Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.

abstract：:Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and...

journal_title：Open biology

authors： Coomes SM,Pelly VS,Wilson MS

更新日期：2013-01-23 00:00:00

abstract：:During mouse preimplantation embryo development, the classically described second cell-fate decision involves the specification and segregation, in blastocyst inner cell mass (ICM), of primitive endoderm (PrE) from pluripotent epiblast (EPI). The active role of fibroblast growth factor (Fgf) signalling during PrE diff...

journal_title：Open biology

authors： Thamodaran V,Bruce AW

更新日期：2016-09-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb), the aetiological agent of tuberculosis, has evolved to scavenge nutrients from the confined environment of host macrophages with mycobacterial ATP-binding cassette (ABC) transporters playing a key role in nutrient acquisition. Mtb-UspC (Rv2318) is the solute-binding protein of the ess...

journal_title：Open biology

authors： Fullam E,Prokes I,Fütterer K,Besra GS

更新日期：2016-06-01 00:00:00

abstract：:The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...

journal_title：Open biology

authors： Espinosa-Medina I,Garcia-Marques J,Cepko C,Lee T

更新日期：2019-12-01 00:00:00

abstract：:Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This quest...

journal_title：Open biology

authors： Gopinath K,Venclovas C,Ioerger TR,Sacchettini JC,McKinney JD,Mizrahi V,Warner DF

更新日期：2013-02-13 00:00:00

abstract：:Pseudomonas aeruginosa are noscomially acquired, opportunistic pathogens that pose a major threat to the health of burns patients and the immunocompromised. We sequenced the genomes of P. aeruginosa isolates RNS_PA1, RNS_PA46 and RNS_PAE05, which displayed resistance to almost all frontline antibiotics, including gent...

journal_title：Open biology

authors： Roy Chowdhury P,Scott M,Worden P,Huntington P,Hudson B,Karagiannis T,Charles IG,Djordjevic SP

更新日期：2016-03-01 00:00:00

abstract：:AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...

journal_title：Open biology

authors： Burla R,Carcuro M,Torre ML,Fratini F,Crescenzi M,D'Apice MR,Spitalieri P,Raffa GD,Astrologo L,Lattanzi G,Cundari E,Raimondo D,Biroccio A,Gatti M,Saggio I

更新日期：2016-08-01 00:00:00

abstract：:Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the morphogenesis and body patterning during the development of metazoan species. In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal ...

journal_title：Open biology

authors： He CW,Liao CP,Pan CL

更新日期：2018-10-03 00:00:00

abstract：:Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report that tumour cells ...

journal_title：Open biology

authors： Uriostegui-Arcos M,Aguayo-Ortiz R,Valencia-Morales MDP,Melchy-Pérez E,Rosenstein Y,Dominguez L,Zurita M

更新日期：2020-06-01 00:00:00

abstract：:During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been ...

journal_title：Open biology

authors： Mihajlović AI,Bruce AW

更新日期：2017-11-01 00:00:00

abstract：:Nutrient fluctuations in the cellular environment promote changes in cell metabolism and growth to adapt cell proliferation accordingly. The target of rapamycin (TOR) signalling network plays a key role in the coordination of growth and cell proliferation with the nutrient environment and, importantly, nutrient limita...

journal_title：Open biology

authors： Lie S,Banks P,Lawless C,Lydall D,Petersen J

更新日期：2018-05-01 00:00:00

abstract：:Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as regulators of cellular events by their ability to form microdoma...

journal_title：Open biology

authors： Olsen ASB,Færgeman NJ

更新日期：2017-05-01 00:00:00

abstract：:ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori...

journal_title：Open biology

authors： Skouloubris S,Djaout K,Lamarre I,Lambry JC,Anger K,Briffotaux J,Liebl U,de Reuse H,Myllykallio H

更新日期：2015-06-01 00:00:00

abstract：:RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to knock down a targeted gene's expression. However, in other species,...

journal_title：Open biology

authors： Tayler A,Heschuk D,Giesbrecht D,Park JY,Whyard S

更新日期：2019-12-01 00:00:00

abstract：:Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...

journal_title：Open biology

authors： Yan B,Hu Y,Ma T,Wang Y

更新日期：2018-10-10 00:00:00

abstract：:Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively. Here, we report the first molecular and functional characterization of SS/ASTC-type signalling in a deuterostome inver...

journal_title：Open biology

authors： Zhang Y,Yañez Guerra LA,Egertová M,Zampronio CG,Jones AM,Elphick MR

更新日期：2020-09-01 00:00:00

abstract：:Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced mitochondrial genome and divergent metabolic processes. The factors contributing to these divergent processes are still poorly understood and could serve as potential ...

journal_title：Open biology

authors： Klug D,Mair GR,Frischknecht F,Douglas RG

更新日期：2016-04-01 00:00:00

abstract：:Reproductive behaviour is important for animals to keep their species existing on Earth. A key question is how to generate more and healthier progenies by choosing optimal mates. In Drosophila melanogaster, males use multiple sensory cues, including vision, olfaction and gustation, to achieve reproductive success. The...

journal_title：Open biology

authors： Zhuang L,Sun Y,Hu M,Wu C,La X,Chen X,Feng Y,Wang X,Hu Y,Xue L

更新日期：2016-06-01 00:00:00

abstract：:The presence of foetal DNA in the plasma of pregnant women has opened up new possibilities for non-invasive prenatal diagnosis. The use of circulating foetal DNA for the non-invasive prenatal detection of foetal chromosomal aneuploidies is challenging as foetal DNA represents a minor fraction of maternal plasma DNA. I...

journal_title：Open biology

authors： Lo YM

更新日期：2012-06-01 00:00:00

abstract：:In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...

journal_title：Open biology

authors： Urano D,Chen JG,Botella JR,Jones AM

更新日期：2013-03-27 00:00:00

abstract：:Acute nociceptive pain is an undesirable feeling but has a physiological significance as a warning system for living organisms. Conversely, chronic pain is lacking physiological significance, but rather represents a confusion of nerve functions. The neuropathic pain that occurs after peripheral nerve injury (PNI) is p...

journal_title：Open biology

authors： Inoue K

更新日期：2018-11-28 00:00:00

abstract：:In most animals, the bulk of sperm DNA is packaged with sperm nuclear basic proteins (SNBPs), a diverse group of highly basic chromosomal proteins notably comprising mammalian protamines. The replacement of histones with SNBPs during spermiogenesis allows sperm DNA to reach an extreme level of compaction, but little i...

journal_title：Open biology

authors： Kimura S,Loppin B

更新日期：2016-11-01 00:00:00

abstract：:Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin com...

journal_title：Open biology

authors： Liu W,Wang Z,Yang J,Wang Y,Li K,Huang B,Yan B,Wang T,Li M,Zou Z,Yang J,Xiao G,Cui ZK,Liu A,Bai X

更新日期：2019-05-31 00:00:00

abstract：:Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engage super-enhancers by recruiting acetylation writers depositing permis...

journal_title：Open biology

authors： Jahangiri L,Tsaprouni L,Trigg RM,Williams JA,Gkoutos GV,Turner SD,Pereira J

更新日期：2020-07-01 00:00:00

abstract：:Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive TNF signalling can lead to hyper active downstream nuclear factor (NF)-κβ signalling in turn amplifying a cell's inflammatory response and exa...

journal_title：Open biology

authors： Totzke J,Scarneo SA,Yang KW,Haystead TAJ

更新日期：2020-09-01 00:00:00

abstract：:The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expressio...

journal_title：Open biology

authors： Carrillo D,Muñoz JP,Huerta H,Leal G,Corvalán A,León O,Calaf GM,Urzúa U,Boccardo E,Tapia JC,Aguayo F

更新日期：2017-11-01 00:00:00

abstract：:Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites surviving in restricted tissue sites, which include the gastrointestinal tract. There is considerable debate about the replicative status of these persistent parasites and whether there is a role for dormancy in long-term infe...

journal_title：Open biology

authors： Ward AI,Olmo F,Atherton RL,Taylor MC,Kelly JM

更新日期：2020-12-01 00:00:00

abstract：:Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...

journal_title：Open biology

authors： Granadillo Rodríguez M,Flath B,Chelico L

更新日期：2020-12-01 00:00:00

abstract：:With the widespread use of avermectins (AVMs) for managing parasitic and agricultural pests, the resistance of worms and insects to AVMs has emerged as a serious threat to human health and agriculture worldwide. The reduced penetration of AVMs is one of the main reasons for the development of the resistance to the che...

journal_title：Open biology

authors： Chen LP,Wang P,Sun YJ,Wu YJ

更新日期：2016-04-01 00:00:00

abstract：:Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

journal_title：Open biology

authors： Banack SA,Dunlop RA,Cox PA

更新日期：2020-06-01 00:00:00