Abstract:
:Background In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. Methods From October 2013 to July 2015, patients with elective transcatheter aortic valve implantation and a subsequent inpatient cardiac rehabilitation were enrolled in the prospective cohort multicentre study. Frailty-Index (including cognition, nutrition, autonomy and mobility), Short Form-12 (SF-12), six-minute walk distance (6MWD) and maximum work load in bicycle ergometry were performed at admission and discharge of cardiac rehabilitation. The relation between patient characteristics and improvements in 6MWD, maximum work load or SF-12 scales were studied univariately and multivariately using regression models. Results One hundred and thirty-six patients (80.6 ± 5.0 years, 47.8% male) were enrolled. 6MWD and maximum work load increased by 56.3 ± 65.3 m ( p < 0.001) and 8.0 ± 14.9 watts ( p < 0.001), respectively. An improvement in SF-12 (physical 2.5 ± 8.7, p = 0.001, mental 3.4 ± 10.2, p = 0.003) could be observed. In multivariate analysis, age and higher education were significantly associated with a reduced 6MWD, whereas cognition and obesity showed a positive predictive value. Higher cognition, nutrition and autonomy positively influenced the physical scale of SF-12. Additionally, the baseline values of SF-12 had an inverse impact on the change during cardiac rehabilitation. Conclusions Cardiac rehabilitation can improve functional capacity as well as quality of life and reduce frailty in patients after transcatheter aortic valve implantation. An individually tailored therapy with special consideration of cognition and nutrition is needed to maintain autonomy and empower octogenarians in coping with challenges of everyday life.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Eichler S,Salzwedel A,Reibis R,Nothroff J,Harnath A,Schikora M,Butter C,Wegscheider K,Völler Hdoi
10.1177/2047487316679527subject
Has Abstractpub_date
2017-02-01 00:00:00pages
257-264issue
3eissn
2047-4873issn
2047-4881pii
2047487316679527journal_volume
24pub_type
杂志文章,多中心研究abstract:BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/2047487312460520
更新日期:2014-02-01 00:00:00
abstract::Background Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487316679904
更新日期:2017-03-01 00:00:00
abstract::Aerobic exercise intensity prescription is a key issue in cardiac rehabilitation, being directly linked to both the amount of improvement in exercise capacity and the risk of adverse events during exercise. This joint position statement aims to provide professionals with up-to-date information regarding the identifica...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,实务指引
doi:10.1177/2047487312460484
更新日期:2013-06-01 00:00:00
abstract::Background Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487317752948
更新日期:2018-04-01 00:00:00
abstract:AIMS:To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS:PLATO (n = 18,624) was a multicentre, double-blind, randomized trial in ACS, that showed a 16% reduction in cardiovascular death (CV-death), myocar...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314533215
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown. OBJECTIVE:The purpose of this study was to investigate the prevalence of abdominal obesity and its association with recurrent atherosclerotic cardiovascular disease in ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319898019
更新日期:2020-12-01 00:00:00
abstract::Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and app...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316663873
更新日期:2016-12-01 00:00:00
abstract:AIMS:Recent European guidelines recommend in patients with atherosclerotic cardiovascular disease to achieve a reduction of low-density lipoprotein-cholesterol of at least 50% if the baseline low-density lipoprotein-cholesterol level is between 1.8 and 3.5 mmol/L. Systematic reviews have associated a given statin/dose ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319874898
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Endothelial dysfunction is central to the pathogenesis of coronary artery disease, but the role of local and circulating endothelial progenitor cells in maintaining vascular health is poorly understood. We hypothesised that impaired local and circulating vascular repair mechanisms predispose to endothelial d...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487315600169
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Patients with symptoms of depression and/or anxiety - emotional distress - after a myocardial infarction (MI) have been shown to have worse prognosis and increased healthcare costs. However, whether specific subgroups of patients with emotional distress are more vulnerable is less well established. The purpo...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319841475
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to im...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314552764
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) are often elderly and their primary chronic symptom is severe exercise intolerance that results in a reduced quality of life (QOL).Thus, improvement of exercise capacity and QOL presents an important clinical outcome in HFpEF patients. Alth...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487314564729
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Extracellular matrix-degrading proteinases are upregulated in atherosclerotic lesions and can contribute to subsequent pathological events. In the present nested case-control study, we investigated the association of serum concentrations of matrix metalloproteinases MMP-7, MMP-8, and MMP-13, tissue inhibitor...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312465524
更新日期:2014-07-01 00:00:00
abstract:AIMS:To investigate the clinical relevance of contemporary cut-offs of left ventricular ejection fraction (LVEF) including an intermediate phenotype with mid-range reduced ejection fraction among patients with coronary artery disease undergoing percutaneous coronary intervention. METHODS AND RESULTS:Patient-level data...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319841939
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:South Asians presenting with chest pain in the UK experience disproportionately greater delays with respect to diagnosis and treatment for acute myocardial infarction (AMI). The duration of time between symptom onset and hospital intervention is a critical delay for AMI but there are limited data amongst Sou...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312447844
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Patients with coronary heart disease often suffer from an impaired health-related quality of life (HRQoL). A healthier lifestyle not only extends individuals' lengths of life but might also improve their HRQoL. The aim of this study was to explore the relation between self-reported lifestyle changes and HRQo...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487312473846
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the validity and reliability of the HeartQoL instrument in a population of stable coronary patients. DESIGN:Analyses are based on the cross-sectional EUROASPIRE IV (EUROpean Action on Secondary and Primary prevention through Intervention to Reduce Events) survey. ME...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487315604837
更新日期:2016-05-01 00:00:00
abstract::Background In view of the increasing heart failure epidemic and awareness of the adverse impact of environmental pollution on human health, we investigated the association of left ventricular structure and function with air pollutants in a general population. Methods In 671 randomly recruited Flemish (51.7% women; mea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317715109
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:In order to improve national cardiovascular disease (CVD) epidemiology and prevention, we systematically reviewed and analyzed the relevant literature produced in the last three decades for Spain. DESIGN:Systematic Review. METHODS:We searched for all the articles aiming to monitor CVD clinical endpoints an...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487312455314
更新日期:2013-08-01 00:00:00
abstract::Using data from the Seven Countries Study of Cardiovascular Diseases, the first study to conduct international comparisons of men in different European, USA, and Japanese cohorts, we examined the effect of diet-associated inflammation on prediction of coronary heart disease-, other major cardiovascular disease- and al...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320903866
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Although the mortality of coronary heart disease (CHD) has declined in Western countries during the last decades, studies have suggested that the prevention and treatment of CHD may not have been as effective in women as in men. We examined gender- and age-specific trends in incidence, case fatality and the ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711421081
更新日期:2012-10-01 00:00:00
abstract::Background There are few reviews comparing the long-term outcomes of the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in a hypertensive population because both are effective in reducing blood pressure. None of them compared angiotensin-converting enzyme inhibitors or angiotensin ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487317728766
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Urban middle-socioeconomic status (SES) subjects have high burden of cardiovascular risk factors in low-income countries. To determine secular trends in risk factors among this population and to correlate risks with educational status we performed epidemiological studies in India. METHODS:Five cross-section...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711424567
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Quadriceps strength is related to exercise capacity in normal subjects and different patient populations, but the relationship between maximal quadriceps isometric strength (QIS) and different exercise capacity levels in coronary artery disease (CAD) patients has not been systematically evaluated yet. METHO...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313492252
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The contribution of sufficient sleep duration to lower CVD risk in addition to sufficient physical activity, a healthy diet, (moderate) alcohol consumption, and non-smoking has not been investigated yet. DESIGN:The MORGEN study is a prospective cohort study including 8128 men and 9759 women aged 20-65 years...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313493057
更新日期:2014-11-01 00:00:00
abstract:AIMS:The aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques. METHODS:CVD risk was estimated in 210 eligible SLE patients...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320906650
更新日期:2020-03-02 00:00:00
abstract::There are large variations in the incidence, registration methods and reported causes of sudden cardiac arrest/sudden cardiac death (SCA/SCD) in competitive and recreational athletes. A crucial question is to which degree these variations are genuine or partly due to methodological incongruities. This paper discusses ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,实务指引
doi:10.1177/2047487315599891
更新日期:2016-04-01 00:00:00
abstract::Background Physical fitness has been shown to predict cardiovascular death during long-term follow-up. In the present study we aimed to investigate how physical fitness and other cardiovascular risk factors at middle-age influenced the risk of cardiovascular death during the early (0-11 years), intermediate (12-23 yea...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487318793459
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:In clinical practice, individuals at increased risk of cardiovascular diseases (CVD) are identified on the basis of age, sex, smoking, blood pressure, and serum total and high-density lipoprotein cholesterol. We examined whether CVD risk prediction improved when obesity (body mass index ≥30 kg/m(2)) and prem...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312444233
更新日期:2013-10-01 00:00:00
abstract::Background The ratio of estimated glomerular filtration rate (eGFR) to kidney size reflects the kidney's capacity for filtration per kidney volume or kidney length. High ratios of eGFR to kidney size, which might indicate glomerular hyperfiltration, could be related to kidney function decline, cardiovascular disease a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487317690950
更新日期:2017-06-01 00:00:00