Liver 'organ on a chip'.


:The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity of this organ make it a crucial system of study to better understand human physiology, disease, and response to exogenous compounds. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems.


Exp Cell Res


Beckwitt CH,Clark AM,Wheeler S,Taylor DL,Stolz DB,Griffith L,Wells A




Has Abstract


2018-02-01 00:00:00














  • High YBX1 expression indicates poor prognosis and promotes cell migration and invasion in nasopharyngeal carcinoma.

    abstract::Y-box binding protein-1 (YBX1) is a multifunctional protein and often acts as an indicator of poor prognosis in cancers. Increasing evidence has shown that the levels of YBX1 protein were closely associated with multidrug resistance, relapse, metastasis and poor prognosis in cancers. However, its role in nasopharyngea...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Zhou LL,Ni J,Feng WT,Yao R,Yue S,Zhu YN,Tang HY,Lv LY,Feng JF,Zhu WG

    更新日期:2017-12-01 00:00:00

  • The cytochrome b5 tail anchors and stabilizes subdomains of human DNA topoisomerase II alpha in the cytoplasm of retrovirally infected mammalian cells.

    abstract::DNA topoisomerase II (topo II) is the target of many anticancer drugs and is often altered in drug-resistant cell lines. In some tumor cell lines truncated isoforms of topo IIalpha are localized to the cytoplasm. To study the localization and function of individual enzyme domains, we have epitope-tagged several fragme...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Soltermann A,Ernst A,Leroy D,Stahel RA,Gasser SM

    更新日期:1999-06-15 00:00:00

  • Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells.

    abstract::The glial cell line-derived neurotrophic factor (GDNF) is involved in the development and maintenance of neural tissues. Mutations in components of its signaling pathway lead to severe migration deficits of neuronal crest stem cells, tumor formation, or ablation of the urinary system. In animal models of Parkinson's d...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Pahnke J,Mix E,Knoblich R,Müller J,Zschiesche M,Schubert B,Koczan D,Bauer P,Böttcher T,Thiesen HJ,Lazarov L,Wree A,Rolfs A

    更新日期:2004-07-15 00:00:00

  • Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib.

    abstract::High-grade gliomas (HGG), are the most common aggressive brain tumours in adults. Inhibitors targeting growth factor signalling pathways in glioma have shown a low clinical response rate. To accurately evaluate response to targeted therapies further in vitro studies are necessary. Growth factor pathway expression usin...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Kinsella P,Howley R,Doolan P,Clarke C,Madden SF,Clynes M,Farrell M,Amberger-Murphy V

    更新日期:2012-03-10 00:00:00

  • Prosaposin: a new player in cell death prevention of U937 monocytic cells.

    abstract::We report that prosaposin binds to U937 and is active as a protective factor on tumor necrosis factor alpha (TNFalpha)-induced cell death. The prosaposin-derived saposin C binds to U937 cells in a concentration-dependent manner, suggesting that prosaposin behaves similarly. Prosaposin binding induces U937 cell death p...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Misasi R,Garofalo T,Di Marzio L,Mattei V,Gizzi C,Hiraiwa M,Pavan A,Grazia Cifone M,Sorice M

    更新日期:2004-08-01 00:00:00

  • Cardiac apoptosis caused by elevated cholesterol level in experimental autoimmune myocarditis.

    abstract::It has been reported that cholesterol-lowing agents can ameliorate severity of myocarditis. However, the beneficial effect of the agents has been claimed to be independent of cholesterol reduction as there is no significant change in the plasma cholesterol level in myocarditis. In the present study, using experimental...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Chang H,Wang Y,Wu Y,Ma P,Song Y,Liu C,Ye Y,Qi JH,Qi Z

    更新日期:2020-10-01 00:00:00

  • RelA/NF-kappaB transcription factor associates with alpha-actinin-4.

    abstract::The NF-kappaB/RelA family of transcription factors regulates inducible transcription of a large number of genes in response to diverse stimuli. Little is known, however, about the location of NF-kappaB in the cytoplasm and the transport mechanism to the nucleus. We found that NF-kappaB is associated with the actin-bin...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Babakov VN,Petukhova OA,Turoverova LV,Kropacheva IV,Tentler DG,Bolshakova AV,Podolskaya EP,Magnusson KE,Pinaev GP

    更新日期:2008-03-10 00:00:00

  • Control of Drosophila embryo patterning by transcriptional co-regulators.

    abstract::A combination of broadly expressed transcriptional activators and spatially restricted repressors are used to pattern embryos into cells of different fate. Transcriptional co-regulators are essential mediators of transcription factor function, and contribute to selective transcriptional responses in embryo development...

    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


    authors: Mannervik M

    更新日期:2014-02-01 00:00:00

  • 5-azacytidine reactivates the erythroid differentiation potential of the myeloid-restricted murine cell line 32D Ro.

    abstract::32D cells grown for 1 year in interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) generated the 32D Ro cell line which retained the parental mast cell phenotype but lost ability to generate erythroid cells in response to erythropoietin (EPO). In order to clarify the mechanisms underlying such restri...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Baiocchi M,Di Rico C,Di Pietro R,Di Baldassarre A,Migliaccio AR

    更新日期:2003-05-01 00:00:00

  • Differential effects of bcl-2 on cell death triggered under ATP-depleting conditions.

    abstract::The intracellular ATP concentration decides on the onset of either apoptosis or necrosis in Jurkat cells exposed to death stimuli. Bcl-2 can block apoptotic demise, which occurs preferably under conditions of high cellular ATP levels. Here, we investigated the effects of Bcl-2 on the necrotic type of cell demise that ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Single B,Leist M,Nicotera P

    更新日期:2001-01-01 00:00:00

  • Fetal-adult phenotype transition, in terms of the serum dependency and growth factor requirements, of human skin fibroblast migration.

    abstract::Since the migration of human fetal skin fibroblasts into a denuded area of a cell monolayer has been demonstrated to be serum-independent (fetal phenotype), whereas that of adult-donor skin fibroblasts is serum-dependent (adult phenotype), a study was carried out to determine at which life stage the fetal-adult phenot...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Kondo H,Yonezawa Y

    更新日期:1995-10-01 00:00:00

  • Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.

    abstract::The signals generated by the IFNgamma receptor to initiate mRNA translation and generation of protein products that mediate IFNgamma responses are largely unknown. In the present study, we provide evidence for the existence of an IFNgamma-dependent signaling cascade activated downstream of the phosphatidylinositol (PI...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Lekmine F,Sassano A,Uddin S,Smith J,Majchrzak B,Brachmann SM,Hay N,Fish EN,Platanias LC

    更新日期:2004-04-15 00:00:00

  • Variations in signal-mediated nuclear transport during the cell cycle in BALB/c 3T3 cells.

    abstract::Signal-mediated nuclear import was investigated in proliferating BALB/c 3T3 cells 1, 2, 4, 6, 8, 12, 18, and 21 h after the onset of anaphase. Using nucleoplasmin-coated colloidal gold particles to assay transport capacity, it was found that import was greatest at 1 h postanaphase (after complete reformation of the nu...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Feldherr CM,Akin D

    更新日期:1994-11-01 00:00:00

  • Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma.

    abstract::PDGF acts as an autocrine and paracrine factor in certain tumors through upregulation of the PDGF beta-receptor expression. In order to elucidate the control mechanism for the receptor expression, we have isolated an enhancer from two P1 clones that together contain a 102 kb NotI region covering the entire human PDGFR...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Kaneko M,Yang W,Matsumoto Y,Watt F,Funa K

    更新日期:2006-07-01 00:00:00

  • Determination of downstream targets of FGF signalling using gene trap and cDNA subtractive approaches.

    abstract::Signalling through the fibroblast growth factor family (FGF) of ligands is essential for normal mammalian embryonic development. At a cellular level, many details of the molecular basis of the signal transduction process have been uncovered, but our knowledge of the identity of the downstream effectors of the FGF sign...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Tateossian H,Powles N,Dickinson R,Ficker M,Maconochie M

    更新日期:2004-01-01 00:00:00

  • AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.

    abstract::Upregulated ERK1/2 activity is often correlated with AKT activation during prostate cancer (PCa) progression, yet their functional relation needs elucidation. Using androgen-deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT-mediated B-Raf regulation is...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Hong SK,Jeong JH,Chan AM,Park JI

    更新日期:2013-07-15 00:00:00

  • An amino acid change in novel protein D123 is responsible for temperature-sensitive G1-phase arrest in a mutant of rat fibroblast line 3Y1.

    abstract::A temperature-sensitive mutant of rat fibroblast line 3Y1, 3Y1tsD123, is arrested in the G1 phase of the cell cycle at restrictive temperature. Using a human cDNA expression library, we succeeded in the molecular cloning of a cDNA (designated as D123 cDNA) that functionally complemented the temperature-sensitive mutat...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Okuda A,Kimura G

    更新日期:1996-03-15 00:00:00

  • Organization of early and late replicating DNA in human chromosome territories.

    abstract::It has been suggested that DNA organized into replication foci during S-phase remains stably aggregated in non-S-phase cells and that these stable aggregates provide fundamental units of nuclear or chromosome architecture [C. Meng and R. Berezney (1991) J. Cell Biol. 115, 95a; E. Sparvoli et al. (1994) J. Cell Sci. 10...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Zink D,Bornfleth H,Visser A,Cremer C,Cremer T

    更新日期:1999-02-25 00:00:00

  • Characterization of Caedibacter endonucleobionts from the macronucleus of Paramecium caudatum and the identification of a mutant with blocked R-body synthesis.

    abstract::Cytology, DNA and host-symbiont relationships of x-like endosymbionts from Paramecium caudatum are described. The symbionts (Caedibacter caryophila, sp. nov.) live in the macronuclei of their hosts. They confer the killer trait upon their hosts and appear well adapted to their endonucleobiotic way of life. R bodies (p...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Schmidt HJ,Görtz HD,Pond FR,Quackenbush RL

    更新日期:1988-01-01 00:00:00

  • Complement 5a stimulates macrophage polarization and contributes to tumor metastases of colon cancer.

    abstract::Inflammatory cells such as macrophages can play a pro-tumorigenic role in the tumor stroma. Tumor-associated macrophages (TAMs) generally display an M2 phenotype with tumor-promoting activity; however, the mechanisms regulating the TAM phenotype remain unclear. Complement 5a (C5a) is a cytokine-like polypeptide that i...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Piao C,Zhang WM,Li TT,Zhang CC,Qiu S,Liu Y,Liu S,Jin M,Jia LX,Song WC,Du J

    更新日期:2018-05-15 00:00:00

  • Beta-interferon for multiple sclerosis.

    abstract::Interferon beta is widely used as first-line treatment for relapsing remitting multiple sclerosis (RRMS). Several products are marketed world-wide, and biosimilar products are emerging. Interferon beta reduces relapse rates by about 1/3, and reduces the appearance of new MRI lesions by about 2/3, and some studies have...

    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


    authors: Rudick RA,Goelz SE

    更新日期:2011-05-15 00:00:00

  • Aberrant expression of basic fibroblast growth factor in NIH-3T3 cells alters drug resistance and gene amplification potential.

    abstract::We have investigated the genetic stability of NIH-3T3 cells transfected with sequences coding for basic fibroblast growth factor (bFGF) by determining drug resistance and gene amplification potential. Colony-forming experiments and fluctuation analyses showed that the frequency and rate of resistance to N-(phosphonace...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Huang A,Jin H,Wright JA

    更新日期:1994-08-01 00:00:00

  • Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells.

    abstract::The Rab11 family of small GTPases is composed of three members, Rab11a, Rab11b, and Rab25. While recent work on Rab11a and Rab25 has yielded some insights into their function, Rab11b has received little attention. Therefore, we sought to examine the distribution of endogenous Rab11b in epithelial cells. In rabbit gast...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Lapierre LA,Dorn MC,Zimmerman CF,Navarre J,Burnette JO,Goldenring JR

    更新日期:2003-11-01 00:00:00

  • Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis.

    abstract::KRIT1 is a disease gene responsible for Cerebral Cavernous Malformations (CCM). It encodes for a protein containing distinct protein-protein interaction domains, including three NPXY/F motifs and a FERM domain. Previously, we isolated KRIT1B, an isoform characterized by the alternative splicing of the 15th coding exon...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Francalanci F,Avolio M,De Luca E,Longo D,Menchise V,Guazzi P,Sgrò F,Marino M,Goitre L,Balzac F,Trabalzini L,Retta SF

    更新日期:2009-01-15 00:00:00

  • Intercellular adhesion induced by anti-alpha 3 integrin (VLA-3) antibodies.

    abstract::We generated four monoclonal antibodies (mAbs) specific for human alpha 3 integrin (VLA-3 alpha subunit). All of them were found to induce homotypic cell aggregation of HT1080 fibrosarcoma and SN12C renal carcinoma cells, both of which express high levels of alpha 3 integrin. The antibodies also induced the cell aggre...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Takeuchi K,Tsuji T,Hakomori S,Irimura T

    更新日期:1994-03-01 00:00:00

  • Trafficking of receptor tyrosine kinases to the nucleus.

    abstract::It has been known for at least 20 years that growth factors induce the internalization of cognate receptor tyrosine kinases (RTKs). The internalized receptors are then sorted to lysosomes or recycled to the cell surface. More recently, data have been published to indicate other intracellular destinations for the inter...

    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


    authors: Carpenter G,Liao HJ

    更新日期:2009-05-15 00:00:00

  • A study of the effect of ultraviolet light on the division potential of human diploid fibroblasts.

    abstract::Culture and UV (254 nm) irradiation conditions that are suggested as appropriate for a study of the effect of UV on the limited in vitro lifespan of a normal human diploid fibroblast (HDF) strain are first described. An inoculation density at each subcultivation of 1.8 x 10(4) viable cells/cm-2 permits the decline in ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Kantor GJ,Mulkie JR,Hull DR

    更新日期:1978-05-01 00:00:00

  • Differential regulation of X-chromosome-linked inhibitor of apoptosis protein (XIAP) and caspase-3 by NMDA in developing hippocampal neurons; involvement of the mitochondrial pathway in NMDA-mediated neuronal survival.

    abstract::N-methyl-d-aspartate (NMDA) subtype of glutamate receptors plays an important role during brain development and receptor activation has been shown to promote neuronal survival. The mechanisms by which NMDA increases neuronal survival are not fully understood. Here, we show that treatment with low concentrations of NMD...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Korhonen L,Näpänkangas U,Steen H,Chen Y,Martinez R,Lindholm D

    更新日期:2004-05-01 00:00:00

  • Protein kinase calpha is an effector of hexamethylene bisacetamide-induced differentiation of Friend erythroleukemia cells.

    abstract::The program of biochemical and molecular events necessary for commitment to erythroid cell differentiation is particularly well characterized in murine Friend erythroleukemia cell lines. Commitment to hemoglobin synthesis in response to a variety of chemical inducers, including hexamethylene bisacetamide and dimethyl ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Mallia CM,Aguirre V,McGary E,Tang Y,Scandurro AB,Liu C,Noguchi CT,Beckman BS

    更新日期:1999-02-01 00:00:00

  • Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.

    abstract::Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is know...

    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


    authors: Mirantes C,Passegué E,Pietras EM

    更新日期:2014-12-10 00:00:00