Abstract：
:A very serious case of DFSA (drug facilitated sexual assault) is presented, in which a six-year-old girl died following sedation with γ-hydroxybutyric acid (GHB). She had been sexually abused by a relative. Samples of cardiac blood, bile, vitreous humour, liver, kidney, brain tissues and hair were analysed by a LC-MS/MS method. The following GHB concentrations were determined: cardiac blood: 150 mg/l; bile: 292mg/l; vitreous humour: 58mg/l; liver: 100 mg/kg; kidney: 124.5 mg/kg, brain: 110 mg/kg. Very high GHB levels were found in the proximal part of the hair sample (about 40.9 ng/mg). In distal segments of hair - up to 12 cm distant from the hair scalp - GHB concentrations were higher than the overall found endogenous range of 2-3 ng/mg. Police investigations revealed that the uncle had also administered GHB to the older half-sister. Therefore, a sample of her hair was analysed accordingly, but unremarkable results were obtained. Comparing our toxicological results with police investigations and the offender's statements it can be assumed that the 6-year-old girl had ingested GHB. By exclusion of other causes of death a lethal intoxication with GHB could be confirmed.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Mehling LM,Johansen SS,Wang X,Doberentz E,Madea B,Hess Cdoi
10.1016/j.forsciint.2015.12.044subject
Has Abstractpub_date
2016-02-01 00:00:00pages
e25-31eissn
0379-0738issn
1872-6283pii
S0379-0738(16)00002-5journal_volume
259pub_type
杂志文章abstract：:The level of information provided by ink evidence to the criminal and civil justice system is limited. The limitations arise from the weakness of the interpretative framework currently used, as proposed in the ASTM 1422-05 and 1789-04 on ink analysis. It is proposed to use the likelihood ratio from the Bayes theorem t...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.11.016
更新日期：2009-03-10 00:00:00
abstract：:The procedure used in this laboratory for removing and identifying contamination of hair specimens with drugs is demonstrated by its application to hair contaminated by various experimental models. The models include soaking; coating with drug followed by sweat conditions for 6 h; and soaking in a very high concentrat...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.04.024
更新日期：2004-10-29 00:00:00
abstract：:The objective of the present work was to compare previously published methods and provide validation data to detect simultaneously cocaine (COC), benzoylecgonine (BE) and norcocaine (NCOC) in nail. Finger and toenail samples (5mg) were cut in very small pieces and submitted to an initial procedure for external deconta...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.07.021
更新日期：2006-06-02 00:00:00
abstract：:The Finnish guidelines for workplace drug testing outlined here represent what is considered the best practice for workplace drug testing to be followed in Finland. The guidelines are based on the act on the protection of privacy in working life (759/2004), the occupational health care act (1383/2001) and the decree o...
journal_title：Forensic science international
pub_type： 指南,杂志文章
doi：10.1016/j.forsciint.2007.03.006
更新日期：2008-01-30 00:00:00
abstract：:Despite numerous instrumental achievements, canines are still considered the most effective field method for explosive detection. However, due to strict explosive regulations and safety requirements, it can be a challenge for agencies with "bomb dogs" to train using neat explosive materials. This establishes a need fo...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.05.019
更新日期：2011-10-10 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.07.009
更新日期：2016-10-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.08.014
更新日期：2014-11-01 00:00:00
abstract：:Restriction fragment length polymorphism analysis (RFLP-analysis) was carried out on blood samples from 616 unrelated Danish Caucasians. DNA was restricted with Hinf I and analyzed with the single locus variable number tandem repeats (VNTR) probes MS1, MS31, MS43a and YNH24. The effect of the sample size on the estima...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90275-5
更新日期：1994-05-13 00:00:00
abstract：:We have performed a population genetic study on a population from South Saxony-Anhalt, Germany. The allele distributions of the systems DYS19, DYS385, DYS389I/II DYS390, DYS391, DYS392 and DYS393 were investigated in a sample of 234 unrelated males. PCR products were detected using capillary electrophoresis on the ABI...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.01.004
更新日期：2005-12-20 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.038
更新日期：2007-04-11 00:00:00
abstract：:The examination of damage to a paper towel, an item of evidence in a murder case, is described. Simulations performed with selected tools and the observation of the lacerations present on the towel permitted to infer that they were originated by cleaning of a pointed and sharp implement. Some marks, considered charact...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.04.078
更新日期：2005-03-10 00:00:00
abstract：:The spectrophotometric method for the determination of carboxyhemoglobin (HbCO) in blood reported by Fretwurst and Meinecke was modified so as to give the same values of percentage HbCO (HbCO%) as those determined by the oxygen electrode method. Values of HbCO% of nine practical samples determined by both the oxygen e...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(81)90157-2
更新日期：1981-09-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00107-x
更新日期：2002-06-25 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.11.006
更新日期：2007-10-02 00:00:00
abstract：:In an investigation of postmortem ethanol diffusion deuterium-labeled ethanol-d6 was instilled by peroral gavage immediately after death by CO into the stomach of rat carcasses which were subsequently kept for 12-72 h at 5 or 30 degrees C. The heart blood, abdominal fluid and several tissues were collected and analyze...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01820-4
更新日期：1995-12-29 00:00:00
abstract：:The feasibility of detecting methamphetamine and its major metabolite, amphetamine, in postmortem tissues over a 2-year period was examined. It is important to determine if the abuse and toxic effects of drugs can be proved from evidence found in decayed, submerged, or stained tissue materials. The blood, urine, liver...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90270-9
更新日期：1990-11-01 00:00:00
abstract：:In Australia, particularly Western Australia, there is a relative paucity of contemporary population-specific morphometric standards for the estimation of sex from unknown skeletal remains. This is largely a historical artefact from lacking, or poorly documented, repositories of human skeletons available for study. Ho...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.11.008
更新日期：2012-04-10 00:00:00
abstract：:Understanding bone trauma characteristics is a fundamental component of forensic investigations that can assist in understanding the nature of blunt trauma related deaths. The variation of each blunt force trauma (BFT) injury is dependent on a magnitude of factors including, age, sex, health, angle of impact, impact m...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2020.110140
更新日期：2020-02-01 00:00:00
abstract：:The forensic toxicology community has recognized flunitrazepam and its metabolite (7-aminoflunitrazepam) as compounds of concern for several years. In this procedure, the analytes were extracted from whole blood and urine onto single mode solid phase cartridges (butyl) using nitrazepam as an internal standard. The col...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.03.019
更新日期：2006-03-10 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/0379-0738(94)90230-5
更新日期：1994-02-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.12.012
更新日期：2015-03-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.08.027
更新日期：2014-11-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00124-3
更新日期：1999-11-08 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.06.011
更新日期：2005-04-20 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(83)90129-9
更新日期：1983-05-01 00:00:00
abstract：:Benzodiazepines are one of the most widely prescribed drugs for the treatment of a wide spectrum of clinical disorders. They are used as anticonvulsants, anxiolytics, hypnotics or muscle relaxants with different duration of action. In this paper, a simple and sensitive method for the determination of benzodiazepines i...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00226-7
更新日期：2000-09-11 00:00:00
abstract：:The determination of sex is considered one of the first essential steps in positive identification. The current study aspires to accomplish a threefold purpose: to develop an easy and rapid sex determination technique using digital radiographs from the proximal epiphysis of the femur, to develop a simplified tool for ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.04.014
更新日期：2009-08-10 00:00:00
abstract：:Since gamma-hydroxybutyrate (GHB) is present in both blood and urine of the general population as an endogenous compound, toxicologists must be able to discriminate between these endogenous levels and a concentration resulting from exogenous exposure. The implementation of a cut-off concentration must be done cautious...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.02.036
更新日期：2004-07-16 00:00:00
abstract：:Chemicals associated with clandestine drug laboratories are often disposed of covertly into soil, sewerage systems, or public waste management facilities. There are two significant issues relating to such dumps of materials; they might contain valuable evidence as to drug manufacture, and they might be a source of pol...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00110-5
更新日期：2003-06-24 00:00:00
abstract：:Stature estimation is a standard procedure in the fields of forensic and biological anthropology, bio-archaeology and paleoanthropology, in order to gain biological insights into the individuals/populations studied. The most accurate stature estimation method is based on anatomical reconstruction (i.e., the Fully meth...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.01.009
更新日期：2013-03-10 00:00:00
