当前位置： SCI文献检索 > EXPERIMENTAL CELL RESEARCH期刊下所有文献 > EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer.

EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer.

Abstract：

:Blood vessels are one of the major routes for the dissemination of cancer cells. Malignant tumors release growth factors such as vascular endothelial growth factor(VEGF) to induce angiogenesis, thereby promoting metastasis. Here, we report that The Drosophila Eyes Absent Homologue 1 (EYA1), which is overexpressed in colorectal tumor cells, can promote colorectal tumor angiogenesis by coordinating with the hypoxia-inducible factor 1 (HIF-1α) to increase the expression of VEGF-A. Moreover, data indicated that the enhancement of HIF-1α expression by Eya1 depended on its ability to activate the phosphatidylinositol 3-kinase (PI3K) signaling pathways to increase the phosphorylation of AKT subunits. Overexpression of Eya1 increased tumor angiogenesis in vivo and in vitro. Our study suggested that Eya1 is essential in regulating cancer cell-mediated angiogenesis and contributes to tumor growth, and that Eya1 provides a potential and specific target for new anti-angiogenesis drug development.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Cai S,Cheng X,Liu Y,Lin Z,Zeng W,Yang C,Liu L,Chukwuebuka OA,Li W

doi

10.1016/j.yexcr.2018.02.028

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

37-46

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(18)30111-3

journal_volume

367

pub_type

杂志文章

相关文献

EXPERIMENTAL CELL RESEARCH文献大全
  • Thromboxane synthase suppression induces lung cancer cell apoptosis via inhibiting NF-κB.

    abstract：:Accumulating evidence shows that the inhibition of thromboxane synthase (TXS) induced apoptosis in cancer cells. TXS inhibitor 1-Benzylimidzole (1-BI) can trigger apoptosis in lung cancer cells but the mechanism is not fully defined. In this study, lung cancer cells were treated with 1-BI. In this study, the level of ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2010.07.003

    authors： Leung KC,Li MY,Leung BC,Hsin MK,Mok TS,Underwood MJ,Chen GG

    更新日期：2010-12-10 00:00:00

  • The expression pattern of the pyruvate dehydrogenase E1 alpha subunit genes during spermatogenesis in adult mouse.

    abstract：:The expression patterns of the testis-specific and somatic forms of the pyruvate dehydrogenase (PDH) E1 alpha subunit genes were examined in adult mouse testis by in situ hybridization with specific cDNA probes and by immunostaining. A considerable increase in the mRNA level of the testis-specific PDH E1 alpha gene wa...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(92)90459-l

    authors： Takakubo F,Dahl HH

    更新日期：1992-03-01 00:00:00

  • The different roles of myosin IIA and myosin IIB in contraction of 3D collagen matrices by human fibroblasts.

    abstract：:Contraction of 3D collagen matrices by fibroblasts frequently is used as an in vitro model of wound closure. Different iterations of the model - all conventionally referred to as "contraction" - involve different morphological patterns. During floating matrix contraction, cells initially are round without stress fiber...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2014.04.013

    authors： Liu Z,Ho CH,Grinnell F

    更新日期：2014-08-15 00:00:00

  • A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells.

    abstract：:Co-cultures of lutropin receptor (LHR) positive and negative Leydig cells were used to test the hypothesis that the LHR provokes phosphorylation of the extracellular regulated kinases (ERK1/2) using intracellular and intercellular pathways. Addition of hCG to MA-10 cells (LHR positive) stimulates phosphorylation of th...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2007.06.025

    authors： Shiraishi K,Ascoli M

    更新日期：2008-01-01 00:00:00

  • Anchorage-independent culture of bovine granulosa cells: the effects of basic fibroblast growth factor and dibutyryl cAMP on cell division and differentiation.

    abstract：:During ovarian folliculogenesis granulosa cells divide while in contact with stromal cells and other granulosa cells. Following ovulation, however, they cease dividing and differentiate into large luteal cells. When cultured in monolayer, granulosa cells spontaneously differentiate into luteal cells, thus confounding ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1994.1084

    authors： Lavranos TC,Rodgers HF,Bertoncello I,Rodgers RJ

    更新日期：1994-04-01 00:00:00

  • Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes.

    abstract：:There is strong evidence that the senescent phenotype, whether induced by telomere shortening, oxidative damage, or oncogenic stimuli, is an important tumor suppressive mechanism. The melanocyte is a cell of neural crest origin that produces the pigment melanin and can develop into malignant melanomas. To understand h...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1999.4688

    authors： Haddad MM,Xu W,Schwahn DJ,Liao F,Medrano EE

    更新日期：1999-12-15 00:00:00

  • Induction of human high K(M) 5'-nucleotidase in cultured 293 cells.

    abstract：:Human 293 cells were stably transfected with a plasmid introducing a receptor for the ecdysone analog muristerone. The cells were further stably transfected with muristerone-inducible expression vectors carrying either the cDNA for the human high K(M) 5'-nucleotidase or the coding sequence of the nucleotidase linked t...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1999.4681

    authors： Gazziola C,Moras M,Ferraro P,Gallinaro L,Verin R,Rampazzo C,Reichard P,Bianchi V

    更新日期：1999-12-15 00:00:00

  • Human autoantibody to topoisomerase II.

    abstract：:The rheumatic diseases are characterized by the production of autoantibodies that are usually directed against components of the cell nucleus. In this communication, we describe autoantibodies that recognize DNA topoisomerase II (anti-topoII) present in the serum of a patient with systemic lupus erythematosus. Several...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(89)90067-0

    authors： Hoffmann A,Heck MM,Bordwell BJ,Rothfield NF,Earnshaw WC

    更新日期：1989-02-01 00:00:00

  • Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice.

    abstract：:Utilizing both the TET-OFF and TET-ON systems in combination with transcriptional control elements of the Tie-2 gene, we have established a series of transgenic activator and responder mice for TET-regulated endothelial cell-specific transgene expression in double transgenic mouse embryos and in adult mice. TET-regula...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2007.12.026

    authors： Deutsch U,Schlaeger TM,Dehouck B,Döring A,Tauber S,Risau W,Engelhardt B

    更新日期：2008-04-01 00:00:00

  • Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs.

    abstract：:LC3, a mammalian homologue of yeast Atg8, is assumed to play an important part in bulk sequestration and degradation of cytoplasm (macroautophagy), and is widely used as an indicator of this process. To critically examine its role, we followed the autophagic flux of LC3 in rat hepatocytes during conditions of maximal ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2015.02.003

    authors： Szalai P,Hagen LK,Sætre F,Luhr M,Sponheim M,Øverbye A,Mills IG,Seglen PO,Engedal N

    更新日期：2015-04-10 00:00:00

  • CHO cell aggregation induced by fibronectin-coated beads. Differences between wild-type and adhesion-variant cells.

    abstract：:ADvF11 (F11), a Chinese Hamster Ovary (CHO) cell variant, is defective in its ability to adhere to fibronectin (Fn)-coated substrata but will adhere to substrata coated with poly-L-lysine, conA or extracellular matrix (ECM) [1]. We have observed that both F11 and CHO wild-type (WT) cells were able to bind 3H-Fn beads ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(84)90236-2

    authors： Cheung E,Juliano RL

    更新日期：1984-05-01 00:00:00

  • Coordination of growth and differentiation in the fetal lung.

    abstract：:The male fetal lung begins to synthesize surfactant later in gestation than the female. This delay appears to be caused by androgens. We hypothesized that male fetal lung differentiation is delayed as a consequence of an extended phase of growth which is elicited by androgens. We observed that in vivo fetal lung prote...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(90)90281-e

    authors： Nielsen HC,Kirk WO,Sweezey N,Torday JS

    更新日期：1990-05-01 00:00:00

  • Isolation of a fraction enriched in the trans-Golgi network from baby hamster kidney cells.

    abstract：:Incubation of cultured cells at 20 degrees C blocks the transport of newly synthesized plasma membrane proteins, and the proteins accumulate intracellularly in a terminally glycosylated form. When baby hamster kidney cells are infected with the ts O45 mutant of vesicular stomatitis virus, and incubated at 20 degrees C...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(88)90190-5

    authors： de Curtis I,Howell KE,Simons K

    更新日期：1988-04-01 00:00:00

  • Multiple roles of alpha-smooth muscle actin in mechanotransduction.

    abstract：:Alpha-smooth muscle actin (SMA), an actin isoform that contributes to cell-generated mechanical tension, is normally restricted to cells of vascular smooth muscle, but SMA can also be expressed in certain non-muscle cells, most notably myofibroblasts. These cells are present in healing wounds, scars, and fibrocontract...

    journal_title：Experimental cell research

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexcr.2005.11.004

    authors： Wang J,Zohar R,McCulloch CA

    更新日期：2006-02-01 00:00:00

  • Domain analysis of the actin-binding and actin-remodeling activities of drebrin.

    abstract：:Drebrin is an actin-binding protein which is expressed at highly levels in neurons. When introduced into fibroblasts, it has been known to bind to F-actin and to cause remodeling of F-actin. Here, we performed a domain analysis of the actin-binding and actin-remodeling activities of drebrin. Various fragments of drebr...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1999.4663

    authors： Hayashi K,Ishikawa R,Kawai-Hirai R,Takagi T,Taketomi A,Shirao T

    更新日期：1999-12-15 00:00:00

  • Assembly of the nucleolar precursor bodies in human male pronuclei is correlated with an early RNA synthetic activity.

    abstract：:The nucleolar precursor bodies (NPBs) are electrondense, homogeneous, and finely filamentous intranuclear structures occurring in mammalian zygotes during the early postfertilization development and subsequently transforming into nucleoli. In this study we addressed the question if the assembly of the NPBs is correlat...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(90)90050-k

    authors： Tesarik J,Kopecny V

    更新日期：1990-11-01 00:00:00

  • Localization of the nerve growth factor receptor on fetal human Schwann cells in culture.

    abstract：:Previous studies have established that Schwann cells (SC) in culture express an NGF receptor. In this study, cultures of fetal human SC were established from fetal nerves and various light microscopic (LM) and electron microscopic (EM) techniques were used to localize the NGF receptor on the SC. Results indicate that ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(89)90253-x

    authors： Assouline JG,Pantazis NJ

    更新日期：1989-06-01 00:00:00

  • BAG6 is a novel microtubule-binding protein that regulates ciliogenesis by modulating the cell cycle and interacting with γ-tubulin.

    abstract：:Microtubule-binding proteins provide an alternative and vital pathway to the functional diversity of microtubules. Considerable work is still required to understand the complexities of microtubule-associated cellular processes and to identify novel microtubule-binding proteins. In this study, we identify Bcl2-associat...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2019.111776

    authors： He X,Zhang Y,Yang L,Feng J,Yang S,Li T,Zhong T,Li Q,Xie W,Liu M,Zhou J,Li D,Xie S

    更新日期：2020-02-01 00:00:00

  • Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities.

    abstract：:The Alternative Reading Frame (ARF) protein suppresses tumorigenesis through p53-dependent and p53-independent pathways. Most of ARF's anti-proliferative activity is conferred by sequences in its first exon. Previous work showed specific amino acid changes occurred in that region during primate evolution, so we progra...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2009.01.010

    authors： di Tommaso A,Hagen J,Tompkins V,Muniz V,Dudakovic A,Kitzis A,Ladeveze V,Quelle DE

    更新日期：2009-04-15 00:00:00

  • A semiautomated fluorescence-based cell-to-cell fusion assay for gp120-gp41 and CD4 expressing cells.

    abstract：:A novel fluorescence-based method was developed to measure HIV envelope glycoprotein (env)-CD4-mediated cell fusion. This method measures the spread of a fluorescent dye as the cytosolic compartments of adjacent cells become contiguous upon cell-to-cell fusion. Calcein-labeled CD4+ Sup-T1 cells were seeded onto a mono...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1998.3939

    authors： Pine PS,Weaver JL,Oravecz T,Pall M,Ussery M,Aszalos A

    更新日期：1998-04-10 00:00:00

  • Laminin-induced process outgrowth from isolated fetal rat C-cells.

    abstract：:A method for isolation of C-cells from rat fetuses was developed, and the morphological plasticity of the cells in primary culture systems was tested. Thyroid-parathyroid-ultimobranchial body (UB) complexes from 16-day rat fetuses were treated with 0.1% collagenase and 1000 PU/ml Dispase at 37 degrees C for 1 h. After...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(92)90373-g

    authors： Nishiyama I,Fujii T

    更新日期：1992-02-01 00:00:00

  • Investigation of the role of G1/S cell cycle mediators in cellular senescence.

    abstract：:Cellular senescence is a state of irreversible cell cycle arrest in which normal cells at the end of their lifespan fail to enter into DNA synthesis upon serum or growth factor stimulation. We examined whether proteins required for G1/S cell cycle progression were irreversibly down-regulated in senescent human fibrobl...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1993.1306

    authors： Afshari CA,Vojta PJ,Annab LA,Futreal PA,Willard TB,Barrett JC

    更新日期：1993-12-01 00:00:00

  • Cultured astrocytes form a syncytium after maturation.

    abstract：:The formation of functional gap junctions between astrocytes was investigated during differentiation of these cells in culture. Precursor cells of GFA (glial fibrillary acidic) protein-positive astrocytes were cultured in a chemically defined medium as a homogeneous population. These cells were rarely coupled to one n...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/s0014-4827(85)80001-x

    authors： Fischer G,Kettenmann H

    更新日期：1985-08-01 00:00:00

  • Overexpression of miR-182 inhibits ossification of ligamentum flavum cells by targeting NAMPT.

    abstract：:Ossification of the ligamentum flavum (OLF) is a debilitating disease resulting from the development of ectopic bone formation, which leads to the compression of the spinal cord. Nicotinamide phosphoribosyltransferase (NAMPT) was found to be upregulated and microRNA-182 (miR-182) was downregulated in OLF tissue. We in...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2018.03.008

    authors： Zhang Q,Shen Y,Jiang Y,Zhao S,Zhou D,Xu N

    更新日期：2018-06-15 00:00:00

  • The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid.

    abstract：:Quinolinic acid (QUIN) is a glutamate agonist which markedly enhances the vulnerability of neural cells to excitotoxicity. QUIN is produced from the amino acid tryptophan through the kynurenine pathway (KP). Dysregulation of this pathway is associated with neurodegenerative conditions. In this study we treated striata...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2014.02.024

    authors： Pierozan P,Ferreira F,Ortiz de Lima B,Gonçalves Fernandes C,Totarelli Monteforte P,de Castro Medaglia N,Bincoletto C,Soubhi Smaili S,Pessoa-Pureur R

    更新日期：2014-04-01 00:00:00

  • Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line.

    abstract：:We recently observed a 25-fold increase in the activity of ornithine decarboxylase (ODC) 6 h after treatment of G1-synchronized CTLL-2 cells with interleukin-2 (IL-2). Here we show that the ODC mRNA content increased in parallel with the ODC activity during the first hours of stimulation with IL-2, resulting in a 25-f...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(89)90201-2

    authors： Legraverend C,Potter A,Hölttä E,Alitalo K,Andersson LC

    更新日期：1989-03-01 00:00:00

  • Mitochondria control acute and chronic responses to hypoxia.

    abstract：:There are numerous mechanisms by which mammals respond to hypoxia. These include acute changes in pulmonary arterial tone due to smooth muscle cell contraction, acute increases in respiration triggered by the carotid body chemosensory cells, and chronic changes such as induction of red blood cell proliferation and ang...

    journal_title：Experimental cell research

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexcr.2017.03.034

    authors： McElroy GS,Chandel NS

    更新日期：2017-07-15 00:00:00

  • Embryonic lineage of vascular smooth muscle cells determines responses to collagen matrices and integrin receptor expression.

    abstract：:Developmental studies have demonstrated that the vascular smooth muscle cells (VSMC) present within the elastic arteries are differentiated from two definitive origins, the neural crest and the mesoderm. Cells from these distinct progenitors differ in their ability to determine long-range spatial order of the extracel...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1996.0258

    authors： Thieszen SL,Dalton M,Gadson PF,Patterson E,Rosenquist TH

    更新日期：1996-08-25 00:00:00

  • Internalization of the hyaluronan receptor CD44 by chondrocytes.

    abstract：:Chondrocytes express CD44 as a primary receptor for the matrix macromolecule hyaluronan. Hyaluronan is responsible for the retention and organization of proteoglycan within cartilage, and hyaluronan-chondrocyte interactions are important for the assembly and maintenance of the cartilage matrix. Bovine articular chondr...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1999.4641

    authors： Aguiar DJ,Knudson W,Knudson CB

    更新日期：1999-11-01 00:00:00

  • bFGF suppresses serum-deprivation-induced apoptosis in a human lens epithelial cell line.

    abstract：:There is increasing evidence that basic fibroblast growth factor (bFGF) plays an important role in cell proliferation, differentiation, and survival in various systems. In the eye, although a truncated, dominant negative bFGF receptor in transgenic mice induced defective lens development and caused lens fiber cells to...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1999.4450

    authors： Wang Y,He H,Zigler JS Jr,Iwata T,Ibaraki N,Reddy VN,Carper D

    更新日期：1999-05-25 00:00:00