Abstract:
: Background: Conservative nonsurgical treatment has traditionally been applied to lymphedema. Early surgical procedures were invasive and disfiguring and their long-term success was often limited. In contrast, contemporary surgical techniques are much less invasive and have been shown to be effective in reducing excess limb volume, the risk of cellulitis, and the need for compression garments. Microsurgical procedures such as lymphovenous anastomosis and vascularized lymph node transfer can treat the excess fluid component of lymphedema and are gaining in popularity. In this study, we first evaluate the possibility of generating lymphedema in the hind limb of a rabbit and then describe its treatment with microsurgical lymph node transfer without lymph vessel transfer. Methods and Results: In experimental rabbit models, animals first underwent surgery in which the popliteal lymph node was removed to create lymphedema in the hind limb. After 15 days, another operation was performed to excise the contralateral popliteal lymph node and transfer it to the limb with lymphedema. Our model showed that lymph node transfer was able to reduce lymphedema in the rabbit's hind limb; intervened hind limb: basal volume (51.94 ± 11.23), volume day transfer (73.40 ± 26.47), and final volume (50.13 ± 12). Conclusion: We have developed a feasible model to microsurgically induce and treat lymphedema by lymph node transfer that shows promising results.
journal_name
Lymphat Res Bioljournal_title
Lymphatic research and biologyauthors
Fernández Peñuela R,Casaní Arazo L,Masiá Ayala Jdoi
10.1089/lrb.2018.0038subject
Has Abstractpub_date
2019-08-01 00:00:00pages
413-417issue
4eissn
1539-6851issn
1557-8585journal_volume
17pub_type
杂志文章abstract:: Background: Surgical excision and/or radiation targeting of regional lymph nodes are an essential component in the clinical management of cancer. Importantly, a more accurate understanding of lymphatic anatomy could enable refinement of present treatment strategies. Given ...
journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0007
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
pub_type: 杂志文章
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journal_title:Lymphatic research and biology
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doi:10.1089/lrb.2017.0042
更新日期:2018-04-01 00:00:00
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Lymphatic research and biology
pub_type: 杂志文章
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journal_title:Lymphatic research and biology
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journal_title:Lymphatic research and biology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Lymphatic research and biology
pub_type: 杂志文章
doi:10.1089/lrb.2019.0073
更新日期:2020-08-01 00:00:00
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journal_title:Lymphatic research and biology
pub_type: 杂志文章
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journal_title:Lymphatic research and biology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Lymphatic research and biology
pub_type: 临床试验,杂志文章,随机对照试验
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