当前位置： SCI文献检索 > FORENSIC SCIENCE INTERNATIONAL期刊下所有文献 > Protein-based medicines analysis by Raman spectroscopy for the detection of counterfeits.

Protein-based medicines analysis by Raman spectroscopy for the detection of counterfeits.

Abstract：

:Protein-based medicines, or large molecule medicines, are innovative products used to treat various diseases like hepatitis or cancer. This new generation of molecules are usually expensive, and thus represents an attractive target for the counterfeiters. Due to the complexity of their chemical structure, their analysis for counterfeit detection is more difficult than small molecule medicines. The aim of the article is to demonstrate that Raman spectroscopy and microscopy can be used for the fast analysis of counterfeits of protein-based medicines. Twelve types of medicines, under liquid or lyophilized form, have been analyzed by a Raman spectrometer through their glass packaging and ten of them also by a Raman microscope with drop deposition on a gold plate. The optimization of the acquisition parameters has first been described. Then the identification of the studied products has been presented with the attribution of the protein bands observed on the spectra. Finally the methods were successfully applied to seven counterfeits of these products and their chemical composition identified by spectral analysis. Counterfeits can indeed be detected if the excipient profile differs, if no protein is present, or if the genuine sample has been strongly diluted by the counterfeiters. Raman spectroscopy and microscopy have thus proved efficient for the fast analysis of counterfeits of protein-based medicines.

journal_name

Forensic Sci Int

journal_title

Forensic science international

authors

Dégardin K,Desponds A,Roggo Y

doi

10.1016/j.forsciint.2017.07.012

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

313-325

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(17)30270-0

journal_volume

278

pub_type

杂志文章

相关文献

FORENSIC SCIENCE INTERNATIONAL文献大全
  • Postmortem serotonin (5-HT) concentrations in the cerebrospinal fluid of medicolegal cases.

    abstract：:In a medicolegal study the postmortem serotonin (5-HT) cerebrospinal fluid (CSF) concentrations were determined in routine autopsies using a high performance liquid chromatographic procedure with electrochemical detection. There was no correlation between 5-HT concentrations and age, sex or blood alcohol concentration...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2004.02.023

    authors： Musshoff F,Menting T,Madea B

    更新日期：2004-06-10 00:00:00

  • Post mortem vitreous magnesium in adult population.

    abstract：BACKGROUND:The study of post mortem vitreous magnesium (Mg) is less common than sodium (Na), chloride (Cl) and potassium (K) in the forensic literature. There is no accepted normal range for post mortem vitreous Mg and the relationship between post mortem vitreous Mg levels and post mortem interval (PMI), other electro...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2017.12.038

    authors： Tse R,Garland J,Kesha K,Morrow P,Lam L,Elstub H,Cala AD,Palmiere C,Stables S

    更新日期：2018-03-01 00:00:00

  • Genetic variation at eight STR loci in the Korean population.

    abstract：:The frequency distributions of eight STR loci were surveyed in 510 unrelated individuals from the Korean population ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(00)00334-0

    authors： Han MS,Kang PW,Choi DH,Lee YH,Choi SK,Kim W

    更新日期：2001-02-01 00:00:00

  • Comparative regression analysis of concurrent elimination-phase blood and breath alcohol concentration measurements to determine hourly degradation rates.

    abstract：:Following the introduction of limit values for blood alcohol and breath alcohol concentrations of 0.5 g/kg and 0.25 mg/L, respectively, as provided under s. 24 a of the German Road Traffic Act the question is whether also breath alcohol concentrations can be back calculated to the time of the traffic offence in cases ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2004.03.023

    authors： Jachau K,Sauer S,Krause D,Wittig H

    更新日期：2004-07-16 00:00:00

  • Willems I VS Willems II: A comparative study of accuracy in 5-15 year old Indian children.

    abstract：BACKGROUND:Studies testing the Willems method of age estimation with gender-specific scores on different population groups have reported consistently more accurate results over other methods. Not enough is known about the validity of Willems non-gender specific scores. AIM:The present study aimed to compare the accura...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2016.05.012

    authors： Hegde S,Patodia A,Dixit U

    更新日期：2016-09-01 00:00:00

  • A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylenedioxymethylamphetamine, amphetamine, dimethylamphetamine and p-methoxyamphetamine.

    abstract：:Amphetamine-type substances (ATS), like other synthetically derived compounds, can be produced by a multitude of synthetic pathways using a variety of precursors and reagents, resulting in a large number of possible contaminants (by-products, intermediates and impurities). This review article describes the common cont...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2012.10.040

    authors： Stojanovska N,Fu S,Tahtouh M,Kelly T,Beavis A,Kirkbride KP

    更新日期：2013-01-10 00:00:00

  • On the theory and practice of Essen-Möller's W value and Gürtler's paternity index (PI).

    abstract：:In cases of disputed parentage the biostatistical information is contained in the frequencies X and Y (as defined by Essen-M oller ); X denotes the hypothesis "paternity", Y the hypothesis "non-paternity". Essen-M oller proposed a probability of paternity which includes both values: W = X/(X + Y) (where X + Y becomes ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(84)90010-0

    authors： Hummel K

    更新日期：1984-05-01 00:00:00

  • An automatic method for skeletal patterns classification using craniomaxillary variables on a Colombian population.

    abstract：BACKGROUND:The mandibular bone is an important part of the forensic facial reconstruction and it has the possibility of getting lost in skeletonized remains; for this reason, it is necessary to facilitate the identification process simulating the mandibular position only through craniomaxillary measures, for this task,...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2015.12.025

    authors： Niño-Sandoval TC,Guevara Perez SV,González FA,Jaque RA,Infante-Contreras C

    更新日期：2016-04-01 00:00:00

  • A comparative study of ethchlorvynol levels in blood versus bone marrow.

    abstract：:Bone marrow may be utilized as an alternative biological sample in cases where uncontaminated blood samples are not available for analyses. Bone marrow/blood ratios of ethchlorvynol as a function of time and dosage level were determined in 40 rabbits. A modified quantitative analysis that produced accurate and reprodu...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(81)90167-5

    authors： Winek CL,Cibulas W Jr,Wahba WW

    更新日期：1981-05-01 00:00:00

  • Scientific standards for studies in forensic genetics.

    abstract：:Forensic molecular genetics has evolved from a rapidly developing field with changing technologies into a highly recognized and generally accepted forensic science, leading to the establishment of national DNA databases with DNA profiles from suspects and convicted offenders. DNA evidence has taken a central role by c...

    journal_title：Forensic science international

    pub_type： 杂志文章,评审

    doi：10.1016/j.forsciint.2006.06.067

    authors： Schneider PM

    更新日期：2007-01-17 00:00:00

  • Non-equilibrium pH gradient electrophoresis (NEPHGE) on ultrathin polyacrylamide gels containing separators: improved erythrocyte phosphoglucomutase (PGM) and esterase D (EsD) diagnosis in red cell lysates and bloodstains.

    abstract：:Two rapid and reliable electrophoretic techniques for PGM1 and EsD typing on ultrathin polyacrylamide gels are described. They have been based on non-equilibrium pH gradient electrophoresis and on the addition of chemical spacers (EPPS for PGM1 and HEPES for EsD) to the gel mixture. ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(89)90197-7

    authors： Destro-Bisol G,Spinella A

    更新日期：1989-07-01 00:00:00

  • A dedicated internal standard in fragment length analysis of hyperpolymorphic short tandem repeats.

    abstract：:Some of the most polymorphic short tandem repeats (STRs) have alleles differing in size by as little as one basepair. Since sizing precision with commercially available internal standards ordinarily does not allow safe discrimination at this level, typing is accomplished through comparisons with allelic ladders run on...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(97)02137-3

    authors： Dupuy BM,Olaisen B

    更新日期：1997-05-05 00:00:00

  • The chemistry of death--Adipocere degradation in modern graveyards.

    abstract：:The formation of adipocere slows further decomposition and preserves corpses for decades or even centuries. This resistance to degradation is a serious problem, especially with regard to the reuse of graves after regular resting times. We present results from an exhumation series in modern graveyards where coffins fro...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2015.09.010

    authors： Fiedler S,Berns AE,Schwark L,Woelk AT,Graw M

    更新日期：2015-12-01 00:00:00

  • Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre.

    abstract：:In literature, cases of nutmeg abuse have been described repeatedly, but only one fatal case of poisoning was reported [1]. In the present case, myristicin (4 microg/ml) was detected for the first time in the postmortal serum of a 55-year-old woman. Identification was achieved with the aid of UV-VIS spectroscopy and T...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(00)00369-8

    authors： Stein U,Greyer H,Hentschel H

    更新日期：2001-04-15 00:00:00

  • Terraskin® the paper made from stone: a study of a new writing support for forensic purposes.

    abstract：:Can a mineral paper be called paper? Until now all known writing supports have been ancient stones and tablets, parchment, and paper of vegetable origin, such as papyrus and fiber pulp paper. Some years ago polymeric banknotes appeared in Australia, and in 2004 mineral paper (stone plus polymer) emerged as an ecologic...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2012.02.018

    authors： Ezcurra M

    更新日期：2012-07-10 00:00:00

  • Studies on ABH antigen grouping of ammoniacal extracts of bloodstains by absorption-elution.

    abstract：:The effects of absorption time, titer of antiserum or lectin in the absorption stage, and elution temperature on relative antibody or lectin yield in elutes in the absorption-elution procedure were studied in bloodstains and ammoniacal extracts of bloodstains using conventional grouping reagents. In addition, monoclon...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(86)90182-9

    authors： Gaensslen RE,Lee HC,DeGraw SS,Carroll-Reho J

    更新日期：1986-07-14 00:00:00

  • DNA methylation age estimation in blood samples of living and deceased individuals using a multiplex SNaPshot assay.

    abstract：:Many studies in the forensic field have reported that analysis of DNA methylation is the most reliable method of predicting age. In a previous study, 5 CpG sites located in ELOVL2, FHL2, KLF14, C1orf132 and TRIM59 genes were tested for age prediction purposes in blood, saliva and buccal swab samples from Korean indivi...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2020.110267

    authors： Dias HC,Cordeiro C,Pereira J,Pinto C,Real FC,Cunha E,Manco L

    更新日期：2020-06-01 00:00:00

  • Histological examination of the temporal bone in medicolegal cases of asphyxia.

    abstract：:Histological findings of the temporal bone in 23 autopsy cases of various asphyxial fatalities were studied. The temporal bones of 12 cases who died of tumors including mammary cancer, gastric cancer, myxoma of heart and craniopharyngioma, the bones of 3 cases of heart attack and the bones of 17 cases who died of vari...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(90)90243-r

    authors： Ito Y,Kimura H

    更新日期：1990-02-01 00:00:00

  • Development of a candidate method for forensic microbial genotyping using multiplex pyrosequencing combined with a universal biotinylated primer.

    abstract：:Bacterial genotyping can be used for crime scene investigations and contribute to the attribution of biological attacks for microbial forensics. PyroMark ID Pyrosequencer as an accurate detection platform for single nucleotide polymorphisms (SNPs) has been applied to identify and resolve microorganisms involved in clo...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.11.004

    authors： Gu Y,Mao X,Zha L,Hou Y,Yun L

    更新日期：2015-01-01 00:00:00

  • Cytochrome b gene for species identification of the conservation animals.

    abstract：:A partial DNA sequence of cytochrome b gene was used to identify the remains of endangered animals and species endemic to Taiwan. The conservation of animals species included in this study were: the formosan gem-faced civets, leopard cats, tigers, clouded leopards, lion, formosan muntjacs, formosan sika deers, formosa...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(01)00403-0

    authors： Hsieh HM,Chiang HL,Tsai LC,Lai SY,Huang NE,Linacre A,Lee JC

    更新日期：2001-10-15 00:00:00

  • May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects?

    abstract：:Suicide attempts are one of the risk factors of suicide. Possible mechanisms by which Toxoplasma gondii may affect human behavior and it may also cause humans to attempt suicide. The aim of this study is to find out whether or not T. gondii is one of the reasons in suicide attempts. We investigated the sero-positivity...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2010.02.020

    authors： Yagmur F,Yazar S,Temel HO,Cavusoglu M

    更新日期：2010-06-15 00:00:00

  • Genetic polymorphisms of 15 STR loci in two Tibetan populations from Tibet Changdu and Naqu, China.

    abstract：:The allelic distribution of 15 short tandem repeat (STR) loci included in the AmpFl STR Identifiler kit was examined in 100 Changdu Tibetan and 118 Naqu Tibetan unrelated individuals living in the Tibet Province, PR China. The distribution of these observed genotypes was not significantly different from the expected d...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2006.03.012

    authors： Kang L,Yuan D,Yang F,Liu K,Za X

    更新日期：2007-07-04 00:00:00

  • Positive identification by X-rays bone trabeculae comparison.

    abstract：:Positive (certain, absolute) identification of human remains needs a scientific comparison between ante mortem and post-mortem biologic features, as fingerprint, odontological, radiological or DNA comparisons. X-rays comparison has been extensively used, usually comparing some peculiarities such as outlines of the bon...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.09.019

    authors： Quatrehomme G,Biglia E,Padovani B,du Jardin P,Alunni V

    更新日期：2014-12-01 00:00:00

  • An autopsy case of an infant with Joubert syndrome who died unexpectedly and a review of the literature.

    abstract：:The present report describes the unexpected death of a 6-month-old female infant who had been clinically diagnosed with Joubert syndrome. This is a relatively rare congenital neurological disorder characterized by hypoplasia/aplasia of cerebellar vermis, which transmits information from the body to the cerebellum, and...

    journal_title：Forensic science international

    pub_type： 杂志文章,评审

    doi：10.1016/j.forsciint.2008.06.003

    authors： Ishikawa T,Zhu BL,Li DR,Zhao D,Michiue T,Maeda H

    更新日期：2008-08-06 00:00:00

  • Delayed death in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project 15-year population-based report.

    abstract：:A fraction of SIDS cases have death delayed by successful CPR, yet they have not been compared to SIDS cases which were found dead or not successfully resuscitated. Our aims were to: (1) determine the percent of SIDS cases in the San Diego SIDS Research Project database for whom death was delayed by CPR and subsequent...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2007.09.009

    authors： Krous HF,Haas EA,Chadwick AE,Masoumi H,Mhoyan A,Stanley C

    更新日期：2008-04-07 00:00:00

  • The effectiveness of strong afterglow phosphor powder in the detection of fingermarks.

    abstract：:There are numerous types of fluorescent fingermark powders or reagents used with the visualization of latent fingermarks deposited on multicolored substrate surfaces that can present a contrast problem if developed with regular fingermark powders. The developed fingermarks can show bright fluorescence upon exposure to...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2008.10.008

    authors： Liu L,Zhang Z,Zhang L,Zhai Y

    更新日期：2009-01-10 00:00:00

  • Gasoline on hands: preliminary study on collection and persistence.

    abstract：:The identification of an arsonist remains one of the most difficult challenges a fire investigation has to face. Seeking and detection of traces of gasoline could provide a valuable information to link a suspect with an arson scene where gasoline was used to set-up the fire. In this perspective, a first study was unde...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2007.06.017

    authors： Darrer M,Jacquemet-Papilloud J,Delémont O

    更新日期：2008-03-05 00:00:00

  • The effect of sample size on the estimation of the frequency of DNA-profiles in RFLP-analysis.

    abstract：:Restriction fragment length polymorphism analysis (RFLP-analysis) was carried out on blood samples from 616 unrelated Danish Caucasians. DNA was restricted with Hinf I and analyzed with the single locus variable number tandem repeats (VNTR) probes MS1, MS31, MS43a and YNH24. The effect of the sample size on the estima...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(94)90275-5

    authors： Eriksen B,Svensmark O

    更新日期：1994-05-13 00:00:00

  • New alleles and mutational events in D12S391 and D8S1132: sequence data from an eastern German population.

    abstract：:To investigate the DNA mutation rate and pattern in the hypervariable short tandem repeat (STR) locus D12S391 and in the locus D8S1132, samples from an eastern German population (Dresden area) were analysed. A duplex PCR was applied, using short amplification products for D12S391 (129-177bp) and a modified reverse pri...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(01)00596-5

    authors： Hering S,Müller E

    更新日期：2001-12-27 00:00:00

  • Allele frequencies for STR loci of the Powerplex 16 multiplex system in five endogamous populations of India.

    abstract：:Allele frequencies for the 15 STR locus of PowerPlex 16 were analyzed in 95 healthy unrelated individuals belonging to five important population groups inhabiting different part of India. Fifteen loci studied are Penta E, D18S51, D21S11, THO1,D3S1358, FGA, TPOX, D8S1179, vWA, Amelogenin, Penta D, CSF1PO, D16S539, D7S8...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(02)00021-x

    authors： Kashyap VK,Sarkar N,Trivedi R

    更新日期：2002-04-18 00:00:00