A Randomized Controlled Trial Comparing Platelet-Rich Plasma, Low-Level Laser Therapy, and Complex Decongestive Physiotherapy in Patients with Lower Limb Lymphedema.


: Background: Platelet-rich plasma (PRP) is an autologous concentrated preparation of platelets characterized by lymphangiogenetic and tissue-repairing effects. Although PRP has been safely used in many different fields, there is no clinical study regarding the use of PRP in lymphedema treatment in humans. We assessed the clinical outcomes of PRP in patients with lower extremity lymphedema (LEL) in a randomized controlled trial. Methods and Results: Patients with secondary LEL were randomly allocated to one of three groups consisting of treatment with PRP with complex decongestive physiotherapy (PRP+CDP group), low-level laser therapy with CDP (LLLT+CDP group), and only CDP (CDP group). Assessment of Lymphedema Quality of-Life Questionnaire (LYMQOL) for health-related quality of life, lower-extremity-circumference (LEC) for edema, tissue dielectric constant (TDC) for extremity volume, 6-minute walking test (6MWT) for functional capacity, and numeric rating scale (NRS) scoring for extremity fullness were evaluated both before and after treatment. Forty-five patients (68.8% female) with mean age 40.84 ± 15.81 years were included in the study. Significant differences in LYMQOL, LEC, NRS, and TDC values both before and after treatment were found in all groups; however, there were no statistically significant difference in values between the three groups. In the PRP+CDP group, LYMQOL values had a larger effect size than the other two groups. Significant differences in 6MWT values both before and after treatment were found in PRP+CDP and LLLT+CDP groups; however, there was no statistically significant difference in the CDP group. Conclusion: This is the first clinical study to evaluate the usage of PRP in patients with secondary LEL. PRP might be an additional treatment option of lymphedema management; however, more clinical trials in humans are needed to yield more evidence in the usage of PRP in patients with lymphedema.


Lymphat Res Biol


Akgul A,Tarakci E,Arman N,Civi T,Irmak S




Has Abstract


2020-10-01 00:00:00












  • Risk stratification in hemangiomas of infancy.

    abstract::Hemangiomas of infancy are very common tumors, but they are heterogeneous in their behavior. A small, but significant, subset causes medical complications or permanent disfigurement, but due to their heterogeneity, there is no appropriate "one size fits all" approach to management. In addition, the rapid evolution of ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Frieden IJ

    更新日期:2003-01-01 00:00:00

  • Assessment of segmental arm soft tissue composition in breast cancer-related lymphedema: a pilot study using dual energy X-ray absorptiometry and bioimpedance spectroscopy.

    abstract:BACKGROUND:Changes in arm soft tissue composition, especially increased adipose tissue, has been found in advanced, non-pitting breast cancer-related lymphedema (BCRL). The aim of this study was to examine whether these changes were localized to any particular region of the arm and whether they occurred in lymphedema w...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Czerniec SA,Ward LC,Meerkin JD,Kilbreath SL

    更新日期:2015-03-01 00:00:00

  • Extracellular RNA Profile in Mesenteric Lymph from Exemplar Rat Models of Acute and Critical Illness.

    abstract:: Background: Mesenteric lymph (ML) has been implicated in the development of multiple organ dysfunction syndrome in critical illness. Extracellular RNAs play a role in cell-to-cell communication during physiological and disease processes but they are rarely studied in ML. W...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Hong J,Blenkiron C,Tsai P,Premkumar R,Nachkebia S,Tun SM,Petzer A,Windsor JA,Hickey AJ,Phillips AR

    更新日期:2019-10-01 00:00:00

  • Postoperative evolution of thickness and echogenicity of cutis and subcutis of patients with and without breast cancer-related lymphedema.

    abstract:BACKGROUND:Compared to volume/circumference measurements to diagnose lymphedema, thickening and disturbance of echogenicity of cutis and subcutis associated with the development of lymphedema is measured directly by ultrasonography. The aim of the present study was to investigate the evolution of thickness and echogeni...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Devoogdt N,Pans S,De Groef A,Geraerts I,Christiaens MR,Neven P,Vergote I,Van Kampen M

    更新日期:2014-03-01 00:00:00

  • Lymphatic Stomata in the Adult Human Pulmonary Ligament.

    abstract:BACKGROUND:Lymphatic stomata are small lymphatic openings in the serosal membrane that communicate with the serosal cavity. Although these stomata have primarily been studied in experimental mammals, little is known concerning the presence and properties of lymphatic stomata in the adult human pleura. Thus, adult human...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Oshiro H,Miura M,Iobe H,Kudo T,Shimazu Y,Aoba T,Okudela K,Nagahama K,Sakamaki K,Yoshida M,Nagao T,Nakaya T,Kurata A,Ohtani O

    更新日期:2015-06-01 00:00:00

  • Yellow nail syndrome: treatment of lymphedema using low pressure compression.

    abstract::The present report describes a case with the triad of yellow nail syndrome (YNS) and the use of low-pressure compression pump as treatment of lymphedema in YNS. A 71-year-old woman presented with bilateral lower extremity lymphedema, yellow nails, and recurrent bilateral pleural effusion. In this case, we specifically...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Polat AK,Dang HT,Soran A

    更新日期:2012-03-01 00:00:00

  • Lymphedema Impact and Prevalence International Study: The Canadian Data.

    abstract:: Background: Chronic edema/lymphedema is defined as edema present for more than 3 months. It is underrecognized and undertreated. The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Keast DH,Moffatt C,Janmohammad A

    更新日期:2019-04-01 00:00:00

  • Lymphatic Endothelial Cells under Mechanical Stress: Altered Expression of Inflammatory Cytokines and Fibrosis.

    abstract:BACKGROUND:Secondary lymphedema, resulting from damage to lymphatic vessels, is a common sequela following surgical removal of lymph nodes for cancer. Current therapeutics for treating lymphedema are limited and further research on underlying causes is warranted. Published studies on molecular mechanisms of lymphedema ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Wang S,Nie D,Rubin JP,Kokai L

    更新日期:2017-06-01 00:00:00

  • Clinical Benefits of Supervised Home Care of the Morbidity Management and Disability Prevention Under National Filariasis Elimination Programme.

    abstract:: Introduction: Mass drug administration and morbidity management and disability prevention (MMDP) though considered as two pillars of global program for elimination of filariasis, implementation of MMDP was disregarded in several endemic countries. Limb hygiene is the main ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: De Britto L,Kamaraj P,Vijayalakshmi G,Das LK,Krishnakumari A,Anbusivam S,Supriya VK,Yuvaraj J

    更新日期:2020-12-01 00:00:00

  • Normative Interlimb Impedance Ratios: Implications for Early Diagnosis of Uni- and Bilateral, Upper and Lower Limb Lymphedema.

    abstract:: Background: Bioimpedance spectroscopy detects unilateral lymphedema if the ratio of extracellular fluid (ECF) between arms or between legs is outside three standard deviations (SDs) of the normative mean. Detection of bilateral lymphedema, common after bilateral breast or ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Steele ML,Janda M,Vagenas D,Ward LC,Cornish BH,Box R,Gordon S,Matthews M,Poppitt SD,Plank LD,Yip W,Rowan A,Reul-Hirche H,Obermair A,Hayes SC

    更新日期:2018-12-01 00:00:00

  • Outcomes in Vascularized Lymph Node Transplantation in Rabbits: A Reliable Model for Improving the Surgical Approach to Lymphedema.

    abstract:: Background: Conservative nonsurgical treatment has traditionally been applied to lymphedema. Early surgical procedures were invasive and disfiguring and their long-term success was often limited. In contrast, contemporary surgical techniques are much less invasive and have...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Fernández Peñuela R,Casaní Arazo L,Masiá Ayala J

    更新日期:2019-08-01 00:00:00

  • Comparison of intermittent pneumatic compression with manual lymphatic drainage for treatment of breast cancer-related lymphedema.

    abstract:BACKGROUND:The aim of this prospective controlled study was to assess the efficacy of two different combination treatment modalities of lymphedema (LE). Manual lymphatic drainage (MLD) and compression bandage combination (complex decongestive therapy) have been compared with intermittent pneumatic compression (IPC) plu...

    journal_title:Lymphatic research and biology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gurdal SO,Kostanoglu A,Cavdar I,Ozbas A,Cabioglu N,Ozcinar B,Igci A,Muslumanoglu M,Ozmen V

    更新日期:2012-09-01 00:00:00

  • Electrical Stimulation in the Treatment of Lymphedema and Associated Skin Ulcers.

    abstract:: Background: Lymphedema is a disorder in which lymph accumulates in the interstitial spaces due to poor lymphatic flow resulting from hypoplasia or aplasia of the lymphatic vessels, or to morpho-functional alterations that impair lymphatic flow. Lymphedema is a debilitating...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Baglivo M,Martelli F,Paolacci S,Manara E,Michelini S,Bertelli M

    更新日期:2020-06-01 00:00:00

  • HGF and MET mutations in primary and secondary lymphedema.

    abstract:BACKGROUND:Lymphedema is the abnormal accumulation of protein-rich fluid in the interstitial space. Primary lymphedema is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance. Three genes, FLT4 (VEGFR3), FOXC2, and SOX18 cause varying forms of primary lymphedema. In industr...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Finegold DN,Schacht V,Kimak MA,Lawrence EC,Foeldi E,Karlsson JM,Baty CJ,Ferrell RE

    更新日期:2008-01-01 00:00:00

  • Lymphedema Leads to Fat Deposition in Muscle and Decreased Muscle/Water Volume After Liposuction: A Magnetic Resonance Imaging Study.

    abstract:BACKGROUND:Lymphedema leads to adipose tissue deposition. Water-fat magnetic resonance imaging (MRI) can quantify and localize fat and water. The presence of excess fat and excess water/muscle in the subfascial compartment of the lymphedematous limb has not been investigated before. The aim of this study was to investi...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Hoffner M,Peterson P,Månsson S,Brorson H

    更新日期:2018-04-01 00:00:00

  • Developmental angiogenesis of the central nervous system.

    abstract::The vasculature of the central nervous system (CNS) is highly specialized with a blood-brain-barrier, reciprocal neuroepithelial-endothelial cell interactions and extensive pericyte coverage. Developmentally, numerous important signaling pathways participate in CNS angiogenesis to orchestrate the precise timing and sp...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Mancuso MR,Kuhnert F,Kuo CJ

    更新日期:2008-01-01 00:00:00

  • Assessment of breast cancer-related lymphedema: a comparison of moisture meter and spot bioimpedance measurement.

    abstract:BACKGROUND:Tissue dielectric constant (TDC) and spot bioimpedance measurement (BIA) have a role in the assessment of tissue composition changes in breast cancer-related lymphedema (BCRL). Our aims were to determine whether TDC and spot BIA measures could detect inter-limb differences in BCRL, explore the relationship b...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Czerniec SA,Ward LC,Kilbreath SL

    更新日期:2015-03-01 00:00:00

  • Reliability of the MoistureMeterD Compact Device and the Pitting Test to Evaluate Local Tissue Water in Subjects with Breast Cancer-Related Lymphedema.

    abstract:: Background: Local tissue water in patients with breast cancer-related lymphedema (BCRL) can be assessed by measurement of the tissue dielectric constant using the MoistureMeterD Compact® (MMDC) device, or by performing the pitting test. Although these assessment methods ar...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: De Vrieze T,Gebruers N,Nevelsteen I,De Groef A,Tjalma WAA,Thomis S,Dams L,Van der Gucht E,Penen F,Devoogdt N

    更新日期:2020-04-01 00:00:00

  • Risk Factors Related to Lower Limb Edema, Compression, and Physical Activity During Pregnancy: A Retrospective Study.

    abstract:OBJECTIVE:The aim of the article was to assess risk factors and to analyze methods applied in the prevention and treatment of lower limb edema in pregnant women with a particular focus on compression therapy and exercise. MATERIALS AND METHODS:Fifty-four women during the early 24-hour period following delivery were as...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Ochalek K,Pacyga K,Curyło M,Frydrych-Szymonik A,Szygula Z

    更新日期:2017-06-01 00:00:00

  • Systematic review of quality of life and patient reported outcomes in patients with oncologic related lower extremity lymphedema.

    abstract:BACKGROUND:Lower limb lymphedema (LLL) is a common complication of cancer treatment. The disease is chronic and progressive with no cure. Although a common and significant source of morbidity, the impact of this condition on health-related quality of life (HRQOL) has only recently been addressed. In effort to identify ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Cemal Y,Jewell S,Albornoz CR,Pusic A,Mehrara BJ

    更新日期:2013-03-01 00:00:00

  • Low Lymphatic Pumping Pressure in the Legs Is Associated with Leg Edema and Lower Quality of Life in Healthy Volunteers.

    abstract:BACKGROUND:Lymph is pumped through the collecting lymphatic vessels by both intrinsic and extrinsic forces, propelling it downstream back into circulation. The intrinsic lymph pump relies on the spontaneous contraction of lymphatic muscles to generate the force of pumping lymph (P(lp)). However, the association between...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Saito T,Unno N,Yamamoto N,Inuzuka K,Tanaka H,Sano M,Sugisawa R,Katahashi K,Konno H

    更新日期:2015-06-01 00:00:00

  • Blood Flow Velocity in Brachial and Subclavian Vessels Immediately After Compressive Procedures for Treatment of Postcancer Therapy Lymphedema in Breast Cancer: A Randomized Blind Clinical Trial.

    abstract:OBJECTIVE:This study sought to evaluate the effect of elastic compression, functional compressive bandaging, and kinesiotherapy on blood flow of the upper limb with lymphedema secondary to the treatment of breast cancer. METHODS:This was a randomized blind crossover clinical trial with a washout period of 7 days betwe...

    journal_title:Lymphatic research and biology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rezende MS,Marsengo AL,de Jesus Guirro RR,de Oliveira Guirro EC

    更新日期:2017-03-01 00:00:00

  • Intra- and Inter-Rater Reliability of Bioimpedance in the Evaluation of Lymphedema Secondary to Treatment of Breast Cancer.

    abstract::The objective of the study was to evaluate the intra- and inter-rater reliability of bioimpedance in determining upper limb volume in women with lymphedema resulting from breast cancer treatment, as well as its correlation with the upper limb volume calculated by circumferential measurement. A blind cross-sectional st...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Ferro AP,Ferreira VTK,Rezende MS,de Souza TR,Almeida AM,Guirro RRJ,Guirro ECO

    更新日期:2018-06-01 00:00:00

  • Acute Cardiovascular Responses to the Application of Manual Lymphatic Drainage in Different Body Regions.

    abstract:: Background: The purpose of this study was to investigate acute cardiovascular responses to manual lymphatic drainage (MLD) on different parts of the body. Materials and Methods: Thirty healthy individuals (10 women and 20 men) ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Esmer M,Keser I,Erer D,Kupeli B

    更新日期:2019-06-01 00:00:00

  • Increased lymphangiogenesis and hemangiogenesis in infant cornea.

    abstract:BACKGROUND:Corneal lymphangiogenesis (LG) and hemangiogenesis (HG) accompany many diseases after inflammatory, infectious, traumatic or chemical insults. They also contribute to transplant rejection. It is known that corneal transplants in infants or children have a higher rejection rate than in adults. However, it has...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Yuen D,Leu R,Sadovnikova A,Chen L

    更新日期:2011-01-01 00:00:00

  • Passive pressure-diameter relationship and structural composition of rat mesenteric lymphangions.

    abstract:BACKGROUND:Lymph flow depends on both the rate of lymph production by tissues and the extent of passive and active pumping. Here we aim to characterize the passive mechanical properties of a lymphangion in both mid-lymphangion and valve segments to assess regional differences along a lymphangion, as well as evaluating ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Rahbar E,Weimer J,Gibbs H,Yeh AT,Bertram CD,Davis MJ,Hill MA,Zawieja DC,Moore JE Jr

    更新日期:2012-12-01 00:00:00

  • Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix.

    abstract::Exciting studies involving the molecular regulation of lymphangiogenesis in lymphatic-associated disorders (e.g., wound healing, lymphedema and tumor metastasis) have focused renewed attention on the intrinsic relationship between lymphatic endothelial cells (LECs) and extracellular matrix (ECM) microenvironment. ECM ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Ji RC

    更新日期:2006-01-01 00:00:00

  • Electrode Equivalence for Use in Bioimpedance Spectroscopy Assessment of Lymphedema.

    abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) is commonly used in the assessment and monitoring of lymphedema. This study investigated electrodes as a source of variability that could impact the accuracy of BIS in the clinic and determined if Ag/AgCl electrocardiograph (ECG) electrodes could be used as an alternative to i...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Svensson BJ,Dylke ES,Ward LC,Kilbreath SL

    更新日期:2019-02-01 00:00:00

  • Determining the precision of dual energy x-ray absorptiometry and bioelectric impedance spectroscopy in the assessment of breast cancer-related lymphedema.

    abstract:BACKGROUND:The composition of breast cancer-related lymphedema (BCRL) has been shown to evolve from the initial accumulation of fluid to the development of fibrotic lesions and abnormal fat deposition. Therefore, precise and reliable assessments of BCRL are required to develop accurate staging and management. Although ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Newman AL,Rosenthall L,Towers A,Hodgson P,Shay CA,Tidhar D,Vigano A,Kilgour RD

    更新日期:2013-06-01 00:00:00

  • Surgical Treatment of Primary Lymphedema.

    abstract::Primary lymphedema is due to abnormal congenital development or dysfunction in the lymphatic system. Limited data exist on the prevalence of primary lymphedema and there are only few studies focusing on primary lymphedema. The purpose of this article is to review the current options for surgical treatment of primary l...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Lee JH,Chang DW

    更新日期:2017-09-01 00:00:00