Abstract:
BACKGROUND:The incidence of metabolic syndrome (MetS), diabetes mellitus (DM), and their coexistence is increasing but whether MetS increases cardiovascular risk beyond component risk factors is controversial. DESIGN:We compared the risk of cardiovascular death, myocardial infarction, or stroke among patients with MetS, newly detected DM, established DM, or coexistent MetS and DM in the global REduction of Atherothrombosis for Continued Health (REACH) registry. METHODS:Outpatients with or at risk for atherothrombosis were recruited between 1 December 2003 and 31 December 2004 and followed up to 4 years for cardiovascular events. Risk was compared in patients with or without MetS or DM after adjustment for age, sex, risk factors, vascular disease, fasting blood glucose, therapy, and region. RESULTS:Among 44,548 REACH participants, 17,887 (40%) were without MetS or DM; 6459 had MetS (15%); 12,059 had established DM (27%); 7503 had both (17%); and 640 had newly detected DM (1%). Presence of MetS was not associated with higher cardiovascular events (12.6%, adjusted HR 0.98, 95% CI 0.89-1.08). In addition, once DM was evident, patients with coexistent MetS had similar increased risk (16.1%, adjusted HR 1.33, 95% CI 1.21-1.47) as DM alone (16.7%, adjusted HR 1.36, 95% CI 1.24-1.48). Newly detected DM was associated with increased cardiovascular risk (18.5%, adjusted HR 1.26, 95% CI 1.02-1.57), similar to longstanding DM. MetS was associated with incident DM (adjusted OR 1.94). CONCLUSIONS:In the REACH registry, presence of newly detected DM but not metabolic syndrome was associated with an increased risk of cardiovascular events.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Udell JA,Steg PG,Scirica BM,Eagle KA,Ohman EM,Goto S,Alsheikh-Ali AA,Porath A,Corbalan R,Umez-Eronini AA,Hoffman EB,Wilson PW,Bhatt DL,Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators.doi
10.1177/2047487313500541subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1531-40issue
12eissn
2047-4873issn
2047-4881pii
2047487313500541journal_volume
21pub_type
杂志文章,多中心研究abstract::Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity also translates into cardiovascular health benefits in older adults. Therefore, we aimed to c...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317737628
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abstract:BACKGROUND:Evaluation of health-related quality of life (HRQL) is important in improving the quality of patient care. The aim of this study was to determine the psychometric properties of the HeartQoL in patients with ischemic heart disease (IHD), specifically angina, myocardial infarction (MI), or ischemic heart failu...
journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
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pub_type: 杂志文章,meta分析
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
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pub_type: 杂志文章,meta分析,评审
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journal_title:European journal of preventive cardiology
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