Abstract:
BACKGROUND:Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-based heart failure management in a large registry at heart failure outpatient clinics. DESIGN AND METHODS:We studied 8351 heart failure with reduced ejection fraction patients at 34 Dutch outpatient clinics between 2013 and 2016. The mean age was 72.3 ± 11.8 years and we divided age into three categories: less than 60 years (13.9%); 60-74 years (36.0%); and 75 years and over (50.2%). RESULTS:Elderly heart failure with reduced ejection fraction patients (≥75 years) received significantly fewer beta-blockers (77.8% vs. 84.2%), renin-angiotensin system inhibitors (75.2% vs. 89.7%), mineralocorticoid receptor antagonists (50.6% vs. 59.6%) and ivabradine (2.9% vs. 9.3%), but significantly more diuretics (88.1% vs. 72.6%) compared to patients aged less than 60 years (Pfor all trends < 0.01). Moreover, the prescribed target dosages were significantly lower in elderly patients. Also, implantable cardioverter defibrillator (18.9% vs. 44.1%) and cardiac resynchronisation therapy device (14.6% vs. 16.7%) implantation rates were significantly lower in elderly patients. A similar trend in drug prescription was observed in patients with heart failure with mid-range ejection fraction as in heart failure with reduced ejection fraction. CONCLUSION:With increasing age, heart failure with reduced ejection fraction patients less often received guideline-recommended medication prescriptions and also in a lower dosage. In addition, a lower percentage of implantable cardioverter defibrillator and cardiac resynchronisation therapy device implantation in elderly patients was observed.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Veenis JF,Brunner-La Rocca HP,Linssen GC,Geerlings PR,Van Gent MW,Aksoy I,Oosterom L,Moons AH,Hoes AW,Brugts JJ,CHECK-HF investigators.doi
10.1177/2047487319835042subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1399-1407issue
13eissn
2047-4873issn
2047-4881journal_volume
26pub_type
杂志文章abstract:BACKGROUND:The 6-minute walk test (6 MWT) is widely used to assess exercise tolerance in cardiac rehabilitation (CR). However, previous research shows it to be insufficiently responsive, especially for patients with a relatively high maximal exercise tolerance at baseline. We therefore designed a 6-minute walk/run test...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312437038
更新日期:2013-02-01 00:00:00
abstract:AIMS:To investigate whether levels of thyroid-stimulating hormone (TSH) within the normal range are associated with an increased risk of new vascular events and mortality in patients with clinical manifest vascular diseases and whether this relation is influenced by adiposity. METHODS AND RESULTS:Prospective cohort st...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711416045
更新日期:2012-08-01 00:00:00
abstract:AIMS:Exposure to airborne particulate matter has been consistently associated with early death and increased morbidity, particularly raising the risk of cardiovascular disease. Obesity, one of the leading cardiovascular disease risk factors, increases susceptibility to the adverse effects of particulate matter exposure...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318815320
更新日期:2019-04-01 00:00:00
abstract::Atrial fibrillation is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in approximately 25% of patients, which is four to six times more common than in similarly aged patients of the general population. Atrial fibrillation is poorly tolerated by HCM patients, largely due to their d...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319828474
更新日期:2019-02-06 00:00:00
abstract:AIMS:Cardiovascular health metrics predict the risk not only of cardiovascular diseases but also of several types of cancers. Microvascular endothelial dysfunction can predict future cardiovascular adverse events, but the predictive value of microvascular endothelial dysfunction for future risk of solid-tumor cancer ha...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319884246
更新日期:2020-04-01 00:00:00
abstract::Aims HIV-infected persons may have elevated risks for heart failure, but factors associated with heart failure in the modern era of HIV therapy are insufficiently understood. Despite substantial disagreement between physician-adjudicated heart failure and heart failure diagnosis codes, few studies of HIV cohorts have ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317732432
更新日期:2017-11-01 00:00:00
abstract:AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study p...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711432514
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital hea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318812502
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Extracellular matrix-degrading proteinases are upregulated in atherosclerotic lesions and can contribute to subsequent pathological events. In the present nested case-control study, we investigated the association of serum concentrations of matrix metalloproteinases MMP-7, MMP-8, and MMP-13, tissue inhibitor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312465524
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Patients with coronary heart disease often suffer from an impaired health-related quality of life (HRQoL). A healthier lifestyle not only extends individuals' lengths of life but might also improve their HRQoL. The aim of this study was to explore the relation between self-reported lifestyle changes and HRQo...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487312473846
更新日期:2014-07-01 00:00:00
abstract::Clinical guidelines should be based on the best available evidence and are of great importance for patient care and disease prevention. In this respect, the 2013 American College of Cardiology/American Heart Association report is highly appreciated and well-recognized. The report included critical questions concerning...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314567001
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Statin intolerance is a barrier to effective lipid-lowering treatment. A significant number of patients stop prescribed statins, or can take only a reduced dose, because of adverse events attributed to the statin, and are then considered statin-intolerant. METHODS:Examination of differences between statin a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487315602861
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The burden of premature atrial beats (PABs) at 24-h electrocardiographic (ECG) monitoring correlates with the risk of atrial fibrillation. It is unknown whether prolonged and intense exercise increases the burden of PABs, thus contributing to the higher prevalence of atrial fibrillation observed in middle-ag...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319880042
更新日期:2020-09-01 00:00:00
abstract:AIMS:The aim of this study was to evaluate the effect of microsomal triglyceride transfer protein inhibitor (lomitapide) in patients with homozygous familial hypercholesterolaemia. METHODS AND RESULTS:In 12 homozygous familial hypercholesterolaemia patients treated with lipid-lowering drugs ± biweekly lipoprotein aphe...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319870007
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to im...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314552764
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315626547
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Poor adherence to medical treatment represents a major health problem. A subject's misperception of his own cardiovascular risk has been indicated as a key driver for low compliance with preventive measures. This study analysed the relationship between objectively calculated short- and long-term cardiovascul...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314543074
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320909300
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in h...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487314552797
更新日期:2015-09-01 00:00:00
abstract::Background Insomnia symptoms have been suggested to be associated with the risk of cardio-cerebral events. However, the results of previous studies have been inconsistent. Therefore, we conducted a meta-analysis to examine whether there were associations between cardio-cerebral vascular events and insomnia symptoms, i...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487317702043
更新日期:2017-07-01 00:00:00
abstract::Background In view of the increasing heart failure epidemic and awareness of the adverse impact of environmental pollution on human health, we investigated the association of left ventricular structure and function with air pollutants in a general population. Methods In 671 randomly recruited Flemish (51.7% women; mea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317715109
更新日期:2017-09-01 00:00:00
abstract::There are large variations in the incidence, registration methods and reported causes of sudden cardiac arrest/sudden cardiac death (SCA/SCD) in competitive and recreational athletes. A crucial question is to which degree these variations are genuine or partly due to methodological incongruities. This paper discusses ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,实务指引
doi:10.1177/2047487315599891
更新日期:2016-04-01 00:00:00
abstract::Cancer and cardiovascular diseases are the leading causes of death in high-income countries. Cardiovascular complications can be found in cancer patients, being the result of so-called 'cardio-toxicity'. Therefore, it becomes essential to thoroughly investigate the origin of cardiac damage and the strategy to prevent ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319874900
更新日期:2019-10-06 00:00:00
abstract:INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487314560663
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In clinical practice, individuals at increased risk of cardiovascular diseases (CVD) are identified on the basis of age, sex, smoking, blood pressure, and serum total and high-density lipoprotein cholesterol. We examined whether CVD risk prediction improved when obesity (body mass index ≥30 kg/m(2)) and prem...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312444233
更新日期:2013-10-01 00:00:00
abstract::The beneficial effect of exercise training and exercise-based cardiac rehabilitation on symptom-free exercise capacity,cardiovascular and skeletal muscle function, quality of life, general healthy lifestyle, and reduction of depressive symptoms and psychosocial stress is nowadays well recognized. However, it remains l...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487312437063
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Cardiovascular risk factors tend to be clustered. Variations in clusters across populations have not been widely investigated. This study aims to compare the prevalence and clustering of major cardiovascular risk factors between adults in the Netherlands and China. METHODS:A total of 6542 Dutch adults was r...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316648474
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/2047487312460520
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The complexity of treatment regimens, costs and pill burden decrease the medication adherence and contribute to shortfall in cardiovascular preventive drug coverage. The polypill, a fixed dose combination pill of established drugs, is expected to increase adherence and reduce the costs whilst preventing majo...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314550803
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The purpose of this investigation was to identify a quantitative dose-response relationship for enhancing maximal oxygen consumption (VO2max) in healthy sedentary older adults after controlled endurance training. METHODS AND RESULTS:This meta-analysis of controlled clinical trials included 1257 exercisers a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487315582322
更新日期:2016-03-01 00:00:00