Abstract：
BACKGROUND:Statin intolerance is a barrier to effective lipid-lowering treatment. A significant number of patients stop prescribed statins, or can take only a reduced dose, because of adverse events attributed to the statin, and are then considered statin-intolerant. METHODS:Examination of differences between statin and placebo in withdrawal rates due to adverse events - a good measure of tolerability - in statin cardiovascular outcome trials in patients with advanced disease and complex medical histories, who may be more vulnerable to adverse effects. The arguments commonly used to dismiss safety and tolerability data in statin clinical trials are examined. RESULTS:Rates of withdrawal due to adverse events in trials in patients with advanced disease and complex medical histories are consistently similar in the statin and placebo groups. We find no support for arguments that statin cardiovascular outcome trials do not translate to clinical practice. CONCLUSIONS:Given the absence of any signal of intolerance in clinical trials, it appears that statin intolerance in the clinic is commonly due to the nocebo effect causing patients to attribute background symptoms to the statin. Consistent with this, over 90% of patients who have stopped treatment because of an adverse event can tolerate a statin if re-challenged. Consequently, new agents, including monoclonal antibodies to proprotein convertase subtilisin/kexin type 9, will be useful when added to statin therapy but should rarely be used as a statin substitute.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Tobert JA,Newman CBdoi
10.1177/2047487315602861subject
Has Abstractpub_date
2016-05-01 00:00:00pages
891-6issue
8eissn
2047-4873issn
2047-4881pii
2047487315602861journal_volume
23pub_type
杂志文章,评审abstract：:Background Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487316679904
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:While cardiorespiratory fitness is strongly related to survival, there are limited data regarding musculoskeletal fitness indicators. Our aim was to evaluate the association between the ability to sit and rise from the floor and all-cause mortality. DESIGN:Retrospective cohort. METHODS:2002 adults aged 51-...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487312471759
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Cardiac rehabilitation programmes are strongly recommended for all forms of coronary artery disease to reduce recurrent events and mortality. Few patients seem to participate in these programmes after elective percutaneous coronary intervention (PCI). The aim of this study was to assess changes in lifestyle ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487312447751
更新日期：2013-10-01 00:00:00
abstract：AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study p...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711432514
更新日期：2013-02-01 00:00:00
abstract：:Background In contemporary atrial fibrillation trials most deaths are cardiac related, whereas stroke and bleeding represent only a small subset of deaths. We aimed to evaluate the long-term risk of cardiac events and all-cause mortality in individuals with atrial fibrillation compared to no atrial fibrillation. Desig...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487317715769
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The global coronavirus disease 2019 pandemic has highlighted the importance of understanding the cardiovascular implications of coronavirus infections, with more severe disease in those with cardiovascular co-morbidities, and resulting cardiac manifestations such as myocardial injury, arrhythmias, and heart ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320925965
更新日期：2020-07-01 00:00:00
abstract：:Background Patient activity (PA) has been demonstrated to predict all-cause mortality. However, the association between PA and cardiac death is unclear. Aims The aims of this study were to determine whether PA can predict cardiac death and what is the cut-off of PA to discriminate cardiac death, as well as the mechani...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487316688982
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Few data have assessed the incidence, site and predictors of infections following cardiac surgery after discharge, particularly during an early rehabilitation phase. AIM:To assess the epidemiology and predictors of infections occurring after cardiac surgery. METHODS:Data prospectively recorded from 5464 pa...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487315576129
更新日期：2016-04-01 00:00:00
abstract：:Despite the proven efficacy and cost-effectiveness of contemporary cardiovascular rehabilitation programmes, the referral to/uptake of and adherence to cardiovascular rehabilitation remains inadequate. In addition, heterogeneity persists amongst different cardiovascular rehabilitation centres in Europe, despite the av...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320924912
更新日期：2020-06-01 00:00:00
abstract：AIMS:Self-monitoring and self-titration of antihypertensives (self-management) is a novel intervention which improves blood pressure control. However, little evidence exists regarding the cost-effectiveness of self-monitoring of blood pressure in general and self-management in particular. This study aimed to evaluate w...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/2047487313501886
更新日期：2014-12-01 00:00:00
abstract：:Aims HIV-infected persons may have elevated risks for heart failure, but factors associated with heart failure in the modern era of HIV therapy are insufficiently understood. Despite substantial disagreement between physician-adjudicated heart failure and heart failure diagnosis codes, few studies of HIV cohorts have ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317732432
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320909300
更新日期：2020-03-03 00:00:00
abstract：:Background In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. Methods From October 2013 ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/2047487316679527
更新日期：2017-02-01 00:00:00
abstract：:Using data from the Seven Countries Study of Cardiovascular Diseases, the first study to conduct international comparisons of men in different European, USA, and Japanese cohorts, we examined the effect of diet-associated inflammation on prediction of coronary heart disease-, other major cardiovascular disease- and al...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320903866
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the effect of a physical activity telemonitoring program on daily physical activity level, oxygen uptake capacity (VO(2peak)), and cardiovascular risk profile in coronary artery disease (CAD) patients who completed phase II cardiac rehabilitation (CR). METHODS:Eight...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/2047487313514018
更新日期：2015-02-01 00:00:00
abstract：:Aims To explore the predictive and explanatory factors on the incidence of cardiovascular disease and the impact of visit-to-visit variability (VVV) of risk factors on incident cardiovascular disease in people with type 2 diabetes with no history of prior cardiovascular disease. Methods We performed a historical cohor...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317707293
更新日期：2017-07-01 00:00:00
abstract：:Background There are few reviews comparing the long-term outcomes of the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in a hypertensive population because both are effective in reducing blood pressure. None of them compared angiotensin-converting enzyme inhibitors or angiotensin ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487317728766
更新日期：2017-12-01 00:00:00
abstract：:Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析
doi：10.1177/2047487317739978
更新日期：2018-02-01 00:00:00
abstract：AIMS:Prevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population. METHODS AND RESULTS:We report cross-sectional data from the prospective Characteristics and Course o...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320922636
更新日期：2020-05-06 00:00:00
abstract：OBJECTIVE:To determine the cost-effectiveness of apixaban versus warfarin in patients with atrial fibrillation (AF) with a moderate to severe risk of stroke, from an Australian government-perspective. METHODS:A decision-analytic Markov model was constructed to assess the cost-effectiveness of apixaban versus warfarin,...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313514019
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The purpose of this investigation was to identify a quantitative dose-response relationship for enhancing maximal oxygen consumption (VO2max) in healthy sedentary older adults after controlled endurance training. METHODS AND RESULTS:This meta-analysis of controlled clinical trials included 1257 exercisers a...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析
doi：10.1177/2047487315582322
更新日期：2016-03-01 00:00:00
abstract：AIMS:To investigate whether levels of thyroid-stimulating hormone (TSH) within the normal range are associated with an increased risk of new vascular events and mortality in patients with clinical manifest vascular diseases and whether this relation is influenced by adiposity. METHODS AND RESULTS:Prospective cohort st...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711416045
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-...
journal_title：European journal of preventive cardiology
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doi：10.1177/2047487319835042
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Intermittent claudication, defined as fatigue or pain in the legs while walking, is a common symptom in peripheral arterial disease. Although exercise effectively improves function and manages symptoms, adherence rates are not ideal. The high levels of pain experienced in traditional exercise programmes may ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319846997
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:We are unaware of any previous investigation that has compared the relationship of key cardiopulmonary exercise testing (CPX) variables to various measures of pathophysiology between heart failure-reduced ejection fraction (HFrEF) and HF-preserved ejection fraction (HFpEF) cohorts that are well matched with ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313476962
更新日期：2014-07-01 00:00:00
abstract：:Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposi...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487319848105
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/2047487314547655
更新日期：2015-09-01 00:00:00
abstract：AIMS:To investigate the clinical relevance of contemporary cut-offs of left ventricular ejection fraction (LVEF) including an intermediate phenotype with mid-range reduced ejection fraction among patients with coronary artery disease undergoing percutaneous coronary intervention. METHODS AND RESULTS:Patient-level data...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319841939
更新日期：2019-08-01 00:00:00
abstract：:Aerobic exercise intensity prescription is a key issue in cardiac rehabilitation, being directly linked to both the amount of improvement in exercise capacity and the risk of adverse events during exercise. This joint position statement aims to provide professionals with up-to-date information regarding the identifica...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,实务指引
doi：10.1177/2047487312460484
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Hypertension complicated with left ventricular hypertrophy (LVH) and diastolic dysfunction is one of the most common risks for heart failure with preserved ejection fraction (HFpEF). This study was designed to evaluate the influences of long-term beta-blocker prescription in these patients. METHODS:This ret...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487316636260
更新日期：2016-09-01 00:00:00
