Molecular genetic characteristics of influenza A virus clinically isolated during 2011-2016 influenza seasons in Korea.

Abstract:

BACKGROUND:The influenza virus is reportedly associated with 3-5 million cases of severe illness and 250 000-500 000 deaths annually worldwide. OBJECTIVES:We investigated the variation of influenza A virus in Korea and examined the association with death. METHODS:A total of 13 620 cases were enrolled in the Hospital-based Influenza Morbidity & Mortality surveillance system in Korea during 2011-2016. Among these cases, a total of 4725 were diagnosed with influenza using RT-PCR (influenza A; n = 3696, influenza B; n = 928, co-infection; n = 101). We used 254 viral sequences from the 3696 influenza A cases for phylogenetic analysis using the BioEdit and MEGA 6.06 programs. RESULTS:We found that the sequences of A/H3N2 in the 2011-2012 season belong to subgroup 3C.1, whereas the sequences in the 2012-2013 season pertain to subgroup 3C.2. The sequences in the 2013-2014 and 2014-2015 seasons involve subgroups 3C.3a and 3C.2a. The A/H1N1pdm09 subtype belongs to subgroup 6 and contains two clusters. In addition, sequence analysis confirmed the several substitutions of internal genes and gene substitutions associated with drug resistance (I222V in NA and S31N in M2) in the fatal cases. While statistical analysis found no significant associations between genetic differences in the viruses and mortality, mortality was associated with certain host factors, such as chronic lung disease. CONCLUSIONS:In conclusion, influenza A virus clade changes occurred in Korea during the 2011-2016 seasons. These data, along with antigenic analysis, can aid in selecting effective vaccine strains. We confirmed that fatality in influenza A cases was related to underlying patient diseases, such as chronic lung disease, and further studies are needed to confirm associations between mortality and viral genetic substitutions.

authors

Lee HS,Noh JY,Song JY,Cheong HJ,Choi WS,Jeong HW,Wie SH,Kim WJ

doi

10.1111/irv.12549

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

497-507

issue

4

eissn

1750-2640

issn

1750-2659

journal_volume

12

pub_type

杂志文章
  • Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model.

    abstract:BACKGROUND:A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of viros...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00256.x

    authors: Pedersen G,Major D,Roseby S,Wood J,Madhun AS,Cox RJ

    更新日期:2011-11-01 00:00:00

  • An outbreak of the 2009 influenza a (H1N1) virus in a children's hospital.

    abstract:CONTEXT:Preventing nosocomial transmission of influenza is essential to reduce the morbidity and mortality associated with this infection. In October 2009, an outbreak of the 2009 influenza A (H1N1) virus occurred in a hematology ward of a children's hospital over a 21-day period and involved two patients and four heal...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00322.x

    authors: Bearden A,Friedrich TC,Goldberg TL,Byrne B,Spiegel C,Schult P,Safdar N

    更新日期:2012-09-01 00:00:00

  • Is abdominal obesity associated with the 2009 influenza A (H1N1) pandemic in Korean school-aged children?

    abstract:OBJECTIVE:Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. METHODS:This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. RESULTS:We found that H1N1 infection was associa...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00318.x

    authors: Kim CO,Nam CM,Lee DC,Chang J,Lee JW

    更新日期:2012-09-01 00:00:00

  • Influenza surveillance capacity improvements in Africa during 2011-2017.

    abstract:BACKGROUND:Influenza surveillance helps time prevention and control interventions especially where complex seasonal patterns exist. We assessed influenza surveillance sustainability in Africa where influenza activity varies and external funds for surveillance have decreased. METHODS:We surveyed African Network for Inf...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12818

    authors: Igboh LS,McMorrow M,Tempia S,Emukule GO,Talla Nzussouo N,McCarron M,Williams T,Weatherspoon V,Moen A,Fawzi D,Njouom R,Nakoune E,Dauoda C,Kavunga-Membo H,Okeyo M,Heraud JM,Mambule IK,Sow SO,Tivane A,Lagare A,Adebay

    更新日期:2020-11-04 00:00:00

  • Transmission parameters of the A/H1N1 (2009) influenza virus pandemic: a review.

    abstract:BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/j.1750-2659.2011.00234.x

    authors: Boëlle PY,Ansart S,Cori A,Valleron AJ

    更新日期:2011-09-01 00:00:00

  • Molecular and demographic analysis of respiratory syncytial virus infection in patients admitted to King Chulalongkorn Memorial Hospital, Thailand, 2007.

    abstract:OBJECTIVES:To preliminary preview the molecular character and its possible clinical correlation of RSV subgroups in Thailand. DESIGN:Cross-sectional analytic design. SETTING:Admitted acute lower respiratory tract infection patients of King Chulalongkorn Memorial Hospital, Bangkok, during Jun-Dec, 2007 were recruited....

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2010.00152.x

    authors: Boonyasuppayakorn S,Kowitdamrong E,Bhattarakosol P

    更新日期:2010-09-01 00:00:00

  • Estimating the secondary attack rate and serial interval of influenza-like illnesses using social media.

    abstract:OBJECTIVES:Knowledge of the secondary attack rate (SAR) and serial interval (SI) of influenza is important for assessing the severity of seasonal epidemics of the virus. To date, such estimates have required extensive surveys of target populations. Here, we propose a method for estimating the intrafamily SAR and SI fro...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12321

    authors: Yom-Tov E,Johansson-Cox I,Lampos V,Hayward AC

    更新日期:2015-07-01 00:00:00

  • Clinic accessibility and clinic-level predictors of the geographic variation in 2009 pandemic influenza vaccine coverage in Montreal, Canada.

    abstract:BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12227

    authors: Charland KM,de Montigny L,Brownstein JS,Buckeridge DL

    更新日期:2014-05-01 00:00:00

  • The Influenza Primer Design Resource: a new tool for translating influenza sequence data into effective diagnostics.

    abstract:BACKGROUND:Recent outbreaks of highly pathogenic avian influenza and multiple occurrences of zoonotic infection and deaths in humans have sparked a dramatic increase in influenza research. In order to rapidly identify and help prevent future influenza outbreaks, numerous laboratories around the world are working to dev...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2007.00031.x

    authors: Bose ME,Littrell JC,Patzer AD,Kraft AJ,Metallo JA,Fan J,Henrickson KJ

    更新日期:2008-01-01 00:00:00

  • Factors associated with influenza vaccination among healthcare workers in acute care hospitals in Canada.

    abstract:BACKGROUND:Influenza vaccine coverage rates among healthcare workers (HCWs) in acute care facilities in Canada remain below national targets. OBJECTIVE:To determine factors associated with influenza vaccine uptake among HCWs. METHODS:This secondary analysis of a prospective cohort study included HCWs aged 18-69 years...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12545

    authors: Hussain H,McGeer A,McNeil S,Katz K,Loeb M,Simor A,Powis J,Langley J,Muller M,Canadian Health Care Worker Study Group.,Coleman BL

    更新日期:2018-05-01 00:00:00

  • No evidence of a link between influenza vaccines and Guillain-Barre syndrome-associated antiganglioside antibodies.

    abstract:BACKGROUND:Guillain-Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside a...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2011.00294.x

    authors: Wang DJ,Boltz DA,McElhaney J,McCullers JA,Webby RJ,Webster RG

    更新日期:2012-05-01 00:00:00

  • Coenzyme Q10 in acute influenza.

    abstract:OBJECTIVES:The goal of this investigation was to determine if acute influenza infection is associated with depletion of CoQ10 compared to healthy controls and to determine any associations between CoQ10 levels and illness severity and inflammatory biomarkers. PATIENTS AND METHODS:We analyzed serum CoQ10 concentrations...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/irv.12608

    authors: Chase M,Cocchi MN,Liu X,Andersen LW,Holmberg MJ,Donnino MW

    更新日期:2019-01-01 00:00:00

  • Cost-effectiveness analysis of antiviral treatment in the management of seasonal influenza A: point-of-care rapid test versus clinical judgment.

    abstract:BACKGROUND:A point-of-care rapid test (POCRT) may help early and targeted use of antiviral drugs for the management of influenza A infection. OBJECTIVE:(i) To determine whether antiviral treatment based on a POCRT for influenza A is cost-effective and, (ii) to determine the thresholds of key test parameters (sensitivi...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12359

    authors: Nshimyumukiza L,Douville X,Fournier D,Duplantie J,Daher RK,Charlebois I,Longtin J,Papenburg J,Guay M,Boissinot M,Bergeron MG,Boudreau D,Gagné C,Rousseau F,Reinharz D

    更新日期:2016-03-01 00:00:00

  • Inactivated pandemic 2009 H1N1 influenza A virus human vaccines have different efficacy after homologous challenge in the ferret model.

    abstract:BACKGROUND:The 2009 pandemic H1N1 (A(H1N1)pdm09) influenza A virus (IAV) has replaced the previous seasonal H1N1 strain in humans and continues to circulate worldwide. The comparative performance of inactivated A(H1N1)pdm09 influenza vaccines remains of considerable interest. The objective of this study was to evaluate...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12784

    authors: Vidaña B,Brookes SM,Everett HE,Garcon F,Nuñez A,Engelhardt O,Major D,Hoschler K,Brown IH,Zambon M

    更新日期:2021-01-01 00:00:00

  • Influenza antivirals currently in late-phase clinical trial.

    abstract::Influenza antiviral drugs are important for the control of influenza, most specifically for the treatment of influenza patients with severe disease following infection with a seasonal influenza virus, a newly emerging influenza strain, or in the event of a pandemic. Many influenza antivirals that are currently under i...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12446

    authors: Koszalka P,Tilmanis D,Hurt AC

    更新日期:2017-05-01 00:00:00

  • Pre-dispensing of antivirals to high-risk individuals in an influenza pandemic.

    abstract::We consider the net benefits of pre-dispensing antivirals to high-risk individuals during an influenza pandemic, where the measure of the benefit is the number of severe outcomes (such as deaths or hospitalizations) prevented by antivirals in the whole population. One potential benefit of pre-dispensing is that indivi...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2009.00128.x

    authors: Goldstein E,Miller JC,O'Hagan JJ,Lipsitch M

    更新日期:2010-03-01 00:00:00

  • Immunogenicity and safety of a 2009 pandemic influenza A (H1N1) monovalent vaccine in Chinese infants aged 6-35 months: a randomized, double-blind, controlled phase I clinical trial.

    abstract:OBJECTIVES:The goal of this double-blind, randomized, controlled clinical trial was to assess the safety and immunogenicity of two different doses of a monovalent split-virion 2009 pandemic influenza A/H1N1 vaccine without adjuvant in Chinese infants aged 6-35 months. DESIGN AND SETTING  Subjects were randomly assigned...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/irv.12028

    authors: Li YP,Li W,Liang XF,Liu Y,Huang XC,Li CG,Li RC,Wang JZ,Wang HQ,Yin WD

    更新日期:2013-11-01 00:00:00

  • Human bocavirus amongst an all-ages population hospitalised with acute lower respiratory infections in Cambodia.

    abstract:BACKGROUND:Human bocavirus (HBoV) is a novel parvovirus that is associated with respiratory and gastrointestinal tract disease. OBJECTIVES:To investigate the prevalence and genetic diversity of HBoV amongst hospitalized patients with acute lower respiratory infection (ALRI) in Cambodia. STUDY DESIGN:  Samples were co...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2012.00369.x

    authors: Arnott A,Vong S,Rith S,Naughtin M,Ly S,Guillard B,Deubel V,Buchy P

    更新日期:2013-03-01 00:00:00

  • The genetic match between vaccine strains and circulating seasonal influenza A viruses in Vietnam, 2001-2009.

    abstract:BACKGROUND:Vietnam is currently developing domestic capability to manufacture influenza vaccines but information on the genetic and antigenic characteristics of locally circulating seasonal influenza viruses is limited. To assess the relevance of WHO recommended vaccine strains to the situation in Vietnam, we analyzed ...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12038

    authors: Vuong CD,Hoang PM,Nguyen HL,Nguyen HT,Nguyen TC,Le TT,Dennis DT,Kapella BK,Kile JC,Le MQ

    更新日期:2013-11-01 00:00:00

  • 1918 pandemic morbidity: The first wave hits the poor, the second wave hits the rich.

    abstract:BACKGROUND:Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." OBJECTIVES:To study the associations between influenz...

    journal_title:Influenza and other respiratory viruses

    pub_type: 历史文章,杂志文章

    doi:10.1111/irv.12541

    authors: Mamelund SE

    更新日期:2018-05-01 00:00:00

  • Antivirals in seasonal and pandemic influenza--future perspectives.

    abstract::Antiviral drugs continue to be an important option for the treatment of influenza disease and will likely be the only option during the early phases of pandemic. However, the limited number of drug classes licensed for treatment of influenza raises several issues, particularly in the face of drug resistance. Two class...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12049

    authors: Wathen MW,Barro M,Bright RA

    更新日期:2013-01-01 00:00:00

  • Characteristics of respiratory viral infections during influenza season in Canadian Hutterite Communities.

    abstract:OBJECTIVES:To determined the pathogen-specific incidence of respiratory virus infection in Hutterite communities occurring over the 2008-2009 influenza season and assess temporal characteristics of respiratory illness related to infection. METHODS:3273 participants community members enrolled in a cluster randomized tr...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/irv.12021

    authors: Kim TH,Russell ML,Fonseca K,Aoki F,Horsman G,Van Caeseele P,Chokani K,Voight M,Babiuk L,Moss L,Webby R,Earn DJ,Singh P,Howse C,Loeb M

    更新日期:2013-11-01 00:00:00

  • Severe acute respiratory infections caused by 2009 pandemic influenza A (H1N1) among American Indians--southwestern United States, May 1-July 21, 2009.

    abstract:BACKGROUND:During April-July 2009, U.S. hospitalization rates for 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were estimated at 4·5/100 000 persons. We describe rates and risk factors for H1N1pdm09 infection among American Indians (AIs) in four isolated southwestern U.S. communities served by the India...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12123

    authors: Suryaprasad A,Redd JT,Hancock K,Branch A,Steward-Clark E,Katz JM,Fry AM,Cheek JE,Influenza Serology Working Group.,American Indian and Alaska Native Pandemic Influenza A (H1N1) Investigation Team.

    更新日期:2013-11-01 00:00:00

  • Mortality attributable to pandemic influenza A (H1N1) 2009 in San Luis Potosí, Mexico.

    abstract:BACKGROUND:Acute respiratory infections are a leading cause of morbidity and mortality worldwide. Starting in 2009, pandemic influenza A(H1N1) 2009 virus has become one of the leading respiratory pathogens worldwide. However, the overall impact of this virus as a cause of mortality has not been clearly defined. OBJECT...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2010.00187.x

    authors: Comas-García A,García-Sepúlveda CA,Méndez-de Lira JJ,Aranda-Romo S,Hernández-Salinas AE,Noyola DE

    更新日期:2011-03-01 00:00:00

  • The national inventory of core capabilities for pandemic influenza preparedness and response: an instrument for planning and evaluation.

    abstract:BACKGROUND:Reviews of the global response to the 2009 pandemic of influenza A/H1N1 affirmed the importance of assessment of preparedness and response capabilities. DESIGN:The U. S. Centers for Disease Control and Prevention (CDC) and partners developed the National Inventory of Core Capabilities for Pandemic Influenza...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12218

    authors: MacDonald G,Moen AC,St Louis ME

    更新日期:2014-03-01 00:00:00

  • A comparative antibody study of the potential susceptibility of Thoroughbred and non-Thoroughbred horse populations in Ireland to equine influenza virus.

    abstract:BACKGROUND:In Ireland, horses may be protected against equine influenza virus (EIV) as a result of natural exposure or vaccination. Current mandatory vaccination programmes are targeted at highly mobile horses. A correlation between antibody levels as measured by single radial haemolysis (SRH) and protective immunity a...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/j.1750-2659.2010.00163.x

    authors: Gildea S,Arkins S,Cullinane A

    更新日期:2010-11-01 00:00:00

  • Influenza hospitalization epidemiology from a severe acute respiratory infection surveillance system in Jordan, January 2008-February 2014.

    abstract:BACKGROUND:Acute respiratory infections (ARIs) are a major cause of morbidity and mortality worldwide. Influenza typically contributes substantially to the burden of ARI, but only limited data are available on influenza activity and seasonality in Jordan. METHODS:Syndromic case definitions were used to identify indivi...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12354

    authors: Al-Abdallat M,Dawson P,Haddadin AJ,El-Shoubary W,Dueger E,Al-Sanouri T,Said MM,Talaat M

    更新日期:2016-03-01 00:00:00

  • Respiratory syncytial virus, an ongoing medical dilemma: an expert commentary on respiratory syncytial virus prophylactic and therapeutic pharmaceuticals currently in clinical trials.

    abstract::As the most important viral cause of severe respiratory disease in infants and increasing recognition as important in the elderly and immunocompromised, respiratory syncytial virus (RSV) is responsible for a massive health burden worldwide. Prophylactic antibodies were successfully developed against RSV. However, thei...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,评审

    doi:10.1111/irv.12313

    authors: Broadbent L,Groves H,Shields MD,Power UF

    更新日期:2015-07-01 00:00:00

  • Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis.

    abstract:BACKGROUND:Pregnant women have an elevated risk of illness and hospitalisation from influenza. Pregnant women are recommended to be prioritised for influenza vaccination during any stage of pregnancy. The risk of seasonal influenza varies substantially throughout the year in temperate climates; however, there is limite...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章,meta分析

    doi:10.1111/irv.12649

    authors: Cuningham W,Geard N,Fielding JE,Braat S,Madhi SA,Nunes MC,Christian LM,Lin SY,Lee CN,Yamaguchi K,Bisgaard H,Chawes B,Chao AS,Blanchard-Rohner G,Schlaudecker EP,Fisher BM,McVernon J,Moss R

    更新日期:2019-09-01 00:00:00

  • Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013.

    abstract:BACKGROUND:Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. METHODS:During August 2011-May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-yea...

    journal_title:Influenza and other respiratory viruses

    pub_type: 杂志文章

    doi:10.1111/irv.12302

    authors: Kittikraisak W,Suntarattiwong P,Levy J,Fernandez S,Dawood FS,Olsen SJ,Chotpitayasunondh T

    更新日期:2015-03-01 00:00:00