Fatal doxepin intoxication--suicide or slow gradual intoxication?

Abstract:

:The differentiation of intoxication courses is one of the most difficult challenges for forensic pathologists and toxicologists. The case of a 52-year-old female inpatient of a psychiatric clinic with multiple medications who died from doxepin intoxication is reported. Concentrations of doxepin metabolites and isomers, pharmacokinetic modelling and genotyping of the doxepin-metabolizing cytochrome P450 (CYP) enzymes led to the following conclusion: the lethal doxepin concentration of 2100 ng/mL was more likely to have been reached due to drug interactions and genetic peculiarities leading to a reduction of the metabolic capacity and not by an acute (suicidal) overdose.

journal_name

Forensic Sci Int

authors

Neukamm MA,Vogt S,Hermanns-Clausen M,Naue J,Thierauf A,Auwärter V

doi

10.1016/j.forsciint.2012.08.050

subject

Has Abstract

pub_date

2013-04-10 00:00:00

pages

82-4

issue

1-3

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(12)00437-9

journal_volume

227

pub_type

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