Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling.

Abstract:

:Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.

journal_name

Lymphat Res Biol

authors

Bennuru S,Nutman TB

doi

10.1089/lrb.2009.0022

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

215-9

issue

4

eissn

1539-6851

issn

1557-8585

journal_volume

7

pub_type

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