Abstract:
INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaudioside A) on cardiovascular risk factors, using data from randomised clinical trials (RCTs). METHODS:Electronic searches were conducted in Medline, Embase, Amed, Cinahl and The Cochrane Library. We also searched Google Scholar, and hand searched the bibliography of retrieved full texts. The reporting quality of included studies was assessed using the Cochrane criteria. Two reviewers independently determined the eligibility, assessed the reporting quality, and extracted the data. RESULTS:Nine studies with a total of 756 participants were included. There was a variation in the reporting quality of included studies. Meta-analysis revealed a non-significant difference in systolic blood pressure between steviol glycoside and placebo, mean difference (MD): -2.98 mm Hg (-6.23 to 0.27). Significant reductions in diastolic blood pressure and fasting blood glucose were observed. There was no significant effect on blood lipid profile. Heterogeneity was significant. Adverse events included abdominal fullness, epigastric pain, and dizziness. CONCLUSION:The evidence from published RCTs suggests that stevioside may generate reductions in blood pressure and fasting blood glucose. The sizes of the effects are small, and the substantial heterogeneity limits the robustness of any conclusions. Rebaudioside A does not appear to have any significant effects on blood pressure or cardiovascular risk factors. Available clinical trials vary in design and reporting quality, and some are characterised by inadequate sample sizes. In addition, the participants in most of the trials have high cardiovascular risk. Further clinical trials and regulatory assessments are warranted.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Onakpoya IJ,Heneghan CJdoi
10.1177/2047487314560663subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1575-87issue
12eissn
2047-4873issn
2047-4881pii
2047487314560663journal_volume
22pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Cardiac rehabilitation programmes are strongly recommended for all forms of coronary artery disease to reduce recurrent events and mortality. Few patients seem to participate in these programmes after elective percutaneous coronary intervention (PCI). The aim of this study was to assess changes in lifestyle ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312447751
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The incidence of metabolic syndrome (MetS), diabetes mellitus (DM), and their coexistence is increasing but whether MetS increases cardiovascular risk beyond component risk factors is controversial. DESIGN:We compared the risk of cardiovascular death, myocardial infarction, or stroke among patients with Met...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487313500541
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:There is strong evidence to suggest that social deprivation is linked to health inequalities. In the UK, concerns have been raised regarding disparities in the outcomes of acute cardiac services within the National Health Service (NHS). This study explored whether differences exist in (a) elective hospital p...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314567000
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:This study investigates secular trends in ischaemic heart disease (IHD) and stroke mortality by socioeconomic status (SES) in Australia to determine if absolute and relative differences between low and high SES areas have changed over time. METHODS:IHD and stroke mortality data for adults aged 35-74 years a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711427505
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:While cardiorespiratory fitness is strongly related to survival, there are limited data regarding musculoskeletal fitness indicators. Our aim was to evaluate the association between the ability to sit and rise from the floor and all-cause mortality. DESIGN:Retrospective cohort. METHODS:2002 adults aged 51-...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312471759
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:In order to improve national cardiovascular disease (CVD) epidemiology and prevention, we systematically reviewed and analyzed the relevant literature produced in the last three decades for Spain. DESIGN:Systematic Review. METHODS:We searched for all the articles aiming to monitor CVD clinical endpoints an...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487312455314
更新日期:2013-08-01 00:00:00
abstract::Background Inverse associations of the Mediterranean diet (MedDiet) and physical activity with cardiovascular disease have been previously reported. We investigated the individual and combined contributions of both to this inverse association in a Mediterranean cohort. Design We used data from 19,536 participants from...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487318783263
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Extracellular vesicles are released upon cellular activation and mediate inter-cellular communication. Individual species of extracellular vesicles might have divergent roles in vascular homeostasis and may show different responses to therapies such as exercise training. AIMS:We examine endothelial effects ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320919894
更新日期:2020-05-07 00:00:00
abstract::Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Metho...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316684054
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Population-based risk factor combinations and residual risks for coronary heart disease (CHD) patients on statins were assessed in order to bridge the gap between knowledge on relative effects from clinical trials and absolute risk from real-world practice. DESIGN:Population-based, retrospective 1-year cros...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826710392668
更新日期:2012-02-01 00:00:00
abstract::Clinical guidelines should be based on the best available evidence and are of great importance for patient care and disease prevention. In this respect, the 2013 American College of Cardiology/American Heart Association report is highly appreciated and well-recognized. The report included critical questions concerning...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314567001
更新日期:2016-02-01 00:00:00
abstract::Background Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487317752948
更新日期:2018-04-01 00:00:00
abstract::Aims To evaluate safety and efficacy of moderate intensity interval exercise training early after heart failure decompensation on exercise tolerance and health-related quality of life (HRQoL). Methods and results This is a prospective randomized controlled study. We screened 234 consecutive patients admitted with deco...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/2047487317724575
更新日期:2018-01-01 00:00:00
abstract::The United States Food and Drug Administration (FDA) has introduced manufacturing standards for dietary supplements, including red yeast rice, to assure their identity, purity, strength, and composition. One supplement commonly used to self-treat high cholesterol, red yeast rice, may contain monacolin K, an ingredient...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317715714
更新日期:2017-09-01 00:00:00
abstract:AIMS:European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets in high- and very high-risk patients and the addition of adjuvant treatments to statins in uncontrolled patients. We aimed to assess (a) achievement of prior and new European Society of Cardiolog...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320914115
更新日期:2020-03-31 00:00:00
abstract:INTRODUCTION:While there is evidence of poor health behaviours in anxious and depressed cardiac patients, it is possible that sociodemographic factors explain these associations. Few previous studies have adequately controlled for confounders. The present study investigated health behaviours in anxious and depressed ca...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487312449593
更新日期:2013-12-01 00:00:00
abstract::Aims High concentrations of air pollutants are associated with increased risk for myocardial infarction. The European Union has defined statutory limits for air pollutants based on upper absolute concentrations. We evaluated the association between rapid changes in air pollutants and the risk of myocardial infarction ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318755804
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314547655
更新日期:2015-09-01 00:00:00
abstract::This review highlights the increased risk of cardiovascular disease and the dismal prognosis after acute coronary events when diabetes is present. Although there have been improvements in this area, diabetes still confers an increased risk. In order to achieve successful outcomes in individuals with diabetes, extensiv...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487317709554
更新日期:2017-06-01 00:00:00
abstract::Aims To explore the predictive and explanatory factors on the incidence of cardiovascular disease and the impact of visit-to-visit variability (VVV) of risk factors on incident cardiovascular disease in people with type 2 diabetes with no history of prior cardiovascular disease. Methods We performed a historical cohor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317707293
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The purpose of this investigation was to identify a quantitative dose-response relationship for enhancing maximal oxygen consumption (VO2max) in healthy sedentary older adults after controlled endurance training. METHODS AND RESULTS:This meta-analysis of controlled clinical trials included 1257 exercisers a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487315582322
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Identification of individuals at risk for developing atrial fibrillation (AF) will help to target screening and preventive interventions. We aimed to validate the CHARGE-AF model (including variables age, race, height, weight, blood pressure, smoking, antihypertensive medication, diabetes, myocardial infarct...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314544045
更新日期:2015-07-01 00:00:00
abstract:AIMS:Functional capacity is an important endpoint for therapies oriented to older adults with cardiovascular diseases. The literature on predictors of exercise capacity is sparse in the elderly population. In a longitudinal European study on effectiveness of cardiac rehabilitation of seven European countries in elderly...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319894676
更新日期:2020-11-01 00:00:00
abstract::Background The relationships between dietary intake of soy foods and risk of cardiovascular disease are uncertain. The aims of this study were to evaluate and summarize the evidence on the association between consumption of soy and risk of cardiovascular disease (including stroke and coronary heart disease). Methods W...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487316686441
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The contribution of sufficient sleep duration to lower CVD risk in addition to sufficient physical activity, a healthy diet, (moderate) alcohol consumption, and non-smoking has not been investigated yet. DESIGN:The MORGEN study is a prospective cohort study including 8128 men and 9759 women aged 20-65 years...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313493057
更新日期:2014-11-01 00:00:00
abstract:AIMS:Reviews of clinical practice guidelines have repeatedly concluded that only a minority of guideline recommendations are supported by high-quality evidence from randomised controlled trials. The aim of this study is to evaluate whether these findings apply to the whole cardiovascular evidence base or specific recom...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319868540
更新日期:2019-12-01 00:00:00
abstract::Background In contemporary atrial fibrillation trials most deaths are cardiac related, whereas stroke and bleeding represent only a small subset of deaths. We aimed to evaluate the long-term risk of cardiac events and all-cause mortality in individuals with atrial fibrillation compared to no atrial fibrillation. Desig...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487317715769
更新日期:2017-09-01 00:00:00
abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487317739978
更新日期:2018-02-01 00:00:00
abstract::Aims Haemodynamic parameters during and after exercise test seem to have a role in predicting cardiovascular events. We sought to evaluate the potential different responses in exercise capacity, heart rate and blood pressure levels in relation to major cardiovascular disease risk factors, among individuals undergoing ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317726069
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Patients with coronary heart disease often suffer from an impaired health-related quality of life (HRQoL). A healthier lifestyle not only extends individuals' lengths of life but might also improve their HRQoL. The aim of this study was to explore the relation between self-reported lifestyle changes and HRQo...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487312473846
更新日期:2014-07-01 00:00:00