Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre.

Abstract:

:In literature, cases of nutmeg abuse have been described repeatedly, but only one fatal case of poisoning was reported [1]. In the present case, myristicin (4 microg/ml) was detected for the first time in the postmortal serum of a 55-year-old woman. Identification was achieved with the aid of UV-VIS spectroscopy and TLC; for quantification, HPLC was used. Because also flunitrazepam (0.072 microg/ml) was found, death had probably been due to the combined toxic effect of both substances. From 1996 to 1998, in a series of cases, seven poisonings with nutmeg were recorded by the Erfurt Poison Information Centre. Even where higher doses (20-80 g of powder) had been ingested, a life-threatening situation was never observed. In one of these cases, a myristicin blood level of 2 microg/ml was measured 8h after ingestion of two to three tablespoonful of nutmeg powder (approx. 14-21 g, or 280-420 mg/kg).

journal_name

Forensic Sci Int

authors

Stein U,Greyer H,Hentschel H

doi

10.1016/s0379-0738(00)00369-8

keywords:

subject

Has Abstract

pub_date

2001-04-15 00:00:00

pages

87-90

issue

1

eissn

0379-0738

issn

1872-6283

pii

S0379073800003698

journal_volume

118

pub_type

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