The synthesis and investigation of impurities found in Clandestine Laboratories: Baeyer-Villiger Route Part I; Synthesis of P2P from benzaldehyde and methyl ethyl ketone.

Abstract:

:The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.

journal_name

Forensic Sci Int

authors

Doughty D,Painter B,Pigou PE,Johnston MR

doi

10.1016/j.forsciint.2016.03.034

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

55-66

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(16)30120-7

journal_volume

263

pub_type

杂志文章
  • LC-MS-MS method for simultaneous determination of THCCOOH and THCCOOH-glucuronide in urine: Application to workplace confirmation tests.

    abstract::Cannabis is the one of the most frequently detected drug in workplace drug testing and in cases of driving under influence of drugs, and there is a greater demand for sensitive, rapid and reliable methods for confirming the presence of this drug in biological samples. This paper describes an LC-MS-MS procedure for dir...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2010.05.004

    authors: Felli M,Martello S,Chiarotti M

    更新日期:2011-01-30 00:00:00

  • Estimating crime scene temperatures from nearby meteorological station data.

    abstract::The importance of temperature data in minimum postmortem interval (minPMI) estimations in criminal investigations is well known. To maximise the accuracy of minPMI estimations, it is imperative to investigate the different components involved in temperature modelling, such as the duration of temperature data logger pl...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2019.110028

    authors: Hofer IMJ,Hart AJ,Martín-Vega D,Hall MJR

    更新日期:2020-01-01 00:00:00

  • Statistical examination of hair color as a potential biasing factor in hair analysis.

    abstract::We review eight different data sets in this paper for the purposes of assessing the possibility that reported color of hair can produce a systematic bias in the interpretation of hair assays. We review studies or data sets that include heroin and its metabolites, cocaine and its metabolites, MDMA and its analogs, and ...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审

    doi:10.1016/s0379-0738(99)00147-4

    authors: Mieczkowski T,Newel R

    更新日期:2000-01-10 00:00:00

  • Pupillary effects in habitual cannabis consumers quantified with pupillography.

    abstract::Driving under the influence of alcohol (DUIA) and drugs (DUID) is considered an elevated risk for traffic safety. When assessing a driver's fitness to drive, standardized and objective measurement methods are still required, in order to clarify the question whether an individual is under the influence of substances ac...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2020.110559

    authors: Campobasso CP,De Micco F,Corbi G,Keller T,Hartung B,Daldrup T,Monticelli F

    更新日期:2020-12-01 00:00:00

  • Illegal drugs and delinquency.

    abstract::An interrelation between consumption of illegal drugs and committing an indictable offence has been repeatedly discussed in literature. In a retrospective study serum concentrations of illegal and legal drugs as well as data originating from police reports and examinations by physicians taking blood from individuals b...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2013.01.031

    authors: Kirschbaum KM,Grigoleit L,Hess C,Madea B,Musshoff F

    更新日期:2013-03-10 00:00:00

  • Interaction between apnea, prone sleep position and gliosis in the brainstems of victims of SIDS.

    abstract::Among 27,000 infants studied prospectively to characterize their sleep-wake behavior, 38 infants died suddenly and unexpectedly under 6 months of age. Of these, 26 died from sudden infant death syndrome (SIDS), 5 from congenital cardiac abnormalities, 2 from infected pulmonary dysplasia, 2 from septic shock with multi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(02)00138-x

    authors: Sawaguchi T,Franco P,Kato I,Shimizu S,Kadhim H,Groswasser J,Sottiaux M,Togari H,Kobayashi M,Nishida H,Sawaguchi A,Kahn A

    更新日期:2002-09-14 00:00:00

  • Czech population data on 10 short tandem repeat loci of SGM Plus STR system kit using DNA purified in FTA cards.

    abstract::A population study on 10 short tandem repeat (STR) loci was performed on 202 unrelated Czech Caucasians. DNA, initially frozen, was thawed and placed FTA paper. The DNA was purified in situ. DNA was amplified by PCR using the AmpFlSTR SGM Plus amplification kit. ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(00)00384-4

    authors: Vanek D,Hradil R,Budowle B

    更新日期:2001-06-01 00:00:00

  • The role of the forensic pathologist in the investigation of fatal traffic accidents--the Finnish system.

    abstract::In Finland about one-half of the fatal traffic accidents are investigated by special Boards of Inquiry. The cumulating data serves multidisciplinary sciences, juridical and insurance purposes and legislation. The participating physicians benefit from the systematic work of the Boards in many ways. As an example of the...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(78)90004-x

    authors: Karkola K

    更新日期:1978-11-01 00:00:00

  • The cholesterol levels in median nerve and post-mortem interval evaluation.

    abstract::Cholesterol levels in the median nerve were studied at various post-mortem intervals (PMIs). Single median nerve samples were collected from the wrists of 36 subjects during forensic autopsies of subjects with known circumstances and times of death. Although the absolute values varied, increments in cholesterol concen...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.01.004

    authors: Vacchiano G,Maldonado AL,Ros MM,Di Lorenzo P,Pieri M

    更新日期:2016-08-01 00:00:00

  • Histomorphometric age estimation from the femoral cortex: A test of three methods in an Australian population.

    abstract::Histological methods can be used forensically to estimate age-at-death based on patterns of change in osteon shape, size, and population density, all of which result from the continuous process of bone remodelling. The present study examines the applicability of three existing histological age-at-death estimation meth...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2019.109950

    authors: Maggio A,Franklin D

    更新日期:2019-10-01 00:00:00

  • DNA methylation age estimation in blood samples of living and deceased individuals using a multiplex SNaPshot assay.

    abstract::Many studies in the forensic field have reported that analysis of DNA methylation is the most reliable method of predicting age. In a previous study, 5 CpG sites located in ELOVL2, FHL2, KLF14, C1orf132 and TRIM59 genes were tested for age prediction purposes in blood, saliva and buccal swab samples from Korean indivi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2020.110267

    authors: Dias HC,Cordeiro C,Pereira J,Pinto C,Real FC,Cunha E,Manco L

    更新日期:2020-06-01 00:00:00

  • Large-scale in-vivo Caucasian facial soft tissue thickness database for craniofacial reconstruction.

    abstract::A large-scale study of facial soft tissue depths of Caucasian adults was conducted. Over a 2-years period, 967 Caucasian subjects of both sexes, varying age and varying body mass index (BMI) were studied. A user-friendly and mobile ultrasound-based system was used to measure, in about 20min per subject, the soft tissu...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2006.02.034

    authors: De Greef S,Claes P,Vandermeulen D,Mollemans W,Suetens P,Willems G

    更新日期:2006-05-15 00:00:00

  • Validation of a method to detect cocaine and its metabolites in nails by gas chromatography-mass spectrometry.

    abstract::The objective of the present work was to compare previously published methods and provide validation data to detect simultaneously cocaine (COC), benzoylecgonine (BE) and norcocaine (NCOC) in nail. Finger and toenail samples (5mg) were cut in very small pieces and submitted to an initial procedure for external deconta...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2005.07.021

    authors: Valente-Campos S,Yonamine M,de Moraes Moreau RL,Silva OA

    更新日期:2006-06-02 00:00:00

  • The experimental and numerical study of indirect effect of a rifle bullet on the bone.

    abstract::We study the transient indirect effect of a rifle bullet on bone in the gelatin-bone composite target experimentally and computationally. The process of a 56 type 7.62-mm rifle bullet penetrating the composite target has been simulated using numerical method. The experiment provided the criteria for verifying the corr...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2015.10.032

    authors: Zhang X,Xu C,Wen Y,Luo S

    更新日期:2015-12-01 00:00:00

  • Analysis of the D1S80 (pMCT118) VNTR locus polymorphism in a native Kuwaiti population by the polymerase chain reaction.

    abstract::We have determined the allele and genotype frequencies at the hypervariable locus D1S80 in a native Kuwaiti population using the polymerase chain reaction technique and subsequent high resolution gel electrophoresis. In a sample of 200 individuals, 21 alleles and 57 genotypes were detected. The alleles with 18 and 24 ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(95)01881-6

    authors: al-Nassar KE,Mathew J,Thomas N,Fatania HR

    更新日期:1996-04-02 00:00:00

  • Organ weight in 684 adult autopsies: new tables for a Caucasoid population.

    abstract::The weights of normal organs were retrospectively culled for the years 1987-1991 from 684 forensic autopsy cases. All the subjects were Caucasoid adults who died of external causes and showed no pathological changes. The weights of the following organs were available: the heart, the right and the left lung, the liver,...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(00)00401-1

    authors: de la Grandmaison GL,Clairand I,Durigon M

    更新日期:2001-06-15 00:00:00

  • Hair combing to collect organic gunshot residues (OGSR).

    abstract::A protocol is presented for the collection and analysis of gunshot residues (GSR) from hair. A fine-toothed comb is used for collection of the residues. A small zip-closure bag serves as a container for both sample storage and extraction of the characteristic organic powder additives. The success of this residue recov...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(03)00207-x

    authors: MacCrehan WA,Layman MJ,Secl JD

    更新日期:2003-08-12 00:00:00

  • Studies about quantitative examination of laser printed documents based on image physical metric.

    abstract::In the field of questioned document examinations, the disadvantages of qualitative examination based on expert experience are becoming more and more obvious. In the source determination of laser-printed documents, the quantitative evaluation based on image quality is more and more important. In this paper, the ImageXp...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2020.110603

    authors: Li B,Qu Y,Wang C,Zhou G

    更新日期:2021-01-01 00:00:00

  • Ocfentanil overdose fatality in the recreational drug scene.

    abstract::This paper describes the first reported death involving ocfentanil, a potent synthetic opioid and structure analogue of fentanyl abused as a new psychoactive substance in the recreational drug scene. A 17-year-old man with a history of illegal substance abuse was found dead in his home after snorting a brown powder pu...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.07.005

    authors: Coopman V,Cordonnier J,De Leeuw M,Cirimele V

    更新日期:2016-09-01 00:00:00

  • Sexual dimorphism of ossified costal cartilage. Radiograph scan study on Caucasian men and women (Czech population).

    abstract::The aim of our study was to evaluate differences between males and females based on patterns of costal cartilage ossification and also with respect to ageing. We provided diagnosis of ossifications from two files of radiograms. The first group consisted of 1044 chest and abdominal radiograms of patients (537 men and 5...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2009.06.009

    authors: Rejtarová O,Hejna P,Rejtar P,Bukac J,Slízová D,Krs O

    更新日期:2009-10-30 00:00:00

  • Pilot study of feature-based algorithm for breech face comparison.

    abstract::A novel feature-based method, which is scale invariant feature transform (SIFT) and RANdom SAmple Consensus (RANSAC) integration algorithm, is introduced to promote the automated identification of the breech face impression, the most common mark left on the cartridge used for firearm evidence. SIFT algorithm is employ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2018.02.026

    authors: Zhang H,Gu J,Chen J,Sun F,Wang H

    更新日期:2018-05-01 00:00:00

  • Finnish guidelines for workplace drug testing.

    abstract::The Finnish guidelines for workplace drug testing outlined here represent what is considered the best practice for workplace drug testing to be followed in Finland. The guidelines are based on the act on the protection of privacy in working life (759/2004), the occupational health care act (1383/2001) and the decree o...

    journal_title:Forensic science international

    pub_type: 指南,杂志文章

    doi:10.1016/j.forsciint.2007.03.006

    authors: Lillsunde P,Haavanlammi K,Partinen R,Mukala K,Lamberg M

    更新日期:2008-01-30 00:00:00

  • Determining comparative elemental profile using handheld X-ray fluorescence in humans, elephants, dogs, and dolphins: Preliminary study for species identification.

    abstract::Species identification is a crucial step in forensic anthropological studies. The aim of this study was to determine elemental profiles in bones from four mammal species, to be used for species discrimination. Human, elephant, dog, and dolphin bones were scanned by X-ray fluorescence (XRF); the differences in elementa...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.03.056

    authors: Nganvongpanit K,Buddhachat K,Klinhom S,Kaewmong P,Thitaram C,Mahakkanukrauh P

    更新日期:2016-06-01 00:00:00

  • Nuclear and mitochondrial DNA quantification of various forensic materials.

    abstract::Due to the different types and quality of forensic evidence materials, their DNA content can vary substantially, and particularly low quantities can impact the results in an identification analysis. In this study, the quantity of mitochondrial and nuclear DNA was determined in a variety of materials using a previously...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2005.11.024

    authors: Andréasson H,Nilsson M,Budowle B,Lundberg H,Allen M

    更新日期:2006-12-01 00:00:00

  • Synthesis of 4-methyl-5-arylpyrimidines and 4-arylpyrimidines: route specific markers for the Leuckardt preparation of amphetamine, 4-methoxyamphetamine, and 4-methylthioamphetamine.

    abstract::General synthetic routes to 4-methyl-5-arylpyrimidines and 5-arylpyrimidines are described. 4-Benzylpyrimidine, 4-methyl-5-phenylpyrimidine, 4-(4-methoxybenzyl)pyrimidine, and 4-methyl-5-(4-methoxyphenyl)pyrimidine have been positively identified as route-specific by-products in the Leuckardt preparations of amphetami...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(00)00311-x

    authors: Kirkbride KP,Ward AD,Jenkins NF,Klass G,Coumbaros JC

    更新日期:2001-01-01 00:00:00

  • Adulterants encountered in the illicit cocaine market.

    abstract::Illicit cocaine samples (156), seized on Rome's illegal market between January 1996 and June 1997, were examined. Both the purity of the cocaine and the presence of substances employed for dilution were determined for each sample. Adulterants were found in many of the street samples analysed. Lidocaine (average 14.7%)...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(98)00102-9

    authors: Fucci N,De Giovanni N

    更新日期:1998-08-12 00:00:00

  • The effect of mark enhancement techniques on the subsequent detection of semen/spermatozoa.

    abstract::Fingermarks, footwear marks, blood and semen are amongst the most commonly encountered types of evidence at crime scenes. Previous work has extensively investigated fingermark and blood enhancement techniques and a sequence developed to maximise evidence recovery; however, there is limited research as to the effect of...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2014.08.027

    authors: Simmons R,Deacon P,Phillips DJ,Farrugia K

    更新日期:2014-11-01 00:00:00

  • Hair concentrations and self-reported abuse history of 20 amphetamine and ecstasy users.

    abstract::Hair samples of 20 volunteers of the techno-music scene, who more or less regularly consumed ecstasy tablets and speed and anonymously reported their abuse history, were analyzed in one to seven 3 cm segments for amphetamine (A), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDM...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(97)00123-0

    authors: Rothe M,Pragst F,Spiegel K,Harrach T,Fischer K,Kunkel J

    更新日期:1997-09-19 00:00:00

  • Contribution of postmortem multidetector CT scanning to identification of the deceased in a mass disaster: Experience gained from the 2009 Victorian bushfires.

    abstract::CT scanning of the deceased is an established technique performed on all individuals admitted to VIFM over the last 5 years. It is used primarily to assist pathologists in determining cause and manner of death but is also invaluable for identification of unknown deceased individuals where traditional methods are not p...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2010.05.026

    authors: O'Donnell C,Iino M,Mansharan K,Leditscke J,Woodford N

    更新日期:2011-02-25 00:00:00

  • Analysis of the possible use of liquid crystals in fingerprinting.

    abstract::Preliminary results concerning the use of liquid crystals (LC) in fingerprinting are given. These were based on thin layers of liquid crystals, changing colours (observed in linear polarized light) due to dissolved organic matter, transferred from fingers' surfaces. The possibility is shown of using LC to illustrate n...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(91)90137-8

    authors: Bładek J,Moszczyński J

    更新日期:1991-07-01 00:00:00