Abstract:
:The differentiation of intoxication courses is one of the most difficult challenges for forensic pathologists and toxicologists. The case of a 52-year-old female inpatient of a psychiatric clinic with multiple medications who died from doxepin intoxication is reported. Concentrations of doxepin metabolites and isomers, pharmacokinetic modelling and genotyping of the doxepin-metabolizing cytochrome P450 (CYP) enzymes led to the following conclusion: the lethal doxepin concentration of 2100 ng/mL was more likely to have been reached due to drug interactions and genetic peculiarities leading to a reduction of the metabolic capacity and not by an acute (suicidal) overdose.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Neukamm MA,Vogt S,Hermanns-Clausen M,Naue J,Thierauf A,Auwärter Vdoi
10.1016/j.forsciint.2012.08.050subject
Has Abstractpub_date
2013-04-10 00:00:00pages
82-4issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(12)00437-9journal_volume
227pub_type
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