brage S,Khaw KT,Peters RJ,Wareham NJ

doi

10.1177/2047487317737628

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

200-208

issue

2

eissn

2047-4873

issn

2047-4881

journal_volume

25

pub_type

杂志文章
  • Age differences in contemporary treatment of patients with chronic heart failure and reduced ejection fraction.

    abstract:BACKGROUND:Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319835042

    authors: Veenis JF,Brunner-La Rocca HP,Linssen GC,Geerlings PR,Van Gent MW,Aksoy I,Oosterom L,Moons AH,Hoes AW,Brugts JJ,CHECK-HF investigators.

    更新日期:2019-09-01 00:00:00

  • Effect of coronavirus infection on the human heart: A scoping review.

    abstract:BACKGROUND:The global coronavirus disease 2019 pandemic has highlighted the importance of understanding the cardiovascular implications of coronavirus infections, with more severe disease in those with cardiovascular co-morbidities, and resulting cardiac manifestations such as myocardial injury, arrhythmias, and heart ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320925965

    authors: Ho JS,Tambyah PA,Ho AF,Chan MY,Sia CH

    更新日期:2020-07-01 00:00:00

  • Sacubitril-valsartan versus enalapril for acute decompensated heart failure: a cost-effectiveness analysis.

    abstract:BACKGROUND:The Comparison of Sacubitril-Valsartan versus Enalapril on Effect on NT-proBNP in Patients Stabilised from an Acute Heart Failure Episode (PIONEER-HF) trial demonstrated significant reductions in N-terminal pro-B-type natriuretic peptide. Our study explored the cost-effectiveness of the use of sacubitril-val...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319878953

    authors: Perera K,Ademi Z,Liew D,Zomer E

    更新日期:2019-10-04 00:00:00

  • ST segment/heart rate hysteresis improves the diagnostic accuracy of ECG stress test for coronary artery disease in patients with left ventricular hypertrophy.

    abstract:BACKGROUND:The exercise electrocardiographic stress test (ExET) is the most widely used non-invasive diagnostic method to detect coronary artery disease. However, the sole ST depression criteria (ST-max) have poor specificity for coronary artery disease in patients with left ventricular hypertrophy. We hypothesised tha...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487316655259

    authors: Zimarino M,Montebello E,Radico F,Gallina S,Perfetti M,Iachini Bellisarii F,Severi S,Limbruno U,Emdin M,De Caterina R

    更新日期:2016-10-01 00:00:00

  • Association of renal resistive index with aortic pulse wave velocity in hypertensive patients.

    abstract:BACKGROUND:Recent data suggest that renal haemodynamic parameters obtained by duplex Doppler sonography, especially the intrarenal resistive index (RI), may be associated with systemic vascular changes. However, conflicting data exist about the independent relationship between aortic stiffness and RI. The aim of this s...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487314524683

    authors: Geraci G,Mulè G,Geraci C,Mogavero M,D'Ignoto F,Morreale M,Foraci AC,Cottone S

    更新日期:2015-04-01 00:00:00

  • Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study.

    abstract:BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320909300

    authors: Östgren CJ,Söderberg S,Festin K,Angerås O,Bergström G,Blomberg A,Brandberg J,Cederlund K,Eliasson M,Engström G,Erlinge D,Fagman E,Hagström E,Lind L,Mannila M,Nilsson U,Oldgren J,Ostenfeld E,Persson A,Persson J,Per

    更新日期:2020-03-03 00:00:00

  • Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway.

    abstract::Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in appa...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487317703826

    authors: Ueland T,Laugsand LE,Vatten LJ,Janszky I,Platou C,Michelsen AE,Damås JK,Aukrust P,Åsvold BO

    更新日期:2017-07-01 00:00:00

  • Association of coronary heart disease mortality with risk factors according to length of follow-up and serum cholesterol level in men: the Oslo Study cohort.

    abstract:AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study p...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711432514

    authors: Holme I,Tonstad S

    更新日期:2013-02-01 00:00:00

  • Variability in strength of red yeast rice supplements purchased from mainstream retailers.

    abstract::The United States Food and Drug Administration (FDA) has introduced manufacturing standards for dietary supplements, including red yeast rice, to assure their identity, purity, strength, and composition. One supplement commonly used to self-treat high cholesterol, red yeast rice, may contain monacolin K, an ingredient...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317715714

    authors: Cohen PA,Avula B,Khan IA

    更新日期:2017-09-01 00:00:00

  • Use of a Multidrug Pill In Reducing cardiovascular Events (UMPIRE): rationale and design of a randomised controlled trial of a cardiovascular preventive polypill-based strategy in India and Europe.

    abstract::The use of preventive medications in people at high risk of cardiovascular disease is conceptually straightforward, yet in practice the adoption of such measures is disappointingly low, plus there is wide international variation in preventive therapies. Several barriers might explain this shortfall and variation, but ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487312463278

    authors: Thom S,Field J,Poulter N,Patel A,Prabhakaran D,Stanton A,Grobbee DE,Bots ML,Reddy KS,Cidambi R,Rodgers A

    更新日期:2014-02-01 00:00:00

  • Long term impact of one daily unit of physical exercise at school on cardiovascular risk factors in school children.

    abstract:BACKGROUND:Obesity and physical inactivity in children correlate with the presence of cardiovascular risk factors. The aim of this prospective, randomised, interventional study was to examine the long term impact of additional physical exercise lessons at school on fitness and cardiovascular risk factors. METHODS:We r...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487316632966

    authors: Müller UM,Walther C,Adams V,Mende M,Adam J,Fikenzer K,Machalica KC,Erbs S,Linke A,Schuler G

    更新日期:2016-09-01 00:00:00

  • Angiotensin-converting enzyme inhibitors reduce mortality compared to angiotensin receptor blockers: Systematic review and meta-analysis.

    abstract::Background There are few reviews comparing the long-term outcomes of the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in a hypertensive population because both are effective in reducing blood pressure. None of them compared angiotensin-converting enzyme inhibitors or angiotensin ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/2047487317728766

    authors: Salvador GL,Marmentini VM,Cosmo WR,Junior EL

    更新日期:2017-12-01 00:00:00

  • Blood pressure variations and low blood pressure values at home after hospital discharge in older hypertensives: post-discharge blood pressure variations.

    abstract:BACKGROUND:Blood pressure (BP) variations occurring after hospital discharge in a population of older hypertensives have not been previously investigated. DESIGN:elderly (≥65 years) hypertensives admitted to the geriatric acute ward of a university-teaching hospital were enrolled in this prospective observational stud...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711403067

    authors: Astengo M,Bonetto M,Isaia G,Comba M,Fonte G,Bo M

    更新日期:2012-06-01 00:00:00

  • The HeartQoL: part II. Validation of a new core health-related quality of life questionnaire for patients with ischemic heart disease.

    abstract:BACKGROUND:Evaluation of health-related quality of life (HRQL) is important in improving the quality of patient care. The aim of this study was to determine the psychometric properties of the HeartQoL in patients with ischemic heart disease (IHD), specifically angina, myocardial infarction (MI), or ischemic heart failu...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487312450545

    authors: Oldridge N,Höfer S,McGee H,Conroy R,Doyle F,Saner H,(for the HeartQoL Project Investigators).

    更新日期:2014-01-01 00:00:00

  • Cardiac rehabilitation of elderly patients in eight rehabilitation units in western Europe: Outcome data from the EU-CaRE multi-centre observational study.

    abstract:AIMS:The European Cardiac Rehabilitation in the Elderly (EU-CaRE) HORIZON 2020 project compares the sustainable effects of cardiac rehabilitation (CR) in elderly patients. METHODS AND RESULTS:A total of 1633 patients with coronary artery disease (CAD) or heart valve replacement (HVR), with or without revascularization...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320903869

    authors: Prescott E,Eser P,Mikkelsen N,Holdgaard A,Marcin T,Wilhelm M,Gil CP,González-Juanatey JR,Moatemri F,Iliou MC,Schneider S,Schromm E,Zeymer U,Meindersma EP,Crocamo A,Ardissino D,Kolkman EK,Prins LF,van der Velde AE,Va

    更新日期:2020-11-01 00:00:00

  • Serum tissue-degrading proteinases and incident cardiovascular disease events.

    abstract:BACKGROUND:Extracellular matrix-degrading proteinases are upregulated in atherosclerotic lesions and can contribute to subsequent pathological events. In the present nested case-control study, we investigated the association of serum concentrations of matrix metalloproteinases MMP-7, MMP-8, and MMP-13, tissue inhibitor...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487312465524

    authors: Tuomainen AM,Kormi I,Havulinna AS,Tervahartiala T,Salomaa V,Sorsa T,Pussinen PJ

    更新日期:2014-07-01 00:00:00

  • Validity and reliability of the HeartQoL questionnaire in a large sample of stable coronary patients: The EUROASPIRE IV Study of the European Society of Cardiology.

    abstract:BACKGROUND:The aim of this study was to investigate the validity and reliability of the HeartQoL instrument in a population of stable coronary patients. DESIGN:Analyses are based on the cross-sectional EUROASPIRE IV (EUROpean Action on Secondary and Primary prevention through Intervention to Reduce Events) survey. ME...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487315604837

    authors: De Smedt D,Clays E,Höfer S,Oldridge N,Kotseva K,Maggioni AP,Janssen B,De Bacquer D,EUROASPIRE Investigators.

    更新日期:2016-05-01 00:00:00

  • Achievement of European guideline-recommended lipid levels post-percutaneous coronary intervention: A population-level observational cohort study.

    abstract:AIMS:European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets in high- and very high-risk patients and the addition of adjuvant treatments to statins in uncontrolled patients. We aimed to assess (a) achievement of prior and new European Society of Cardiolog...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320914115

    authors: Harris DE,Lacey A,Akbari A,Torabi F,Smith D,Jenkins G,Obaid D,Chase A,Gravenor M,Halcox J

    更新日期:2020-03-31 00:00:00

  • A comparison of the prevalence and clustering of major cardiovascular risk factors in the Netherlands and China.

    abstract:BACKGROUND:Cardiovascular risk factors tend to be clustered. Variations in clusters across populations have not been widely investigated. This study aims to compare the prevalence and clustering of major cardiovascular risk factors between adults in the Netherlands and China. METHODS:A total of 6542 Dutch adults was r...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487316648474

    authors: Wang X,Bots ML,Yang F,Sun J,He S,Hoes AW,Niu J,Vaartjes I

    更新日期:2016-11-01 00:00:00

  • Interaction of maternal smoking and preterm birth on future risk of maternal cardiovascular disease: A population-based record linkage study.

    abstract:BACKGROUND:While associations of smoking and preterm birth (PTB) with maternal cardiovascular disease (CVD) risks have been established, it is unknown whether the coexistence of these two conditions could synergistically increase the risks. METHODS:We linked birth records of 902,008 mothers with singleton infants duri...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487315593836

    authors: Ngo AD,Roberts CL,Chen JS,Figtree G

    更新日期:2016-04-01 00:00:00

  • Accuracy of smartphone apps for heart rate measurement.

    abstract::Background Smartphone manufacturers offer mobile health monitoring technology to their customers, including apps using the built-in camera for heart rate assessment. This study aimed to test the diagnostic accuracy of such heart rate measuring apps in clinical practice. Methods The feasibility and accuracy of measurin...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/2047487317702044

    authors: Coppetti T,Brauchlin A,Müggler S,Attinger-Toller A,Templin C,Schönrath F,Hellermann J,Lüscher TF,Biaggi P,Wyss CA

    更新日期:2017-08-01 00:00:00

  • Impact of orlistat initiation on cardiovascular treatment use: a 6-year population-based cohort study.

    abstract:BACKGROUND:Trials of weight-loss drugs indicate some benefits on lipids, blood glucose, or blood pressure levels. Since obesity is associated with increased cardiovascular (CV) medication use and pharmaceutical costs, weight-loss drug use could beneficially impact CV medication use. OBJECTIVE:We examined the temporal ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711406058

    authors: Czernichow S,Knol MJ,Fezeu L,Grobbee DE

    更新日期:2012-06-01 00:00:00

  • Prevalence of exertional oscillatory ventilation in continuous-flow left ventricular assist device recipients.

    abstract:BACKGROUND:Exercise oscillatory ventilation is an ominous outcome sign in heart failure due to reduced left ventricular ejection fraction; currently, the prevalence of exercise oscillatory ventilation is unknown in left ventricular assist device recipients. METHODS:We studied cardiopulmonary exercise testing in heart ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487318801415

    authors: Pistono M,Gnemmi M,Imparato A,Komici K,Corrà U

    更新日期:2018-11-01 00:00:00

  • Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the community.

    abstract:BACKGROUND:The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left ventricular diastolic dysfunction is a prognostic indicator of heart failure, in particularly of heart failure with preserved ejection fraction and of future cardiovascular and all-...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487318816774

    authors: Gohar A,Kievit RF,Valstar GB,Hoes AW,Van Riet EE,van Mourik Y,Bertens LC,Boonman-Winter LJ,Bots ML,Den Ruijter HM,Rutten FH

    更新日期:2019-04-01 00:00:00

  • Impaired vascular function and repair in patients with premature coronary artery disease.

    abstract:BACKGROUND:Endothelial dysfunction is central to the pathogenesis of coronary artery disease, but the role of local and circulating endothelial progenitor cells in maintaining vascular health is poorly understood. We hypothesised that impaired local and circulating vascular repair mechanisms predispose to endothelial d...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487315600169

    authors: Brittan M,Hunter A,Boulberdaa M,Fujisawa T,Skinner EM,Shah AS,Baker AH,Mills NL

    更新日期:2015-12-01 00:00:00

  • C-reactive protein and serum creatinine, but not haemoglobin A1c, are independent predictors of coronary heart disease risk in non-diabetic Chinese.

    abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487315626547

    authors: Salim A,Tai ES,Tan VY,Welsh AH,Liew R,Naidoo N,Wu Y,Yuan JM,Koh WP,van Dam RM

    更新日期:2016-08-01 00:00:00

  • Physical fitness is a modifiable predictor of early cardiovascular death: A 35-year follow-up study of 2014 healthy middle-aged men.

    abstract::Background Physical fitness has been shown to predict cardiovascular death during long-term follow-up. In the present study we aimed to investigate how physical fitness and other cardiovascular risk factors at middle-age influenced the risk of cardiovascular death during the early (0-11 years), intermediate (12-23 yea...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487318793459

    authors: Engeseth K,Prestgaard EE,Mariampillai JE,Grundvold I,Liestol K,Kjeldsen SE,Bodegard J,Erikssen JE,Gjesdal K,Skretteberg PT

    更新日期:2018-10-01 00:00:00

  • Psychological interventions for coronary heart disease: Cochrane systematic review and meta-analysis.

    abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1177/2047487317739978

    authors: Richards SH,Anderson L,Jenkinson CE,Whalley B,Rees K,Davies P,Bennett P,Liu Z,West R,Thompson DR,Taylor RS

    更新日期:2018-02-01 00:00:00

  • Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice.

    abstract::Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposi...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487319848105

    authors: Cabassi A,Tedeschi S,Perlini S,Verzicco I,Volpi R,Gonzi G,Canale SD

    更新日期:2020-05-01 00:00:00

  • Hospital delay in South Asian patients with acute ST-elevation myocardial infarction in the UK.

    abstract:BACKGROUND:South Asians presenting with chest pain in the UK experience disproportionately greater delays with respect to diagnosis and treatment for acute myocardial infarction (AMI). The duration of time between symptom onset and hospital intervention is a critical delay for AMI but there are limited data amongst Sou...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487312447844

    authors: Kendall H,Marley A,Patel JV,Khan JM,Blann AD,Lip GY,Dwivedi G

    更新日期:2013-10-01 00:00:00