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Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography-tandem mass spectrometry.

Abstract：

:A high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) technique was developed for the simultaneous determination of five non-steroidal anti-inflammatory oxicam drugs (ampiroxicam, tenoxicam, piroxicam, meloxicam and lornoxicam) in human plasma. These five oxicam drugs and isoxicam (internal standard) were extracted from human plasma with an Oasis(®) MAX cartridge column and analysed on a Unison UK-C18 column (2.0 mm × 100 mm, 3 μm) with an acetonitrile:10mM formic ammonium buffer (pH 3.0) (50:50) mobile phase at 0.20 ml/min at 37°C. The analytes were detected using a tandem mass spectrometer, equipped with an electrospray ion source (ESI). The instrument was used in multiple-reaction-monitoring (MRM) mode. The extraction yields from a 200 μl human plasma sample (containing 10 ng of each drugs) with the Oasis(®) MAX cartridge column were 93.3-102.5%. The detection limits were 0.01-6.5 ng/ml (S/N=3). Our developed method is very useful for the simultaneous determination of five oxicam (non-steroidal anti-inflammatory) drugs in human plasma by LC/MS/MS.

journal_name

Forensic Sci Int

journal_title

Forensic science international

authors

Shirako J,Kawasaki M,Komine K,Kunisue Y,Terada M,Sasaki C,Irie W,Murakami C,Tonooka K,Tomobe K,Shinozuka T

doi

10.1016/j.forsciint.2012.11.016

subject

Has Abstract

pub_date

2013-04-10 00:00:00

pages

100-2

issue

1-3

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(12)00534-8

journal_volume

227

pub_type

杂志文章

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