Abstract:
INTRODUCTION:3-methoxyphencyclidine (3-MeO-PCP) appeared on the illicit drug market in 2011 and is an analogue of phencyclidine, which exhibits anesthetic, analgesic and hallucinogenic properties. In this paper, we report data from a non-fatal intoxication and seven deaths involving 3-MeO-PCP in Sweden during the period March 2014 until June 2016. CASE DESCRIPTIONS:The non-fatal intoxication case, a 19-year-old male with drug problems and a medical history of depression, was found awake but tachycardic, hypertensive, tachypnoeic and catatonic at home. After being hospitalized, his condition worsened as he developed a fever and lactic acidosis concomitant with psychomotor agitation and hallucinations. After 22h of intensive care, the patient had made a complete recovery. During his hospitalization, a total of four blood samples were collected at different time points. The seven autopsy cases, six males and one female, were all in their twenties to thirties with psychiatric problems and/or an ongoing drug abuse. METHODS:3-MeO-PCP was identified with liquid chromatography (LC)/time-of-flight technology and quantified using LC-tandem mass spectrometry. RESULTS:In the clinical case, the concentration of 3-MeO-PCP was 0.14μg/g at admission, 0.08μg/g 2.5h after admission, 0.06μg/g 5h after admission and 0.04μg/g 17h after admission. The half-life of 3-MeO-PCP was estimated to 11h. In the autopsy cases, femoral blood concentrations ranged from 0.05μg/g to 0.38μg/g. 3-MeO-PCP was the sole finding in the case with the highest concentration and the cause of death was established as intoxication with 3-MeO-PCP. In the remaining six autopsy cases, other medications and drugs of abuse were present as well. CONCLUSION:Despite being scheduled in January 2015, 3-MeO-PCP continues to be abused in Sweden. Exposure to 3-MeO-PCP may cause severe adverse events and even death, especially if the user does not receive life-supporting treatment.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Johansson A,Lindstedt D,Roman M,Thelander G,Nielsen EI,Lennborn U,Sandler H,Rubertsson S,Ahlner J,Kronstrand R,Kugelberg FCdoi
10.1016/j.forsciint.2017.02.034subject
Has Abstractpub_date
2017-06-01 00:00:00pages
76-82eissn
0379-0738issn
1872-6283pii
S0379-0738(17)30088-9journal_volume
275pub_type
杂志文章abstract::The purpose of this study is to estimate the age of cadavers by histomorphometry of the femur. Seventy-two Japanese males ranged from 43 days to 92 years old and 26 females ranged from 2 to 88 years old were used. The thickness of sections was adjusted at 50 to 70 microns by grinding with sand paper. The sections were...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(98)00136-4
更新日期:1998-11-30 00:00:00
abstract::Gladiator remains from a recently unearthed cemetery in ancient Ephesus (Turkey) offer a unique opportunity for proving common theories involving the weaponry and techniques of gladiator fighting based on the evidence supplied by cranial bones. This mass grave is the first of its kind to undergo a thorough osteologica...
journal_title:Forensic science international
pub_type: 历史文章,杂志文章
doi:10.1016/j.forsciint.2005.10.010
更新日期:2006-07-13 00:00:00
abstract::We present two non fatal cases of intoxication with carbofuran (CBF) documented by hair analysis. Carbofuran and 3-hydroxycarbofuran (OHCBF, its main metabolite) hair concentrations were determined using a liquid chromatography-tandem mass spectrometry method. The obtained results were surprising if we consider severa...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.05.011
更新日期:2011-10-10 00:00:00
abstract::Although most cases involving entomological evidence occur in urban environments and under indoor conditions, there is a lack of studies determining the insect fauna of forensic importance in those environments. In the current paper we provide the first data on the composition of the forensically important insect spec...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2014.12.012
更新日期:2015-03-01 00:00:00
abstract::It is well-known that secular trends affect human stature and constitution, and this fact should be taken into consideration in forensic anthropology, especially in stature estimation. Recently, stature-group-specific equations have been developed to take into account these variations. The aim of the present study is ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2019.109973
更新日期:2019-11-01 00:00:00
abstract::Sodium oxybate (Xyrem®), the sodium salt of γ- hydroxybutyric acid (GHB), is a first-line treatment of the symptoms induced by type 1 narcolepsy (NT1) and it is highly effective in improving sleep architecture, decreasing excessive daytime sleepiness and the frequency of cataplexy attacks. Using an ultra-high-performa...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2017.01.015
更新日期:2017-05-01 00:00:00
abstract::HLA-DQA1 and polymarker (LDLR, GYPA, HBGG, D7S8, and GC) genotypic and allelic frequencies are determined for a population sample of 102 unrelated Basque individuals using PCR-based methodology. All six loci met Hardy-Weinberg expectations in at least two of the three analyses performed (HLA-DQA1 failed to meet Hardy-...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(99)00202-9
更新日期:2000-02-14 00:00:00
abstract::The growth of five variables of the tibia (diaphyseal length, diaphyseal length plus distal epiphysis, condylo-malleolar length, sagittal diameter of the proximal epiphysis, maximum breadth of the distal epiphysis) were analysed using polynomial regression in order to evaluate their significance and capacity for age a...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.07.038
更新日期:2012-01-10 00:00:00
abstract::Establishing a person's identity can be a very difficult process. Dental, fingerprint and DNA comparisons are probably the most common techniques used in this context, allowing fast and secure identification processes. However, since they cannot always be used, sometimes it is necessary to apply different and less kno...
journal_title:Forensic science international
pub_type: 杂志文章,评审
doi:10.1016/j.forsciint.2006.04.010
更新日期:2007-01-05 00:00:00
abstract::To determine how long pathological findings persist after burial and which factors play a role in decomposition of a corpse, we evaluated all bodies exhumed under the auspices of the Institute of Legal Medicine at the Hannover Medical School between 1978 and 1997. A total of 87 exhumations (54 men, 33 women) were perf...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2004.11.018
更新日期:2005-11-25 00:00:00
abstract::The hair of 97 cases were analysed for ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE, including ethyl myristate, ethyl palmitate, ethyl oleate and ethyl stearate) according to the Society of Hair Testing guidelines to examine the role of both tests in documenting chronic excessive alcohol drinking, particu...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2014.03.012
更新日期:2014-10-01 00:00:00
abstract::The level of information provided by ink evidence to the criminal and civil justice system is limited. The limitations arise from the weakness of the interpretative framework currently used, as proposed in the ASTM 1422-05 and 1789-04 on ink analysis. It is proposed to use the likelihood ratio from the Bayes theorem t...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2008.11.016
更新日期:2009-03-10 00:00:00
abstract::A novel feature-based method, which is scale invariant feature transform (SIFT) and RANdom SAmple Consensus (RANSAC) integration algorithm, is introduced to promote the automated identification of the breech face impression, the most common mark left on the cartridge used for firearm evidence. SIFT algorithm is employ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2018.02.026
更新日期:2018-05-01 00:00:00
abstract::Munchausen syndrome by proxy (MSBP) is a special form of child abuse in which an adult repeatedly produces symptoms of illness in a person under his/her care. In most cases the perpetrators are mothers who repeatedly and in different ways produce or feign symptoms of illness in their children in order to obtain medica...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2003.07.007
更新日期:2003-11-26 00:00:00
abstract::A genetic locus D1S80 containing a variable number of tandem repeats (VNTR) has been used extensively in forensic analysis and paternity testing. In the current research, the D1S80 locus was amplified using polymerase chain reaction (PCR) technology and the alleles detected using a high sensitivity infrared (IR) fluor...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(97)00043-1
更新日期:1997-05-23 00:00:00
abstract::With research providing conflicting results from different habitats across the globe, the effect of clothing on decomposition is unclear; some studies indicate clothing increases decomposition rate by facilitating increased insect activity, and others conclude clothing prolongs the decay process. In South Africa, such...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2020.110197
更新日期:2020-04-01 00:00:00
abstract::A cadaver and dead plant organic matter, or litter, are rich energy sources that undergo a complex decomposition process, which impact the surrounding environmental microbiota. Advances in molecular microbiology techniques, with study of the 16S RNA genes, in particular, have highlighted the application of forensic ec...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2017.04.024
更新日期:2017-07-01 00:00:00
abstract::Photoluminescence spectra of dry untreated semen have been measured and a suggested method for rapid detection of untreated semen stains is derived from these measurements. The method is presented in the form of a flow chart to cover most crime scene situations. The absorption spectrum of dry untreated blood has also ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(91)90194-n
更新日期:1991-10-01 00:00:00
abstract::The investigations were carried out on 99 brains of which 83 exhibited macroscopic features of brain oedema. The tissue investigated came from four regions of the brain: the cortex of frontal and occipital regions, the white matter and the tissue of the pons varioli. The percentage of water in these regions was evalua...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(87)90047-8
更新日期:1987-10-01 00:00:00
abstract::Forensic molecular genetics has evolved from a rapidly developing field with changing technologies into a highly recognized and generally accepted forensic science, leading to the establishment of national DNA databases with DNA profiles from suspects and convicted offenders. DNA evidence has taken a central role by c...
journal_title:Forensic science international
pub_type: 杂志文章,评审
doi:10.1016/j.forsciint.2006.06.067
更新日期:2007-01-17 00:00:00
abstract::DNA from the short tandem repeat (STR) system HUMTH01 was amplified by the polymerase chain reaction (PCR) and analyzed by vertical electrophoresis in polyacrylamide gels followed by silver staining. DNA samples from 100 unrelated Danes, 147 unrelated Greenland Eskimos, and 89 Danish mother/child pairs were analyzed. ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(94)90378-6
更新日期:1994-09-06 00:00:00
abstract::The 4977 bp deletion of mitochondrial DNA (mtDNA) accumulates in postmitotic tissues with advancing age. The purpose of our study was to detect and quantify these deletion even in blood cells with a high turnover activity. Whole venous blood, isolated human platelets and peripheral blood mononuclear cells (PBMCs) were...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(00)00249-8
更新日期:2000-09-11 00:00:00
abstract::Three novel fluorescent dyes were evaluated for the detection of latent fingermarks on different types and colors of adhesive tapes. Compared with the conventional reagents used to reveal latent fingermarks on these surfaces, these new fluorescent dyes have many advantages. They are highly selective to fingermarks, re...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2016.03.053
更新日期:2016-06-01 00:00:00
abstract::A total of 201 males from Somalia were typed for the Y-chromosome STRs DYS19, DYS385a/b, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438 and DYS439 with the PowerPlex Y kit (Promega). A total of 96 different haplotypes were observed and the haplotype diversity was 0.9715. The number of unique haplo...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2005.01.011
更新日期:2005-07-16 00:00:00
abstract::Our aim was to investigate the reason for relatively low detection rates for opioids and fentanyl in particular in post-mortem cases in the State of Hamburg. We re-analysed 822 blood samples from two different time periods, 2011/12 and 2016. These samples had been previously analysed in accordance with post-mortem rou...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2019.109970
更新日期:2019-12-01 00:00:00
abstract::In this study, we report the chemical analyses of various non-pathological, tuberculosis and syphilis infected bone samples from different burial environments by Fourier transform infrared spectroscopy (FT-IR), in the framework of a general study of diagenesis. Dating human skeletal remains is one of the most importan...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2007.05.008
更新日期:2008-02-25 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) is an increasingly popular drug of abuse that causes stimulation, euphoria, anxiolysis or hypnosis, depending on the dose used. Low doses of the drug are used recreationally, and also implicated in drug-facilitated sexual assaults. Because of the unusually steep dose-response curves, accide...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2007.06.001
更新日期:2007-08-06 00:00:00
abstract::Despite numerous instrumental achievements, canines are still considered the most effective field method for explosive detection. However, due to strict explosive regulations and safety requirements, it can be a challenge for agencies with "bomb dogs" to train using neat explosive materials. This establishes a need fo...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.05.019
更新日期:2011-10-10 00:00:00
abstract::The analysis of condom traces has recently been added to the standard forensic examination protocol of sexual assault and rape cases. Several recent studies have thus focussed on the detection of condom components and classification of the chemical profiles using statistics, obtaining very promising results. The purpo...
journal_title:Forensic science international
pub_type: 杂志文章,评审
doi:10.1016/j.forsciint.2020.110255
更新日期:2020-05-01 00:00:00
abstract::In this paper, a high performance liquid chromatographic method with fluorescence detection (HPLC-FL) for the determination of fenfluramine (Fen) and norfenfluramine (Norf) in human hair as biomarker metabolites of N-nitrosofenfluramine (N-Fen) is described. Washed and cut hair segments were extracted by ultrasonicati...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2004.03.018
更新日期:2004-11-10 00:00:00