Abstract:
:Background Cardiac rehabilitation (CR) improves the symptoms, exercise capacity and quality of life of chronic heart failure (CHF) patients. Its effects on new plasma biomarkers of prognostic importance are unknown. The present study aimed at analysing the effects of a structured CR programme on plasma cardiac biomarkers in a large population of patients with CHF and reduced left ventricular ejection fraction (LVEF). Methods We enrolled 107 consecutive CHF patients with LVEF ≤ 45% in an ambulatory CR programme. Peak VO2 and plasma levels of Galectin-3, mid-regional proANP (MR-proADM), soluble suppressor of tumorigenicity 2 (sST2) and mid-regional pro-adrenomedullin (MR-proANP) were assessed at inclusion and at the end of CR. Twenty-four unenrolled patients were managed with standard medical care and evaluated over the same period (no-CR group). Results Galectin-3, sST2, MR-proADM and MR-proANP plasma levels decreased after CR, with respective median reductions of 6.3% for Galectin 3 ( p < 0.001), 7.4% for sST2 ( p = 0.036), 6.4% for MR-proADM ( p = 0.001) and 16% for MR-proANP ( p < 0.001). MR-proADM was negatively correlated with peak VO2 (ρ = -0.529, 95% confidence interval [CI] -0.654 to -0.375, p < 0.001), and so were their relative variations along the course of CR (ρ = -0.357, 95% CI -0.518 to -0.172, p < 0.001). No change occurred in terms of biomarkers in the no-CR group. Conclusions Plasma cardiac biomarkers such as Galectin-3, MR-proADM, sST2 and MR-proANP all decreased after CR in CHF patients, suggesting an overall improvement in the neuro-hormonal profile.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Billebeau G,Vodovar N,Sadoune M,Launay JM,Beauvais F,Cohen-Solal Adoi
10.1177/2047487317705488subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1127-1135issue
11eissn
2047-4873issn
2047-4881journal_volume
24pub_type
临床试验,杂志文章abstract:BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/2047487312460520
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abstract::Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity also translates into cardiovascular health benefits in older adults. Therefore, we aimed to c...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314533215
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abstract:BACKGROUND:Several selected population-based studies have emphasized the significance of resting heart rate as an independent cardiovascular risk factor. However, there are no data available for using resting heart rate as a cardiovascular risk predictor in contemporary primary care. Thus, the aim of our analysis was t...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826710394304
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
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更新日期:2016-01-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-06-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-09-01 00:00:00
abstract::Aims Despite the benefits of regular physical activity participation following acute myocardial infarction, little is known about gender differences in physical activity among patients after acute myocardial infarction. We described, by gender, physical activity trajectories pre- and post-acute myocardial infarction, ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:While cardiorespiratory fitness is strongly related to survival, there are limited data regarding musculoskeletal fitness indicators. Our aim was to evaluate the association between the ability to sit and rise from the floor and all-cause mortality. DESIGN:Retrospective cohort. METHODS:2002 adults aged 51-...
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更新日期:2014-07-01 00:00:00
abstract::Background Epidemiological studies on smoking and atrial fibrillation have been inconsistent, with some studies showing a positive association while others have found no association. It is also unclear whether there is a dose-response relationship between the number of cigarettes smoked or pack-years and the risk of a...
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:Prospective relationships between sedentary behaviour and cardiorespiratory and metabolic markers need to be better delineated in adults with different physical activity levels. We examined the separate and combined relationships of work and leisure time sitting and moderate to vigorous physical activity (MV...
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pub_type: 杂志文章,多中心研究
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abstract:AIMS:Prevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population. METHODS AND RESULTS:We report cross-sectional data from the prospective Characteristics and Course o...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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更新日期:2020-05-06 00:00:00