Liver 'organ on a chip'.

Abstract:

:The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity of this organ make it a crucial system of study to better understand human physiology, disease, and response to exogenous compounds. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems.

journal_name

Exp Cell Res

authors

Beckwitt CH,Clark AM,Wheeler S,Taylor DL,Stolz DB,Griffith L,Wells A

doi

10.1016/j.yexcr.2017.12.023

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

15-25

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(17)30678-X

journal_volume

363

pub_type

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