Immune activation by a multigene family of lectins with variable tandem repeats in oriental river prawn (Macrobrachium nipponense).

abstract：:Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively. Here, we report the first molecular and functional characterization of SS/ASTC-type signalling in a deuterostome inver...

journal_title：Open biology

authors： Zhang Y,Yañez Guerra LA,Egertová M,Zampronio CG,Jones AM,Elphick MR

更新日期：2020-09-01 00:00:00

abstract：:Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison ...

journal_title：Open biology

authors： Sanchez de Groot N,Gomes RA,Villar-Pique A,Babu MM,Coelho AV,Ventura S

更新日期：2015-02-01 00:00:00

abstract：:The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL in its conserved STAN motif has been shown to promote its interaction with Sas6. However, S...

journal_title：Open biology

authors： Dzhindzhev NS,Tzolovsky G,Lipinszki Z,Abdelaziz M,Debski J,Dadlez M,Glover DM

更新日期：2017-12-01 00:00:00

abstract：:DNA methylation has been investigated for many years, but recent technologies have allowed for single-cell- and single-base-resolution DNA methylation datasets and more accurate assessment of DNA methylation dynamics at the key genomic regions that regulate gene expression in human early embryonic development. In this...

journal_title：Open biology

authors： Luo R,Bai C,Yang L,Zheng Z,Su G,Gao G,Wei Z,Zuo Y,Li G

更新日期：2018-10-31 00:00:00

abstract：:Most animals have separate sexes. The differential expression of gene products, in particular that of gene regulators, is underlying sexual dimorphism. Analyses of sex-biased expression have focused mostly on protein-coding genes. Several lines of evidence indicate that microRNAs, a class of major gene regulators, are...

journal_title：Open biology

authors： Marco A

更新日期：2014-04-02 00:00:00

abstract：:Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing ...

journal_title：Open biology

authors： Markiewicz E,Barnard S,Haines J,Coster M,van Geel O,Wu W,Richards S,Ainsbury E,Rothkamm K,Bouffler S,Quinlan RA

更新日期：2015-04-01 00:00:00

abstract：:Intercalation allows cells to exchange positions in a spatially oriented manner in an array of diverse processes, spanning convergent extension in embryonic gastrulation to the formation of tubular organs. However, given the co-occurrence of cell intercalation and changes in cell shape, it is sometimes difficult to as...

journal_title：Open biology

authors： Casani S,Casanova J,Llimargas M

更新日期：2020-11-01 00:00:00

abstract：:Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms under...

journal_title：Open biology

authors： Wu YY,Chiu FL,Yeh CS,Kuo HC

更新日期：2019-01-31 00:00:00

abstract：:AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...

journal_title：Open biology

authors： Burla R,Carcuro M,Torre ML,Fratini F,Crescenzi M,D'Apice MR,Spitalieri P,Raffa GD,Astrologo L,Lattanzi G,Cundari E,Raimondo D,Biroccio A,Gatti M,Saggio I

更新日期：2016-08-01 00:00:00

abstract：:The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...

journal_title：Open biology

authors： Espinosa-Medina I,Garcia-Marques J,Cepko C,Lee T

更新日期：2019-12-01 00:00:00

abstract：:Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...

journal_title：Open biology

authors： Wang N,Zhou Z,Wu T,Liu W,Yin P,Pan C,Yu X

更新日期：2016-03-01 00:00:00

abstract：:Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...

journal_title：Open biology

authors： Cabruja M,Mondino S,Tsai YT,Lara J,Gramajo H,Gago G

更新日期：2017-02-01 00:00:00

abstract：:Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the m...

journal_title：Open biology

authors： Haq S,Ramakrishna S

更新日期：2017-06-01 00:00:00

abstract：:The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...

journal_title：Open biology

authors： Cai K,Li T,Guo L,Guo H,Zhu W,Yan L,Li F

更新日期：2019-09-27 00:00:00

abstract：:During mouse preimplantation embryo development, the classically described second cell-fate decision involves the specification and segregation, in blastocyst inner cell mass (ICM), of primitive endoderm (PrE) from pluripotent epiblast (EPI). The active role of fibroblast growth factor (Fgf) signalling during PrE diff...

journal_title：Open biology

authors： Thamodaran V,Bruce AW

更新日期：2016-09-01 00:00:00

abstract：:We here address the question of whether there is any correlation between subjective preference for simple configurations within a specific visual domain such as motion and strength of activity in visual areas in which that domain is emphasized. We prepared several distinctive patterns of dots in motion with various ch...

journal_title：Open biology

authors： Zeki S,Stutters J

更新日期：2012-02-01 00:00:00

abstract：:The presence of foetal DNA in the plasma of pregnant women has opened up new possibilities for non-invasive prenatal diagnosis. The use of circulating foetal DNA for the non-invasive prenatal detection of foetal chromosomal aneuploidies is challenging as foetal DNA represents a minor fraction of maternal plasma DNA. I...

journal_title：Open biology

authors： Lo YM

更新日期：2012-06-01 00:00:00

abstract：:Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...

journal_title：Open biology

authors： Schulte T,Liu L,Panas MD,Thaa B,Dickson N,Götte B,Achour A,McInerney GM

更新日期：2016-07-01 00:00:00

abstract：:The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial function and insulin secretion in β-cells, and the reported association of PD...

journal_title：Open biology

authors： Deas E,Piipari K,Machhada A,Li A,Gutierrez-del-Arroyo A,Withers DJ,Wood NW,Abramov AY

更新日期：2014-05-07 00:00:00

abstract：:The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...

journal_title：Open biology

authors： Loxley GM,Unsworth J,Turton MJ,Jebb A,Lilley KS,Simpson DM,Rigden DJ,Hurst JL,Beynon RJ

更新日期：2017-09-01 00:00:00

abstract：:Membrane-associated histidine kinases (HKs) in two-component systems respond to environmental stimuli by autophosphorylation and phospho-transfer. HK typically contains a periplasmic sensor domain that regulates the cytoplasmic kinase domain through a conserved cytoplasmic linker. How signal is transduced from the lig...

journal_title：Open biology

authors： Liu J,Yang J,Wen J,Yang Y,Wei X,Zhang X,Wang YP

更新日期：2014-06-01 00:00:00

abstract：:Reproductive behaviour is important for animals to keep their species existing on Earth. A key question is how to generate more and healthier progenies by choosing optimal mates. In Drosophila melanogaster, males use multiple sensory cues, including vision, olfaction and gustation, to achieve reproductive success. The...

journal_title：Open biology

authors： Zhuang L,Sun Y,Hu M,Wu C,La X,Chen X,Feng Y,Wang X,Hu Y,Xue L

更新日期：2016-06-01 00:00:00

abstract：:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, ...

journal_title：Open biology

authors： Sun X,Zhu MJ

更新日期：2017-08-01 00:00:00

abstract：:Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome. Instead, the minus-ends of the MTs become anchored at apical non-centrosomal microtubule organizing centres (n-MTOCs). For...

journal_title：Open biology

authors： Goldspink DA,Rookyard C,Tyrrell BJ,Gadsby J,Perkins J,Lund EK,Galjart N,Thomas P,Wileman T,Mogensen MM

更新日期：2017-02-01 00:00:00

abstract：:Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries and thus prevent silencing of expressed genes. Here we show that lo...

journal_title：Open biology

authors： Verrier L,Taglini F,Barrales RR,Webb S,Urano T,Braun S,Bayne EH

更新日期：2015-05-01 00:00:00

abstract：:T-cell identity is established by the expression of a clonotypic T-cell receptor (TCR), generated by somatic rearrangement of TCRα and β genes. The properties of the TCR determine both the degree of self-reactivity and the repertoire of antigens that can be recognized. For CD8 T cells, the relationship between TCR ide...

journal_title：Open biology

authors： Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL

更新日期：2016-11-01 00:00:00

abstract：:With the widespread use of avermectins (AVMs) for managing parasitic and agricultural pests, the resistance of worms and insects to AVMs has emerged as a serious threat to human health and agriculture worldwide. The reduced penetration of AVMs is one of the main reasons for the development of the resistance to the che...

journal_title：Open biology

authors： Chen LP,Wang P,Sun YJ,Wu YJ

更新日期：2016-04-01 00:00:00

abstract：:During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been ...

journal_title：Open biology

authors： Mihajlović AI,Bruce AW

更新日期：2017-11-01 00:00:00

abstract：:Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engage super-enhancers by recruiting acetylation writers depositing permis...

journal_title：Open biology

authors： Jahangiri L,Tsaprouni L,Trigg RM,Williams JA,Gkoutos GV,Turner SD,Pereira J

更新日期：2020-07-01 00:00:00

abstract：:Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these flagellum forms and differentiation between these two flagellum form...

journal_title：Open biology

authors： Sunter JD,Moreira-Leite F,Gull K

更新日期：2018-11-21 00:00:00