High-throughput dense reconstruction of cell lineages.

Abstract:

:The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent eruption of new tools that allow the reconstruction of lineages based on the phylogenetic analysis of DNA mutations induced during development. Combined with single-cell RNA sequencing, these tools promise to solve the lineage of complex model organisms at single-cell resolution. Here, we compile the conference consensus on the technological and computational challenges emerging from the use of the new strategies, as well as potential solutions.

journal_name

Open Biol

journal_title

Open biology

authors

Espinosa-Medina I,Garcia-Marques J,Cepko C,Lee T

doi

10.1098/rsob.190229

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

190229

issue

12

issn

2046-2441

journal_volume

9

pub_type

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