Abstract：
:With the constantly increasing sensitivity and robustness of liquid chromatography-mass spectrometry-based instruments combined with enhanced reproducibility as well as mass accuracy and resolution, LC-MS(/MS) has become an integral part of sports drug testing programs particularly concerning the detection of peptide hormones. Although several of the relevant peptidic drugs such as insulins (Humalog LisPro, Novolog Aspart, etc.), growth hormone releasing peptides (GHRPs, e.g., GHRP-2, GHRP-6, Hexarelin, etc.), and insulin-like growth factors (e.g., IGF-1, IGF-2, long-R(3)-IGF-1) are currently analyzed using dedicated top-down analytical procedures, i.e. employing specifically tailored sample preparation procedures followed by targeted LC-MS(/MS) measurements focusing on intact analytes, first approaches towards multi-analyte methods have been established. These allow the determination of the prohibited substances in blood and urine doping control specimens following therapeutic applications. In addition, the use of new complementary devices such as ion mobility analyzers, e.g., in hybrid mass spectrometers yielded promising data for the differentiation of isobaric insulins, which outlines the potential to further accelerate and multiplex doping control analytical assays to meet the continuously increasing demands of rapid and unambiguous test methods. Moreover, the potential of LC-MS/MS to target recombinant peptide hormones such as human growth hormone using bottom-up approaches has been demonstrated by targeting proteotypic peptides that unambiguously differentiate the recombinant molecule from the naturally occurring and endogenously produced analog.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Thevis M,Thomas A,Schänzer Wdoi
10.1016/j.forsciint.2011.06.015subject
Has Abstractpub_date
2011-12-10 00:00:00pages
35-41issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(11)00296-9journal_volume
213pub_type
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journal_title：Forensic science international
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abstract：:A portable near infrared spectrometer was applied to the presumptive identification of psychotropic drugs based on library searching. Data-treatment methods (mathematical pretreatment and library search algorithm) were examined on the basis of differentiation ability. The optimized mathematical pretreatment was a stan...
journal_title：Forensic science international
pub_type： 杂志文章
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abstract：:Considering the high use of inkjet printing in forgery cases, the classification of inkjet printing is particularly important in questioned document examination. In this work, a universal GC-MS method has been developed to analyze various ink components extracted from inkjet printouts. The results indicated that sever...
journal_title：Forensic science international
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journal_title：Forensic science international
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更新日期：2005-10-29 00:00:00
abstract：:One hundred and seventy nine cases of acute poisoning constituting 1.1% of all admissions to the medical unit over 3 years were analysed. Eighty-three per cent of the patients were under 30 years of age and 72% were males. The common agents were: OP insecticides in 51%, kerosene oil in 12%, rat poison in 8% and drugs ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(88)90221-6
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abstract：:Bacterial genotyping can be used for crime scene investigations and contribute to the attribution of biological attacks for microbial forensics. PyroMark ID Pyrosequencer as an accurate detection platform for single nucleotide polymorphisms (SNPs) has been applied to identify and resolve microorganisms involved in clo...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.11.004
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abstract：:The hairy maggot blow fly, Chrysomya rufifacies (Diptera: Calliphoridae), is a forensically important fly often encountered on human and other vertebrate remains in temperate and tropic regions throughout the world including Australia, Asia, Central America and North America. C. rufifacies was reared under controlled ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.09.023
更新日期：2014-12-01 00:00:00
abstract：:Forensic molecular genetics has evolved from a rapidly developing field with changing technologies into a highly recognized and generally accepted forensic science, leading to the establishment of national DNA databases with DNA profiles from suspects and convicted offenders. DNA evidence has taken a central role by c...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2006.06.067
更新日期：2007-01-17 00:00:00
abstract：OBJECTIVES:To evaluate medical statement conclusions in the criminal-legal process in suspected cases of child sexual abuse (CSA). STUDY DESIGN:An observational study of a random sample of 130 medically examined, police reported CSA suspected cases during 2001-2009. Medical statements were evaluated and their conclusi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.03.006
更新日期：2014-06-01 00:00:00
abstract：:Two sewing needles were found in a woman's cranial cavity by X-ray examination after she had sustained traffic injury. After investigation and analysis, it has been confirmed that the sewing needles were inserted by others when she was an infant, and not by the traffic injury. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(01)00470-4
更新日期：2001-10-15 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.06.032
更新日期：2014-09-01 00:00:00
abstract：:Human hair is among the most common kind of evidence secured at crime scenes. Although DNA analysis through STR-typing is possible in principle, it is not very promising for telogenic hair or single hairs. For the mixed traces frequently found in practice, composed of different hair from an unknown number of individua...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.12.018
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abstract：:The aim of this study was to investigate the role of time and different real-life storage conditions on the composition of different varieties of cannabis products (hashish and marijuana). Six high-potency cannabis products constituted by herbal and resin materials containing different initial concentrations of delta ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.02.058
更新日期：2019-05-01 00:00:00
abstract：:Sixty nine participants in the United Kingdom national external quality assessment scheme for drugs of abuse in urine reported details of their sample extraction technique by questionnaire. Laboratories were categorised by differences in technique and their analytical test results compared for samples containing D-amf...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00383-2
更新日期：2001-06-01 00:00:00
abstract：:Gunshot residue (GSR) analysis is a frequently used forensic method for investigating shooting events. In this process, GSR-particles are detected on pertinent objects, often the hands of a suspect, with energy dispersive X-ray microanalysis in a scanning electron microscope. The question asked in court is usually the...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.01.034
更新日期：2012-07-10 00:00:00
abstract：:As part of a transcultural investigation of violent behavior in Denmark and South America an analysis was made during a one year period of the incidents involving deliberate violence as registered at 3 Danish emergency wards, and at the Institute of Forensic Medicine in Copenhagen. In the three emergency wards a total...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(89)90146-1
更新日期：1989-02-01 00:00:00
abstract：:A high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) technique was developed for the simultaneous determination of five non-steroidal anti-inflammatory oxicam drugs (ampiroxicam, tenoxicam, piroxicam, meloxicam and lornoxicam) in human plasma. These five oxicam drugs and isoxicam (internal stan...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.11.016
更新日期：2013-04-10 00:00:00
abstract：:Forensic personnel may face a daunting task when searching for buried weapons at crime scenes or potential disposal sites. In particular, it is common to search for a small firearm that was discarded or buried by a perpetrator. When performing forensic searches, it is recommended to first use non-invasive methods such...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.10.019
更新日期：2011-05-20 00:00:00
abstract：:Two likelihood ratio (LR) approaches are presented to evaluate the strength of evidence of MDMA tablet comparisons. The first one is based on a more 'traditional' comparison of MDMA tablets by using distance measures (e.g., Pearson correlation distance or a Euclidean distance). In this approach, LRs are calculated usi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.06.006
更新日期：2009-10-30 00:00:00
abstract：:Histological methods can be used forensically to estimate age-at-death based on patterns of change in osteon shape, size, and population density, all of which result from the continuous process of bone remodelling. The present study examines the applicability of three existing histological age-at-death estimation meth...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.109950
更新日期：2019-10-01 00:00:00
abstract：:A 26-year-old male was found naked and excited in the backyard of his neighbor's house. He was carried to a nearby hospital, and returned home with his family, but took a sudden turn for the worse and died. In a judicial autopsy, the ethanol concentration of blood was found to be 0.58 milligrams, and methamphetamine (...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90209-s
更新日期：1993-12-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(96)02008-7
更新日期：1996-11-11 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.02.028
更新日期：2019-04-01 00:00:00
abstract：:Allele frequency data and forensic efficiency parameters for 10 STR loci: D3S1358, vWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01 and FGA, were estimated from a sample of 207 unrelated individuals in Lodz region of Poland. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00268-8
更新日期：2003-10-14 00:00:00
abstract：:Human teeth are biological structures that resist extreme conditions thus becoming a useful source of DNA for human forensic identification purposes. When it is possible, forensic prefer only non-damaged teeth whereas those with cavities are usually rejected to avoid both external and internal bacterial contamination....
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.08.021
更新日期：2015-12-01 00:00:00
abstract：:A very serious case of DFSA (drug facilitated sexual assault) is presented, in which a six-year-old girl died following sedation with γ-hydroxybutyric acid (GHB). She had been sexually abused by a relative. Samples of cardiac blood, bile, vitreous humour, liver, kidney, brain tissues and hair were analysed by a LC-MS/...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.12.044
更新日期：2016-02-01 00:00:00
abstract：:Bullet embolism is a well known but a relatively rare phenomenon in common medicolegal autopsy practice. We present a homicide case of a bullet embolism to the left popliteal artery with interesting trajectory of projectile through the chest wall and right heart ventricle into the aortic lumen. Since in our presented ...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2003.09.014
更新日期：2004-01-06 00:00:00
abstract：:A total of 13 STR loci were typed from over 200 Caucasians from the Strathclyde region in the west of Scotland. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00317-0
更新日期：2001-02-15 00:00:00
abstract：:Current research literature contains very few international, cross-cultural comparison studies of persons adjudicated 'Not Criminally Responsible on Account of Mental Disorder' (NCRMD). This study explores and compares the demographic differences between persons found NCRMD in British Columbia, Canada and Hunan, China...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.12.001
更新日期：2006-12-20 00:00:00
abstract：:Allele frequencies and haplotypes for 12 Y-chromosomal STR loci included in the Powerplex System (Promega, Madison, USA) were determined in a sample of 113 unrelated males of Belgian origin. Ninety-nine different haplotypes were observed with an overall haplotype diversity of 0.997. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.02.010
更新日期：2005-08-11 00:00:00
