Abstract:
BACKGROUND:The purpose of this investigation was to identify a quantitative dose-response relationship for enhancing maximal oxygen consumption (VO2max) in healthy sedentary older adults after controlled endurance training. METHODS AND RESULTS:This meta-analysis of controlled clinical trials included 1257 exercisers and 845 controls with a mean age of 67.45 ± 5.25 years. Effect sizes were calculated for training-induced VO2max changes. Different training regimens were analyzed and compared. The weighted net change of the mean VO2max values showed a significant increase of 3.78 ml/kg per min (95% confidence interval = 3.29 to 4.27; p < 0.0001) in response to aerobic training. Interstudy differences in VO2max changes were significantly related to exercise intensity, and explained approximately 11% of the variance of the VO2max responses. VO2max improved significantly at 35%-50% heart rate reserve (HRR) and continued improving at a greater rate with increasing "dose". The largest VO2max-improvement adaptation was achieved with a mean intensity of 66%-73% HRR. The magnitudes of the VO2max adaptation are identical to exercise at 57%-65% HRR and at 75%-80% HRR. Higher intensity doses more than 75-80% HRR did not lead to greater enhancement of VO2max improvements but, conversely, resulted in large declines. CONCLUSIONS:Our data provide quantitative insight into the magnitude of VO2max alterations as affected by exercise intensity, duration, frequency, and program length. The shapes of the dose-response curves are not simply linear, but with many similar trends and noteworthy characteristics. Aerobic training at a mean intensity of 66%-73% HRR with 40-50 min per session for 3-4 day/week for 30-40 weeks appears to be effective and optimal for maximum cardiorespiratory benefits in healthy sedentary older adults.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Huang G,Wang R,Chen P,Huang SC,Donnelly JE,Mehlferber JPdoi
10.1177/2047487315582322subject
Has Abstractpub_date
2016-03-01 00:00:00pages
518-29issue
5eissn
2047-4873issn
2047-4881pii
2047487315582322journal_volume
23pub_type
杂志文章,meta分析abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315626547
更新日期:2016-08-01 00:00:00
abstract:AIMS:The aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques. METHODS:CVD risk was estimated in 210 eligible SLE patients...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320906650
更新日期:2020-03-02 00:00:00
abstract:BACKGROUND:Although the mortality of coronary heart disease (CHD) has declined in Western countries during the last decades, studies have suggested that the prevention and treatment of CHD may not have been as effective in women as in men. We examined gender- and age-specific trends in incidence, case fatality and the ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711421081
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:While associations of smoking and preterm birth (PTB) with maternal cardiovascular disease (CVD) risks have been established, it is unknown whether the coexistence of these two conditions could synergistically increase the risks. METHODS:We linked birth records of 902,008 mothers with singleton infants duri...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487315593836
更新日期:2016-04-01 00:00:00
abstract::Aims Despite the benefits of regular physical activity participation following acute myocardial infarction, little is known about gender differences in physical activity among patients after acute myocardial infarction. We described, by gender, physical activity trajectories pre- and post-acute myocardial infarction, ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316679905
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:There is strong evidence to suggest that social deprivation is linked to health inequalities. In the UK, concerns have been raised regarding disparities in the outcomes of acute cardiac services within the National Health Service (NHS). This study explored whether differences exist in (a) elective hospital p...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314567000
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Statin intolerance is a barrier to effective lipid-lowering treatment. A significant number of patients stop prescribed statins, or can take only a reduced dose, because of adverse events attributed to the statin, and are then considered statin-intolerant. METHODS:Examination of differences between statin a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487315602861
更新日期:2016-05-01 00:00:00
abstract::This review highlights the increased risk of cardiovascular disease and the dismal prognosis after acute coronary events when diabetes is present. Although there have been improvements in this area, diabetes still confers an increased risk. In order to achieve successful outcomes in individuals with diabetes, extensiv...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487317709554
更新日期:2017-06-01 00:00:00
abstract::Aims To explore the predictive and explanatory factors on the incidence of cardiovascular disease and the impact of visit-to-visit variability (VVV) of risk factors on incident cardiovascular disease in people with type 2 diabetes with no history of prior cardiovascular disease. Methods We performed a historical cohor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317707293
更新日期:2017-07-01 00:00:00
abstract::The benefits of physical activity are well established, leading to both cardiovascular and non-cardiovascular benefits, improving quality of life and reducing mortality. Despite such striking body of evidence, patients with hypertrophic cardiomyopathy are often discouraged by health professionals to practice physical a...
journal_title:European journal of preventive cardiology
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更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:Exercise oscillatory ventilation is an ominous outcome sign in heart failure due to reduced left ventricular ejection fraction; currently, the prevalence of exercise oscillatory ventilation is unknown in left ventricular assist device recipients. METHODS:We studied cardiopulmonary exercise testing in heart ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318801415
更新日期:2018-11-01 00:00:00
abstract:AIMS:Exercise is recommended as prevention, management, and control of all stages of hypertension. There are still controversies about the optimal training dose, frequency, and intensity. We aimed to study the effect of aerobic interval training on blood pressure and myocardial function in hypertensive patients. METHO...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/1741826711400512
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Obesity and physical inactivity in children correlate with the presence of cardiovascular risk factors. The aim of this prospective, randomised, interventional study was to examine the long term impact of additional physical exercise lessons at school on fitness and cardiovascular risk factors. METHODS:We r...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487316632966
更新日期:2016-09-01 00:00:00
abstract::Aims Haemodynamic parameters during and after exercise test seem to have a role in predicting cardiovascular events. We sought to evaluate the potential different responses in exercise capacity, heart rate and blood pressure levels in relation to major cardiovascular disease risk factors, among individuals undergoing ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317726069
更新日期:2017-10-01 00:00:00
abstract:AIMS:Recent European guidelines recommend in patients with atherosclerotic cardiovascular disease to achieve a reduction of low-density lipoprotein-cholesterol of at least 50% if the baseline low-density lipoprotein-cholesterol level is between 1.8 and 3.5 mmol/L. Systematic reviews have associated a given statin/dose ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319874898
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Cardiovascular risk factors are known to be associated between parents and offspring. However, whether these associations are reflected in increased offspring mortality has not been extensively studied. DESIGN:This was a family study of 32,536 father-offspring and 39,614 mother-offspring pairs who participa...
journal_title:European journal of preventive cardiology
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doi:10.1177/2047487314562118
更新日期:2016-01-01 00:00:00
abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487317739978
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:We are unaware of any previous investigation that has compared the relationship of key cardiopulmonary exercise testing (CPX) variables to various measures of pathophysiology between heart failure-reduced ejection fraction (HFrEF) and HF-preserved ejection fraction (HFpEF) cohorts that are well matched with ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313476962
更新日期:2014-07-01 00:00:00
abstract::Background In view of the increasing heart failure epidemic and awareness of the adverse impact of environmental pollution on human health, we investigated the association of left ventricular structure and function with air pollutants in a general population. Methods In 671 randomly recruited Flemish (51.7% women; mea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317715109
更新日期:2017-09-01 00:00:00
abstract:AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study p...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711432514
更新日期:2013-02-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320919894
更新日期:2020-05-07 00:00:00
abstract::Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Metho...
journal_title:European journal of preventive cardiology
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更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Previous cross-sectional surveys in different European countries within the EUROASPIRE programme demonstrated a high prevalence of modifiable risk factors, unhealthy lifestyles and inadequate drug treatment in coronary heart disease patients. Comparable data for ischaemic stroke patients is lacking. METHODS...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487314546825
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The contribution of sufficient sleep duration to lower CVD risk in addition to sufficient physical activity, a healthy diet, (moderate) alcohol consumption, and non-smoking has not been investigated yet. DESIGN:The MORGEN study is a prospective cohort study including 8128 men and 9759 women aged 20-65 years...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313493057
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Blood pressure (BP) variations occurring after hospital discharge in a population of older hypertensives have not been previously investigated. DESIGN:elderly (≥65 years) hypertensives admitted to the geriatric acute ward of a university-teaching hospital were enrolled in this prospective observational stud...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711403067
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Few data have assessed the incidence, site and predictors of infections following cardiac surgery after discharge, particularly during an early rehabilitation phase. AIM:To assess the epidemiology and predictors of infections occurring after cardiac surgery. METHODS:Data prospectively recorded from 5464 pa...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487315576129
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:In clinical practice, individuals at increased risk of cardiovascular diseases (CVD) are identified on the basis of age, sex, smoking, blood pressure, and serum total and high-density lipoprotein cholesterol. We examined whether CVD risk prediction improved when obesity (body mass index ≥30 kg/m(2)) and prem...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312444233
更新日期:2013-10-01 00:00:00
abstract:AIMS:The aim of this study was to evaluate the effect of microsomal triglyceride transfer protein inhibitor (lomitapide) in patients with homozygous familial hypercholesterolaemia. METHODS AND RESULTS:In 12 homozygous familial hypercholesterolaemia patients treated with lipid-lowering drugs ± biweekly lipoprotein aphe...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319870007
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The test-retest reliability for multiple cardiopulmonary exercise test (CPX) variables has not been compared in a single study and the influence of different diseases on test-retest reliability has not been examined. We investigated different measures of test-retest reliability for multiple variables and com...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313518474
更新日期:2014-04-01 00:00:00
abstract:AIMS:To investigate whether levels of thyroid-stimulating hormone (TSH) within the normal range are associated with an increased risk of new vascular events and mortality in patients with clinical manifest vascular diseases and whether this relation is influenced by adiposity. METHODS AND RESULTS:Prospective cohort st...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711416045
更新日期:2012-08-01 00:00:00