The importance of lymphatics in cerebrospinal fluid transport.

Abstract:

:Despite the fact that the central nervous system parenchyma does not contain lymphatics, extracranial lymphatic vessels play a very important role in volumetric cerebrospinal fluid (CSF) transport. The most important extracranial location at which lymphatics gain access to CSF is in the nasal submucosa after CSF convects through the cribriform plate. At relatively low intracranial pressures (ICPs), the majority of cranial CSF absorption occurs through this pathway. Global CSF transport parameters in the late gestation fetus and adult sheep are very similar, even though significant numbers of arachnoid projections seem to exist only in the adult. Therefore, extracranial lymphatic vessels play an important role in CSF transport before birth and may represent the primary mechanism for CSF absorption in the neonate. Based on these considerations, hydrocephalus may involve reduced CSF transport to, or into extracranial lymphatic absorption sites.

journal_name

Lymphat Res Biol

authors

Johnston M

doi

10.1089/15396850360495682

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

41-4; discussion 45

issue

1

eissn

1539-6851

issn

1557-8585

journal_volume

1

pub_type

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