Abstract:
BACKGROUND:Lymphedema of limbs affects a large mass of tissues. Pathological changes develop in skin and subcutaneous tissue. Bacterial retention in edema fluid is followed by chronic inflammatory reaction. The question arises whether the chronic processes affecting a large mass of limb tissues are reflected in the serum by appearance of specific proteins accumulating and subsequently absorbed from the lymphedematous tissues Aim: To measure the concentration of serum proteins (1) participating in cellular disintegration such as caspase 1, sFas, high-mobility group box 1 (HMGB1), and serpin, (2) cell growth regulating factors such as cortisol, human growth hormone, keratinocyte growth factor, and insulin-like growth factor (IGF), and (3) angiogenic and growth factors such as angiopoetins 1 and 2, adiponectin, leptin, and transforming growth factor beta. RESULTS:We found (1) increased concentration of serum caspase 1, sFas, serpin, and HMGB1 accounting for cellular destruction, (2) raised levels of cortisol and IGF, confirming active cellular processes, and (3) elevated concentrations of angiopoetin 1, adiponectin, and leptin, indicating proliferation of adipose tissue. CONCLUSIONS:Proteins appearing in serum in high concentrations in patients with lymphedema without systemic clinical and biochemical signs of inflammation indicate that multiple processes of destruction and rebuilding proceed in the lymphedematous tissues. Measuring concentration of caspase 1, sFas, serpin, HMGB1 protein, adiponectin, and leptin give insight into these processes. Lymphedema should be considered as tissue process characterized not only by increase in mobile tissue fluid volume but also tissue restructuring. Compression and drainage therapy should be complemented by anti-inflammatory medication.
journal_name
Lymphat Res Bioljournal_title
Lymphatic research and biologyauthors
Zaleska MT,Olszewski WLdoi
10.1089/lrb.2017.0003subject
Has Abstractpub_date
2017-09-01 00:00:00pages
246-251issue
3eissn
1539-6851issn
1557-8585journal_volume
15pub_type
杂志文章abstract:: Background: Platelet-rich plasma (PRP) is an autologous concentrated preparation of platelets characterized by lymphangiogenetic and tissue-repairing effects. Although PRP has been safely used in many different fields, there is no clinical study regarding the use of PRP in...
journal_title:Lymphatic research and biology
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abstract::Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarrin...
journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
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pub_type: 杂志文章,多中心研究
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journal_title:Lymphatic research and biology
pub_type: 杂志文章,多中心研究
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journal_title:Lymphatic research and biology
pub_type: 杂志文章,评审
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
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