Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations.

abstract：:The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL in its conserved STAN motif has been shown to promote its interaction with Sas6. However, S...

journal_title：Open biology

authors： Dzhindzhev NS,Tzolovsky G,Lipinszki Z,Abdelaziz M,Debski J,Dadlez M,Glover DM

更新日期：2017-12-01 00:00:00

abstract：:Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...

journal_title：Open biology

authors： Granadillo Rodríguez M,Flath B,Chelico L

更新日期：2020-12-01 00:00:00

abstract：:Cancer cells undergo many different alterations during their transformation, including genetic and epigenetic events. The controlled division of healthy cells can be impaired through the downregulation of tumour suppressor genes. Here, we provide an update of the mechanisms in which epigenetically altered coding and n...

journal_title：Open biology

authors： Llinàs-Arias P,Esteller M

更新日期：2017-09-01 00:00:00

abstract：:The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS). This interaction controls the localization and movement of these signalling proteins, but whether such control depends on ...

journal_title：Open biology

authors： Sun C,Marcello M,Li Y,Mason D,Lévy R,Fernig DG

更新日期：2016-03-01 00:00:00

abstract：:Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries and thus prevent silencing of expressed genes. Here we show that lo...

journal_title：Open biology

authors： Verrier L,Taglini F,Barrales RR,Webb S,Urano T,Braun S,Bayne EH

更新日期：2015-05-01 00:00:00

abstract：:During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been ...

journal_title：Open biology

authors： Mihajlović AI,Bruce AW

更新日期：2017-11-01 00:00:00

abstract：:The presence of foetal DNA in the plasma of pregnant women has opened up new possibilities for non-invasive prenatal diagnosis. The use of circulating foetal DNA for the non-invasive prenatal detection of foetal chromosomal aneuploidies is challenging as foetal DNA represents a minor fraction of maternal plasma DNA. I...

journal_title：Open biology

authors： Lo YM

更新日期：2012-06-01 00:00:00

abstract：:T-cell identity is established by the expression of a clonotypic T-cell receptor (TCR), generated by somatic rearrangement of TCRα and β genes. The properties of the TCR determine both the degree of self-reactivity and the repertoire of antigens that can be recognized. For CD8 T cells, the relationship between TCR ide...

journal_title：Open biology

authors： Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL

更新日期：2016-11-01 00:00:00

abstract：:In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then diffe...

journal_title：Open biology

authors： Donczew M,Mackiewicz P,Wróbel A,Flärdh K,Zakrzewska-Czerwińska J,Jakimowicz D

更新日期：2016-04-01 00:00:00

abstract：:Intercalation allows cells to exchange positions in a spatially oriented manner in an array of diverse processes, spanning convergent extension in embryonic gastrulation to the formation of tubular organs. However, given the co-occurrence of cell intercalation and changes in cell shape, it is sometimes difficult to as...

journal_title：Open biology

authors： Casani S,Casanova J,Llimargas M

更新日期：2020-11-01 00:00:00

abstract：:Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these flagellum forms and differentiation between these two flagellum form...

journal_title：Open biology

authors： Sunter JD,Moreira-Leite F,Gull K

更新日期：2018-11-21 00:00:00

abstract：:The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...

journal_title：Open biology

authors： Loxley GM,Unsworth J,Turton MJ,Jebb A,Lilley KS,Simpson DM,Rigden DJ,Hurst JL,Beynon RJ

更新日期：2017-09-01 00:00:00

abstract：:'Epichromatin', the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). 'Chromomeres', punctate chromatin particles approximately 200-300 nm in diamet...

journal_title：Open biology

authors： Olins DE,Olins AL

更新日期：2018-06-01 00:00:00

abstract：:Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy production and for the supply of metabolic intermediates necessary to su...

journal_title：Open biology

authors： Groenewoud MJ,Zwartkruis FJ

更新日期：2013-12-18 00:00:00

abstract：:Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...

journal_title：Open biology

authors： Cabruja M,Mondino S,Tsai YT,Lara J,Gramajo H,Gago G

更新日期：2017-02-01 00:00:00

abstract：:The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray crystallography contains about 85% of the entire complex, but it lacks...

journal_title：Open biology

authors： Morales-Rios E,Watt IN,Zhang Q,Ding S,Fearnley IM,Montgomery MG,Wakelam MJ,Walker JE

更新日期：2015-09-01 00:00:00

abstract：:The innate immune response is the first line of defence against infection. Germ-line-encoded receptors recognize conserved molecular motifs from both exogenous and endogenous sources. Receptor activation results in the initiation of a pro-inflammatory immune response that enables the resolution of infection. Understan...

journal_title：Open biology

authors： Bryant CE,Monie TP

更新日期：2012-04-01 00:00:00

abstract：:Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced mitochondrial genome and divergent metabolic processes. The factors contributing to these divergent processes are still poorly understood and could serve as potential ...

journal_title：Open biology

authors： Klug D,Mair GR,Frischknecht F,Douglas RG

更新日期：2016-04-01 00:00:00

abstract：:RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. While RANKL and its membrane bound receptor RANK (TNFRSF11A) are expressed in the adult central nervous system and have been implicat...

journal_title：Open biology

authors： Gutierrez H,Kisiswa L,O'Keeffe GW,Smithen MJ,Wyatt S,Davies AM

更新日期：2013-01-08 00:00:00

abstract：:Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

journal_title：Open biology

authors： Banack SA,Dunlop RA,Cox PA

更新日期：2020-06-01 00:00:00

abstract：:Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms under...

journal_title：Open biology

authors： Wu YY,Chiu FL,Yeh CS,Kuo HC

更新日期：2019-01-31 00:00:00

abstract：:The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated by HH, which promotes its endocytosis and destabilization, but the m...

journal_title：Open biology

authors： Brigui A,Hofmann L,Argüelles C,Sanial M,Holmgren RA,Plessis A

更新日期：2015-10-01 00:00:00

abstract：:Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of fusion. This enables rapid and efficient neurotransmitter secretion during presynaptic depolarization by an action potential. Extensive research has revealed that...

journal_title：Open biology

authors： Held RG,Kaeser PS

更新日期：2018-02-01 00:00:00

abstract：:Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or ...

journal_title：Open biology

authors： Cha J,Sun X,Bartos A,Fenelon J,Lefèvre P,Daikoku T,Shaw G,Maxson R,Murphy BD,Renfree MB,Dey SK

更新日期：2013-04-24 00:00:00

abstract：:Pseudomonas aeruginosa are noscomially acquired, opportunistic pathogens that pose a major threat to the health of burns patients and the immunocompromised. We sequenced the genomes of P. aeruginosa isolates RNS_PA1, RNS_PA46 and RNS_PAE05, which displayed resistance to almost all frontline antibiotics, including gent...

journal_title：Open biology

authors： Roy Chowdhury P,Scott M,Worden P,Huntington P,Hudson B,Karagiannis T,Charles IG,Djordjevic SP

更新日期：2016-03-01 00:00:00

abstract：:Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most notably been documented for lymphocytes and monocytes. In contrast, as neutrophils are traditionally considered, to be short-lived,...

journal_title：Open biology

authors： Beyrau M,Bodkin JV,Nourshargh S

更新日期：2012-11-01 00:00:00

abstract：:Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...

journal_title：Open biology

authors： Schulte T,Liu L,Panas MD,Thaa B,Dickson N,Götte B,Achour A,McInerney GM

更新日期：2016-07-01 00:00:00

abstract：:Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as regulators of cellular events by their ability to form microdoma...

journal_title：Open biology

authors： Olsen ASB,Færgeman NJ

更新日期：2017-05-01 00:00:00

abstract：:Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison ...

journal_title：Open biology

authors： Sanchez de Groot N,Gomes RA,Villar-Pique A,Babu MM,Coelho AV,Ventura S

更新日期：2015-02-01 00:00:00

abstract：:In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...

journal_title：Open biology

authors： Urano D,Chen JG,Botella JR,Jones AM

更新日期：2013-03-27 00:00:00