Abstract:
:In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the corresponding molecules in animals but transmit signals by atypical mechanisms and effector proteins to control growth, cell proliferation, defence, stomate movements, channel regulation, sugar sensing and some hormonal responses. In this review, we summarize the current knowledge on the molecular regulation of plant G proteins, their effectors and the physiological functions studied mainly in two model organisms: Arabidopsis thaliana and rice (Oryza sativa). We also look at recent progress on structural analyses, systems biology and evolutionary studies.
journal_name
Open Bioljournal_title
Open biologyauthors
Urano D,Chen JG,Botella JR,Jones AMdoi
10.1098/rsob.120186subject
Has Abstractpub_date
2013-03-27 00:00:00pages
120186issue
3issn
2046-2441pii
rsob.120186journal_volume
3pub_type
杂志文章,评审相关文献
Open Biology文献大全abstract::Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors. They interact with nuclear receptors using short linear motifs (SLiMs) termed co-repressor for nuclear receptor (CoRNR) boxes. Here, we identify ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150063
更新日期:2015-08-01 00:00:00
abstract::The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170135
更新日期:2017-09-01 00:00:00
abstract::Gating of AMPA- and kainate-selective ionotropic glutamate receptors can be defined in terms of ligand affinity, efficacy and the rate and extent of desensitization. Crucial insights into all three elements have come from structural studies of the ligand-binding domain (LBD). In particular, binding-cleft closure is as...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.130051
更新日期:2013-05-29 00:00:00
abstract::We here address the question of whether there is any correlation between subjective preference for simple configurations within a specific visual domain such as motion and strength of activity in visual areas in which that domain is emphasized. We prepared several distinctive patterns of dots in motion with various ch...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.120001
更新日期:2012-02-01 00:00:00
abstract::The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore. However, recent efforts towards biochemical reconstitution of diverse kinetochore...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200284
更新日期:2020-11-01 00:00:00
abstract::In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits, has become a widely researched field in human genetics. With the increasing availability of genome-wide association study summary statistics, as well as the establishment of deeply phenotyped sample collections, it is now possi...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170125
更新日期:2017-11-01 00:00:00
abstract::Tn5 transposase is a bacterial enzyme that integrates a DNA fragment into genomic DNA, and is used as a tool for detecting nucleosome-free regions of genomic DNA in eukaryotes. However, in chromatin, the DNA targeting by Tn5 transposase has remained unclear. In the present study, we reconstituted well-positioned 601 d...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190116
更新日期:2019-08-30 00:00:00
abstract::Mycobacterium tuberculosis (Mtb), the aetiological agent of tuberculosis, has evolved to scavenge nutrients from the confined environment of host macrophages with mycobacterial ATP-binding cassette (ABC) transporters playing a key role in nutrient acquisition. Mtb-UspC (Rv2318) is the solute-binding protein of the ess...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160105
更新日期:2016-06-01 00:00:00
abstract::In mammals, the testis-specific bromodomain and extra terminal (BET) protein BRDT is essential for spermatogenesis. In Drosophila, it was recently reported that the tBRD-1 protein is similarly required for male fertility. Interestingly, however, tBRD-1 has two conserved bromodomains in its N-terminus but it lacks an e...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140145
更新日期:2015-02-01 00:00:00
abstract::The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190074
更新日期:2019-09-27 00:00:00
abstract::Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.180086
更新日期:2018-10-10 00:00:00
abstract::AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160103
更新日期:2016-08-01 00:00:00
abstract::Most animals have separate sexes. The differential expression of gene products, in particular that of gene regulators, is underlying sexual dimorphism. Analyses of sex-biased expression have focused mostly on protein-coding genes. Several lines of evidence indicate that microRNAs, a class of major gene regulators, are...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140024
更新日期:2014-04-02 00:00:00
abstract::The innate immune response is the first line of defence against infection. Germ-line-encoded receptors recognize conserved molecular motifs from both exogenous and endogenous sources. Receptor activation results in the initiation of a pro-inflammatory immune response that enables the resolution of infection. Understan...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120015
更新日期:2012-04-01 00:00:00
abstract::Genomic regions with repeated sequences are unstable and prone to rapid DNA diversification. However, the role of tandem repeats within the coding region is not fully characterized. Here, we have identified a new hypervariable C-type lectin gene family with different numbers of tandem repeats (Rlecs; R means repeat) i...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200141
更新日期:2020-09-01 00:00:00
abstract::Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160277
更新日期:2017-02-01 00:00:00
abstract::Intercalation allows cells to exchange positions in a spatially oriented manner in an array of diverse processes, spanning convergent extension in embryonic gastrulation to the formation of tubular organs. However, given the co-occurrence of cell intercalation and changes in cell shape, it is sometimes difficult to as...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200329
更新日期:2020-11-01 00:00:00
abstract::The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...
journal_title:Open biology
pub_type: 共识发展会议,杂志文章
doi:10.1098/rsob.190229
更新日期:2019-12-01 00:00:00
abstract::Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively. Here, we report the first molecular and functional characterization of SS/ASTC-type signalling in a deuterostome inver...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200172
更新日期:2020-09-01 00:00:00
abstract::Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope. Generally, the enzymatic activity can only be induced by perturbation of the cell envelope integrity ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160073
更新日期:2016-09-01 00:00:00
abstract::In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190244
更新日期:2020-05-01 00:00:00
abstract::T-cell identity is established by the expression of a clonotypic T-cell receptor (TCR), generated by somatic rearrangement of TCRα and β genes. The properties of the TCR determine both the degree of self-reactivity and the repertoire of antigens that can be recognized. For CD8 T cells, the relationship between TCR ide...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160293
更新日期:2016-11-01 00:00:00
abstract::Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report that tumour cells ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200050
更新日期:2020-06-01 00:00:00
abstract::Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160078
更新日期:2016-07-01 00:00:00
abstract::Membrane-associated histidine kinases (HKs) in two-component systems respond to environmental stimuli by autophosphorylation and phospho-transfer. HK typically contains a periplasmic sensor domain that regulates the cytoplasmic kinase domain through a conserved cytoplasmic linker. How signal is transduced from the lig...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140023
更新日期:2014-06-01 00:00:00
abstract::Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engage super-enhancers by recruiting acetylation writers depositing permis...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200121
更新日期:2020-07-01 00:00:00
abstract::Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150011
更新日期:2015-04-01 00:00:00
abstract::The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expressio...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170111
更新日期:2017-11-01 00:00:00
abstract::Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites surviving in restricted tissue sites, which include the gastrointestinal tract. There is considerable debate about the replicative status of these persistent parasites and whether there is a role for dormancy in long-term infe...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200261
更新日期:2020-12-01 00:00:00
abstract::Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140088
更新日期:2014-09-01 00:00:00