Postmortem serotonin (5-HT) concentrations in the cerebrospinal fluid of medicolegal cases.

Abstract:

:In a medicolegal study the postmortem serotonin (5-HT) cerebrospinal fluid (CSF) concentrations were determined in routine autopsies using a high performance liquid chromatographic procedure with electrochemical detection. There was no correlation between 5-HT concentrations and age, sex or blood alcohol concentration using a postmortem delay < or = 3 days. In suicides the suboccipital CSF concentrations were significantly decreased compared to the levels measured in the control group (8.55+/-5.99 ng/ml versus 20.15+/-13.56 ng/ml). Additionally, a decrease of 5-HT was found in the suboccipital CSF of opiate fatalities (15.56+/-13.52 ng/ml). The results support the hypothesis that decreased 5-HT concentrations in the CSF are characteristic in suicides. However, due to a rather broad overlapping of values between suicides and controls the results failed to define a possible cut-off level in the 5-HT CSF concentration to distinguish between a suicidal and a non-suicidal incident.

journal_name

Forensic Sci Int

authors

Musshoff F,Menting T,Madea B

doi

10.1016/j.forsciint.2004.02.023

keywords:

subject

Has Abstract

pub_date

2004-06-10 00:00:00

pages

211-9

issue

2-3

eissn

0379-0738

issn

1872-6283

pii

S0379073804001094

journal_volume

142

pub_type

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