A brain-derived metric for preferred kinetic stimuli.

abstract：:Indirect flight muscles (IFMs) in adult Drosophila provide the key power stroke for wing beating. They also serve as a valuable model for studying muscle development. An age-dependent decline in Drosophila free flight has been documented, but its relation to gross muscle structure has not yet been explored satisfactor...

journal_title：Open biology

authors： Chaturvedi D,Prabhakar S,Aggarwal A,Atreya KB,VijayRaghavan K

更新日期：2019-06-28 00:00:00

abstract：:The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expressio...

journal_title：Open biology

authors： Carrillo D,Muñoz JP,Huerta H,Leal G,Corvalán A,León O,Calaf GM,Urzúa U,Boccardo E,Tapia JC,Aguayo F

更新日期：2017-11-01 00:00:00

abstract：:At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side ch...

journal_title：Open biology

authors： Kinoshita T

更新日期：2020-03-01 00:00:00

abstract：:In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then diffe...

journal_title：Open biology

authors： Donczew M,Mackiewicz P,Wróbel A,Flärdh K,Zakrzewska-Czerwińska J,Jakimowicz D

更新日期：2016-04-01 00:00:00

abstract：:Understanding gene regulation requires knowledge of changes in transcription factor (TF) activities. Simultaneous direct measurement of numerous TF activities is currently impossible. Nevertheless, statistical approaches to infer TF activities have yielded non-trivial and verifiable predictions for individual TFs. Her...

journal_title：Open biology

authors： Rolfe MD,Ocone A,Stapleton MR,Hall S,Trotter EW,Poole RK,Sanguinetti G,Green J,SysMO-SUMO Consortium.

更新日期：2012-07-01 00:00:00

abstract：:Gating of AMPA- and kainate-selective ionotropic glutamate receptors can be defined in terms of ligand affinity, efficacy and the rate and extent of desensitization. Crucial insights into all three elements have come from structural studies of the ligand-binding domain (LBD). In particular, binding-cleft closure is as...

journal_title：Open biology

authors： Nayeem N,Mayans O,Green T

更新日期：2013-05-29 00:00:00

abstract：:Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

journal_title：Open biology

authors： Banack SA,Dunlop RA,Cox PA

更新日期：2020-06-01 00:00:00

abstract：:Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...

journal_title：Open biology

authors： Yan B,Hu Y,Ma T,Wang Y

更新日期：2018-10-10 00:00:00

abstract：:During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been ...

journal_title：Open biology

authors： Mihajlović AI,Bruce AW

更新日期：2017-11-01 00:00:00

abstract：:In most animals, the bulk of sperm DNA is packaged with sperm nuclear basic proteins (SNBPs), a diverse group of highly basic chromosomal proteins notably comprising mammalian protamines. The replacement of histones with SNBPs during spermiogenesis allows sperm DNA to reach an extreme level of compaction, but little i...

journal_title：Open biology

authors： Kimura S,Loppin B

更新日期：2016-11-01 00:00:00

abstract：:Skeletal vasculature plays a central role in the maintenance of microenvironments for osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients, vasculature provides a number of inductive factors termed as angiocrine signals. Blood vessels drive recruitment of osteoblast precursors and bone format...

journal_title：Open biology

authors： Sivan U,De Angelis J,Kusumbe AP

更新日期：2019-10-31 00:00:00

abstract：:The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray crystallography contains about 85% of the entire complex, but it lacks...

journal_title：Open biology

authors： Morales-Rios E,Watt IN,Zhang Q,Ding S,Fearnley IM,Montgomery MG,Wakelam MJ,Walker JE

更新日期：2015-09-01 00:00:00

abstract：:Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these flagellum forms and differentiation between these two flagellum form...

journal_title：Open biology

authors： Sunter JD,Moreira-Leite F,Gull K

更新日期：2018-11-21 00:00:00

abstract：:In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...

journal_title：Open biology

authors： Russo A

更新日期：2020-05-01 00:00:00

abstract：:Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope. Generally, the enzymatic activity can only be induced by perturbation of the cell envelope integrity ...

journal_title：Open biology

authors： Wang X,Jiang F,Zheng J,Chen L,Dong J,Sun L,Zhu Y,Liu B,Yang J,Yang G,Jin Q

更新日期：2016-09-01 00:00:00

abstract：:Redox conditions change in events such as immune and platelet activation, and during viral infection, but the biochemical consequences are not well characterized. There is evidence that some disulfide bonds in membrane proteins are labile while others that are probably structurally important are not exposed at the pro...

journal_title：Open biology

authors： Metcalfe C,Cresswell P,Ciaccia L,Thomas B,Barclay AN

更新日期：2011-11-01 00:00:00

abstract：:Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...

journal_title：Open biology

authors： Cabruja M,Mondino S,Tsai YT,Lara J,Gramajo H,Gago G

更新日期：2017-02-01 00:00:00

abstract：:Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This quest...

journal_title：Open biology

authors： Gopinath K,Venclovas C,Ioerger TR,Sacchettini JC,McKinney JD,Mizrahi V,Warner DF

更新日期：2013-02-13 00:00:00

abstract：:The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated by HH, which promotes its endocytosis and destabilization, but the m...

journal_title：Open biology

authors： Brigui A,Hofmann L,Argüelles C,Sanial M,Holmgren RA,Plessis A

更新日期：2015-10-01 00:00:00

abstract：:Membrane-associated histidine kinases (HKs) in two-component systems respond to environmental stimuli by autophosphorylation and phospho-transfer. HK typically contains a periplasmic sensor domain that regulates the cytoplasmic kinase domain through a conserved cytoplasmic linker. How signal is transduced from the lig...

journal_title：Open biology

authors： Liu J,Yang J,Wen J,Yang Y,Wei X,Zhang X,Wang YP

更新日期：2014-06-01 00:00:00

abstract：:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, ...

journal_title：Open biology

authors： Sun X,Zhu MJ

更新日期：2017-08-01 00:00:00

abstract：:RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to knock down a targeted gene's expression. However, in other species,...

journal_title：Open biology

authors： Tayler A,Heschuk D,Giesbrecht D,Park JY,Whyard S

更新日期：2019-12-01 00:00:00

abstract：:The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS). This interaction controls the localization and movement of these signalling proteins, but whether such control depends on ...

journal_title：Open biology

authors： Sun C,Marcello M,Li Y,Mason D,Lévy R,Fernig DG

更新日期：2016-03-01 00:00:00

abstract：:In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...

journal_title：Open biology

authors： Urano D,Chen JG,Botella JR,Jones AM

更新日期：2013-03-27 00:00:00

abstract：:The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...

journal_title：Open biology

authors： Loxley GM,Unsworth J,Turton MJ,Jebb A,Lilley KS,Simpson DM,Rigden DJ,Hurst JL,Beynon RJ

更新日期：2017-09-01 00:00:00

abstract：:Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...

journal_title：Open biology

authors： Schulte T,Liu L,Panas MD,Thaa B,Dickson N,Götte B,Achour A,McInerney GM

更新日期：2016-07-01 00:00:00

abstract：:Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and...

journal_title：Open biology

authors： Coomes SM,Pelly VS,Wilson MS

更新日期：2013-01-23 00:00:00

abstract：:Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing ...

journal_title：Open biology

authors： Markiewicz E,Barnard S,Haines J,Coster M,van Geel O,Wu W,Richards S,Ainsbury E,Rothkamm K,Bouffler S,Quinlan RA

更新日期：2015-04-01 00:00:00

abstract：:AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...

journal_title：Open biology

authors： Burla R,Carcuro M,Torre ML,Fratini F,Crescenzi M,D'Apice MR,Spitalieri P,Raffa GD,Astrologo L,Lattanzi G,Cundari E,Raimondo D,Biroccio A,Gatti M,Saggio I

更新日期：2016-08-01 00:00:00

abstract：:Tn5 transposase is a bacterial enzyme that integrates a DNA fragment into genomic DNA, and is used as a tool for detecting nucleosome-free regions of genomic DNA in eukaryotes. However, in chromatin, the DNA targeting by Tn5 transposase has remained unclear. In the present study, we reconstituted well-positioned 601 d...

journal_title：Open biology

authors： Sato S,Arimura Y,Kujirai T,Harada A,Maehara K,Nogami J,Ohkawa Y,Kurumizaka H

更新日期：2019-08-30 00:00:00