Abstract:
AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study prospective cohort of 14,846 men aged 40-49 years was followed from screening in 1972-73 until 2006, during which time 1655 subjects died of CHD. Multivariate-adjusted Cox proportional models compared hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD mortality across 0-12, 12-24, and 24-33 years of follow-up. Interactions between risk factors and quartile level of total serum cholesterol were assessed. RESULTS:Total cholesterol, blood pressure, and cigarette smoking were associated with CHD mortality in multivariate analyses across all follow-up periods. Nonfasting triglyceride levels were associated with CHD in multivariate analyses (0-12 years, HR 1.12, 95% CI 1.00-1.25; 12-24 years, HR 1.13, 95% CI 1.04-1.23; 24-33 years, HR 1.09, 95% CI 1.00-1.19; 0-33 years, HR 1.10, 95% CI 1.05-1.16). A metabolic risk factor score (based on blood pressure, triglycerides, body mass index, and glucose) retained predictivity across all periods. The relations between systolic blood pressure, triglycerides, and metabolic risk factor score to CHD were stronger in the lower than the upper quartiles of serum cholesterol (p < 0.001). CONCLUSIONS:Conventional risk factors and nonfasting triglycerides increased CHD mortality across all periods of follow-up. The association with metabolic variables was strongest in men with low total cholesterol levels supporting the idea that lowering cholesterol should be the primary target of primary prevention.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Holme I,Tonstad Sdoi
10.1177/1741826711432514subject
Has Abstractpub_date
2013-02-01 00:00:00pages
168-75issue
1eissn
2047-4873issn
2047-4881pii
1741826711432514journal_volume
20pub_type
杂志文章abstract:AIMS:The aim of this study was to evaluate the effect of microsomal triglyceride transfer protein inhibitor (lomitapide) in patients with homozygous familial hypercholesterolaemia. METHODS AND RESULTS:In 12 homozygous familial hypercholesterolaemia patients treated with lipid-lowering drugs ± biweekly lipoprotein aphe...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319870007
更新日期:2020-01-01 00:00:00
abstract::Background There are few reviews comparing the long-term outcomes of the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in a hypertensive population because both are effective in reducing blood pressure. None of them compared angiotensin-converting enzyme inhibitors or angiotensin ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-12-01 00:00:00
abstract:AIMS:Prevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population. METHODS AND RESULTS:We report cross-sectional data from the prospective Characteristics and Course o...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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更新日期:2020-05-06 00:00:00
abstract::Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected me...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318772945
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:We are unaware of any previous investigation that has compared the relationship of key cardiopulmonary exercise testing (CPX) variables to various measures of pathophysiology between heart failure-reduced ejection fraction (HFrEF) and HF-preserved ejection fraction (HFpEF) cohorts that are well matched with ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313476962
更新日期:2014-07-01 00:00:00
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journal_title:European journal of preventive cardiology
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abstract:AIMS:Cardiovascular health metrics predict the risk not only of cardiovascular diseases but also of several types of cancers. Microvascular endothelial dysfunction can predict future cardiovascular adverse events, but the predictive value of microvascular endothelial dysfunction for future risk of solid-tumor cancer ha...
journal_title:European journal of preventive cardiology
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abstract:BACKGROUND:Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital hea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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abstract:INTRODUCTION:While there is evidence of poor health behaviours in anxious and depressed cardiac patients, it is possible that sociodemographic factors explain these associations. Few previous studies have adequately controlled for confounders. The present study investigated health behaviours in anxious and depressed ca...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314533215
更新日期:2015-06-01 00:00:00
abstract::Background Inverse associations of the Mediterranean diet (MedDiet) and physical activity with cardiovascular disease have been previously reported. We investigated the individual and combined contributions of both to this inverse association in a Mediterranean cohort. Design We used data from 19,536 participants from...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487318783263
更新日期:2018-07-01 00:00:00
abstract::Background In view of the increasing heart failure epidemic and awareness of the adverse impact of environmental pollution on human health, we investigated the association of left ventricular structure and function with air pollutants in a general population. Methods In 671 randomly recruited Flemish (51.7% women; mea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317715109
更新日期:2017-09-01 00:00:00
abstract:AIMS:Previous prospective studies of the association between mortality and physical activity have generally not fully accounted for the interplay between movement behaviours. A compositional data modelling approach accounts for relative scale and co-dependency in time-use data across physical activity behaviours of the...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319867783
更新日期:2019-08-05 00:00:00
abstract:AIMS:European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets in high- and very high-risk patients and the addition of adjuvant treatments to statins in uncontrolled patients. We aimed to assess (a) achievement of prior and new European Society of Cardiolog...
journal_title:European journal of preventive cardiology
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doi:10.1177/2047487320914115
更新日期:2020-03-31 00:00:00
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journal_title:European journal of preventive cardiology
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更新日期:2020-07-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319841939
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Intermittent claudication, defined as fatigue or pain in the legs while walking, is a common symptom in peripheral arterial disease. Although exercise effectively improves function and manages symptoms, adherence rates are not ideal. The high levels of pain experienced in traditional exercise programmes may ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319846997
更新日期:2019-10-01 00:00:00
abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487317739978
更新日期:2018-02-01 00:00:00
abstract::Background Physical fitness has been shown to predict cardiovascular death during long-term follow-up. In the present study we aimed to investigate how physical fitness and other cardiovascular risk factors at middle-age influenced the risk of cardiovascular death during the early (0-11 years), intermediate (12-23 yea...
journal_title:European journal of preventive cardiology
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更新日期:2018-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-08-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487319848105
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The exercise electrocardiographic stress test (ExET) is the most widely used non-invasive diagnostic method to detect coronary artery disease. However, the sole ST depression criteria (ST-max) have poor specificity for coronary artery disease in patients with left ventricular hypertrophy. We hypothesised tha...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316655259
更新日期:2016-10-01 00:00:00
abstract::Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and app...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316663873
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Obesity and physical inactivity in children correlate with the presence of cardiovascular risk factors. The aim of this prospective, randomised, interventional study was to examine the long term impact of additional physical exercise lessons at school on fitness and cardiovascular risk factors. METHODS:We r...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487316632966
更新日期:2016-09-01 00:00:00
abstract::Background Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316679904
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Cardiac rehabilitation programmes are strongly recommended for all forms of coronary artery disease to reduce recurrent events and mortality. Few patients seem to participate in these programmes after elective percutaneous coronary intervention (PCI). The aim of this study was to assess changes in lifestyle ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312447751
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Lifestyle-based preventive cardiology aims to combat the global burden of cardiovascular disease. There have been rapid advances in lifestyle and behavioural interventions aimed at preventing cardiovascular disease in individuals at high risk and in the general population. This study is the first bibliometri...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319854827
更新日期:2019-06-17 00:00:00
abstract:OBJECTIVES:To assess the practices of physicians in 12 European countries in the primary prevention of cardiovascular disease (CVD). METHODS:In 2009, 806 physicians from 12 European countries answered a questionnaire, delivered electronically or by post, regarding their assessment of patients with cardiovascular risk ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/1741826711407705
更新日期:2012-06-01 00:00:00