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Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line.

Abstract：

:We recently observed a 25-fold increase in the activity of ornithine decarboxylase (ODC) 6 h after treatment of G1-synchronized CTLL-2 cells with interleukin-2 (IL-2). Here we show that the ODC mRNA content increased in parallel with the ODC activity during the first hours of stimulation with IL-2, resulting in a 25-fold increase at 6 h. Between 6 and 24 h the ODC mRNA content continued to increase steadily up to 50-fold, even after the ODC activity had returned to low basal levels. In the case of density-arrested CTLL-2 cells deprived of IL-2 for 16 h, the IL-2-mediated increase in ODC mRNA was 2-fold at 1 h and 5-fold at 8 h, irrespective of the capability of the cells to resume their cycle. There was no marked increase in the rate of transcription of the ODC gene, at least during the first 2 h of stimulation with IL-2. These findings suggest that the regulation of the ODC activity by IL-2 is a primary event in IL-2-induced cell proliferation and occurs at the post-transcriptional level, possibly by stabilizing the ODC mRNA and affecting the efficiency of translation of the messenger.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Legraverend C,Potter A,Hölttä E,Alitalo K,Andersson LC

doi

10.1016/0014-4827(89)90201-2

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

273-81

issue

1

eissn

0014-4827

issn

1090-2422

pii

0014-4827(89)90201-2

journal_volume

181

pub_type

杂志文章

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