A Randomized Controlled Trial Comparing Platelet-Rich Plasma, Low-Level Laser Therapy, and Complex Decongestive Physiotherapy in Patients with Lower Limb Lymphedema.


: Background: Platelet-rich plasma (PRP) is an autologous concentrated preparation of platelets characterized by lymphangiogenetic and tissue-repairing effects. Although PRP has been safely used in many different fields, there is no clinical study regarding the use of PRP in lymphedema treatment in humans. We assessed the clinical outcomes of PRP in patients with lower extremity lymphedema (LEL) in a randomized controlled trial. Methods and Results: Patients with secondary LEL were randomly allocated to one of three groups consisting of treatment with PRP with complex decongestive physiotherapy (PRP+CDP group), low-level laser therapy with CDP (LLLT+CDP group), and only CDP (CDP group). Assessment of Lymphedema Quality of-Life Questionnaire (LYMQOL) for health-related quality of life, lower-extremity-circumference (LEC) for edema, tissue dielectric constant (TDC) for extremity volume, 6-minute walking test (6MWT) for functional capacity, and numeric rating scale (NRS) scoring for extremity fullness were evaluated both before and after treatment. Forty-five patients (68.8% female) with mean age 40.84 ± 15.81 years were included in the study. Significant differences in LYMQOL, LEC, NRS, and TDC values both before and after treatment were found in all groups; however, there were no statistically significant difference in values between the three groups. In the PRP+CDP group, LYMQOL values had a larger effect size than the other two groups. Significant differences in 6MWT values both before and after treatment were found in PRP+CDP and LLLT+CDP groups; however, there was no statistically significant difference in the CDP group. Conclusion: This is the first clinical study to evaluate the usage of PRP in patients with secondary LEL. PRP might be an additional treatment option of lymphedema management; however, more clinical trials in humans are needed to yield more evidence in the usage of PRP in patients with lymphedema.


Lymphat Res Biol


Akgul A,Tarakci E,Arman N,Civi T,Irmak S




Has Abstract


2020-10-01 00:00:00












  • Risk Factors Related to Lower Limb Edema, Compression, and Physical Activity During Pregnancy: A Retrospective Study.

    abstract:OBJECTIVE:The aim of the article was to assess risk factors and to analyze methods applied in the prevention and treatment of lower limb edema in pregnant women with a particular focus on compression therapy and exercise. MATERIALS AND METHODS:Fifty-four women during the early 24-hour period following delivery were as...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Ochalek K,Pacyga K,Curyło M,Frydrych-Szymonik A,Szygula Z

    更新日期:2017-06-01 00:00:00

  • Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix.

    abstract::Exciting studies involving the molecular regulation of lymphangiogenesis in lymphatic-associated disorders (e.g., wound healing, lymphedema and tumor metastasis) have focused renewed attention on the intrinsic relationship between lymphatic endothelial cells (LECs) and extracellular matrix (ECM) microenvironment. ECM ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Ji RC

    更新日期:2006-01-01 00:00:00

  • Reliability of the MoistureMeterD Compact Device and the Pitting Test to Evaluate Local Tissue Water in Subjects with Breast Cancer-Related Lymphedema.

    abstract:: Background: Local tissue water in patients with breast cancer-related lymphedema (BCRL) can be assessed by measurement of the tissue dielectric constant using the MoistureMeterD Compact® (MMDC) device, or by performing the pitting test. Although these assessment methods ar...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: De Vrieze T,Gebruers N,Nevelsteen I,De Groef A,Tjalma WAA,Thomis S,Dams L,Van der Gucht E,Penen F,Devoogdt N

    更新日期:2020-04-01 00:00:00

  • SF-36 Shows Increased Quality of Life Following Complete Reduction of Postmastectomy Lymphedema with Liposuction.

    abstract::Abstracts Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. METHODS AND RESULTS:Sixty female patients with arm ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Hoffner M,Bagheri S,Hansson E,Manjer J,Troëng T,Brorson H

    更新日期:2017-03-01 00:00:00

  • Systematic review of quality of life and patient reported outcomes in patients with oncologic related lower extremity lymphedema.

    abstract:BACKGROUND:Lower limb lymphedema (LLL) is a common complication of cancer treatment. The disease is chronic and progressive with no cure. Although a common and significant source of morbidity, the impact of this condition on health-related quality of life (HRQOL) has only recently been addressed. In effort to identify ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Cemal Y,Jewell S,Albornoz CR,Pusic A,Mehrara BJ

    更新日期:2013-03-01 00:00:00

  • Passive pressure-diameter relationship and structural composition of rat mesenteric lymphangions.

    abstract:BACKGROUND:Lymph flow depends on both the rate of lymph production by tissues and the extent of passive and active pumping. Here we aim to characterize the passive mechanical properties of a lymphangion in both mid-lymphangion and valve segments to assess regional differences along a lymphangion, as well as evaluating ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Rahbar E,Weimer J,Gibbs H,Yeh AT,Bertram CD,Davis MJ,Hill MA,Zawieja DC,Moore JE Jr

    更新日期:2012-12-01 00:00:00

  • Vascular Alterations in Axillary and Brachial Vessels in Patients with Axillary Web Syndrome After Breast Cancer Surgery.

    abstract:BACKGROUND:Surgical manipulations of the axilla may cause a condition known as Axillary Web Syndrome (AWS). The systems compromised and the sequence of events leading to this syndrome remains unknown. This study evaluated clinical, surgical, and vascular factors associated with onset and duration of AWS after breast ca...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Furlan C,Matheus CN,Jales RM,Derchain S,Sarian LO

    更新日期:2018-06-01 00:00:00

  • Increased lymphangiogenesis and hemangiogenesis in infant cornea.

    abstract:BACKGROUND:Corneal lymphangiogenesis (LG) and hemangiogenesis (HG) accompany many diseases after inflammatory, infectious, traumatic or chemical insults. They also contribute to transplant rejection. It is known that corneal transplants in infants or children have a higher rejection rate than in adults. However, it has...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Yuen D,Leu R,Sadovnikova A,Chen L

    更新日期:2011-01-01 00:00:00

  • Determining the precision of dual energy x-ray absorptiometry and bioelectric impedance spectroscopy in the assessment of breast cancer-related lymphedema.

    abstract:BACKGROUND:The composition of breast cancer-related lymphedema (BCRL) has been shown to evolve from the initial accumulation of fluid to the development of fibrotic lesions and abnormal fat deposition. Therefore, precise and reliable assessments of BCRL are required to develop accurate staging and management. Although ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Newman AL,Rosenthall L,Towers A,Hodgson P,Shay CA,Tidhar D,Vigano A,Kilgour RD

    更新日期:2013-06-01 00:00:00

  • Diagnosing Male Unilateral Upper Limb Lymphedema: Determination of Normatively Determined Thresholds Using Bioimpedance Spectroscopy.

    abstract:: Background: The use of bioimpedance spectroscopy (BIS) for the detection of unilateral upper limb lymphedema is growing. Currently, normatively determined diagnostic thresholds using bioimpedance are available for females only. It is unclear if they are suitable for males ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Xie AZT,Lee MJ,Dylke E

    更新日期:2020-02-01 00:00:00

  • The Relationship Between Clinical and Indocyanine Green Staging in Lymphedema.

    abstract:: Background: Multiple staging systems for classifying the severity of lymphedema exist. The International Society of Lymphology (ISL) stage is considered standard for clinical reporting, but the relationship between clinical and functional/imaging stage remains poorly defin...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Garza RM,Ooi ASH,Falk J,Chang DW

    更新日期:2019-06-01 00:00:00

  • Long-distance transportation of live isolated lymphatic vessels.

    abstract:BACKGROUND:We performed experiments to test whether isolated lymphatic vessels would remain viable after overnight long-distance shipment. METHODS AND RESULTS:Freshly isolated segments of rat mesenteric lymphatic vessels were placed into tubes filled by chilled D-MEM/F12 supplemented with antibiotics and shipped via o...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Gashev AA,Davis MJ

    更新日期:2010-12-01 00:00:00

  • Normative Interlimb Impedance Ratios: Implications for Early Diagnosis of Uni- and Bilateral, Upper and Lower Limb Lymphedema.

    abstract:: Background: Bioimpedance spectroscopy detects unilateral lymphedema if the ratio of extracellular fluid (ECF) between arms or between legs is outside three standard deviations (SDs) of the normative mean. Detection of bilateral lymphedema, common after bilateral breast or ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Steele ML,Janda M,Vagenas D,Ward LC,Cornish BH,Box R,Gordon S,Matthews M,Poppitt SD,Plank LD,Yip W,Rowan A,Reul-Hirche H,Obermair A,Hayes SC

    更新日期:2018-12-01 00:00:00

  • Electrode Equivalence for Use in Bioimpedance Spectroscopy Assessment of Lymphedema.

    abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) is commonly used in the assessment and monitoring of lymphedema. This study investigated electrodes as a source of variability that could impact the accuracy of BIS in the clinic and determined if Ag/AgCl electrocardiograph (ECG) electrodes could be used as an alternative to i...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Svensson BJ,Dylke ES,Ward LC,Kilbreath SL

    更新日期:2019-02-01 00:00:00

  • Quality of Life Improvements in Patients with Lymphedema After Surgical or Nonsurgical Interventions with 1-Year Follow-Up.

    abstract:: Background: Lymphedema may impact patients' health-related quality of life (HRQoL). The purpose of this study was to evaluate HRQoL after two different treatments to the 12-month follow-up point. Methods and Results: Study part...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Klernäs P,Johnsson A,Boyages J,Brorson H,Munnoch A,Johansson K

    更新日期:2020-08-01 00:00:00

  • Primary Lymphedema of the Upper Extremities: Clinical and Lymphoscintigraphic Features in 23 Patients.

    abstract:BACKGROUND:Primary idiopathic lymphedema is an uncommon condition that typically affects the lower extremities. Patients have a malformed lymphatic system that causes subcutaneous fluid and adipose deposition. Rarely, the disease also has been described in the upper extremities. The purpose of this study was to investi...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Goss JA,Maclellan RA,Greene AK

    更新日期:2019-02-01 00:00:00

  • Lymphangiosarcoma complicating extensive congenital mixed vascular malformations.

    abstract::Pediatric hepatic angiosarcoma is a very rare malignant vascular tumor. A few cases have shown pediatric hepatic angiosarcoma occurring on a background of preexisting vascular lesions. We report the case of a newborn girl who presented extensive limbs and upper trunk cutaneous mixed vascular malformations at birth. Th...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Al Dhaybi R,Agoumi M,Powell J,Dubois J,Kokta V

    更新日期:2010-09-01 00:00:00

  • Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling.

    abstract::Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarrin...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章,评审


    authors: Bennuru S,Nutman TB

    更新日期:2009-12-01 00:00:00

  • Lymphedema Impact and Prevalence International Study: The Canadian Data.

    abstract:: Background: Chronic edema/lymphedema is defined as edema present for more than 3 months. It is underrecognized and undertreated. The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Keast DH,Moffatt C,Janmohammad A

    更新日期:2019-04-01 00:00:00

  • Lymphatic Stomata in the Adult Human Pulmonary Ligament.

    abstract:BACKGROUND:Lymphatic stomata are small lymphatic openings in the serosal membrane that communicate with the serosal cavity. Although these stomata have primarily been studied in experimental mammals, little is known concerning the presence and properties of lymphatic stomata in the adult human pleura. Thus, adult human...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Oshiro H,Miura M,Iobe H,Kudo T,Shimazu Y,Aoba T,Okudela K,Nagahama K,Sakamaki K,Yoshida M,Nagao T,Nakaya T,Kurata A,Ohtani O

    更新日期:2015-06-01 00:00:00

  • Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema.

    abstract:BACKGROUND:In arm lymphedema secondary to axillary surgery and radiotherapy (breast cancer-related lymphedema), the swelling is largely epifascial and lymph flow per unit epifascial volume is impaired. The subfascial muscle compartment is not measurably swollen despite the iatrogenic damage to its axillary drainage pat...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Stanton AW,Mellor RH,Cook GJ,Svensson WE,Peters AM,Levick JR,Mortimer PS

    更新日期:2003-01-01 00:00:00

  • Assessment of breast cancer-related lymphedema: a comparison of moisture meter and spot bioimpedance measurement.

    abstract:BACKGROUND:Tissue dielectric constant (TDC) and spot bioimpedance measurement (BIA) have a role in the assessment of tissue composition changes in breast cancer-related lymphedema (BCRL). Our aims were to determine whether TDC and spot BIA measures could detect inter-limb differences in BCRL, explore the relationship b...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Czerniec SA,Ward LC,Kilbreath SL

    更新日期:2015-03-01 00:00:00

  • Near-Infrared Fluorescence Lymphatic Imaging in Lymphangiomatosis.

    abstract:BACKGROUND:Lymphangiomatosis is a rare disorder of the lymphatic system that can impact the dermis, soft tissue, bone, and viscera and can be characterized by lymphangiomas, swelling, and chylous discharge. Whether disordered lymphangiogenesis in lymphangiomatosis affects the function and anatomy of the entire systemic...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Rasmussen JC,Fife CE,Sevick-Muraca EM

    更新日期:2015-09-01 00:00:00

  • Postoperative evolution of thickness and echogenicity of cutis and subcutis of patients with and without breast cancer-related lymphedema.

    abstract:BACKGROUND:Compared to volume/circumference measurements to diagnose lymphedema, thickening and disturbance of echogenicity of cutis and subcutis associated with the development of lymphedema is measured directly by ultrasonography. The aim of the present study was to investigate the evolution of thickness and echogeni...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Devoogdt N,Pans S,De Groef A,Geraerts I,Christiaens MR,Neven P,Vergote I,Van Kampen M

    更新日期:2014-03-01 00:00:00

  • Abdominal lymphatic pump treatment increases leukocyte count and flux in thoracic duct lymph.

    abstract:BACKGROUND:Previous studies suggest that rhythmic compression of the abdomen (abdominal lymphatic pump techniques, LPT) enhances immunity and resistance to infectious disease, but direct evidence of this has not been documented. In this study, the thoracic duct of eight anesthetized mongrel dogs was catheterized, so th...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Hodge LM,King HH,Williams AG Jr,Reder SJ,Belavadi T,Simecka JW,Stoll ST,Downey HF

    更新日期:2007-01-01 00:00:00

  • Acute Cardiovascular Responses to the Application of Manual Lymphatic Drainage in Different Body Regions.

    abstract:: Background: The purpose of this study was to investigate acute cardiovascular responses to manual lymphatic drainage (MLD) on different parts of the body. Materials and Methods: Thirty healthy individuals (10 women and 20 men) ...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Esmer M,Keser I,Erer D,Kupeli B

    更新日期:2019-06-01 00:00:00

  • Extracellular RNA Profile in Mesenteric Lymph from Exemplar Rat Models of Acute and Critical Illness.

    abstract:: Background: Mesenteric lymph (ML) has been implicated in the development of multiple organ dysfunction syndrome in critical illness. Extracellular RNAs play a role in cell-to-cell communication during physiological and disease processes but they are rarely studied in ML. W...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Hong J,Blenkiron C,Tsai P,Premkumar R,Nachkebia S,Tun SM,Petzer A,Windsor JA,Hickey AJ,Phillips AR

    更新日期:2019-10-01 00:00:00

  • Intra- and Inter-Rater Reliability of Bioimpedance in the Evaluation of Lymphedema Secondary to Treatment of Breast Cancer.

    abstract::The objective of the study was to evaluate the intra- and inter-rater reliability of bioimpedance in determining upper limb volume in women with lymphedema resulting from breast cancer treatment, as well as its correlation with the upper limb volume calculated by circumferential measurement. A blind cross-sectional st...

    journal_title:Lymphatic research and biology

    pub_type: 杂志文章


    authors: Ferro AP,Ferreira VTK,Rezende MS,de Souza TR,Almeida AM,Guirro RRJ,Guirro ECO

    更新日期:2018-06-01 00:00:00

  • Comparison of intermittent pneumatic compression with manual lymphatic drainage for treatment of breast cancer-related lymphedema.

    abstract:BACKGROUND:The aim of this prospective controlled study was to assess the efficacy of two different combination treatment modalities of lymphedema (LE). Manual lymphatic drainage (MLD) and compression bandage combination (complex decongestive therapy) have been compared with intermittent pneumatic compression (IPC) plu...

    journal_title:Lymphatic research and biology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gurdal SO,Kostanoglu A,Cavdar I,Ozbas A,Cabioglu N,Ozcinar B,Igci A,Muslumanoglu M,Ozmen V

    更新日期:2012-09-01 00:00:00

  • Blood Flow Velocity in Brachial and Subclavian Vessels Immediately After Compressive Procedures for Treatment of Postcancer Therapy Lymphedema in Breast Cancer: A Randomized Blind Clinical Trial.

    abstract:OBJECTIVE:This study sought to evaluate the effect of elastic compression, functional compressive bandaging, and kinesiotherapy on blood flow of the upper limb with lymphedema secondary to the treatment of breast cancer. METHODS:This was a randomized blind crossover clinical trial with a washout period of 7 days betwe...

    journal_title:Lymphatic research and biology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rezende MS,Marsengo AL,de Jesus Guirro RR,de Oliveira Guirro EC

    更新日期:2017-03-01 00:00:00