Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association.

Abstract:

BACKGROUND:The aim of this study was to test the hypothesis that alcohol consumption, both observational (self-reported) and estimated by genetic instruments, is associated with a risk of atrial fibrillation and to determine whether people with high cardiovascular risk are more sensitive towards alcohol than people with low risk. METHODS:We used data for a total of 88,782 men and women from the Copenhagen City Heart Study 1991-1994 and 2001-2003 and the Copenhagen General Population Study 2003-2010. Information on incident cases of atrial fibrillation was obtained from a validated nationwide register. As a measure of alcohol exposure, both self-reported consumption and genetic variations in alcohol metabolizing genes (ADH1B/ADH1C) were used as instrumental variables. The endpoint was admission to hospital for atrial fibrillation as recorded in a validated hospital register. RESULTS:A total of 3493 cases of atrial fibrillation occurred during follow-up. High alcohol consumption was associated with a risk of atrial fibrillation among men, but not among women. Among the men who drank 28-35 and 35+ drinks/week, the hazards ratios were 1.40 (95% confidence interval 1.09-1.80) and 1.62 (95% confidence interval 1.27-2.05) compared with men who drank < 1 drink/week. Using genotypes as instrumental variables did not reveal a higher risk. Associations in those with high cardiovascular risk were similar to those at lower risk. CONCLUSIONS:Observational alcohol consumption was associated with a higher risk of atrial fibrillation in men. In women, only a high alcohol intake (28+ drinks/week) was associated with a higher risk. Participants with a high cardiovascular risk were no more sensitive towards alcohol than those at low risk. Genetic analysis did not support a causal relationship of linear association between alcohol intake and atrial fibrillation.

journal_name

Eur J Prev Cardiol

authors

Tolstrup JS,Wium-Andersen MK,Ørsted DD,Nordestgaard BG

doi

10.1177/2047487316641804

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1514-23

issue

14

eissn

2047-4873

issn

2047-4881

pii

2047487316641804

journal_volume

23

pub_type

杂志文章,多中心研究
  • Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the community.

    abstract:BACKGROUND:The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left ventricular diastolic dysfunction is a prognostic indicator of heart failure, in particularly of heart failure with preserved ejection fraction and of future cardiovascular and all-...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487318816774

    authors: Gohar A,Kievit RF,Valstar GB,Hoes AW,Van Riet EE,van Mourik Y,Bertens LC,Boonman-Winter LJ,Bots ML,Den Ruijter HM,Rutten FH

    更新日期:2019-04-01 00:00:00

  • Age differences in contemporary treatment of patients with chronic heart failure and reduced ejection fraction.

    abstract:BACKGROUND:Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319835042

    authors: Veenis JF,Brunner-La Rocca HP,Linssen GC,Geerlings PR,Van Gent MW,Aksoy I,Oosterom L,Moons AH,Hoes AW,Brugts JJ,CHECK-HF investigators.

    更新日期:2019-09-01 00:00:00

  • Prevalence and determinants of the precursor stages of heart failure: results from the population-based STAAB cohort study.

    abstract:AIMS:Prevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population. METHODS AND RESULTS:We report cross-sectional data from the prospective Characteristics and Course o...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320922636

    authors: Morbach C,Gelbrich G,Tiffe T,Eichner FA,Christa M,Mattern R,Breunig M,Cejka V,Wagner M,Heuschmann PU,Störk S

    更新日期:2020-05-06 00:00:00

  • Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitat

    abstract::Aerobic exercise intensity prescription is a key issue in cardiac rehabilitation, being directly linked to both the amount of improvement in exercise capacity and the risk of adverse events during exercise. This joint position statement aims to provide professionals with up-to-date information regarding the identifica...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,实务指引

    doi:10.1177/2047487312460484

    authors: Mezzani A,Hamm LF,Jones AM,McBride PE,Moholdt T,Stone JA,Urhausen A,Williams MA,European Association for Cardiovascular Prevention and Rehabilitation.,American Association of Cardiovascular and Pulmonary Rehabilitation.,Canadian Asso

    更新日期:2013-06-01 00:00:00

  • Physical fitness is a modifiable predictor of early cardiovascular death: A 35-year follow-up study of 2014 healthy middle-aged men.

    abstract::Background Physical fitness has been shown to predict cardiovascular death during long-term follow-up. In the present study we aimed to investigate how physical fitness and other cardiovascular risk factors at middle-age influenced the risk of cardiovascular death during the early (0-11 years), intermediate (12-23 yea...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487318793459

    authors: Engeseth K,Prestgaard EE,Mariampillai JE,Grundvold I,Liestol K,Kjeldsen SE,Bodegard J,Erikssen JE,Gjesdal K,Skretteberg PT

    更新日期:2018-10-01 00:00:00

  • Do statin users adhere to a healthy diet and lifestyle? The Australian Diabetes, Obesity and Lifestyle Study.

    abstract::Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Metho...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487316684054

    authors: Johal S,Jamsen KM,Bell JS,Mc Namara KP,Magliano DJ,Liew D,Ryan-Atwood TE,Anderson C,Ilomäki J

    更新日期:2017-04-01 00:00:00

  • Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial.

    abstract:BACKGROUND:The complexity of treatment regimens, costs and pill burden decrease the medication adherence and contribute to shortfall in cardiovascular preventive drug coverage. The polypill, a fixed dose combination pill of established drugs, is expected to increase adherence and reduce the costs whilst preventing majo...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314550803

    authors: Ostovaneh MR,Poustchi H,Hemming K,Marjani H,Pourshams A,Nateghi A,Majed M,Navabakhsh B,Khoshnia M,Jaafari E,Mohammadifard N,Malekzadeh F,Merat S,Sadeghi M,Naemi M,Etemadi A,Thomas GN,Sarrafzadegan N,Cheng KK,Marshal

    更新日期:2015-12-01 00:00:00

  • Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway.

    abstract::Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in appa...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487317703826

    authors: Ueland T,Laugsand LE,Vatten LJ,Janszky I,Platou C,Michelsen AE,Damås JK,Aukrust P,Åsvold BO

    更新日期:2017-07-01 00:00:00

  • Adiponectin, type 2 diabetes and cardiovascular risk.

    abstract:BACKGROUND:Adiponectin is viewed as an insulin-sensitizing hormone with anti-inflammatory effects. In accordance, plasma adiponectin is decreased in metabolic disorders including type 2 diabetes mellitus (T2DM). However, in spite of the apparently beneficially effects, recent data from large prospective studies have co...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487313514894

    authors: Lindberg S,Jensen JS,Bjerre M,Pedersen SH,Frystyk J,Flyvbjerg A,Galatius S,Jeppesen J,Mogelvang R

    更新日期:2015-03-01 00:00:00

  • Psychological interventions for coronary heart disease: Cochrane systematic review and meta-analysis.

    abstract::Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1177/2047487317739978

    authors: Richards SH,Anderson L,Jenkinson CE,Whalley B,Rees K,Davies P,Bennett P,Liu Z,West R,Thompson DR,Taylor RS

    更新日期:2018-02-01 00:00:00

  • Exercise capacity and haemodynamic response among 12,327 individuals with cardio-metabolic risk factors undergoing treadmill exercise.

    abstract::Aims Haemodynamic parameters during and after exercise test seem to have a role in predicting cardiovascular events. We sought to evaluate the potential different responses in exercise capacity, heart rate and blood pressure levels in relation to major cardiovascular disease risk factors, among individuals undergoing ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317726069

    authors: Chrysohoou C,Skoumas J,Georgiopoulos G,Liontou C,Vogiatzi G,Tsioufis K,Lerakis S,Soulis D,Pitsavos C,Tousoulis D

    更新日期:2017-10-01 00:00:00

  • Assessment of peripheral endothelial function predicts future risk of solid-tumor cancer.

    abstract:AIMS:Cardiovascular health metrics predict the risk not only of cardiovascular diseases but also of several types of cancers. Microvascular endothelial dysfunction can predict future cardiovascular adverse events, but the predictive value of microvascular endothelial dysfunction for future risk of solid-tumor cancer ha...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319884246

    authors: Toya T,Sara JD,Corban MT,Taher R,Godo S,Herrmann J,Lerman LO,Lerman A

    更新日期:2020-04-01 00:00:00

  • The benefits of exercise in cancer patients and the criteria for exercise prescription in cardio-oncology.

    abstract::Cancer and cardiovascular diseases are the leading causes of death in high-income countries. Cardiovascular complications can be found in cancer patients, being the result of so-called 'cardio-toxicity'. Therefore, it becomes essential to thoroughly investigate the origin of cardiac damage and the strategy to prevent ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319874900

    authors: D'Ascenzi F,Anselmi F,Fiorentini C,Mannucci R,Bonifazi M,Mondillo S

    更新日期:2019-10-06 00:00:00

  • Trends in cardiovascular diseases and cancer mortality in 45 countries from five continents (1980-2010).

    abstract:BACKGROUND:Cardiovascular diseases (CVD) and cancer are worldwide main causes of death with mortality trends varying across countries with different levels of economic development. DESIGN AND METHODS:We analysed trends in CVD and cancer mortality for 37 European countries, five high-income non-European countries and f...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487313497864

    authors: Araújo F,Gouvinhas C,Fontes F,La Vecchia C,Azevedo A,Lunet N

    更新日期:2014-08-01 00:00:00

  • Sudden cardiac arrest in sports - need for uniform registration: A Position Paper from the Sport Cardiology Section of the European Association for Cardiovascular Prevention and Rehabilitation.

    abstract::There are large variations in the incidence, registration methods and reported causes of sudden cardiac arrest/sudden cardiac death (SCA/SCD) in competitive and recreational athletes. A crucial question is to which degree these variations are genuine or partly due to methodological incongruities. This paper discusses ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,实务指引

    doi:10.1177/2047487315599891

    authors: Solberg EE,Borjesson M,Sharma S,Papadakis M,Wilhelm M,Drezner JA,Harmon KG,Alonso JM,Heidbuchel H,Dugmore D,Panhuyzen-Goedkoop NM,Mellwig KP,Carre F,Rasmusen H,Niebauer J,Behr ER,Thiene G,Sheppard MN,Basso C,Corrado

    更新日期:2016-04-01 00:00:00

  • Statin tolerability: In defence of placebo-controlled trials.

    abstract:BACKGROUND:Statin intolerance is a barrier to effective lipid-lowering treatment. A significant number of patients stop prescribed statins, or can take only a reduced dose, because of adverse events attributed to the statin, and are then considered statin-intolerant. METHODS:Examination of differences between statin a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487315602861

    authors: Tobert JA,Newman CB

    更新日期:2016-05-01 00:00:00

  • Diabetes: Prevalence, prognosis and management of a potent cardiovascular risk factor.

    abstract::This review highlights the increased risk of cardiovascular disease and the dismal prognosis after acute coronary events when diabetes is present. Although there have been improvements in this area, diabetes still confers an increased risk. In order to achieve successful outcomes in individuals with diabetes, extensiv...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487317709554

    authors: Norhammar A,Mellbin L,Cosentino F

    更新日期:2017-06-01 00:00:00

  • Of heart and kidney: a complicated love story.

    abstract::The multiple connections that exist between the cardiovascular system and the kidney lead to a complex cardiovascular and renal medicine relationship. It is well established in the literature that chronic kidney disease (CKD) is an important and independent risk factor for cardiovascular disease (CVD). The prevalence ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487312462826

    authors: Gaita D,Mihaescu A,Schiller A

    更新日期:2014-07-01 00:00:00

  • Long-term efficacy of a tele-health intervention for acute coronary syndrome patients with depression: 12-month results of the MoodCare randomized controlled trial.

    abstract:BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314547655

    authors: O'Neil A,Taylor B,Hare DL,Sanderson K,Cyril S,Venugopal K,Chan B,Atherton JJ,Hawkes A,Walters DL,Oldenburg B,MoodCare Investigator Team.

    更新日期:2015-09-01 00:00:00

  • Tobacco smoking and the risk of atrial fibrillation: A systematic review and meta-analysis of prospective studies.

    abstract::Background Epidemiological studies on smoking and atrial fibrillation have been inconsistent, with some studies showing a positive association while others have found no association. It is also unclear whether there is a dose-response relationship between the number of cigarettes smoked or pack-years and the risk of a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1177/2047487318780435

    authors: Aune D,Schlesinger S,Norat T,Riboli E

    更新日期:2018-09-01 00:00:00

  • Trends in socioeconomic inequalities in mortality from ischaemic heart disease and stroke in Australia, 1979-2006.

    abstract:BACKGROUND:This study investigates secular trends in ischaemic heart disease (IHD) and stroke mortality by socioeconomic status (SES) in Australia to determine if absolute and relative differences between low and high SES areas have changed over time. METHODS:IHD and stroke mortality data for adults aged 35-74 years a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711427505

    authors: Page A,Lane A,Taylor R,Dobson A

    更新日期:2012-12-01 00:00:00

  • High ratios of kidney function to kidney size are related to mortality and kidney function decline in high-risk patients.

    abstract::Background The ratio of estimated glomerular filtration rate (eGFR) to kidney size reflects the kidney's capacity for filtration per kidney volume or kidney length. High ratios of eGFR to kidney size, which might indicate glomerular hyperfiltration, could be related to kidney function decline, cardiovascular disease a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317690950

    authors: van der Sande NG,Blankestijn PJ,Leiner T,van der Graaf Y,de Borst GJ,Cramer MJ,Visseren FL,SMART study group.

    更新日期:2017-06-01 00:00:00

  • Disability after cardiac surgery is the major predictor of infections occurring in the rehabilitation phase.

    abstract:BACKGROUND:Few data have assessed the incidence, site and predictors of infections following cardiac surgery after discharge, particularly during an early rehabilitation phase. AIM:To assess the epidemiology and predictors of infections occurring after cardiac surgery. METHODS:Data prospectively recorded from 5464 pa...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487315576129

    authors: Marcassa C,Pistono M,Maserati R,Giordano A,Giannuzzi P

    更新日期:2016-04-01 00:00:00

  • The case for extended thromboprophylaxis in medically hospitalised patients - not yet made.

    abstract:BACKGROUND:The role of extended thromboprophylaxis is established for surgical patients, but not yet for hospitalised medical patients. DESIGN:This systematic review and meta-analysis sought to explore the role of extended thromboprophylaxis for medically ill hospitalised patients. METHODS:Medline, EMBASE and Cochran...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319836572

    authors: Cao JY,Lee SY,Dunkley S,Adams M,Keech A

    更新日期:2019-03-16 00:00:00

  • Are poor health behaviours in anxious and depressed cardiac patients explained by sociodemographic factors?

    abstract:INTRODUCTION:While there is evidence of poor health behaviours in anxious and depressed cardiac patients, it is possible that sociodemographic factors explain these associations. Few previous studies have adequately controlled for confounders. The present study investigated health behaviours in anxious and depressed ca...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487312449593

    authors: Murphy BM,Grande MR,Navaratnam HS,Higgins RO,Elliott PC,Turner A,Rogerson MC,Worcester MU,Goble AJ

    更新日期:2013-12-01 00:00:00

  • Cardiovascular outcomes for patients with symptomatic peripheral artery disease: A cohort study in The Health Improvement Network (THIN) in the UK.

    abstract::Background Few data are available on risk factors and associations with outcomes in symptomatic peripheral artery disease (PAD) populations in primary care. We assessed characteristics and cardiovascular outcomes in patients with and those without symptomatic peripheral artery disease in UK primary care, and quantifie...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317736824

    authors: Cea Soriano L,Fowkes FGR,Johansson S,Allum AM,García Rodriguez LA

    更新日期:2017-12-01 00:00:00

  • Control of main risk factors after ischaemic stroke across Europe: data from the stroke-specific module of the EUROASPIRE III survey.

    abstract:BACKGROUND:Previous cross-sectional surveys in different European countries within the EUROASPIRE programme demonstrated a high prevalence of modifiable risk factors, unhealthy lifestyles and inadequate drug treatment in coronary heart disease patients. Comparable data for ischaemic stroke patients is lacking. METHODS...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487314546825

    authors: Heuschmann PU,Kircher J,Nowe T,Dittrich R,Reiner Z,Cifkova R,Malojcic B,Mayer O,Bruthans J,Wloch-Kopec D,Prugger C,Heidrich J,Keil U

    更新日期:2015-10-01 00:00:00

  • Cost-effectiveness of apixaban compared to warfarin in the management of atrial fibrillation in Australia.

    abstract:OBJECTIVE:To determine the cost-effectiveness of apixaban versus warfarin in patients with atrial fibrillation (AF) with a moderate to severe risk of stroke, from an Australian government-perspective. METHODS:A decision-analytic Markov model was constructed to assess the cost-effectiveness of apixaban versus warfarin,...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487313514019

    authors: Ademi Z,Pasupathi K,Liew D

    更新日期:2015-03-01 00:00:00

  • Validity and reliability of the HeartQoL questionnaire in a large sample of stable coronary patients: The EUROASPIRE IV Study of the European Society of Cardiology.

    abstract:BACKGROUND:The aim of this study was to investigate the validity and reliability of the HeartQoL instrument in a population of stable coronary patients. DESIGN:Analyses are based on the cross-sectional EUROASPIRE IV (EUROpean Action on Secondary and Primary prevention through Intervention to Reduce Events) survey. ME...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487315604837

    authors: De Smedt D,Clays E,Höfer S,Oldridge N,Kotseva K,Maggioni AP,Janssen B,De Bacquer D,EUROASPIRE Investigators.

    更新日期:2016-05-01 00:00:00

  • Investigation of air pollution and noise on progression of thoracic aortic calcification: results of the Heinz Nixdorf Recall Study.

    abstract:AIMS:Air pollution and noise are potential risk factors for subclinical atherosclerosis. Longitudinal analyses, especially on the interplay of these environmental factors, are scarce and inconsistent. Hence we investigated long-term traffic-related exposure to air pollution and noise with the development and progressio...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319854818

    authors: Hennig F,Moebus S,Reinsch N,Budde T,Erbel R,Jöckel KH,Lehmann N,Hoffmann B,Kälsch H,Heinz Nixdorf Recall Study Investigative Group.

    更新日期:2020-06-01 00:00:00