Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli.

abstract：:Histidine-rich glycoprotein (HRGP) is an abundant heparin-binding plasma protein. We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo. The minimal active HRG...

journal_title：Experimental cell research

authors： Lee C,Dixelius J,Thulin A,Kawamura H,Claesson-Welsh L,Olsson AK

更新日期：2006-08-01 00:00:00

abstract：:The protein kinase mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and growth, with the ribosomal subunit S6 kinase 1 (S6K1) as one of the key downstream signaling effectors. A critical role of mTOR signaling in skeletal muscle differentiation has been identified recently, and an unus...

journal_title：Experimental cell research

authors： Park IH,Erbay E,Nuzzi P,Chen J

更新日期：2005-09-10 00:00:00

abstract：:This study deals with the effects of hyper- and hypo-osmotic media on the ultrastructure of four different types of cells and tissues: rat pheochromocytoma cells of line PC12, mouse Ehrlich ascites tumor cells, rat kidney cortex and intestine. Application of hyper-osmotic conditions induces in the nuclear compartment ...

journal_title：Experimental cell research

authors： Delpire E,Duchêne C,Goessens G,Gilles R

更新日期：1985-09-01 00:00:00

abstract：:Human cyclin D1 forms complexes with several Cdks, with proliferating cell nuclear antigen, and with a recently discovered 21-kDa inhibitor of Cdk activity. Substrates for cyclin D1/Cdks have not been identified in vivo, but it has been proposed that the D class of cyclins might play a role in regulating the activity ...

journal_title：Experimental cell research

authors： Atadja P,Wong H,Veillete C,Riabowol K

更新日期：1995-04-01 00:00:00

abstract：:During ovarian folliculogenesis granulosa cells divide while in contact with stromal cells and other granulosa cells. Following ovulation, however, they cease dividing and differentiate into large luteal cells. When cultured in monolayer, granulosa cells spontaneously differentiate into luteal cells, thus confounding ...

journal_title：Experimental cell research

authors： Lavranos TC,Rodgers HF,Bertoncello I,Rodgers RJ

更新日期：1994-04-01 00:00:00

abstract：:We report that a fatty acid auxotroph of Tetrahymena thermophila (RH179E1) fails to mate, yet retains the ability to co-stimulate normal cells unidirectionally. Thus, co-stimulation can be analyzed experimentally in the absence of pair formation. We show that the co-stimulation of normal cells of one mating type is su...

journal_title：Experimental cell research

authors： Katz M,Conner RL,Baum MP,Orias E

更新日期：1987-03-01 00:00:00

abstract：:To study delayed genetic and epigenetic radiation effects, which may trigger radiation-induced carcinogenesis, we have established single-cell clones from irradiated and non-irradiated primary human fibroblasts. Stable clones were endowed with the same karyotype in all analyzed metaphases after 20 population doublings...

journal_title：Experimental cell research

authors： Flunkert J,Maierhofer A,Dittrich M,Müller T,Horvath S,Nanda I,Haaf T

更新日期：2018-09-15 00:00:00

abstract：:Neural stem cells change their characteristics over time during development: they initially proliferate only and then give rise to neurons first and glial cells later. In the absence of the repressor-type basic helix-loop-helix (bHLH) genes Hes1, Hes3 and Hes5, neural stem cells do not proliferate sufficiently but pre...

journal_title：Experimental cell research

authors： Kageyama R,Ohtsuka T,Hatakeyama J,Ohsawa R

更新日期：2005-06-10 00:00:00

abstract：:The long non-coding RNAs (lncRNAs) have gained much attention due to its essential roles in molecular regulation. As one of the classic lncRNAs, H19 is strongly expressed during embryogenesis and plays a crucial biological function during development. Mesenchymal stem cells (MSCs) are an ideal cell source for tissue e...

journal_title：Experimental cell research

authors： Liu Y,Li G,Zhang JF

更新日期：2017-11-15 00:00:00

abstract：:Most coronary smooth muscle cells(CoSMCs) are differentiated from epicardial progenitor cells(EPCs), but the specific mechanism is not fully investigated. Previous studies have shown that autophagy plays an important role for smooth muscle cells(SMCs) differentiation, yet whether autophagy is involved in the different...

journal_title：Experimental cell research

authors： Liu Y,Liu B,Li Y,Li Y,Du J,Deng S,Jing X,She Q

更新日期：2019-02-15 00:00:00

abstract：:The neurohormone serotonin (5HT) triggers meiosis reinitiation in oocytes of the pelecypod molluscs Spisula solidissima and Ruditapes philippinarum. However, while Spisula oocytes complete maturation, Ruditapes oocytes arrest in metaphase I. Anti-phosphotyrosine antibody revealed that serotonin triggered an early tyro...

journal_title：Experimental cell research

authors： Abdelmajid H,Rivailler P,Krantic S,Guerrier P

更新日期：1994-06-01 00:00:00

abstract：:Plasmid 6.4 kbp DNA, 14 kbp DNA, lambda phage particles, all of which contained herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) gene, or IgM molecules, were mixed with erythrocyte membranes and treated with neutral detergent. The transparent mixture was diluted with phosphate-buffered saline (PBS), followed ...

journal_title：Experimental cell research

authors： Sugawa H,Uchida T,Yoneda Y,Ishiura M,Okada Y

更新日期：1985-08-01 00:00:00

abstract：:An earlier report indicated that a 26-amino-acid peptide (SA), comprised of the nuclear localization signal (NLS) of fibroblast growth factor-1 (FGF-1) and a membrane-permeable peptide, was able to stimulate DNA synthesis after it was taken up by NIH3T3 fibroblasts. Here, we report that SA, but not a mutant with the N...

journal_title：Experimental cell research

authors： Komi A,Suzuki M,Imamura T

更新日期：1998-09-15 00:00:00

abstract：:Apoptosis plays an important role in eliminating dysfunctional damaged cells. For skin, the best characterized injurious environmental agent is ultraviolet (UV) irradiation. Most of the damaging UV irradiation is absorbed in the epidermis and leads to apoptosis of keratinocytes. However, epidermal melanocytes appear t...

journal_title：Experimental cell research

authors： Zhai S,Yaar M,Doyle SM,Gilchrest BA

更新日期：1996-05-01 00:00:00

abstract：:A temperature-sensitive mutant of rat fibroblast line 3Y1, 3Y1tsD123, is arrested in the G1 phase of the cell cycle at restrictive temperature. Using a human cDNA expression library, we succeeded in the molecular cloning of a cDNA (designated as D123 cDNA) that functionally complemented the temperature-sensitive mutat...

journal_title：Experimental cell research

authors： Okuda A,Kimura G

更新日期：1996-03-15 00:00:00

abstract：:The high level and intranuclear location of the cellular phosphoprotein p53 are usually regarded as invariant features of SV40-transformed fibroblast lines. During the development of improved methods for immunocytochemical detection of p53 using SVA31 E7 mouse fibroblasts, we have observed unexpected and marked variat...

journal_title：Experimental cell research

authors： Davis D,Wynford-Thomas D

更新日期：1986-09-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are a type of glial cells with morphological plasticity in the olfactory system. Cultured OECs display the process-bearing and flattened shape. Our previous studies have shown that the frontal application of Slit-2 gradient induced the collapse of leading front, and reversed the soma...

journal_title：Experimental cell research

authors： Wang Y,Huang ZH

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Metastatic and/or recurrent breast carcinomas are leading causes of cancer-related death worldwide. Breast cancer stem cells (BCSCs) have been implicated in cancer metastases and progression, thus, the need for the discovery and development of effective BCSCs-specific therapies against metastatic and triple ...

journal_title：Experimental cell research

authors： Chen JH,Kuo KT,Bamodu OA,Lin YC,Yang RB,Yeh CT,Chao TY

更新日期：2018-09-15 00:00:00

abstract：:The importance of the cytoskeleton in protein synthesis was studied in differentiating L6 rat myoblasts. Soluble and cytoskeletal fractions obtained after gentle, non-ionic detergent lysis of myoblasts and myotubes were analysed for the presence of ribosomes and mRNPs. Polysomal mRNPs were predominantly associated wit...

journal_title：Experimental cell research

authors： Bagchi T,Larson DE,Sells BH

更新日期：1987-01-01 00:00:00

abstract：:The dynamics of lamin disassembly and reassembly during sea urchin male pronuclear development in vitro was investigated. Using five anti-lamin antibodies, we monitored by immunofluorescence and immunoblotting the changes in lamins during sperm chromatin decondensation, nuclear envelope (NE) formation, and male pronuc...

journal_title：Experimental cell research

authors： Collas P,Pinto-Correia C,Poccia DL

更新日期：1995-08-01 00:00:00

abstract：:In chick embryo fibroblasts, the mRNA for extracellular matrix protein tenascin-C is induced 2-fold by cyclic strain (10%, 0.3 Hz, 6 h). This response is attenuated by inhibiting Rho-dependent kinase (ROCK). The RhoA/ROCK signaling pathway is primarily involved in actin dynamics. Here, we demonstrate its crucial impor...

journal_title：Experimental cell research

authors： Sarasa-Renedo A,Tunç-Civelek V,Chiquet M

更新日期：2006-05-01 00:00:00

abstract：:Protein C23 (also called nucleolin or 100-kDa nucleolar protein) is a major nucleolar phosphoprotein involved in ribosome biogenesis. To determine the effects of protein C23 on preribosomal RNA (pre-rRNA) synthesis anti-C23 antiserum was microinjected into nuclei of Chironomus tentans salivary glands. Transcription wa...

journal_title：Experimental cell research

authors： Egyhazi E,Pigon A,Chang JH,Ghaffari SH,Dreesen TD,Wellman SE,Case ST,Olson MO

更新日期：1988-10-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) support wound healing processes. These cells express toll-like receptors (TLRs). TLRs perform important key functions when the immune system is confronted with danger signals. TLR ligation by lipopolysaccharides (LPS) activates MSCs and induces intracellular signaling casca...

journal_title：Experimental cell research

authors： Ruhl T,Kim BS,Beier JP

更新日期：2018-09-15 00:00:00

abstract：:Profilin is one of the major components controlling actin polymerization. Here, profilin I was located in fibroblasts and HeLa cells by the use of two different sets of affinity-purified antibodies. Both antibody preparations labeled nuclei in a speckle-like pattern and displayed extensive colocalization with small nu...

journal_title：Experimental cell research

authors： Skare P,Kreivi JP,Bergström A,Karlsson R

更新日期：2003-05-15 00:00:00

abstract：:The technique of fiber DNA measurement was used to study the possibility that the lengthening of the DNA "S" phase previously reported for mouse premeiotic spermatogonia was due to a reduced number of initiation sites. The mean replicon size of neonatal mouse preleptotene cells was similar to sizes reported for adult ...

journal_title：Experimental cell research

authors： Jagiello G,Sung WK,Van't Hof J

更新日期：1983-07-01 00:00:00

abstract：:Recent reports suggest that several viruses, besides human immunodeficiency virus, induce apoptosis in infected cells. We report here that Sendai virus or Herpes simplex virus type 1 (HSV-1), two potent inducers of interferon-alpha, caused cell death in a consistent number of human peripheral blood mononuclear cells. ...

journal_title：Experimental cell research

authors： Tropea F,Troiano L,Monti D,Lovato E,Malorni W,Rainaldi G,Mattana P,Viscomi G,Ingletti MC,Portolani M

更新日期：1995-05-01 00:00:00

abstract：:Elongation factor-1 delta gene expression was analyzed during sea urchin development. EF-1 delta mRNA is present as a single 2.7-kb transcript in unfertilized eggs and in rapidly dividing cleavage stage embryos. It decreases rapidly 6 h after fertilization and then reappears at the gastrula stage as two transcripts of...

journal_title：Experimental cell research

authors： Delalande C,Monnier A,Minella O,Genevière AM,Mulner-Lorillon O,Bellé R,Cormier P

更新日期：1998-07-10 00:00:00

abstract：:Bax∆2 is a functional pro-apoptotic Bax isoform having alterations in its N-terminus, but sharing the rest of its sequence with Baxα. Bax∆2 is unable to target mitochondria due to the loss of helix α1. Instead, it forms cytosolic aggregates and activates caspase 8. However, the functional domain(s) responsible for Bax...

journal_title：Experimental cell research

authors： Mañas A,Wang S,Nelson A,Li J,Zhao Y,Zhang H,Davis A,Xie B,Maltsev N,Xiang J

更新日期：2017-10-15 00:00:00

abstract：:Adhesion to the extracellular matrix regulates numerous changes in the actin cytoskeleton by regulating the activity of the Rho family of small GTPases. Here, we report that adhesion and the associated changes in cell shape and cytoskeletal tension are all required for GTP-bound RhoA to activate its downstream effecto...

journal_title：Experimental cell research

authors： Bhadriraju K,Yang M,Alom Ruiz S,Pirone D,Tan J,Chen CS

更新日期：2007-10-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) are soft-tissue sarcoma commonly encountered in childhood. RMS cells can acquire invasive behavior and form metastases. The metastatic dissemination implicates many proteases among which are mu-calpain and m-calpain. Study of calpain expression and activity underline the deregulation of calpain ...

journal_title：Experimental cell research

authors： Roumes H,Leloup L,Dargelos E,Brustis JJ,Daury L,Cottin P

更新日期：2010-05-15 00:00:00