Abstract:
BACKGROUND:Extracellular matrix-degrading proteinases are upregulated in atherosclerotic lesions and can contribute to subsequent pathological events. In the present nested case-control study, we investigated the association of serum concentrations of matrix metalloproteinases MMP-7, MMP-8, and MMP-13, tissue inhibitor of metalloproteinase-1 (TIMP-1), and neutrophil elastase (NE) with incident cardiovascular disease (CVD) events. DESIGN:The FINRISK97 cohort included 8090 persons with no history of CVD. During the 10-year follow up, 471 incident CVD cases were ascertained and for them, three individually matched controls (n = 1413) were selected. The CVD events included myocardial infarction, stroke, coronary revascularization, and CVD death. RESULTS:Compared to the controls, the cases had significantly higher serum mean concentrations of MMP-7, MMP-8, and TIMP-1, as well as MMP-7/TIMP-1 ratio. In multivariate analyses adjusted for CVD risk factors, MMP-7, MMP-8, TIMP-1, and MMP-8/TIMP-1 ratio were associated with the risk for incident CVD: OR 1.16 (95% CI 1.03-1.31), OR 1.13 (95% CI 1.01-1.26), OR 1.16 (95% CI 1.02-1.31), and OR 1.13 (95% CI 1.00-1.27) respectively, per SD-increase of log-transformed unit. The associations, however, attenuated into non-significant after adjusting for C-reactive protein (CRP) concentrations. CONCLUSIONS:MMP-7 and MMP-8, which are upregulated during inflammation, can form a proinflammatory tissue destructive cascade. They can be regarded as risk factors, and thus as potential biomarkers for incident CVD. The balance between these MMPs and their tissue inhibitor may indicate vulnerability to plaque rupture.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Tuomainen AM,Kormi I,Havulinna AS,Tervahartiala T,Salomaa V,Sorsa T,Pussinen PJdoi
10.1177/2047487312465524subject
Has Abstractpub_date
2014-07-01 00:00:00pages
806-12issue
7eissn
2047-4873issn
2047-4881pii
2047487312465524journal_volume
21pub_type
杂志文章abstract:BACKGROUND:This study investigates secular trends in ischaemic heart disease (IHD) and stroke mortality by socioeconomic status (SES) in Australia to determine if absolute and relative differences between low and high SES areas have changed over time. METHODS:IHD and stroke mortality data for adults aged 35-74 years a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711427505
更新日期:2012-12-01 00:00:00
abstract::Background Preliminary evidence suggests that peak exercise oxygen pulse - peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden car...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318761679
更新日期:2018-05-01 00:00:00
abstract::Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with conventional risk factor control, significant residual risk remains. Recent evidence on non-traditional determinants of cardiometabolic health has advanced our understanding of lifestyle-disease interactions. Chronic exposure to...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487319869400
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487314560663
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320909300
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:This study aimed to examine the mediating role of psychological distress in the relationship between the physical health component of health-related quality of life (HRQoL) of coronary heart disease patients and their socio-demographic and clinical characteristics. METHODS:This was a cross-sectional study c...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487312451541
更新日期:2014-01-01 00:00:00
abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487317739978
更新日期:2018-02-01 00:00:00
abstract:AIMS:To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS:PLATO (n = 18,624) was a multicentre, double-blind, randomized trial in ACS, that showed a 16% reduction in cardiovascular death (CV-death), myocar...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314533215
更新日期:2015-06-01 00:00:00
abstract::Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,实务指引,评审
doi:10.1177/2047487317702042
更新日期:2017-07-01 00:00:00
abstract::Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in appa...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487317703826
更新日期:2017-07-01 00:00:00
abstract:AIMS:Due to improving cancer treatment results, non-cancer mortality is an important issue for cancer survivors. Cardiovascular diseases are the leading causes of death in Korea and globally. In addition to lowering the risk of cardiovascular disease, the use of statins has led to an overall reduction in cancer mortali...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320905722
更新日期:2020-02-23 00:00:00
abstract:BACKGROUND:The exercise electrocardiographic stress test (ExET) is the most widely used non-invasive diagnostic method to detect coronary artery disease. However, the sole ST depression criteria (ST-max) have poor specificity for coronary artery disease in patients with left ventricular hypertrophy. We hypothesised tha...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316655259
更新日期:2016-10-01 00:00:00
abstract::Demographic changes, progress in medicine technology and regional problems in providing healthcare to low density populations are posing great challenges to our healthcare systems. Rapid progress in computer sciences and information technologies have a great impact on the way healthcare will be delivered in the near f...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316670256
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Extracellular vesicles are released upon cellular activation and mediate inter-cellular communication. Individual species of extracellular vesicles might have divergent roles in vascular homeostasis and may show different responses to therapies such as exercise training. AIMS:We examine endothelial effects ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320919894
更新日期:2020-05-07 00:00:00
abstract::The multiple connections that exist between the cardiovascular system and the kidney lead to a complex cardiovascular and renal medicine relationship. It is well established in the literature that chronic kidney disease (CKD) is an important and independent risk factor for cardiovascular disease (CVD). The prevalence ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487312462826
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND AND AIM:We aimed to investigate cardiovascular risk factors and health behaviours prospectively in a large population of French amateur rugby players. METHODS:An anonymous questionnaire was displayed to rugby players aged over 12 years enrolled in the 2014-2015 French amateur rugby championship from the Bur...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319837066
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To assess the practices of physicians in 12 European countries in the primary prevention of cardiovascular disease (CVD). METHODS:In 2009, 806 physicians from 12 European countries answered a questionnaire, delivered electronically or by post, regarding their assessment of patients with cardiovascular risk ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/1741826711407705
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:The burden of premature atrial beats (PABs) at 24-h electrocardiographic (ECG) monitoring correlates with the risk of atrial fibrillation. It is unknown whether prolonged and intense exercise increases the burden of PABs, thus contributing to the higher prevalence of atrial fibrillation observed in middle-ag...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319880042
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Exercise oscillatory ventilation is an ominous outcome sign in heart failure due to reduced left ventricular ejection fraction; currently, the prevalence of exercise oscillatory ventilation is unknown in left ventricular assist device recipients. METHODS:We studied cardiopulmonary exercise testing in heart ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318801415
更新日期:2018-11-01 00:00:00
abstract:AIMS:Functional capacity is an important endpoint for therapies oriented to older adults with cardiovascular diseases. The literature on predictors of exercise capacity is sparse in the elderly population. In a longitudinal European study on effectiveness of cardiac rehabilitation of seven European countries in elderly...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319894676
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:While associations of smoking and preterm birth (PTB) with maternal cardiovascular disease (CVD) risks have been established, it is unknown whether the coexistence of these two conditions could synergistically increase the risks. METHODS:We linked birth records of 902,008 mothers with singleton infants duri...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487315593836
更新日期:2016-04-01 00:00:00
abstract::Background Statin treatment in association with physical exercise can substantially reduce mortality in dyslipidaemic individuals. However, the available data to compare the efficacy and safety of statins and exercise combination therapy with statin monotherapy are limited. Design Systematic review and meta-analysis. ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487317691874
更新日期:2017-06-01 00:00:00
abstract::Background Cardiac rehabilitation (CR) improves the symptoms, exercise capacity and quality of life of chronic heart failure (CHF) patients. Its effects on new plasma biomarkers of prognostic importance are unknown. The present study aimed at analysing the effects of a structured CR programme on plasma cardiac biomark...
journal_title:European journal of preventive cardiology
pub_type: 临床试验,杂志文章
doi:10.1177/2047487317705488
更新日期:2017-07-01 00:00:00
abstract::Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and app...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316663873
更新日期:2016-12-01 00:00:00
abstract::Background Inverse associations of the Mediterranean diet (MedDiet) and physical activity with cardiovascular disease have been previously reported. We investigated the individual and combined contributions of both to this inverse association in a Mediterranean cohort. Design We used data from 19,536 participants from...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487318783263
更新日期:2018-07-01 00:00:00
abstract::Numerous molecular screening strategies have recently been developed to measure the chemical diversity of a population's biofluids with the ultimate aim to provide clinicians, medical scientists and epidemiologists with a clearer picture of the presence and severity of cardiovascular disease; prognosis; and response t...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316645469
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Cardiovascular diseases (CVD) and cancer are worldwide main causes of death with mortality trends varying across countries with different levels of economic development. DESIGN AND METHODS:We analysed trends in CVD and cancer mortality for 37 European countries, five high-income non-European countries and f...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313497864
更新日期:2014-08-01 00:00:00
abstract:AIMS:Dyslipidaemia is a modifiable cardiovascular risk factor with prognostic implications. Current strategies for lipid management in young adults are largely based on expert recommendations. We investigated the risks of death and cardiovascular disease in relation to each lipid component to establish evidence for pri...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319898571
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to im...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314552764
更新日期:2014-11-01 00:00:00
abstract:AIMS:Recent European guidelines recommend in patients with atherosclerotic cardiovascular disease to achieve a reduction of low-density lipoprotein-cholesterol of at least 50% if the baseline low-density lipoprotein-cholesterol level is between 1.8 and 3.5 mmol/L. Systematic reviews have associated a given statin/dose ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319874898
更新日期:2020-10-01 00:00:00