Lymphatic Endothelial Cells under Mechanical Stress: Altered Expression of Inflammatory Cytokines and Fibrosis.

abstract：:Primary lymphedema is due to abnormal congenital development or dysfunction in the lymphatic system. Limited data exist on the prevalence of primary lymphedema and there are only few studies focusing on primary lymphedema. The purpose of this article is to review the current options for surgical treatment of primary l...

journal_title：Lymphatic research and biology

authors： Lee JH,Chang DW

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The spleen has an important physiological role in maintaining blood volume; this study aimed to determine whether during pathophysiological circumstances, namely endotoxemia, the extrasplenic pathway is dysfunctional. We hypothesize that increased 'leakiness' of lymphatics in response to lipopolysaccharide (...

journal_title：Lymphatic research and biology

authors： Brookes ZL,Mansart A,McGown CC,Ross JJ,Reilly CS,Brown NJ

更新日期：2009-01-01 00:00:00

abstract：: Background: Conservative nonsurgical treatment has traditionally been applied to lymphedema. Early surgical procedures were invasive and disfiguring and their long-term success was often limited. In contrast, contemporary surgical techniques are much less invasive and have...

journal_title：Lymphatic research and biology

authors： Fernández Peñuela R,Casaní Arazo L,Masiá Ayala J

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Lymphedema is the abnormal accumulation of protein-rich fluid in the interstitial space. Primary lymphedema is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance. Three genes, FLT4 (VEGFR3), FOXC2, and SOX18 cause varying forms of primary lymphedema. In industr...

journal_title：Lymphatic research and biology

authors： Finegold DN,Schacht V,Kimak MA,Lawrence EC,Foeldi E,Karlsson JM,Baty CJ,Ferrell RE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Compared to volume/circumference measurements to diagnose lymphedema, thickening and disturbance of echogenicity of cutis and subcutis associated with the development of lymphedema is measured directly by ultrasonography. The aim of the present study was to investigate the evolution of thickness and echogeni...

journal_title：Lymphatic research and biology

authors： Devoogdt N,Pans S,De Groef A,Geraerts I,Christiaens MR,Neven P,Vergote I,Van Kampen M

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Lymphedema can have a negative impact on the function and quality of life (QOL) of patients, but most studies have examined lymphedema as a binary variable, rather than a multidimensional disease that ranges in severity. This study explored the potential impact of lymphedema severity on function and overall QOL...

journal_title：Lymphatic research and biology

authors： Lee TS,Morris CM,Czerniec SA,Mangion AJ

更新日期：2018-02-01 00:00:00

abstract：:Pediatric hepatic angiosarcoma is a very rare malignant vascular tumor. A few cases have shown pediatric hepatic angiosarcoma occurring on a background of preexisting vascular lesions. We report the case of a newborn girl who presented extensive limbs and upper trunk cutaneous mixed vascular malformations at birth. Th...

journal_title：Lymphatic research and biology

authors： Al Dhaybi R,Agoumi M,Powell J,Dubois J,Kokta V

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Lymph flow depends on both the rate of lymph production by tissues and the extent of passive and active pumping. Here we aim to characterize the passive mechanical properties of a lymphangion in both mid-lymphangion and valve segments to assess regional differences along a lymphangion, as well as evaluating ...

journal_title：Lymphatic research and biology

authors： Rahbar E,Weimer J,Gibbs H,Yeh AT,Bertram CD,Davis MJ,Hill MA,Zawieja DC,Moore JE Jr

更新日期：2012-12-01 00:00:00

abstract：: Background: The Lymphedema Functioning, Disability, and Health questionnaire for Upper Limb Lymphedema (Lymph-ICF-UL) is a health-related quality-of-life questionnaire for patients with breast cancer-related lymphedema. Previous testing of this questionnaire showed very go...

journal_title：Lymphatic research and biology

authors： De Vrieze T,Gebruers N,Nevelsteen I,Tjalma WAA,Thomis S,De Groef A,Dams L,Devoogdt N

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Tissue dielectric constant (TDC) and spot bioimpedance measurement (BIA) have a role in the assessment of tissue composition changes in breast cancer-related lymphedema (BCRL). Our aims were to determine whether TDC and spot BIA measures could detect inter-limb differences in BCRL, explore the relationship b...

journal_title：Lymphatic research and biology

authors： Czerniec SA,Ward LC,Kilbreath SL

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Lymph is pumped through the collecting lymphatic vessels by both intrinsic and extrinsic forces, propelling it downstream back into circulation. The intrinsic lymph pump relies on the spontaneous contraction of lymphatic muscles to generate the force of pumping lymph (P(lp)). However, the association between...

journal_title：Lymphatic research and biology

authors： Saito T,Unno N,Yamamoto N,Inuzuka K,Tanaka H,Sano M,Sugisawa R,Katahashi K,Konno H

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Corneal lymphangiogenesis (LG) and hemangiogenesis (HG) accompany many diseases after inflammatory, infectious, traumatic or chemical insults. They also contribute to transplant rejection. It is known that corneal transplants in infants or children have a higher rejection rate than in adults. However, it has...

journal_title：Lymphatic research and biology

authors： Yuen D,Leu R,Sadovnikova A,Chen L

更新日期：2011-01-01 00:00:00

abstract：: Background: Multiple staging systems for classifying the severity of lymphedema exist. The International Society of Lymphology (ISL) stage is considered standard for clinical reporting, but the relationship between clinical and functional/imaging stage remains poorly defin...

journal_title：Lymphatic research and biology

authors： Garza RM,Ooi ASH,Falk J,Chang DW

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:A relative inability to capture a sufficiently large patient population in any one geographic location has traditionally limited research into rare diseases. METHODS AND RESULTS:Clinicians interested in the rare disease lymphangioleiomyomatosis (LAM) have worked with the LAM Treatment Alliance, the MIT Medi...

journal_title：Lymphatic research and biology

authors： Nurok M,Eslick I,Carvalho CR,Costabel U,D'Armiento J,Glanville AR,Harari S,Henske EP,Inoue Y,Johnson SR,Lacronique J,Lazor R,Moss J,Ruoss SJ,Ryu JH,Seyama K,Watz H,Xu KF,Hohmann EL,Moss F

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The composition of breast cancer-related lymphedema (BCRL) has been shown to evolve from the initial accumulation of fluid to the development of fibrotic lesions and abnormal fat deposition. Therefore, precise and reliable assessments of BCRL are required to develop accurate staging and management. Although ...

journal_title：Lymphatic research and biology

authors： Newman AL,Rosenthall L,Towers A,Hodgson P,Shay CA,Tidhar D,Vigano A,Kilgour RD

更新日期：2013-06-01 00:00:00

abstract：:The present report describes a case with the triad of yellow nail syndrome (YNS) and the use of low-pressure compression pump as treatment of lymphedema in YNS. A 71-year-old woman presented with bilateral lower extremity lymphedema, yellow nails, and recurrent bilateral pleural effusion. In this case, we specifically...

journal_title：Lymphatic research and biology

authors： Polat AK,Dang HT,Soran A

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that rhythmic compression of the abdomen (abdominal lymphatic pump techniques, LPT) enhances immunity and resistance to infectious disease, but direct evidence of this has not been documented. In this study, the thoracic duct of eight anesthetized mongrel dogs was catheterized, so th...

journal_title：Lymphatic research and biology

authors： Hodge LM,King HH,Williams AG Jr,Reder SJ,Belavadi T,Simecka JW,Stoll ST,Downey HF

更新日期：2007-01-01 00:00:00

abstract：:Hemangiomas of infancy are very common tumors, but they are heterogeneous in their behavior. A small, but significant, subset causes medical complications or permanent disfigurement, but due to their heterogeneity, there is no appropriate "one size fits all" approach to management. In addition, the rapid evolution of ...

journal_title：Lymphatic research and biology

authors： Frieden IJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Lymphedema leads to adipose tissue deposition. Water-fat magnetic resonance imaging (MRI) can quantify and localize fat and water. The presence of excess fat and excess water/muscle in the subfascial compartment of the lymphedematous limb has not been investigated before. The aim of this study was to investi...

journal_title：Lymphatic research and biology

authors： Hoffner M,Peterson P,Månsson S,Brorson H

更新日期：2018-04-01 00:00:00

abstract：: Background: Chronic edema/lymphedema is defined as edema present for more than 3 months. It is underrecognized and undertreated. The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate ...

journal_title：Lymphatic research and biology

authors： Keast DH,Moffatt C,Janmohammad A

更新日期：2019-04-01 00:00:00

abstract：: Introduction: Mass drug administration and morbidity management and disability prevention (MMDP) though considered as two pillars of global program for elimination of filariasis, implementation of MMDP was disregarded in several endemic countries. Limb hygiene is the main ...

journal_title：Lymphatic research and biology

authors： De Britto L,Kamaraj P,Vijayalakshmi G,Das LK,Krishnakumari A,Anbusivam S,Supriya VK,Yuvaraj J

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Near-infrared fluorescence (NIRF) imaging is a new imaging technique that is used to visualize lymphatic vessels in humans. It has a high spatial and temporal resolution, allowing real-time visualization of lymphatic flow. METHODS AND RESULTS:The current study investigated the intra- and inter-individual va...

journal_title：Lymphatic research and biology

authors： Groenlund JH,Telinius N,Skov SN,Hjortdal V

更新日期：2017-09-01 00:00:00

abstract：:Despite the fact that the central nervous system parenchyma does not contain lymphatics, extracranial lymphatic vessels play a very important role in volumetric cerebrospinal fluid (CSF) transport. The most important extracranial location at which lymphatics gain access to CSF is in the nasal submucosa after CSF conve...

journal_title：Lymphatic research and biology

authors： Johnston M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:The aim of the article was to assess risk factors and to analyze methods applied in the prevention and treatment of lower limb edema in pregnant women with a particular focus on compression therapy and exercise. MATERIALS AND METHODS:Fifty-four women during the early 24-hour period following delivery were as...

journal_title：Lymphatic research and biology

authors： Ochalek K,Pacyga K,Curyło M,Frydrych-Szymonik A,Szygula Z

更新日期：2017-06-01 00:00:00

abstract：: Background: Mesenteric lymph (ML) has been implicated in the development of multiple organ dysfunction syndrome in critical illness. Extracellular RNAs play a role in cell-to-cell communication during physiological and disease processes but they are rarely studied in ML. W...

journal_title：Lymphatic research and biology

authors： Hong J,Blenkiron C,Tsai P,Premkumar R,Nachkebia S,Tun SM,Petzer A,Windsor JA,Hickey AJ,Phillips AR

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Lymphedema of limbs affects a large mass of tissues. Pathological changes develop in skin and subcutaneous tissue. Bacterial retention in edema fluid is followed by chronic inflammatory reaction. The question arises whether the chronic processes affecting a large mass of limb tissues are reflected in the ser...

journal_title：Lymphatic research and biology

authors： Zaleska MT,Olszewski WL

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:It has recently become apparent that the lymph pump is an electrical entity that rivals the heart in complexity. Many interesting currents have been demonstrated by voltage clamping isolated lymphatic smooth muscle cells, but until now the role of these currents in the intact syncitium has not been studied. ...

journal_title：Lymphatic research and biology

authors： Beckett EA,Hollywood MA,Thornbury KD,McHale NG

更新日期：2007-01-01 00:00:00

abstract：: Background: Bioimpedance spectroscopy detects unilateral lymphedema if the ratio of extracellular fluid (ECF) between arms or between legs is outside three standard deviations (SDs) of the normative mean. Detection of bilateral lymphedema, common after bilateral breast or ...

journal_title：Lymphatic research and biology

authors： Steele ML,Janda M,Vagenas D,Ward LC,Cornish BH,Box R,Gordon S,Matthews M,Poppitt SD,Plank LD,Yip W,Rowan A,Reul-Hirche H,Obermair A,Hayes SC

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The putrefaction factor is one of the biggest problems when undertaking unembalmed cadaveric tissue dissections for lymphatic vessel mapping. METHODS:One female bilateral breast and anterior upper torso from an unembalmed human cadaver was studied over an 8-week period. Multiple prefrozen domestic ice brick...

journal_title：Lymphatic research and biology

authors： Pan WR

更新日期：2009-01-01 00:00:00

abstract：:The vasculature of the central nervous system (CNS) is highly specialized with a blood-brain-barrier, reciprocal neuroepithelial-endothelial cell interactions and extensive pericyte coverage. Developmentally, numerous important signaling pathways participate in CNS angiogenesis to orchestrate the precise timing and sp...

journal_title：Lymphatic research and biology

authors： Mancuso MR,Kuhnert F,Kuo CJ

更新日期：2008-01-01 00:00:00