Abstract:
:Background Statin treatment in association with physical exercise can substantially reduce mortality in dyslipidaemic individuals. However, the available data to compare the efficacy and safety of statins and exercise combination therapy with statin monotherapy are limited. Design Systematic review and meta-analysis. Methods We systematically searched PubMed, Embase and the Cochrane Library from database inception until December 2016. We included randomised and non-randomised studies that compared the efficacy and safety of statins and exercise combination therapy with statin monotherapy in patients with dyslipidaemia. Standardised mean differences were calculated and pooled by means of fixed effects models. The risk of bias and heterogeneity among trials was also assessed. Seven articles were assessed in terms of the efficacy of therapy and 13 from the viewpoint of therapeutic safety. Results In terms of efficacy, statins and exercise combination decreased the incidence of diabetes mellitus, improved insulin sensitivity and inflammation, but caused no change in lipid profile compared to statins alone. In terms of safety, statins and exercise combination increased peak oxygen uptake (standardised mean difference 1.01, 95% confidence interval 0.46 to 1.57) compared to statins alone. In contrast to statin-induced myopathy, chronic exercise training prior to statin treatment could counteract statin-induced adverse effects in skeletal muscle. Conclusion Statins and exercise combination therapy is more effective than statin monotherapy in terms of insulin sensitivity, inflammation and exercise capacity. The small number of studies warrants the need for more randomised controlled trials evaluating the efficacy and safety of combination therapy.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Gui YJ,Liao CX,Liu Q,Guo Y,Yang T,Chen JY,Wang YT,Hu JH,Xu DYdoi
10.1177/2047487317691874subject
Has Abstractpub_date
2017-06-01 00:00:00pages
907-916issue
9eissn
2047-4873issn
2047-4881journal_volume
24pub_type
杂志文章,meta分析,评审abstract:AIMS:The aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques. METHODS:CVD risk was estimated in 210 eligible SLE patients...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320906650
更新日期:2020-03-02 00:00:00
abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315626547
更新日期:2016-08-01 00:00:00
abstract:AIMS:Reviews of clinical practice guidelines have repeatedly concluded that only a minority of guideline recommendations are supported by high-quality evidence from randomised controlled trials. The aim of this study is to evaluate whether these findings apply to the whole cardiovascular evidence base or specific recom...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319868540
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The role of extended thromboprophylaxis is established for surgical patients, but not yet for hospitalised medical patients. DESIGN:This systematic review and meta-analysis sought to explore the role of extended thromboprophylaxis for medically ill hospitalised patients. METHODS:Medline, EMBASE and Cochran...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319836572
更新日期:2019-03-16 00:00:00
abstract:BACKGROUND:Extracellular vesicles are released upon cellular activation and mediate inter-cellular communication. Individual species of extracellular vesicles might have divergent roles in vascular homeostasis and may show different responses to therapies such as exercise training. AIMS:We examine endothelial effects ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320919894
更新日期:2020-05-07 00:00:00
abstract::Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,实务指引,评审
doi:10.1177/2047487317702042
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Several selected population-based studies have emphasized the significance of resting heart rate as an independent cardiovascular risk factor. However, there are no data available for using resting heart rate as a cardiovascular risk predictor in contemporary primary care. Thus, the aim of our analysis was t...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826710394304
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital hea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318812502
更新日期:2019-05-01 00:00:00
abstract::Aims Despite the benefits of regular physical activity participation following acute myocardial infarction, little is known about gender differences in physical activity among patients after acute myocardial infarction. We described, by gender, physical activity trajectories pre- and post-acute myocardial infarction, ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316679905
更新日期:2017-01-01 00:00:00
abstract::Numerous molecular screening strategies have recently been developed to measure the chemical diversity of a population's biofluids with the ultimate aim to provide clinicians, medical scientists and epidemiologists with a clearer picture of the presence and severity of cardiovascular disease; prognosis; and response t...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316645469
更新日期:2016-10-01 00:00:00
abstract:AIMS:The European Cardiac Rehabilitation in the Elderly (EU-CaRE) HORIZON 2020 project compares the sustainable effects of cardiac rehabilitation (CR) in elderly patients. METHODS AND RESULTS:A total of 1633 patients with coronary artery disease (CAD) or heart valve replacement (HVR), with or without revascularization...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320903869
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The contribution of sufficient sleep duration to lower CVD risk in addition to sufficient physical activity, a healthy diet, (moderate) alcohol consumption, and non-smoking has not been investigated yet. DESIGN:The MORGEN study is a prospective cohort study including 8128 men and 9759 women aged 20-65 years...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313493057
更新日期:2014-11-01 00:00:00
abstract::Introduction Diabetes and pre-diabetes are highly prevalent in patients with a history of acute coronary syndrome. This is why screening for glucose metabolism disorders is recommended in patients following an acute coronary syndrome. The aim of our study was to determine whether glycated haemoglobin alone compared wi...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317754011
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The effects of increasing high-density lipoprotein cholesterol on cardiovascular outcomes remain uncertain. DESIGN:We conducted a meta-analysis to investigate the effects of high-density lipoprotein cholesterol modifiers (niacin, fibrates and cholesteryl ester transfer protein inhibitors) on cardiovascular ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487318816495
更新日期:2019-03-01 00:00:00
abstract::Aims HIV-infected persons may have elevated risks for heart failure, but factors associated with heart failure in the modern era of HIV therapy are insufficiently understood. Despite substantial disagreement between physician-adjudicated heart failure and heart failure diagnosis codes, few studies of HIV cohorts have ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317732432
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The aim of the study was to investigate the effects of sesame oil on endothelial function and to detect the underlying mechanisms, both in the postprandial state and after long-term consumption. DESIGN:We enrolled 30 hypertensive men in a two-phase study. In the first phase, 26 volunteers consumed 35 g of e...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312437625
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The complexity of treatment regimens, costs and pill burden decrease the medication adherence and contribute to shortfall in cardiovascular preventive drug coverage. The polypill, a fixed dose combination pill of established drugs, is expected to increase adherence and reduce the costs whilst preventing majo...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314550803
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Hypertension complicated with left ventricular hypertrophy (LVH) and diastolic dysfunction is one of the most common risks for heart failure with preserved ejection fraction (HFpEF). This study was designed to evaluate the influences of long-term beta-blocker prescription in these patients. METHODS:This ret...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316636260
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to im...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314552764
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:International guidelines recommend pharmacotherapy combinations for chronic coronary syndromes (CCSs) but medical management remains suboptimal. DESIGN:The CICD-LT registry is investigating short- and long-term outcomes and management in patients in European Society of Cardiology (ESC) member countries, in ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320912491
更新日期:2020-03-31 00:00:00
abstract:BACKGROUND:Lifestyle-based preventive cardiology aims to combat the global burden of cardiovascular disease. There have been rapid advances in lifestyle and behavioural interventions aimed at preventing cardiovascular disease in individuals at high risk and in the general population. This study is the first bibliometri...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319854827
更新日期:2019-06-17 00:00:00
abstract:AIMS:European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets in high- and very high-risk patients and the addition of adjuvant treatments to statins in uncontrolled patients. We aimed to assess (a) achievement of prior and new European Society of Cardiolog...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320914115
更新日期:2020-03-31 00:00:00
abstract::Background The ratio of estimated glomerular filtration rate (eGFR) to kidney size reflects the kidney's capacity for filtration per kidney volume or kidney length. High ratios of eGFR to kidney size, which might indicate glomerular hyperfiltration, could be related to kidney function decline, cardiovascular disease a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317690950
更新日期:2017-06-01 00:00:00
abstract::The clinical benefits of rehabilitation in cardiovascular disease are well established. Among cardiovascular disease patients, however, patients with type 2 diabetes mellitus require a distinct approach. Specific challenges to clinicians and healthcare professionals in patients with type 2 diabetes include the prevale...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487319882820
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) are often elderly and their primary chronic symptom is severe exercise intolerance that results in a reduced quality of life (QOL).Thus, improvement of exercise capacity and QOL presents an important clinical outcome in HFpEF patients. Alth...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487314564729
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND AIM:We aimed to investigate cardiovascular risk factors and health behaviours prospectively in a large population of French amateur rugby players. METHODS:An anonymous questionnaire was displayed to rugby players aged over 12 years enrolled in the 2014-2015 French amateur rugby championship from the Bur...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319837066
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487314560663
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The 6-minute walk test (6 MWT) is widely used to assess exercise tolerance in cardiac rehabilitation (CR). However, previous research shows it to be insufficiently responsive, especially for patients with a relatively high maximal exercise tolerance at baseline. We therefore designed a 6-minute walk/run test...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312437038
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Endothelial dysfunction is central to the pathogenesis of coronary artery disease, but the role of local and circulating endothelial progenitor cells in maintaining vascular health is poorly understood. We hypothesised that impaired local and circulating vascular repair mechanisms predispose to endothelial d...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487315600169
更新日期:2015-12-01 00:00:00
abstract::Background There are few reviews comparing the long-term outcomes of the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in a hypertensive population because both are effective in reducing blood pressure. None of them compared angiotensin-converting enzyme inhibitors or angiotensin ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487317728766
更新日期:2017-12-01 00:00:00