Abstract:
BACKGROUND:Cardiovascular risk factors are known to be associated between parents and offspring. However, whether these associations are reflected in increased offspring mortality has not been extensively studied. DESIGN:This was a family study of 32,536 father-offspring and 39,614 mother-offspring pairs who participated in the HUNT Study, Norway. METHODS:Adjusted hazard ratios (HRs) for offspring total and cardiovascular mortality associated with parental levels of cardiovascular disease risk factors were estimated using Cox regression. RESULTS AND CONCLUSIONS:Fathers' and mothers' reporting of cardiovascular disease (HRs: 1.18; 95% CI 1.04-1.32 and 1.20; 1.07-1.35, respectively), diabetes (HRs: 1.22; 95% CI 1.00-1.49 and 1.21; 1.05-1.40, respectively), and current smoking (HRs: 1.21; 95% CI 1.08-1.36 and 1.30; 1.15-1.47, respectively) was associated with total mortality in offspring. An inverse association was found with maternal height (HR: 0.95; 95% CI 0.91-0.99), and a suggestive inverse association with paternal height (HR: 0.98; 95% CI 0.93-1.03). Relations with offspring cardiovascular mortality were less clear and consistent. Offspring whose parents both had a risk factor did not seem to have higher mortality than would be expected from the independent effects of each parent.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Vik KL,Romundstad P,Carslake D,Davey Smith G,Nilsen TIdoi
10.1177/2047487314562118subject
Has Abstractpub_date
2016-01-01 00:00:00pages
145-53issue
2eissn
2047-4873issn
2047-4881pii
2047487314562118journal_volume
23pub_type
杂志文章abstract::Atrial fibrillation is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in approximately 25% of patients, which is four to six times more common than in similarly aged patients of the general population. Atrial fibrillation is poorly tolerated by HCM patients, largely due to their d...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319828474
更新日期:2019-02-06 00:00:00
abstract:AIMS:Exercise is recommended as prevention, management, and control of all stages of hypertension. There are still controversies about the optimal training dose, frequency, and intensity. We aimed to study the effect of aerobic interval training on blood pressure and myocardial function in hypertensive patients. METHO...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/1741826711400512
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The effects of increasing high-density lipoprotein cholesterol on cardiovascular outcomes remain uncertain. DESIGN:We conducted a meta-analysis to investigate the effects of high-density lipoprotein cholesterol modifiers (niacin, fibrates and cholesteryl ester transfer protein inhibitors) on cardiovascular ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
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abstract:BACKGROUND:Although the mortality of coronary heart disease (CHD) has declined in Western countries during the last decades, studies have suggested that the prevention and treatment of CHD may not have been as effective in women as in men. We examined gender- and age-specific trends in incidence, case fatality and the ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711421081
更新日期:2012-10-01 00:00:00
abstract::The beneficial effect of exercise training and exercise-based cardiac rehabilitation on symptom-free exercise capacity,cardiovascular and skeletal muscle function, quality of life, general healthy lifestyle, and reduction of depressive symptoms and psychosocial stress is nowadays well recognized. However, it remains l...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487312437063
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Cardiovascular risk factors tend to be clustered. Variations in clusters across populations have not been widely investigated. This study aims to compare the prevalence and clustering of major cardiovascular risk factors between adults in the Netherlands and China. METHODS:A total of 6542 Dutch adults was r...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316648474
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abstract:AIMS:To investigate the clinical relevance of contemporary cut-offs of left ventricular ejection fraction (LVEF) including an intermediate phenotype with mid-range reduced ejection fraction among patients with coronary artery disease undergoing percutaneous coronary intervention. METHODS AND RESULTS:Patient-level data...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487314546825
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in h...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
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abstract::The benefits of physical activity are well established, leading to both cardiovascular and non-cardiovascular benefits, improving quality of life and reducing mortality. Despite such striking body of evidence, patients with hypertrophic cardiomyopathy are often discouraged by health professionals to practice physical a...
journal_title:European journal of preventive cardiology
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487316655259
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The incidence of metabolic syndrome (MetS), diabetes mellitus (DM), and their coexistence is increasing but whether MetS increases cardiovascular risk beyond component risk factors is controversial. DESIGN:We compared the risk of cardiovascular death, myocardial infarction, or stroke among patients with Met...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究
doi:10.1177/2047487313500541
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown. OBJECTIVE:The purpose of this study was to investigate the prevalence of abdominal obesity and its association with recurrent atherosclerotic cardiovascular disease in ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319898019
更新日期:2020-12-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319846997
更新日期:2019-10-01 00:00:00
abstract::Background Statin treatment in association with physical exercise can substantially reduce mortality in dyslipidaemic individuals. However, the available data to compare the efficacy and safety of statins and exercise combination therapy with statin monotherapy are limited. Design Systematic review and meta-analysis. ...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1177/2047487317691874
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-...
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487312447751
更新日期:2013-10-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,meta分析
doi:10.1177/2047487318780435
更新日期:2018-09-01 00:00:00
abstract:AIMS:To investigate whether levels of thyroid-stimulating hormone (TSH) within the normal range are associated with an increased risk of new vascular events and mortality in patients with clinical manifest vascular diseases and whether this relation is influenced by adiposity. METHODS AND RESULTS:Prospective cohort st...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/1741826711416045
更新日期:2012-08-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-11-01 00:00:00
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journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487319894676
更新日期:2020-11-01 00:00:00
abstract::Background Cardiac rehabilitation (CR) improves the symptoms, exercise capacity and quality of life of chronic heart failure (CHF) patients. Its effects on new plasma biomarkers of prognostic importance are unknown. The present study aimed at analysing the effects of a structured CR programme on plasma cardiac biomark...
journal_title:European journal of preventive cardiology
pub_type: 临床试验,杂志文章
doi:10.1177/2047487317705488
更新日期:2017-07-01 00:00:00
abstract::Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and app...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487316663873
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314547655
更新日期:2015-09-01 00:00:00
abstract::Using data from the Seven Countries Study of Cardiovascular Diseases, the first study to conduct international comparisons of men in different European, USA, and Japanese cohorts, we examined the effect of diet-associated inflammation on prediction of coronary heart disease-, other major cardiovascular disease- and al...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487320903866
更新日期:2020-02-04 00:00:00
abstract:AIMS:To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS:PLATO (n = 18,624) was a multicentre, double-blind, randomized trial in ACS, that showed a 16% reduction in cardiovascular death (CV-death), myocar...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/2047487314533215
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Cardiovascular diseases (CVD) and cancer are worldwide main causes of death with mortality trends varying across countries with different levels of economic development. DESIGN AND METHODS:We analysed trends in CVD and cancer mortality for 37 European countries, five high-income non-European countries and f...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章
doi:10.1177/2047487313497864
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Statin intolerance is a barrier to effective lipid-lowering treatment. A significant number of patients stop prescribed statins, or can take only a reduced dose, because of adverse events attributed to the statin, and are then considered statin-intolerant. METHODS:Examination of differences between statin a...
journal_title:European journal of preventive cardiology
pub_type: 杂志文章,评审
doi:10.1177/2047487315602861
更新日期:2016-05-01 00:00:00