Abstract:
:In a medicolegal study the postmortem serotonin (5-HT) cerebrospinal fluid (CSF) concentrations were determined in routine autopsies using a high performance liquid chromatographic procedure with electrochemical detection. There was no correlation between 5-HT concentrations and age, sex or blood alcohol concentration using a postmortem delay < or = 3 days. In suicides the suboccipital CSF concentrations were significantly decreased compared to the levels measured in the control group (8.55+/-5.99 ng/ml versus 20.15+/-13.56 ng/ml). Additionally, a decrease of 5-HT was found in the suboccipital CSF of opiate fatalities (15.56+/-13.52 ng/ml). The results support the hypothesis that decreased 5-HT concentrations in the CSF are characteristic in suicides. However, due to a rather broad overlapping of values between suicides and controls the results failed to define a possible cut-off level in the 5-HT CSF concentration to distinguish between a suicidal and a non-suicidal incident.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Musshoff F,Menting T,Madea Bdoi
10.1016/j.forsciint.2004.02.023keywords:
subject
Has Abstractpub_date
2004-06-10 00:00:00pages
211-9issue
2-3eissn
0379-0738issn
1872-6283pii
S0379073804001094journal_volume
142pub_type
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