Application of gamma irradiation knowledge in tissue sterilisation: inactivation of malaria parasite.

Abstract:

:Malaria is one of the exclusion criteria used in selecting tissue donors and the absence of this information can lead to rejection of tissues for transplant. The studies on the malaria parasite have been confined to low dose attenuation of parasites in blood for transfusion purposes. There is no published information relating to the inactivation of malaria parasites with irradiation for the sterilisation of tissues. A dose-surviving parasite population following radiation was replotted using D0 value from a published paper whereby D10 value of 41 Gy was obtained. Calculation of sterilisation dose for achieving SAL 10-6 of malaria parasites demonstrated the effectiveness of the sterilisation dose of 25 kGy being used in tissue banking.

journal_name

Cell Tissue Bank

journal_title

Cell and tissue banking

authors

Myint P

doi

10.1007/s10561-018-9683-4

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

197-200

issue

2

eissn

1389-9333

issn

1573-6814

pii

10.1007/s10561-018-9683-4

journal_volume

19

pub_type

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