Abstract:
:Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison of two amyloid-β-peptide variants, mostly insoluble but differently recruited by the cell (inclusion body versus diffused), reveals small differences in cell fitness and proteome response. We suggest that the levels of oxidative stress act as a sensor to trigger protein recruitment into foci. Our data support a common cytoplasmic response being able to discern and react to the specific properties of polypeptides.
journal_name
Open Bioljournal_title
Open biologyauthors
Sanchez de Groot N,Gomes RA,Villar-Pique A,Babu MM,Coelho AV,Ventura Sdoi
10.1098/rsob.140221subject
Has Abstractpub_date
2015-02-01 00:00:00pages
140221issue
2issn
2046-2441pii
rsob.140221journal_volume
5pub_type
杂志文章相关文献
Open Biology文献大全abstract::In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120186
更新日期:2013-03-27 00:00:00
abstract::'Epichromatin', the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). 'Chromomeres', punctate chromatin particles approximately 200-300 nm in diamet...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.180058
更新日期:2018-06-01 00:00:00
abstract::During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been ...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170210
更新日期:2017-11-01 00:00:00
abstract::Membrane-associated histidine kinases (HKs) in two-component systems respond to environmental stimuli by autophosphorylation and phospho-transfer. HK typically contains a periplasmic sensor domain that regulates the cytoplasmic kinase domain through a conserved cytoplasmic linker. How signal is transduced from the lig...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140023
更新日期:2014-06-01 00:00:00
abstract::Genetic material can be transmitted not only vertically from parent to offspring, but also laterally (horizontally) from one bacterial lineage to another. Lateral genetic transfer is non-uniform; biases in its nature or frequency construct communities of genetic exchange. These biases have been proposed to arise from ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.120112
更新日期:2012-09-01 00:00:00
abstract::The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190074
更新日期:2019-09-27 00:00:00
abstract::Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy production and for the supply of metabolic intermediates necessary to su...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.130185
更新日期:2013-12-18 00:00:00
abstract::We here address the question of whether there is any correlation between subjective preference for simple configurations within a specific visual domain such as motion and strength of activity in visual areas in which that domain is emphasized. We prepared several distinctive patterns of dots in motion with various ch...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.120001
更新日期:2012-02-01 00:00:00
abstract::The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...
journal_title:Open biology
pub_type: 共识发展会议,杂志文章
doi:10.1098/rsob.190229
更新日期:2019-12-01 00:00:00
abstract::During mouse preimplantation embryo development, the classically described second cell-fate decision involves the specification and segregation, in blastocyst inner cell mass (ICM), of primitive endoderm (PrE) from pluripotent epiblast (EPI). The active role of fibroblast growth factor (Fgf) signalling during PrE diff...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160190
更新日期:2016-09-01 00:00:00
abstract::Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as regulators of cellular events by their ability to form microdoma...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170069
更新日期:2017-05-01 00:00:00
abstract::Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries and thus prevent silencing of expressed genes. Here we show that lo...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150045
更新日期:2015-05-01 00:00:00
abstract::Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150258
更新日期:2016-03-01 00:00:00
abstract::Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160277
更新日期:2017-02-01 00:00:00
abstract::In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190244
更新日期:2020-05-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncR...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150262
更新日期:2016-12-01 00:00:00
abstract::In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits, has become a widely researched field in human genetics. With the increasing availability of genome-wide association study summary statistics, as well as the establishment of deeply phenotyped sample collections, it is now possi...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170125
更新日期:2017-11-01 00:00:00
abstract::Gating of AMPA- and kainate-selective ionotropic glutamate receptors can be defined in terms of ligand affinity, efficacy and the rate and extent of desensitization. Crucial insights into all three elements have come from structural studies of the ligand-binding domain (LBD). In particular, binding-cleft closure is as...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.130051
更新日期:2013-05-29 00:00:00
abstract::TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here, we demonstrate the expression of TRPA1 in rodent somatosensory ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160314
更新日期:2017-04-01 00:00:00
abstract::The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray crystallography contains about 85% of the entire complex, but it lacks...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150119
更新日期:2015-09-01 00:00:00
abstract::With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology. As such, they provide a promising system for examining developmental and molecular processes underlying limb morphol...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160252
更新日期:2016-10-01 00:00:00
abstract::At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side ch...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190290
更新日期:2020-03-01 00:00:00
abstract::Wnt/β-catenin signalling controls development and adult tissue homeostasis and causes cancer when inappropriately activated. In unstimulated cells, an Axin1-centred multi-protein complex phosphorylates the transcriptional co-activator β-catenin, marking it for degradation. Wnt signalling antagonizes β-catenin proteoly...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140120
更新日期:2014-11-01 00:00:00
abstract::Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced mitochondrial genome and divergent metabolic processes. The factors contributing to these divergent processes are still poorly understood and could serve as potential ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160034
更新日期:2016-04-01 00:00:00
abstract::Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.180109
更新日期:2018-08-01 00:00:00
abstract::Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200116
更新日期:2020-06-01 00:00:00
abstract::Current ageing theories are far from satisfactory because of the many determinants involved in ageing. The well-known rate-of-living theory assumes that the product (lifetime energy expenditure, LEE) of maximum lifespan (MLS) and mass-specific basal metabolic rate (msBMR) is approximately constant. Although this theor...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170083
更新日期:2017-10-01 00:00:00
abstract::Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the m...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170016
更新日期:2017-06-01 00:00:00
abstract::Ubiquitination is a versatile post-translational modification that regulates a multitude of cellular processes. Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. Linear ubiq...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170026
更新日期:2017-04-01 00:00:00
abstract::RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to knock down a targeted gene's expression. However, in other species,...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190198
更新日期:2019-12-01 00:00:00