Abstract:
:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation and carcinogenesis in the intestine, indicating an essential role of AMPK in intestinal health. AMPK inactivation is an aetiological factor in intestinal dysfunctions. This review summarizes the favourable outcomes of AMPK activation on intestinal health, and discusses AMPK as a potential therapeutic target for intestinal diseases.
journal_name
Open Bioljournal_title
Open biologyauthors
Sun X,Zhu MJdoi
10.1098/rsob.170104subject
Has Abstractpub_date
2017-08-01 00:00:00issue
8issn
2046-2441pii
rsob.170104journal_volume
7pub_type
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