Utility of galectin-3 as a prognostic biomarker in heart failure: where do we stand?

Abstract:

BACKGROUND:Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in heart failure populations. However, the studies have generated conflicting results. Hence a systematic review was done to assess the utility of galectin-3 as a prognostic biomarker in HF. DESIGN:This study was a systematic review. METHODS:A literature search was done using terms 'galectin-3 and heart' and 'galectin-3 and heart failure' in MEDLINE, Science Direct, Scopus, Springer Link, Cochrane Library and Google Scholar for original articles using a predefined inclusion/exclusion criteria. RESULTS:Altogether 27 original articles were selected for the systematic review. Multivariate analysis showed galectin-3 to be ineffective in predicting all-cause mortality and cardiovascular mortality especially under the influence of factors such as estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF) and N-terminal pro-B-type natriuretic peptide (NTproBNP). Galectin-3 was not found to be superior to NTproBNP, sST2, GDF-15 or C-reactive protein (CRP) as a predictor of mortality. However the combination of natriuretic peptides and galectin-3 has been observed to be superior in predicting mortality compared to either of the biomarkers alone. The role of galectin-3 in remodelling has not been conclusively proven as seen in earlier pre-clinical studies. CONCLUSION:The current weight of evidence does not suggest galectin-3 to be a predictor of mortality. However, assessment of galectin-3 in a multi-biomarker panel may have a distinct advantage in prognosticating patients with heart failure.

journal_name

Eur J Prev Cardiol

authors

Srivatsan V,George M,Shanmugam E

doi

10.1177/2047487314552797

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

1096-110

issue

9

eissn

2047-4873

issn

2047-4881

pii

2047487314552797

journal_volume

22

pub_type

杂志文章,评审
  • Management of patients with type 2 diabetes in cardiovascular rehabilitation.

    abstract::The clinical benefits of rehabilitation in cardiovascular disease are well established. Among cardiovascular disease patients, however, patients with type 2 diabetes mellitus require a distinct approach. Specific challenges to clinicians and healthcare professionals in patients with type 2 diabetes include the prevale...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487319882820

    authors: Hansen D,Kraenkel N,Kemps H,Wilhelm M,Abreu A,Pfeiffer AF,Jordão A,Cornelissen V,Völler H

    更新日期:2019-12-01 00:00:00

  • Blood pressure variations and low blood pressure values at home after hospital discharge in older hypertensives: post-discharge blood pressure variations.

    abstract:BACKGROUND:Blood pressure (BP) variations occurring after hospital discharge in a population of older hypertensives have not been previously investigated. DESIGN:elderly (≥65 years) hypertensives admitted to the geriatric acute ward of a university-teaching hospital were enrolled in this prospective observational stud...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711403067

    authors: Astengo M,Bonetto M,Isaia G,Comba M,Fonte G,Bo M

    更新日期:2012-06-01 00:00:00

  • The European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool: A digital training and decision support system for optimized exercise prescription in cardiovascular disease. Concept,

    abstract::Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1177/2047487317702042

    authors: Hansen D,Dendale P,Coninx K,Vanhees L,Piepoli MF,Niebauer J,Cornelissen V,Pedretti R,Geurts E,Ruiz GR,Corrà U,Schmid JP,Greco E,Davos CH,Edelmann F,Abreu A,Rauch B,Ambrosetti M,Braga SS,Barna O,Beckers P,Bussott

    更新日期:2017-07-01 00:00:00

  • Exercise testing in the clinical management of patients affected by pulmonary arterial hypertension.

    abstract::Patients affected by pulmonary arterial hypertension (PAH) show a reduced exercise tolerance with early occurrence of dyspnoea and fatigue. The origin of functional capacity limitation is multifactorial and several mechanisms have been proposed, including right heart failure, which leads to a limited increase in cardi...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/1741826711426635

    authors: Paolillo S,Farina S,Bussotti M,Iorio A,PerroneFilardi P,Piepolil MF,Agostoni P

    更新日期:2012-10-01 00:00:00

  • Accuracy of smartphone apps for heart rate measurement.

    abstract::Background Smartphone manufacturers offer mobile health monitoring technology to their customers, including apps using the built-in camera for heart rate assessment. This study aimed to test the diagnostic accuracy of such heart rate measuring apps in clinical practice. Methods The feasibility and accuracy of measurin...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/2047487317702044

    authors: Coppetti T,Brauchlin A,Müggler S,Attinger-Toller A,Templin C,Schönrath F,Hellermann J,Lüscher TF,Biaggi P,Wyss CA

    更新日期:2017-08-01 00:00:00

  • Effect of the natural sweetener, steviol glycoside, on cardiovascular risk factors: a systematic review and meta-analysis of randomised clinical trials.

    abstract:INTRODUCTION:Many different dietary supplements are currently marketed for the management of hypertension and diabetes, but the evidence for effectiveness is mixed. The objective of this systematic review was to critically appraise and evaluate the evidence for effectiveness of steviol glycosides (stevioside and rebaud...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/2047487314560663

    authors: Onakpoya IJ,Heneghan CJ

    更新日期:2015-12-01 00:00:00

  • Interval training early after heart failure decompensation is safe and improves exercise tolerance and quality of life in selected patients.

    abstract::Aims To evaluate safety and efficacy of moderate intensity interval exercise training early after heart failure decompensation on exercise tolerance and health-related quality of life (HRQoL). Methods and results This is a prospective randomized controlled study. We screened 234 consecutive patients admitted with deco...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/2047487317724575

    authors: Doletsky A,Andreev D,Giverts I,Svet A,Brand A,Kuklina M,Sedov V,Dikur O,Syrkin A,Saner H

    更新日期:2018-01-01 00:00:00

  • Long-term efficacy of a tele-health intervention for acute coronary syndrome patients with depression: 12-month results of the MoodCare randomized controlled trial.

    abstract:BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314547655

    authors: O'Neil A,Taylor B,Hare DL,Sanderson K,Cyril S,Venugopal K,Chan B,Atherton JJ,Hawkes A,Walters DL,Oldenburg B,MoodCare Investigator Team.

    更新日期:2015-09-01 00:00:00

  • Association between consumption of soy and risk of cardiovascular disease: A meta-analysis of observational studies.

    abstract::Background The relationships between dietary intake of soy foods and risk of cardiovascular disease are uncertain. The aims of this study were to evaluate and summarize the evidence on the association between consumption of soy and risk of cardiovascular disease (including stroke and coronary heart disease). Methods W...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/2047487316686441

    authors: Yan Z,Zhang X,Li C,Jiao S,Dong W

    更新日期:2017-05-01 00:00:00

  • Interaction of maternal smoking and preterm birth on future risk of maternal cardiovascular disease: A population-based record linkage study.

    abstract:BACKGROUND:While associations of smoking and preterm birth (PTB) with maternal cardiovascular disease (CVD) risks have been established, it is unknown whether the coexistence of these two conditions could synergistically increase the risks. METHODS:We linked birth records of 902,008 mothers with singleton infants duri...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487315593836

    authors: Ngo AD,Roberts CL,Chen JS,Figtree G

    更新日期:2016-04-01 00:00:00

  • Diabetes: Prevalence, prognosis and management of a potent cardiovascular risk factor.

    abstract::This review highlights the increased risk of cardiovascular disease and the dismal prognosis after acute coronary events when diabetes is present. Although there have been improvements in this area, diabetes still confers an increased risk. In order to achieve successful outcomes in individuals with diabetes, extensiv...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487317709554

    authors: Norhammar A,Mellbin L,Cosentino F

    更新日期:2017-06-01 00:00:00

  • Role of comorbidities in heart failure prognosis Part 2: Chronic kidney disease, elevated serum uric acid.

    abstract::Despite improvements in pharmacotherapy, morbidity and mortality rates in community-based populations with chronic heart failure still remain high. The increase in medical complexity among patients with heart failure may be reflected by an increase in concomitant non-cardiovascular comorbidities, which are recognized ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487320957793

    authors: Tedeschi A,Agostoni P,Pezzuto B,Corra' U,Scrutinio D,La Gioia R,Raimondo R,Passantino A,Piepoli MF

    更新日期:2020-12-01 00:00:00

  • Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitat

    abstract::Aerobic exercise intensity prescription is a key issue in cardiac rehabilitation, being directly linked to both the amount of improvement in exercise capacity and the risk of adverse events during exercise. This joint position statement aims to provide professionals with up-to-date information regarding the identifica...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,实务指引

    doi:10.1177/2047487312460484

    authors: Mezzani A,Hamm LF,Jones AM,McBride PE,Moholdt T,Stone JA,Urhausen A,Williams MA,European Association for Cardiovascular Prevention and Rehabilitation.,American Association of Cardiovascular and Pulmonary Rehabilitation.,Canadian Asso

    更新日期:2013-06-01 00:00:00

  • Impact of physical activity on the risk of cardiovascular disease in middle-aged and older adults: EPIC Norfolk prospective population study.

    abstract::Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity also translates into cardiovascular health benefits in older adults. Therefore, we aimed to c...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317737628

    authors: Lachman S,Boekholdt SM,Luben RN,Sharp SJ,Brage S,Khaw KT,Peters RJ,Wareham NJ

    更新日期:2018-01-01 00:00:00

  • The dysfunction of ammonia in heart failure increases with an increase in the intensity of resistance exercise, even with the use of appropriate drug therapy.

    abstract:BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/2047487312460520

    authors: Medeiros WM,Carvalho AC,Peres P,De Luca FA,Gun C

    更新日期:2014-02-01 00:00:00

  • Do obesity and parental history of myocardial infarction improve cardiovascular risk prediction?

    abstract:BACKGROUND:In clinical practice, individuals at increased risk of cardiovascular diseases (CVD) are identified on the basis of age, sex, smoking, blood pressure, and serum total and high-density lipoprotein cholesterol. We examined whether CVD risk prediction improved when obesity (body mass index ≥30 kg/m(2)) and prem...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487312444233

    authors: van Dis I,Geleijnse JM,Kromhout D,Boer J,Boshuizen H,Verschuren WM

    更新日期:2013-10-01 00:00:00

  • C-reactive protein and serum creatinine, but not haemoglobin A1c, are independent predictors of coronary heart disease risk in non-diabetic Chinese.

    abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487315626547

    authors: Salim A,Tai ES,Tan VY,Welsh AH,Liew R,Naidoo N,Wu Y,Yuan JM,Koh WP,van Dam RM

    更新日期:2016-08-01 00:00:00

  • Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice.

    abstract::Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposi...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487319848105

    authors: Cabassi A,Tedeschi S,Perlini S,Verzicco I,Volpi R,Gonzi G,Canale SD

    更新日期:2020-05-01 00:00:00

  • Percentage low-density lipoprotein-cholesterol response to a given statin dose is not fixed across the pre-treatment range: Real world evidence from clinical practice: Data from the ESC-EORP EUROASPIRE V Study.

    abstract:AIMS:Recent European guidelines recommend in patients with atherosclerotic cardiovascular disease to achieve a reduction of low-density lipoprotein-cholesterol of at least 50% if the baseline low-density lipoprotein-cholesterol level is between 1.8 and 3.5 mmol/L. Systematic reviews have associated a given statin/dose ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319874898

    authors: Bacquer D,Smedt D,Reiner Ž,Tokgözoğlu L,Clays E,Kotseva K,Rydén L,Wood D,Backer G

    更新日期:2020-10-01 00:00:00

  • Standardization and quality improvement of secondary prevention through cardiovascular rehabilitation programmes in Europe: The avenue towards EAPC accreditation programme: A position statement of the Secondary Prevention and Rehabilitation Section of the

    abstract::Despite the proven efficacy and cost-effectiveness of contemporary cardiovascular rehabilitation programmes, the referral to/uptake of and adherence to cardiovascular rehabilitation remains inadequate. In addition, heterogeneity persists amongst different cardiovascular rehabilitation centres in Europe, despite the av...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320924912

    authors: Abreu A,Frederix I,Dendale P,Janssen A,Doherty P,Piepoli MF,Völler H,Secondary Prevention and Rehabilitation Section of EAPC Reviewers: Marco Ambrosetti.,Davos CH

    更新日期:2020-06-01 00:00:00

  • Angiotensin-converting enzyme inhibitors reduce mortality compared to angiotensin receptor blockers: Systematic review and meta-analysis.

    abstract::Background There are few reviews comparing the long-term outcomes of the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in a hypertensive population because both are effective in reducing blood pressure. None of them compared angiotensin-converting enzyme inhibitors or angiotensin ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/2047487317728766

    authors: Salvador GL,Marmentini VM,Cosmo WR,Junior EL

    更新日期:2017-12-01 00:00:00

  • Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial.

    abstract:AIMS:To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS:PLATO (n = 18,624) was a multicentre, double-blind, randomized trial in ACS, that showed a 16% reduction in cardiovascular death (CV-death), myocar...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314533215

    authors: Patel MR,Becker RC,Wojdyla DM,Emanuelsson H,Hiatt WR,Horrow J,Husted S,Mahaffey KW,Steg PG,Storey RF,Wallentin L,James SK

    更新日期:2015-06-01 00:00:00

  • Serum tissue-degrading proteinases and incident cardiovascular disease events.

    abstract:BACKGROUND:Extracellular matrix-degrading proteinases are upregulated in atherosclerotic lesions and can contribute to subsequent pathological events. In the present nested case-control study, we investigated the association of serum concentrations of matrix metalloproteinases MMP-7, MMP-8, and MMP-13, tissue inhibitor...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487312465524

    authors: Tuomainen AM,Kormi I,Havulinna AS,Tervahartiala T,Salomaa V,Sorsa T,Pussinen PJ

    更新日期:2014-07-01 00:00:00

  • Cost-effectiveness of apixaban compared to warfarin in the management of atrial fibrillation in Australia.

    abstract:OBJECTIVE:To determine the cost-effectiveness of apixaban versus warfarin in patients with atrial fibrillation (AF) with a moderate to severe risk of stroke, from an Australian government-perspective. METHODS:A decision-analytic Markov model was constructed to assess the cost-effectiveness of apixaban versus warfarin,...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487313514019

    authors: Ademi Z,Pasupathi K,Liew D

    更新日期:2015-03-01 00:00:00

  • Long-term prescription of beta-blocker delays the progression of heart failure with preserved ejection fraction in patients with hypertension: A retrospective observational cohort study.

    abstract:BACKGROUND:Hypertension complicated with left ventricular hypertrophy (LVH) and diastolic dysfunction is one of the most common risks for heart failure with preserved ejection fraction (HFpEF). This study was designed to evaluate the influences of long-term beta-blocker prescription in these patients. METHODS:This ret...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487316636260

    authors: Gu J,Fan YQ,Bian L,Zhang HL,Xu ZJ,Zhang Y,Chen QZ,Yin ZF,Xie YS,Wang CQ

    更新日期:2016-09-01 00:00:00

  • Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association.

    abstract:BACKGROUND:The aim of this study was to test the hypothesis that alcohol consumption, both observational (self-reported) and estimated by genetic instruments, is associated with a risk of atrial fibrillation and to determine whether people with high cardiovascular risk are more sensitive towards alcohol than people wit...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487316641804

    authors: Tolstrup JS,Wium-Andersen MK,Ørsted DD,Nordestgaard BG

    更新日期:2016-09-01 00:00:00

  • Tobacco smoking and the risk of atrial fibrillation: A systematic review and meta-analysis of prospective studies.

    abstract::Background Epidemiological studies on smoking and atrial fibrillation have been inconsistent, with some studies showing a positive association while others have found no association. It is also unclear whether there is a dose-response relationship between the number of cigarettes smoked or pack-years and the risk of a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1177/2047487318780435

    authors: Aune D,Schlesinger S,Norat T,Riboli E

    更新日期:2018-09-01 00:00:00

  • Atrial fibrillation and the risk for myocardial infarction, all-cause mortality and heart failure: A systematic review and meta-analysis.

    abstract::Background In contemporary atrial fibrillation trials most deaths are cardiac related, whereas stroke and bleeding represent only a small subset of deaths. We aimed to evaluate the long-term risk of cardiac events and all-cause mortality in individuals with atrial fibrillation compared to no atrial fibrillation. Desig...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/2047487317715769

    authors: Ruddox V,Sandven I,Munkhaugen J,Skattebu J,Edvardsen T,Otterstad JE

    更新日期:2017-09-01 00:00:00

  • Prescribing, dosing and titrating exercise in patients with hypertrophic cardiomyopathy for prevention of comorbidities: Ready for prime time.

    abstract::The benefits of physical activity are well established, leading to both cardiovascular and non-cardiovascular benefits, improving quality of life and reducing mortality. Despite such striking body of evidence, patients with hypertrophic cardiomyopathy are often discouraged by health professionals to practice physical a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320928654

    authors: Cavigli L,Olivotto I,Fattirolli F,Mochi N,Favilli S,Mondillo S,Bonifazi M,D'Ascenzi F

    更新日期:2020-06-17 00:00:00

  • Profile and treatment of chronic coronary syndromes in European Society of Cardiology member countries: The ESC EORP CICD-LT registry.

    abstract:BACKGROUND:International guidelines recommend pharmacotherapy combinations for chronic coronary syndromes (CCSs) but medical management remains suboptimal. DESIGN:The CICD-LT registry is investigating short- and long-term outcomes and management in patients in European Society of Cardiology (ESC) member countries, in ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320912491

    authors: Komajda M,Cosentino F,Ferrari R,Kerneis M,Kosmachova E,Laroche C,Maggioni AP,Rittger H,Steg PG,Szwed H,Tavazzi L,Valgimigli M,Gale CP,CICD investigators group.

    更新日期:2020-03-31 00:00:00