Abstract:
:Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposition to a polypharmacy burden represents a favourable substrate for the onset of non-steroidal anti-inflammatory drug-induced deleterious effects. Cardiovascular and renal issues concerning the occurrence of myocardial infarction, atrial fibrillation, heart failure and arterial hypertension, as well as acute or chronic kidney damage, become critical for clinicians in their daily practice. We discuss current available knowledge regarding prostanoid physiology in vascular, cardiac and renal systems, pointing out potential negative non-steroidal anti-inflammatory drug-related issues in clinical practice.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Cabassi A,Tedeschi S,Perlini S,Verzicco I,Volpi R,Gonzi G,Canale SDdoi
10.1177/2047487319848105subject
Has Abstractpub_date
2020-05-01 00:00:00pages
850-867issue
8eissn
2047-4873issn
2047-4881journal_volume
27pub_type
杂志文章,评审abstract:AIMS:Functional capacity is an important endpoint for therapies oriented to older adults with cardiovascular diseases. The literature on predictors of exercise capacity is sparse in the elderly population. In a longitudinal European study on effectiveness of cardiac rehabilitation of seven European countries in elderly...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319894676
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital hea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318812502
更新日期:2019-05-01 00:00:00
abstract:AIMS:Exposure to airborne particulate matter has been consistently associated with early death and increased morbidity, particularly raising the risk of cardiovascular disease. Obesity, one of the leading cardiovascular disease risk factors, increases susceptibility to the adverse effects of particulate matter exposure...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318815320
更新日期:2019-04-01 00:00:00
abstract::Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected me...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318772945
更新日期:2018-07-01 00:00:00
abstract:AIMS:The aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques. METHODS:CVD risk was estimated in 210 eligible SLE patients...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320906650
更新日期:2020-03-02 00:00:00
abstract:BACKGROUND:This study investigates secular trends in ischaemic heart disease (IHD) and stroke mortality by socioeconomic status (SES) in Australia to determine if absolute and relative differences between low and high SES areas have changed over time. METHODS:IHD and stroke mortality data for adults aged 35-74 years a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711427505
更新日期:2012-12-01 00:00:00
abstract::Patients affected by pulmonary arterial hypertension (PAH) show a reduced exercise tolerance with early occurrence of dyspnoea and fatigue. The origin of functional capacity limitation is multifactorial and several mechanisms have been proposed, including right heart failure, which leads to a limited increase in cardi...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/1741826711426635
更新日期:2012-10-01 00:00:00
abstract::Background Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487317752948
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487314560663
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:We are unaware of any previous investigation that has compared the relationship of key cardiopulmonary exercise testing (CPX) variables to various measures of pathophysiology between heart failure-reduced ejection fraction (HFrEF) and HF-preserved ejection fraction (HFpEF) cohorts that are well matched with ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313476962
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left ventricular diastolic dysfunction is a prognostic indicator of heart failure, in particularly of heart failure with preserved ejection fraction and of future cardiovascular and all-...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318816774
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The Comparison of Sacubitril-Valsartan versus Enalapril on Effect on NT-proBNP in Patients Stabilised from an Acute Heart Failure Episode (PIONEER-HF) trial demonstrated significant reductions in N-terminal pro-B-type natriuretic peptide. Our study explored the cost-effectiveness of the use of sacubitril-val...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319878953
更新日期:2019-10-04 00:00:00
abstract:BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) are often elderly and their primary chronic symptom is severe exercise intolerance that results in a reduced quality of life (QOL).Thus, improvement of exercise capacity and QOL presents an important clinical outcome in HFpEF patients. Alth...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487314564729
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320909300
更新日期:2020-03-03 00:00:00
abstract::The clinical benefits of rehabilitation in cardiovascular disease are well established. Among cardiovascular disease patients, however, patients with type 2 diabetes mellitus require a distinct approach. Specific challenges to clinicians and healthcare professionals in patients with type 2 diabetes include the prevale...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487319882820
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the validity and reliability of the HeartQoL instrument in a population of stable coronary patients. DESIGN:Analyses are based on the cross-sectional EUROASPIRE IV (EUROpean Action on Secondary and Primary prevention through Intervention to Reduce Events) survey. ME...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315604837
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315626547
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:There is strong evidence to suggest that social deprivation is linked to health inequalities. In the UK, concerns have been raised regarding disparities in the outcomes of acute cardiac services within the National Health Service (NHS). This study explored whether differences exist in (a) elective hospital p...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487314567000
更新日期:2016-02-01 00:00:00
abstract:AIMS:The aim of this study was to evaluate the effect of microsomal triglyceride transfer protein inhibitor (lomitapide) in patients with homozygous familial hypercholesterolaemia. METHODS AND RESULTS:In 12 homozygous familial hypercholesterolaemia patients treated with lipid-lowering drugs ± biweekly lipoprotein aphe...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319870007
更新日期:2020-01-01 00:00:00
abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487317739978
更新日期:2018-02-01 00:00:00
abstract::Background In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. Methods From October 2013 ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316679527
更新日期:2017-02-01 00:00:00
abstract::Introduction Diabetes and pre-diabetes are highly prevalent in patients with a history of acute coronary syndrome. This is why screening for glucose metabolism disorders is recommended in patients following an acute coronary syndrome. The aim of our study was to determine whether glycated haemoglobin alone compared wi...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317754011
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown. OBJECTIVE:The purpose of this study was to investigate the prevalence of abdominal obesity and its association with recurrent atherosclerotic cardiovascular disease in ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319898019
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The exercise electrocardiographic stress test (ExET) is the most widely used non-invasive diagnostic method to detect coronary artery disease. However, the sole ST depression criteria (ST-max) have poor specificity for coronary artery disease in patients with left ventricular hypertrophy. We hypothesised tha...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316655259
更新日期:2016-10-01 00:00:00
abstract::Background Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316679904
更新日期:2017-03-01 00:00:00
abstract::Aims To explore the predictive and explanatory factors on the incidence of cardiovascular disease and the impact of visit-to-visit variability (VVV) of risk factors on incident cardiovascular disease in people with type 2 diabetes with no history of prior cardiovascular disease. Methods We performed a historical cohor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317707293
更新日期:2017-07-01 00:00:00
abstract::Patients with coeliac disease and myocardial infarction have a more favourable atherosclerotic risk factor profile than controls with myocardial infarction (MI). Therefore, MI prognosis and treatment may differ according to coeliac status. This paper reports on the study of Swedish MI patients with and without coeliac...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313502446
更新日期:2015-01-01 00:00:00
abstract::Background Physical fitness has been shown to predict cardiovascular death during long-term follow-up. In the present study we aimed to investigate how physical fitness and other cardiovascular risk factors at middle-age influenced the risk of cardiovascular death during the early (0-11 years), intermediate (12-23 yea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318793459
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Extracellular matrix-degrading proteinases are upregulated in atherosclerotic lesions and can contribute to subsequent pathological events. In the present nested case-control study, we investigated the association of serum concentrations of matrix metalloproteinases MMP-7, MMP-8, and MMP-13, tissue inhibitor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312465524
更新日期:2014-07-01 00:00:00
abstract::Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317743355
更新日期:2018-02-01 00:00:00