Cardiovascular disease predictors and adipose tissue macrophage polarization: Is there a link?

Abstract:

:Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous and visceral adipose tissues were obtained from 79 subjects, 52 living kidney donors (during nephrectomy) and 27 patients with peripheral artery disease (during arterial tree reconstruction). Methods Macrophage subsets were isolated from adipose tissues and analysed by flow cytometry using CD14, CD16, CD36 and CD163 monoclonal antibodies. The mutually adjusted differences of phagocytic pro-inflammatory (CD14 + CD16 + CD36high), anti-inflammatory (CD14 + CD16-CD163+) and transitional subsets of macrophages were analysed in relation to cardiovascular predictors (sex, age, body mass index, smoking, hypercholesterolaemia, hypertension and statin treatment). Results Age, male sex and hypercholesterolaemia were closely positively associated with the phagocytic pro-inflammatory macrophage subset in visceral adipose tissues. Interestingly, the proportion of phagocytic pro-inflammatory macrophages was relevantly decreased by statin therapy. A strong positive association of body mass index to the phagocytic pro-inflammatory subset was found in subcutaneous adipose tissues only. A minor transitional subpopulation, CD14 + CD16 + CD36lowCD163+, increased with age in both adipose tissues. This transitional subpopulation was also negatively associated with obesity and hypercholesterolaemia in visceral adipose tissues. Conclusion An effect of cardiovascular risk predictors on adipose tissue macrophage subpopulations was revealed. Interestingly, while age, male sex and hypercholesterolaemia were connected with the pro-inflammatory macrophage subpopulation in visceral adipose tissues, body mass index had a prominent effect in subcutaneous adipose tissues only. A decreasing effect of statins on these pro-inflammatory macrophages was documented.

journal_name

Eur J Prev Cardiol

authors

Kralova Lesna I,Petras M,Cejkova S,Kralova A,Fronek J,Janousek L,Thieme F,Tyll T,Poledne R

doi

10.1177/2047487317743355

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

328-334

issue

3

eissn

2047-4873

issn

2047-4881

journal_volume

25

pub_type

杂志文章
  • Investigation of air pollution and noise on progression of thoracic aortic calcification: results of the Heinz Nixdorf Recall Study.

    abstract:AIMS:Air pollution and noise are potential risk factors for subclinical atherosclerosis. Longitudinal analyses, especially on the interplay of these environmental factors, are scarce and inconsistent. Hence we investigated long-term traffic-related exposure to air pollution and noise with the development and progressio...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319854818

    authors: Hennig F,Moebus S,Reinsch N,Budde T,Erbel R,Jöckel KH,Lehmann N,Hoffmann B,Kälsch H,Heinz Nixdorf Recall Study Investigative Group.

    更新日期:2020-06-01 00:00:00

  • Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study.

    abstract:BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320909300

    authors: Östgren CJ,Söderberg S,Festin K,Angerås O,Bergström G,Blomberg A,Brandberg J,Cederlund K,Eliasson M,Engström G,Erlinge D,Fagman E,Hagström E,Lind L,Mannila M,Nilsson U,Oldgren J,Ostenfeld E,Persson A,Persson J,Per

    更新日期:2020-03-03 00:00:00

  • Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction.

    abstract:BACKGROUND:Environmental pollution and weather changes unfavorably impact on cardiovascular disease. However, limited research has focused on ST-elevation myocardial infarction (STEMI), the most severe yet distinctive form of acute coronary syndrome. METHODS AND RESULTS:We appraised the impact of environmental and wea...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320928450

    authors: Biondi-Zoccai G,Frati G,Gaspardone A,Mariano E,Di Giosa AD,Bolignano A,Dei Giudici A,Calcagno S,Scappaticci M,Sciarretta S,Valenti V,Casati R,Visconti G,Penco M,Giannico MB,Peruzzi M,Cavarretta E,Budassi S,Cosma J,F

    更新日期:2020-06-02 00:00:00

  • Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial.

    abstract:BACKGROUND:Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to im...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314552764

    authors: Suchy C,Massen L,Rognmo O,Van Craenenbroeck EM,Beckers P,Kraigher-Krainer E,Linke A,Adams V,Wisløff U,Pieske B,Halle M

    更新日期:2014-11-01 00:00:00

  • Blood pressure variations and low blood pressure values at home after hospital discharge in older hypertensives: post-discharge blood pressure variations.

    abstract:BACKGROUND:Blood pressure (BP) variations occurring after hospital discharge in a population of older hypertensives have not been previously investigated. DESIGN:elderly (≥65 years) hypertensives admitted to the geriatric acute ward of a university-teaching hospital were enrolled in this prospective observational stud...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711403067

    authors: Astengo M,Bonetto M,Isaia G,Comba M,Fonte G,Bo M

    更新日期:2012-06-01 00:00:00

  • Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice.

    abstract::Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposi...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487319848105

    authors: Cabassi A,Tedeschi S,Perlini S,Verzicco I,Volpi R,Gonzi G,Canale SD

    更新日期:2020-05-01 00:00:00

  • Diabetes: Prevalence, prognosis and management of a potent cardiovascular risk factor.

    abstract::This review highlights the increased risk of cardiovascular disease and the dismal prognosis after acute coronary events when diabetes is present. Although there have been improvements in this area, diabetes still confers an increased risk. In order to achieve successful outcomes in individuals with diabetes, extensiv...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487317709554

    authors: Norhammar A,Mellbin L,Cosentino F

    更新日期:2017-06-01 00:00:00

  • High ratios of kidney function to kidney size are related to mortality and kidney function decline in high-risk patients.

    abstract::Background The ratio of estimated glomerular filtration rate (eGFR) to kidney size reflects the kidney's capacity for filtration per kidney volume or kidney length. High ratios of eGFR to kidney size, which might indicate glomerular hyperfiltration, could be related to kidney function decline, cardiovascular disease a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317690950

    authors: van der Sande NG,Blankestijn PJ,Leiner T,van der Graaf Y,de Borst GJ,Cramer MJ,Visseren FL,SMART study group.

    更新日期:2017-06-01 00:00:00

  • The case for extended thromboprophylaxis in medically hospitalised patients - not yet made.

    abstract:BACKGROUND:The role of extended thromboprophylaxis is established for surgical patients, but not yet for hospitalised medical patients. DESIGN:This systematic review and meta-analysis sought to explore the role of extended thromboprophylaxis for medically ill hospitalised patients. METHODS:Medline, EMBASE and Cochran...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319836572

    authors: Cao JY,Lee SY,Dunkley S,Adams M,Keech A

    更新日期:2019-03-16 00:00:00

  • Efficacy and safety of statins and exercise combination therapy compared to statin monotherapy in patients with dyslipidaemia: A systematic review and meta-analysis.

    abstract::Background Statin treatment in association with physical exercise can substantially reduce mortality in dyslipidaemic individuals. However, the available data to compare the efficacy and safety of statins and exercise combination therapy with statin monotherapy are limited. Design Systematic review and meta-analysis. ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/2047487317691874

    authors: Gui YJ,Liao CX,Liu Q,Guo Y,Yang T,Chen JY,Wang YT,Hu JH,Xu DY

    更新日期:2017-06-01 00:00:00

  • Left ventricular function in relation to chronic residential air pollution in a general population.

    abstract::Background In view of the increasing heart failure epidemic and awareness of the adverse impact of environmental pollution on human health, we investigated the association of left ventricular structure and function with air pollutants in a general population. Methods In 671 randomly recruited Flemish (51.7% women; mea...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487317715109

    authors: Yang WY,Zhang ZY,Thijs L,Bijnens EM,Janssen BG,Vanpoucke C,Lefebvre W,Cauwenberghs N,Wei FF,Luttun A,Verhamme P,Van Hecke E,Kuznetsova T,D'hooge J,Nawrot TS,Staessen JA

    更新日期:2017-09-01 00:00:00

  • Trends in socioeconomic inequalities in mortality from ischaemic heart disease and stroke in Australia, 1979-2006.

    abstract:BACKGROUND:This study investigates secular trends in ischaemic heart disease (IHD) and stroke mortality by socioeconomic status (SES) in Australia to determine if absolute and relative differences between low and high SES areas have changed over time. METHODS:IHD and stroke mortality data for adults aged 35-74 years a...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/1741826711427505

    authors: Page A,Lane A,Taylor R,Dobson A

    更新日期:2012-12-01 00:00:00

  • Ability to sit and rise from the floor as a predictor of all-cause mortality.

    abstract:BACKGROUND:While cardiorespiratory fitness is strongly related to survival, there are limited data regarding musculoskeletal fitness indicators. Our aim was to evaluate the association between the ability to sit and rise from the floor and all-cause mortality. DESIGN:Retrospective cohort. METHODS:2002 adults aged 51-...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487312471759

    authors: Brito LB,Ricardo DR,Araújo DS,Ramos PS,Myers J,Araújo CG

    更新日期:2014-07-01 00:00:00

  • Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitat

    abstract::Aerobic exercise intensity prescription is a key issue in cardiac rehabilitation, being directly linked to both the amount of improvement in exercise capacity and the risk of adverse events during exercise. This joint position statement aims to provide professionals with up-to-date information regarding the identifica...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,实务指引

    doi:10.1177/2047487312460484

    authors: Mezzani A,Hamm LF,Jones AM,McBride PE,Moholdt T,Stone JA,Urhausen A,Williams MA,European Association for Cardiovascular Prevention and Rehabilitation.,American Association of Cardiovascular and Pulmonary Rehabilitation.,Canadian Asso

    更新日期:2013-06-01 00:00:00

  • Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial.

    abstract:BACKGROUND:The complexity of treatment regimens, costs and pill burden decrease the medication adherence and contribute to shortfall in cardiovascular preventive drug coverage. The polypill, a fixed dose combination pill of established drugs, is expected to increase adherence and reduce the costs whilst preventing majo...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314550803

    authors: Ostovaneh MR,Poustchi H,Hemming K,Marjani H,Pourshams A,Nateghi A,Majed M,Navabakhsh B,Khoshnia M,Jaafari E,Mohammadifard N,Malekzadeh F,Merat S,Sadeghi M,Naemi M,Etemadi A,Thomas GN,Sarrafzadegan N,Cheng KK,Marshal

    更新日期:2015-12-01 00:00:00

  • Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular disease (Part III).

    abstract::The beneficial effect of exercise training and exercise-based cardiac rehabilitation on symptom-free exercise capacity,cardiovascular and skeletal muscle function, quality of life, general healthy lifestyle, and reduction of depressive symptoms and psychosocial stress is nowadays well recognized. However, it remains l...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,评审

    doi:10.1177/2047487312437063

    authors: Vanhees L,Rauch B,Piepoli M,van Buuren F,Takken T,Börjesson M,Bjarnason-Wehrens B,Doherty P,Dugmore D,Halle M,Writing Group, EACPR.

    更新日期:2012-12-01 00:00:00

  • Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis.

    abstract:BACKGROUND:The incidence of metabolic syndrome (MetS), diabetes mellitus (DM), and their coexistence is increasing but whether MetS increases cardiovascular risk beyond component risk factors is controversial. DESIGN:We compared the risk of cardiovascular death, myocardial infarction, or stroke among patients with Met...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487313500541

    authors: Udell JA,Steg PG,Scirica BM,Eagle KA,Ohman EM,Goto S,Alsheikh-Ali AA,Porath A,Corbalan R,Umez-Eronini AA,Hoffman EB,Wilson PW,Bhatt DL,Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators.

    更新日期:2014-12-01 00:00:00

  • Do statin users adhere to a healthy diet and lifestyle? The Australian Diabetes, Obesity and Lifestyle Study.

    abstract::Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Metho...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487316684054

    authors: Johal S,Jamsen KM,Bell JS,Mc Namara KP,Magliano DJ,Liew D,Ryan-Atwood TE,Anderson C,Ilomäki J

    更新日期:2017-04-01 00:00:00

  • C-reactive protein and serum creatinine, but not haemoglobin A1c, are independent predictors of coronary heart disease risk in non-diabetic Chinese.

    abstract:BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487315626547

    authors: Salim A,Tai ES,Tan VY,Welsh AH,Liew R,Naidoo N,Wu Y,Yuan JM,Koh WP,van Dam RM

    更新日期:2016-08-01 00:00:00

  • Profile and treatment of chronic coronary syndromes in European Society of Cardiology member countries: The ESC EORP CICD-LT registry.

    abstract:BACKGROUND:International guidelines recommend pharmacotherapy combinations for chronic coronary syndromes (CCSs) but medical management remains suboptimal. DESIGN:The CICD-LT registry is investigating short- and long-term outcomes and management in patients in European Society of Cardiology (ESC) member countries, in ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320912491

    authors: Komajda M,Cosentino F,Ferrari R,Kerneis M,Kosmachova E,Laroche C,Maggioni AP,Rittger H,Steg PG,Szwed H,Tavazzi L,Valgimigli M,Gale CP,CICD investigators group.

    更新日期:2020-03-31 00:00:00

  • Quadriceps isometric strength as a predictor of exercise capacity in coronary artery disease patients.

    abstract:BACKGROUND:Quadriceps strength is related to exercise capacity in normal subjects and different patient populations, but the relationship between maximal quadriceps isometric strength (QIS) and different exercise capacity levels in coronary artery disease (CAD) patients has not been systematically evaluated yet. METHO...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487313492252

    authors: Kamiya K,Mezzani A,Hotta K,Shimizu R,Kamekawa D,Noda C,Yamaoka-Tojo M,Matsunaga A,Masuda T

    更新日期:2014-10-01 00:00:00

  • Status of dyslipidemia management and statin undertreatment in Korean cancer survivors: A Korean National Health and Nutrition Examination Survey study.

    abstract:AIMS:Due to improving cancer treatment results, non-cancer mortality is an important issue for cancer survivors. Cardiovascular diseases are the leading causes of death in Korea and globally. In addition to lowering the risk of cardiovascular disease, the use of statins has led to an overall reduction in cancer mortali...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487320905722

    authors: Shin S,Wook Shin D,Young Cho I,Jeong SM,Jung H

    更新日期:2020-02-23 00:00:00

  • Interval training early after heart failure decompensation is safe and improves exercise tolerance and quality of life in selected patients.

    abstract::Aims To evaluate safety and efficacy of moderate intensity interval exercise training early after heart failure decompensation on exercise tolerance and health-related quality of life (HRQoL). Methods and results This is a prospective randomized controlled study. We screened 234 consecutive patients admitted with deco...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/2047487317724575

    authors: Doletsky A,Andreev D,Giverts I,Svet A,Brand A,Kuklina M,Sedov V,Dikur O,Syrkin A,Saner H

    更新日期:2018-01-01 00:00:00

  • The dysfunction of ammonia in heart failure increases with an increase in the intensity of resistance exercise, even with the use of appropriate drug therapy.

    abstract:BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/2047487312460520

    authors: Medeiros WM,Carvalho AC,Peres P,De Luca FA,Gun C

    更新日期:2014-02-01 00:00:00

  • Rapid increases in nitrogen oxides are associated with acute myocardial infarction: A case-crossover study.

    abstract::Aims High concentrations of air pollutants are associated with increased risk for myocardial infarction. The European Union has defined statutory limits for air pollutants based on upper absolute concentrations. We evaluated the association between rapid changes in air pollutants and the risk of myocardial infarction ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487318755804

    authors: Rasche M,Walther M,Schiffner R,Kroegel N,Rupprecht S,Schlattmann P,Schulze PC,Franzke P,Witte OW,Schwab M,Rakers F

    更新日期:2018-11-01 00:00:00

  • The HeartQoL: part II. Validation of a new core health-related quality of life questionnaire for patients with ischemic heart disease.

    abstract:BACKGROUND:Evaluation of health-related quality of life (HRQL) is important in improving the quality of patient care. The aim of this study was to determine the psychometric properties of the HeartQoL in patients with ischemic heart disease (IHD), specifically angina, myocardial infarction (MI), or ischemic heart failu...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/2047487312450545

    authors: Oldridge N,Höfer S,McGee H,Conroy R,Doyle F,Saner H,(for the HeartQoL Project Investigators).

    更新日期:2014-01-01 00:00:00

  • Do obesity and parental history of myocardial infarction improve cardiovascular risk prediction?

    abstract:BACKGROUND:In clinical practice, individuals at increased risk of cardiovascular diseases (CVD) are identified on the basis of age, sex, smoking, blood pressure, and serum total and high-density lipoprotein cholesterol. We examined whether CVD risk prediction improved when obesity (body mass index ≥30 kg/m(2)) and prem...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487312444233

    authors: van Dis I,Geleijnse JM,Kromhout D,Boer J,Boshuizen H,Verschuren WM

    更新日期:2013-10-01 00:00:00

  • Survey of physicians' practices in the control of cardiovascular risk factors: the EURIKA study.

    abstract:OBJECTIVES:To assess the practices of physicians in 12 European countries in the primary prevention of cardiovascular disease (CVD). METHODS:In 2009, 806 physicians from 12 European countries answered a questionnaire, delivered electronically or by post, regarding their assessment of patients with cardiovascular risk ...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1741826711407705

    authors: Dallongeville J,Banegas JR,Tubach F,Guallar E,Borghi C,De Backer G,Halcox JP,Massó-González EL,Perk J,Sazova O,Steg PG,Artalejo FR,EURIKA Investigators.

    更新日期:2012-06-01 00:00:00

  • Long-term efficacy of a tele-health intervention for acute coronary syndrome patients with depression: 12-month results of the MoodCare randomized controlled trial.

    abstract:BACKGROUND:Depression is common after a cardiac event; however it often remains untreated. Previously, we reported the efficacy and feasibility of a 6-month tele-health programme (MoodCare), which integrates depression management into a cardiovascular disease (CVD) risk reduction programme for Acute Coronary Syndrome (...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/2047487314547655

    authors: O'Neil A,Taylor B,Hare DL,Sanderson K,Cyril S,Venugopal K,Chan B,Atherton JJ,Hawkes A,Walters DL,Oldenburg B,MoodCare Investigator Team.

    更新日期:2015-09-01 00:00:00

  • Descriptive bibliometric analysis of global publications in lifestyle-based preventive cardiology.

    abstract:BACKGROUND:Lifestyle-based preventive cardiology aims to combat the global burden of cardiovascular disease. There have been rapid advances in lifestyle and behavioural interventions aimed at preventing cardiovascular disease in individuals at high risk and in the general population. This study is the first bibliometri...

    journal_title:European journal of preventive cardiology

    pub_type: 杂志文章

    doi:10.1177/2047487319854827

    authors: Manyangu G,Dineen B,Geoghegan R,Flaherty G

    更新日期:2019-06-17 00:00:00