Abstract:
:The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Doughty D,Painter B,Pigou PE,Johnston MRdoi
10.1016/j.forsciint.2016.03.034subject
Has Abstractpub_date
2016-06-01 00:00:00pages
55-66eissn
0379-0738issn
1872-6283pii
S0379-0738(16)30120-7journal_volume
263pub_type
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