Abstract:
PURPOSE:Lymphedema can have a negative impact on the function and quality of life (QOL) of patients, but most studies have examined lymphedema as a binary variable, rather than a multidimensional disease that ranges in severity. This study explored the potential impact of lymphedema severity on function and overall QOL. METHODS AND RESULTS:Of the 54 lymphedema patients recruited, 40 reported their most severe swelling to be in a limb. These participants underwent bioimpedance measurement (L-Dex®) and completed either the disabilities of the arm, shoulder, and hand (DASH) questionnaire or the lower extremity functional scale (LEFS). All participants completed the lymphedema quality of life questionnaire (LYMQOL) and were categorized for severity using International Society of Lymphology (ISL) stage. Mild (Stage 0-I), moderate (Stage IIa), and severe (Stage IIb-III) lymphedema accounted for 22%, 50%, and 28% of the participants, respectively. The median [inter-quartile range (IQR)] L-Dex score was 17.8 (6.6-52.7) for arm participants and 36.4 (15.9-93.5) for leg participants. Apart from a mild difference in LYMQOL ARM Appearance domain (p = 0.046), ISL staging did not have any relationship with DASH, LEFS, and LYMQOL domains, or overall QOL. Higher L-Dex was related to poorer function (DASH p = 0.015; LEFS p = 0.019), but was not related to overall QOL of limb lymphedema participants (p > 0.05). CONCLUSIONS:Lymphedema severity did not appear to impact QOL. ISL staging may not be used alone to describe lymphedema severity. Other methods such as bioimpedance, imaging, and self-report of symptoms are required to fully evaluate the impact of lymphedema severity on function and QOL.
journal_name
Lymphat Res Bioljournal_title
Lymphatic research and biologyauthors
Lee TS,Morris CM,Czerniec SA,Mangion AJdoi
10.1089/lrb.2016.0049subject
Has Abstractpub_date
2018-02-01 00:00:00pages
85-91issue
1eissn
1539-6851issn
1557-8585journal_volume
16pub_type
杂志文章abstract:BACKGROUND:In arm lymphedema secondary to axillary surgery and radiotherapy (breast cancer-related lymphedema), the swelling is largely epifascial and lymph flow per unit epifascial volume is impaired. The subfascial muscle compartment is not measurably swollen despite the iatrogenic damage to its axillary drainage pat...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/153968503321642615
更新日期:2003-01-01 00:00:00
abstract:: Background: Platelet-rich plasma (PRP) is an autologous concentrated preparation of platelets characterized by lymphangiogenetic and tissue-repairing effects. Although PRP has been safely used in many different fields, there is no clinical study regarding the use of PRP in...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0064
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Lymphedema is the abnormal accumulation of protein-rich fluid in the interstitial space. Primary lymphedema is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance. Three genes, FLT4 (VEGFR3), FOXC2, and SOX18 cause varying forms of primary lymphedema. In industr...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2008.1524
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The aim of the article was to assess risk factors and to analyze methods applied in the prevention and treatment of lower limb edema in pregnant women with a particular focus on compression therapy and exercise. MATERIALS AND METHODS:Fifty-four women during the early 24-hour period following delivery were as...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2016.0038
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:The putrefaction factor is one of the biggest problems when undertaking unembalmed cadaveric tissue dissections for lymphatic vessel mapping. METHODS:One female bilateral breast and anterior upper torso from an unembalmed human cadaver was studied over an 8-week period. Multiple prefrozen domestic ice brick...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2008.1020
更新日期:2009-01-01 00:00:00
abstract::Abstracts Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. METHODS AND RESULTS:Sixty female patients with arm ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2016.0035
更新日期:2017-03-01 00:00:00
abstract::The knowledge of humoral and cellular factors retained in tissues affected by ineffective lymph transport is necessary to comprehend the pathological mechanisms of the evolving changes in the extremity. In this article, we report our observations on changes in the protein composition of lymph in obstructive lymphedema...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/153968503768330265
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Lymphedema of the arm and/or hand is a well-established complication of breast cancer therapy. The objective of the study was to determine the interest of auto-adjustable MOBIDERM® Autofit night arm sleeve in controlling edema rebound effect in breast cancer-related lymphedema patients just after a successfu...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2017.0026
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Surgical manipulations of the axilla may cause a condition known as Axillary Web Syndrome (AWS). The systems compromised and the sequence of events leading to this syndrome remains unknown. This study evaluated clinical, surgical, and vascular factors associated with onset and duration of AWS after breast ca...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2017.0037
更新日期:2018-06-01 00:00:00
abstract:: Background: The purpose of this study was to investigate acute cardiovascular responses to manual lymphatic drainage (MLD) on different parts of the body. Materials and Methods: Thirty healthy individuals (10 women and 20 men) ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2018.0043
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Lymph is pumped through the collecting lymphatic vessels by both intrinsic and extrinsic forces, propelling it downstream back into circulation. The intrinsic lymph pump relies on the spontaneous contraction of lymphatic muscles to generate the force of pumping lymph (P(lp)). However, the association between...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2014.0015
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The spleen has an important physiological role in maintaining blood volume; this study aimed to determine whether during pathophysiological circumstances, namely endotoxemia, the extrasplenic pathway is dysfunctional. We hypothesize that increased 'leakiness' of lymphatics in response to lipopolysaccharide (...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2008.1019
更新日期:2009-01-01 00:00:00
abstract:: Background: Conservative nonsurgical treatment has traditionally been applied to lymphedema. Early surgical procedures were invasive and disfiguring and their long-term success was often limited. In contrast, contemporary surgical techniques are much less invasive and have...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2018.0038
更新日期:2019-08-01 00:00:00
abstract:: Background: Local tissue water in patients with breast cancer-related lymphedema (BCRL) can be assessed by measurement of the tissue dielectric constant using the MoistureMeterD Compact® (MMDC) device, or by performing the pitting test. Although these assessment methods ar...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0013
更新日期:2020-04-01 00:00:00
abstract:: Background: Lymphedema may impact patients' health-related quality of life (HRQoL). The purpose of this study was to evaluate HRQoL after two different treatments to the 12-month follow-up point. Methods and Results: Study part...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2018.0065
更新日期:2020-08-01 00:00:00
abstract:: Background: Surgical excision and/or radiation targeting of regional lymph nodes are an essential component in the clinical management of cancer. Importantly, a more accurate understanding of lymphatic anatomy could enable refinement of present treatment strategies. Given ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0007
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Changes in arm soft tissue composition, especially increased adipose tissue, has been found in advanced, non-pitting breast cancer-related lymphedema (BCRL). The aim of this study was to examine whether these changes were localized to any particular region of the arm and whether they occurred in lymphedema w...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2014.0033
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Lymphatic stomata are small lymphatic openings in the serosal membrane that communicate with the serosal cavity. Although these stomata have primarily been studied in experimental mammals, little is known concerning the presence and properties of lymphatic stomata in the adult human pleura. Thus, adult human...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2014.0009
更新日期:2015-06-01 00:00:00
abstract::Pediatric hepatic angiosarcoma is a very rare malignant vascular tumor. A few cases have shown pediatric hepatic angiosarcoma occurring on a background of preexisting vascular lesions. We report the case of a newborn girl who presented extensive limbs and upper trunk cutaneous mixed vascular malformations at birth. Th...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2009.0034
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Lower limb lymphedema (LLL) is a common complication of cancer treatment. The disease is chronic and progressive with no cure. Although a common and significant source of morbidity, the impact of this condition on health-related quality of life (HRQOL) has only recently been addressed. In effort to identify ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章,评审
doi:10.1089/lrb.2012.0015
更新日期:2013-03-01 00:00:00
abstract:: Background: Chronic edema/lymphedema is defined as edema present for more than 3 months. It is underrecognized and undertreated. The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0014
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Tissue dielectric constant (TDC) and spot bioimpedance measurement (BIA) have a role in the assessment of tissue composition changes in breast cancer-related lymphedema (BCRL). Our aims were to determine whether TDC and spot BIA measures could detect inter-limb differences in BCRL, explore the relationship b...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2014.0032
更新日期:2015-03-01 00:00:00
abstract::The vasculature of the central nervous system (CNS) is highly specialized with a blood-brain-barrier, reciprocal neuroepithelial-endothelial cell interactions and extensive pericyte coverage. Developmentally, numerous important signaling pathways participate in CNS angiogenesis to orchestrate the precise timing and sp...
journal_title:Lymphatic research and biology
pub_type: 杂志文章,评审
doi:10.1089/lrb.2008.1014
更新日期:2008-01-01 00:00:00
abstract:: Introduction: Mass drug administration and morbidity management and disability prevention (MMDP) though considered as two pillars of global program for elimination of filariasis, implementation of MMDP was disregarded in several endemic countries. Limb hygiene is the main ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0058
更新日期:2020-12-01 00:00:00
abstract:: Background: The use of bioimpedance spectroscopy (BIS) for the detection of unilateral upper limb lymphedema is growing. Currently, normatively determined diagnostic thresholds using bioimpedance are available for females only. It is unclear if they are suitable for males ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2018.0051
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Primary idiopathic lymphedema is an uncommon condition that typically affects the lower extremities. Patients have a malformed lymphatic system that causes subcutaneous fluid and adipose deposition. Rarely, the disease also has been described in the upper extremities. The purpose of this study was to investi...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2017.0085
更新日期:2019-02-01 00:00:00
abstract::Primary lymphedema is due to abnormal congenital development or dysfunction in the lymphatic system. Limited data exist on the prevalence of primary lymphedema and there are only few studies focusing on primary lymphedema. The purpose of this article is to review the current options for surgical treatment of primary l...
journal_title:Lymphatic research and biology
pub_type: 杂志文章,评审
doi:10.1089/lrb.2017.0007
更新日期:2017-09-01 00:00:00
abstract:: Background: The Lymphedema Functioning, Disability, and Health questionnaire for Upper Limb Lymphedema (Lymph-ICF-UL) is a health-related quality-of-life questionnaire for patients with breast cancer-related lymphedema. Previous testing of this questionnaire showed very go...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0073
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Near-infrared fluorescence (NIRF) imaging is a new imaging technique that is used to visualize lymphatic vessels in humans. It has a high spatial and temporal resolution, allowing real-time visualization of lymphatic flow. METHODS AND RESULTS:The current study investigated the intra- and inter-individual va...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2016.0061
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Lymphedema leads to adipose tissue deposition. Water-fat magnetic resonance imaging (MRI) can quantify and localize fat and water. The presence of excess fat and excess water/muscle in the subfascial compartment of the lymphedematous limb has not been investigated before. The aim of this study was to investi...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2017.0042
更新日期:2018-04-01 00:00:00