Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice.

Abstract:

:Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposition to a polypharmacy burden represents a favourable substrate for the onset of non-steroidal anti-inflammatory drug-induced deleterious effects. Cardiovascular and renal issues concerning the occurrence of myocardial infarction, atrial fibrillation, heart failure and arterial hypertension, as well as acute or chronic kidney damage, become critical for clinicians in their daily practice. We discuss current available knowledge regarding prostanoid physiology in vascular, cardiac and renal systems, pointing out potential negative non-steroidal anti-inflammatory drug-related issues in clinical practice.

journal_name

Eur J Prev Cardiol

authors

Cabassi A,Tedeschi S,Perlini S,Verzicco I,Volpi R,Gonzi G,Canale SD

doi

10.1177/2047487319848105

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

850-867

issue

8

eissn

2047-4873

issn

2047-4881

journal_volume

27

pub_type

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