Abstract:
:The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity of this organ make it a crucial system of study to better understand human physiology, disease, and response to exogenous compounds. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Beckwitt CH,Clark AM,Wheeler S,Taylor DL,Stolz DB,Griffith L,Wells Adoi
10.1016/j.yexcr.2017.12.023subject
Has Abstractpub_date
2018-02-01 00:00:00pages
15-25issue
1eissn
0014-4827issn
1090-2422pii
S0014-4827(17)30678-Xjournal_volume
363pub_type
杂志文章,评审abstract::ZO-2 is a MAGUK protein that in confluent epithelial sheets localizes at tight junctions (TJ) whereas in sparse cultures accumulates in clusters at the nucleus. Here, we have characterized several nuclear properties of ZO-2. We observe that ZO-2 is present in the nuclear matrix and co-immunoprecipitates with lamin B(1...
journal_title:Experimental cell research
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journal_title:Experimental cell research
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journal_title:Experimental cell research
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pub_type: 杂志文章
doi:10.1016/j.yexcr.2003.10.003
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journal_title:Experimental cell research
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.yexcr.2010.12.019
更新日期:2011-05-01 00:00:00
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journal_title:Experimental cell research
pub_type: 杂志文章
doi:10.1016/j.yexcr.2005.09.020
更新日期:2006-01-01 00:00:00
abstract::Genomic resources are indispensable for biological investigations in model organisms. In recent years, a number of genomic resources including a full genome assembly, extensive transcriptomic data, as well as genome editing has been developed for the axolotl, a classical model organism for developmental, neurobiologic...
journal_title:Experimental cell research
pub_type: 杂志文章,评审
doi:10.1016/j.yexcr.2020.112143
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abstract:BACKGROUND:CDK8 is associated with the transcriptional Mediator complex and has been shown to regulate several transcription factors implicated in cancer. As a pancreatic cancer oncogene, the role of CDK8 in cancer angiogenesis remains unclear. Here, we investigated the contribution of CDK8 in pancreatic cancer angioge...
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doi:10.1016/j.yexcr.2018.05.033
更新日期:2018-08-15 00:00:00
abstract::Transforming growth factor beta (TGFbeta) can modulate the activity of various MAP kinases. However, how this pathway may mediate TGFbeta-induced malignant phenotypes remains elusive. We investigated the role of autocrine TGFbeta signaling through MAP kinases in the regulation of cell survival in breast carcinoma MCF-...
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