Abstract:
:Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the mechanisms of DUB regulation. In this review paper, we summarize a novel possible mechanism of DUB deubiquitylation by other DUBs. The available data suggest the need for further experiments to validate and characterize this notion of 'Dubbing DUBs'. The current studies indicate that the idea of deubiquitylation of DUBs by other DUBs is still in its infancy. Nevertheless, future research holds the promise of validation of this concept.
journal_name
Open Bioljournal_title
Open biologyauthors
Haq S,Ramakrishna Sdoi
10.1098/rsob.170016subject
Has Abstractpub_date
2017-06-01 00:00:00issue
6issn
2046-2441pii
rsob.170016journal_volume
7pub_type
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