听力与言语-语言病理学

行为科学

医学伦理学

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  • Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate.

    abstract::Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites surviving in restricted tissue sites, which include the gastrointestinal tract. There is considerable debate about the replicative status of these persistent parasites and whether there is a role for dormancy in long-term infe...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200261

    authors: Ward AI,Olmo F,Atherton RL,Taylor MC,Kelly JM

    更新日期:2020-12-01 00:00:00

  • The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.

    abstract::Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200188

    authors: Granadillo Rodríguez M,Flath B,Chelico L

    更新日期:2020-12-01 00:00:00

  • Biochemical evidence for diverse strategies in the inner kinetochore.

    abstract::The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore. However, recent efforts towards biochemical reconstitution of diverse kinetochore...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200284

    authors: Hamilton GE,Davis TN

    更新日期:2020-11-01 00:00:00

  • Unravelling the distinct contribution of cell shape changes and cell intercalation to tissue morphogenesis: the case of the Drosophila trachea.

    abstract::Intercalation allows cells to exchange positions in a spatially oriented manner in an array of diverse processes, spanning convergent extension in embryonic gastrulation to the formation of tubular organs. However, given the co-occurrence of cell intercalation and changes in cell shape, it is sometimes difficult to as...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200329

    authors: Casani S,Casanova J,Llimargas M

    更新日期:2020-11-01 00:00:00

  • Establishment and function of chromatin modification at enhancers.

    abstract::How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome. This is achieved, in part, by enhancers-genetic elements that can increase transcription of both ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200255

    authors: Tafessu A,Banaszynski LA

    更新日期:2020-10-01 00:00:00

  • Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate.

    abstract::Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively. Here, we report the first molecular and functional characterization of SS/ASTC-type signalling in a deuterostome inver...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200172

    authors: Zhang Y,Yañez Guerra LA,Egertová M,Zampronio CG,Jones AM,Elphick MR

    更新日期:2020-09-01 00:00:00

  • Immune activation by a multigene family of lectins with variable tandem repeats in oriental river prawn (Macrobrachium nipponense).

    abstract::Genomic regions with repeated sequences are unstable and prone to rapid DNA diversification. However, the role of tandem repeats within the coding region is not fully characterized. Here, we have identified a new hypervariable C-type lectin gene family with different numbers of tandem repeats (Rlecs; R means repeat) i...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200141

    authors: Huang Y,Huang X,Zhou X,Wang J,Zhang R,Ma F,Wang K,Zhang Z,Dai X,Cao X,Zhang C,Han K,Ren Q

    更新日期:2020-09-01 00:00:00

  • TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases.

    abstract::Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive TNF signalling can lead to hyper active downstream nuclear factor (NF)-κβ signalling in turn amplifying a cell's inflammatory response and exa...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200099

    authors: Totzke J,Scarneo SA,Yang KW,Haystead TAJ

    更新日期:2020-09-01 00:00:00

  • Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response.

    abstract::Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones. There are numerous homologues and isoforms of Hsp70 that participate in a wide variety of cellular functions. This diversity can facilitate adaption or specialization base...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200089

    authors: Larburu N,Adams CJ,Chen CS,Nowak PR,Ali MMU

    更新日期:2020-08-01 00:00:00

  • Core regulatory circuitries in defining cancer cell identity across the malignant spectrum.

    abstract::Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engage super-enhancers by recruiting acetylation writers depositing permis...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200121

    authors: Jahangiri L,Tsaprouni L,Trigg RM,Williams JA,Gkoutos GV,Turner SD,Pereira J

    更新日期:2020-07-01 00:00:00

  • An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease.

    abstract::Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200116

    authors: Banack SA,Dunlop RA,Cox PA

    更新日期:2020-06-01 00:00:00

  • Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer.

    abstract::Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report that tumour cells ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200050

    authors: Uriostegui-Arcos M,Aguayo-Ortiz R,Valencia-Morales MDP,Melchy-Pérez E,Rosenstein Y,Dominguez L,Zurita M

    更新日期:2020-06-01 00:00:00

  • Understanding the mammalian TRAP complex function(s).

    abstract::In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190244

    authors: Russo A

    更新日期:2020-05-01 00:00:00

  • Biosynthesis and biology of mammalian GPI-anchored proteins.

    abstract::At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side ch...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190290

    authors: Kinoshita T

    更新日期:2020-03-01 00:00:00

  • High-throughput dense reconstruction of cell lineages.

    abstract::The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...

    journal_title:Open biology

    pub_type: 共识发展会议,杂志文章

    doi:10.1098/rsob.190229

    authors: Espinosa-Medina I,Garcia-Marques J,Cepko C,Lee T

    更新日期:2019-12-01 00:00:00

  • Efficiency of RNA interference is improved by knockdown of dsRNA nucleases in tephritid fruit flies.

    abstract::RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to knock down a targeted gene's expression. However, in other species,...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190198

    authors: Tayler A,Heschuk D,Giesbrecht D,Park JY,Whyard S

    更新日期:2019-12-01 00:00:00

  • Role of angiocrine signals in bone development, homeostasis and disease.

    abstract::Skeletal vasculature plays a central role in the maintenance of microenvironments for osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients, vasculature provides a number of inductive factors termed as angiocrine signals. Blood vessels drive recruitment of osteoblast precursors and bone format...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.190144

    authors: Sivan U,De Angelis J,Kusumbe AP

    更新日期:2019-10-31 00:00:00

  • Long non-coding RNA LINC00467 regulates hepatocellular carcinoma progression by modulating miR-9-5p/PPARA expression.

    abstract::The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190074

    authors: Cai K,Li T,Guo L,Guo H,Zhu W,Yan L,Li F

    更新日期:2019-09-27 00:00:00

  • Biochemical analysis of nucleosome targeting by Tn5 transposase.

    abstract::Tn5 transposase is a bacterial enzyme that integrates a DNA fragment into genomic DNA, and is used as a tool for detecting nucleosome-free regions of genomic DNA in eukaryotes. However, in chromatin, the DNA targeting by Tn5 transposase has remained unclear. In the present study, we reconstituted well-positioned 601 d...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190116

    authors: Sato S,Arimura Y,Kujirai T,Harada A,Maehara K,Nogami J,Ohkawa Y,Kurumizaka H

    更新日期:2019-08-30 00:00:00

  • Adult Drosophila muscle morphometry through microCT reveals dynamics during ageing.

    abstract::Indirect flight muscles (IFMs) in adult Drosophila provide the key power stroke for wing beating. They also serve as a valuable model for studying muscle development. An age-dependent decline in Drosophila free flight has been documented, but its relation to gross muscle structure has not yet been explored satisfactor...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190087

    authors: Chaturvedi D,Prabhakar S,Aggarwal A,Atreya KB,VijayRaghavan K

    更新日期:2019-06-28 00:00:00

  • Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.

    abstract::Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin com...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180262

    authors: Liu W,Wang Z,Yang J,Wang Y,Li K,Huang B,Yan B,Wang T,Li M,Zou Z,Yang J,Xiao G,Cui ZK,Liu A,Bai X

    更新日期:2019-05-31 00:00:00

  • Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease.

    abstract::Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms under...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180177

    authors: Wu YY,Chiu FL,Yeh CS,Kuo HC

    更新日期:2019-01-31 00:00:00

  • A state-of-the-art perspective on microgliopathic pain.

    abstract::Acute nociceptive pain is an undesirable feeling but has a physiological significance as a warning system for living organisms. Conversely, chronic pain is lacking physiological significance, but rather represents a confusion of nerve functions. The neuropathic pain that occurs after peripheral nerve injury (PNI) is p...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180154

    authors: Inoue K

    更新日期:2018-11-28 00:00:00

  • Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis in Leishmania.

    abstract::Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these flagellum forms and differentiation between these two flagellum form...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180124

    authors: Sunter JD,Moreira-Leite F,Gull K

    更新日期:2018-11-21 00:00:00

  • DNA methylation subpatterns at distinct regulatory regions in human early embryos.

    abstract::DNA methylation has been investigated for many years, but recent technologies have allowed for single-cell- and single-base-resolution DNA methylation datasets and more accurate assessment of DNA methylation dynamics at the key genomic regions that regulate gene expression in human early embryonic development. In this...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180131

    authors: Luo R,Bai C,Yang L,Zheng Z,Su G,Gao G,Wei Z,Zuo Y,Li G

    更新日期:2018-10-31 00:00:00

  • IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5.

    abstract::Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180086

    authors: Yan B,Hu Y,Ma T,Wang Y

    更新日期:2018-10-10 00:00:00

  • Wnt signalling in the development of axon, dendrites and synapses.

    abstract::Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the morphogenesis and body patterning during the development of metazoan species. In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal ...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180116

    authors: He CW,Liao CP,Pan CL

    更新日期:2018-10-03 00:00:00

  • Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis.

    abstract::Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180109

    authors: Pachis ST,Kops GJPL

    更新日期:2018-08-01 00:00:00

  • Epichromatin and chromomeres: a 'fuzzy' perspective.

    abstract::'Epichromatin', the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). 'Chromomeres', punctate chromatin particles approximately 200-300 nm in diamet...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180058

    authors: Olins DE,Olins AL

    更新日期:2018-06-01 00:00:00

  • The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity.

    abstract::Nutrient fluctuations in the cellular environment promote changes in cell metabolism and growth to adapt cell proliferation accordingly. The target of rapamycin (TOR) signalling network plays a key role in the coordination of growth and cell proliferation with the nutrient environment and, importantly, nutrient limita...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180015

    authors: Lie S,Banks P,Lawless C,Lydall D,Petersen J

    更新日期:2018-05-01 00:00:00

  • ELKS active zone proteins as multitasking scaffolds for secretion.

    abstract::Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of fusion. This enables rapid and efficient neurotransmitter secretion during presynaptic depolarization by an action potential. Extensive research has revealed that...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170258

    authors: Held RG,Kaeser PS

    更新日期:2018-02-01 00:00:00

  • Pigment-Dispersing Factor-expressing neurons convey circadian information in the honey bee brain.

    abstract::Pigment-Dispersing Factor (PDF) is an important neuropeptide in the brain circadian network of Drosophila and other insects, but its role in bees in which the circadian clock influences complex behaviour is not well understood. We combined high-resolution neuroanatomical characterizations, quantification of PDF levels...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170224

    authors: Beer K,Kolbe E,Kahana NB,Yayon N,Weiss R,Menegazzi P,Bloch G,Helfrich-Förster C

    更新日期:2018-01-01 00:00:00

  • Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.

    abstract::The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL in its conserved STAN motif has been shown to promote its interaction with Sas6. However, S...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170247

    authors: Dzhindzhev NS,Tzolovsky G,Lipinszki Z,Abdelaziz M,Debski J,Dadlez M,Glover DM

    更新日期:2017-12-01 00:00:00

  • Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells.

    abstract::The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expressio...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170111

    authors: Carrillo D,Muñoz JP,Huerta H,Leal G,Corvalán A,León O,Calaf GM,Urzúa U,Boccardo E,Tapia JC,Aguayo F

    更新日期:2017-11-01 00:00:00

  • Statistical methods to detect pleiotropy in human complex traits.

    abstract::In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits, has become a widely researched field in human genetics. With the increasing availability of genome-wide association study summary statistics, as well as the establishment of deeply phenotyped sample collections, it is now possi...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170125

    authors: Hackinger S,Zeggini E

    更新日期:2017-11-01 00:00:00

  • The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity.

    abstract::During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been ...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170210

    authors: Mihajlović AI,Bruce AW

    更新日期:2017-11-01 00:00:00

  • Mitochondrial determinants of mammalian longevity.

    abstract::Current ageing theories are far from satisfactory because of the many determinants involved in ageing. The well-known rate-of-living theory assumes that the product (lifetime energy expenditure, LEE) of maximum lifespan (MLS) and mass-specific basal metabolic rate (msBMR) is approximately constant. Although this theor...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170083

    authors: Kitazoe Y,Hasegawa M,Tanaka M,Futami M,Futami J

    更新日期:2017-10-01 00:00:00

  • Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus.

    abstract::The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170135

    authors: Loxley GM,Unsworth J,Turton MJ,Jebb A,Lilley KS,Simpson DM,Rigden DJ,Hurst JL,Beynon RJ

    更新日期:2017-09-01 00:00:00

  • Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update.

    abstract::Cancer cells undergo many different alterations during their transformation, including genetic and epigenetic events. The controlled division of healthy cells can be impaired through the downregulation of tumour suppressor genes. Here, we provide an update of the mechanisms in which epigenetically altered coding and n...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170152

    authors: Llinàs-Arias P,Esteller M

    更新日期:2017-09-01 00:00:00

  • AMP-activated protein kinase: a therapeutic target in intestinal diseases.

    abstract::Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, ...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170104

    authors: Sun X,Zhu MJ

    更新日期:2017-08-01 00:00:00

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