Role of angiocrine signals in bone development, homeostasis and disease.

Abstract:

:Skeletal vasculature plays a central role in the maintenance of microenvironments for osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients, vasculature provides a number of inductive factors termed as angiocrine signals. Blood vessels drive recruitment of osteoblast precursors and bone formation during development. Angiogenesis is indispensable for bone repair and regeneration. Dysregulation of the angiocrine crosstalk is a hallmark of ageing and pathobiological conditions in the skeletal system. The skeletal vascular bed is complex, heterogeneous and characterized by distinct capillary subtypes (type H and type L), which exhibit differential expression of angiocrine factors. Furthermore, distinct blood vessel subtypes with differential angiocrine profiles differentially regulate osteogenesis and haematopoiesis, and drive disease states in the skeletal system. This review provides an overview of the role of angiocrine signals in bone during homeostasis and disease.

journal_name

Open Biol

journal_title

Open biology

authors

Sivan U,De Angelis J,Kusumbe AP

doi

10.1098/rsob.190144

subject

Has Abstract

pub_date

2019-10-31 00:00:00

pages

190144

issue

10

issn

2046-2441

journal_volume

9

pub_type

杂志文章,评审
  • Drosophila as a model system to unravel the layers of innate immunity to infection.

    abstract::Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about i...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120075

    authors: Kounatidis I,Ligoxygakis P

    更新日期:2012-05-01 00:00:00

  • Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix.

    abstract::The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS). This interaction controls the localization and movement of these signalling proteins, but whether such control depends on ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150277

    authors: Sun C,Marcello M,Li Y,Mason D,Lévy R,Fernig DG

    更新日期:2016-03-01 00:00:00

  • Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.

    abstract::Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160078

    authors: Schulte T,Liu L,Panas MD,Thaa B,Dickson N,Götte B,Achour A,McInerney GM

    更新日期:2016-07-01 00:00:00

  • A comparison of the Caulobacter NA1000 and K31 genomes reveals extensive genome rearrangements and differences in metabolic potential.

    abstract::The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 4 ° C with a doubling time of 40 h. K31 contains a 5.5 Mb chromosome that codes for mo...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.140128

    authors: Ash K,Brown T,Watford T,Scott LE,Stephens C,Ely B

    更新日期:2014-10-01 00:00:00

  • Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for?

    abstract::Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120157

    authors: Coomes SM,Pelly VS,Wilson MS

    更新日期:2013-01-23 00:00:00

  • An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease.

    abstract::Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200116

    authors: Banack SA,Dunlop RA,Cox PA

    更新日期:2020-06-01 00:00:00

  • High-throughput dense reconstruction of cell lineages.

    abstract::The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...

    journal_title:Open biology

    pub_type: 共识发展会议,杂志文章

    doi:10.1098/rsob.190229

    authors: Espinosa-Medina I,Garcia-Marques J,Cepko C,Lee T

    更新日期:2019-12-01 00:00:00

  • Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update.

    abstract::Cancer cells undergo many different alterations during their transformation, including genetic and epigenetic events. The controlled division of healthy cells can be impaired through the downregulation of tumour suppressor genes. Here, we provide an update of the mechanisms in which epigenetically altered coding and n...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170152

    authors: Llinàs-Arias P,Esteller M

    更新日期:2017-09-01 00:00:00

  • TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin.

    abstract::Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150258

    authors: Wang N,Zhou Z,Wu T,Liu W,Yin P,Pan C,Yu X

    更新日期:2016-03-01 00:00:00

  • A new role for muscle segment homeobox genes in mammalian embryonic diapause.

    abstract::Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.130035

    authors: Cha J,Sun X,Bartos A,Fenelon J,Lefèvre P,Daikoku T,Shaw G,Maxson R,Murphy BD,Renfree MB,Dey SK

    更新日期:2013-04-24 00:00:00

  • Statistical methods to detect pleiotropy in human complex traits.

    abstract::In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits, has become a widely researched field in human genetics. With the increasing availability of genome-wide association study summary statistics, as well as the establishment of deeply phenotyped sample collections, it is now possi...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170125

    authors: Hackinger S,Zeggini E

    更新日期:2017-11-01 00:00:00

  • Expression of a hindlimb-determining factor Pitx1 in the forelimb of the lizard Pogona vitticeps during morphogenesis.

    abstract::With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology. As such, they provide a promising system for examining developmental and molecular processes underlying limb morphol...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160252

    authors: Melville J,Hunjan S,McLean F,Mantziou G,Boysen K,Parry LJ

    更新日期:2016-10-01 00:00:00

  • A state-of-the-art perspective on microgliopathic pain.

    abstract::Acute nociceptive pain is an undesirable feeling but has a physiological significance as a warning system for living organisms. Conversely, chronic pain is lacking physiological significance, but rather represents a confusion of nerve functions. The neuropathic pain that occurs after peripheral nerve injury (PNI) is p...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180154

    authors: Inoue K

    更新日期:2018-11-28 00:00:00

  • Deubiquitylation of deubiquitylases.

    abstract::Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the m...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170016

    authors: Haq S,Ramakrishna S

    更新日期:2017-06-01 00:00:00

  • Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response.

    abstract::Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones. There are numerous homologues and isoforms of Hsp70 that participate in a wide variety of cellular functions. This diversity can facilitate adaption or specialization base...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200089

    authors: Larburu N,Adams CJ,Chen CS,Nowak PR,Ali MMU

    更新日期:2020-08-01 00:00:00

  • Heterotrimeric G protein signalling in the plant kingdom.

    abstract::In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120186

    authors: Urano D,Chen JG,Botella JR,Jones AM

    更新日期:2013-03-27 00:00:00

  • ELKS active zone proteins as multitasking scaffolds for secretion.

    abstract::Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of fusion. This enables rapid and efficient neurotransmitter secretion during presynaptic depolarization by an action potential. Extensive research has revealed that...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170258

    authors: Held RG,Kaeser PS

    更新日期:2018-02-01 00:00:00

  • The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.

    abstract::Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200188

    authors: Granadillo Rodríguez M,Flath B,Chelico L

    更新日期:2020-12-01 00:00:00

  • Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.

    abstract::Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most notably been documented for lymphocytes and monocytes. In contrast, as neutrophils are traditionally considered, to be short-lived,...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120134

    authors: Beyrau M,Bodkin JV,Nourshargh S

    更新日期:2012-11-01 00:00:00

  • Mice, men and the relatives: cross-species studies underpin innate immunity.

    abstract::The innate immune response is the first line of defence against infection. Germ-line-encoded receptors recognize conserved molecular motifs from both exogenous and endogenous sources. Receptor activation results in the initiation of a pro-inflammatory immune response that enables the resolution of infection. Understan...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120015

    authors: Bryant CE,Monie TP

    更新日期:2012-04-01 00:00:00

  • Or47b plays a role in Drosophila males' preference for younger mates.

    abstract::Reproductive behaviour is important for animals to keep their species existing on Earth. A key question is how to generate more and healthier progenies by choosing optimal mates. In Drosophila melanogaster, males use multiple sensory cues, including vision, olfaction and gustation, to achieve reproductive success. The...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160086

    authors: Zhuang L,Sun Y,Hu M,Wu C,La X,Chen X,Feng Y,Wang X,Hu Y,Xue L

    更新日期:2016-06-01 00:00:00

  • Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells.

    abstract::Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncR...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150262

    authors: Lin CY,Kleinbrink EL,Dachet F,Cai J,Ju D,Goldstone A,Wood EJ,Liu K,Jia H,Goustin AS,Kosir MA,Thepsuwan P,Lipovich L

    更新日期:2016-12-01 00:00:00

  • Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus.

    abstract::The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170135

    authors: Loxley GM,Unsworth J,Turton MJ,Jebb A,Lilley KS,Simpson DM,Rigden DJ,Hurst JL,Beynon RJ

    更新日期:2017-09-01 00:00:00

  • Atypical centrioles are present in Tribolium sperm.

    abstract::Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and function. These centrioles originate from the zygote, but because the oocyte does not provide any centrioles, it is surprising that the zygotes of many animals are thou...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160334

    authors: Fishman EL,Jo K,Ha A,Royfman R,Zinn A,Krishnamurthy M,Avidor-Reiss T

    更新日期:2017-03-01 00:00:00

  • Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis.

    abstract::Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180109

    authors: Pachis ST,Kops GJPL

    更新日期:2018-08-01 00:00:00

  • Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans.

    abstract::The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray crystallography contains about 85% of the entire complex, but it lacks...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150119

    authors: Morales-Rios E,Watt IN,Zhang Q,Ding S,Fearnley IM,Montgomery MG,Wakelam MJ,Walker JE

    更新日期:2015-09-01 00:00:00

  • A small mitochondrial protein present in myzozoans is essential for malaria transmission.

    abstract::Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced mitochondrial genome and divergent metabolic processes. The factors contributing to these divergent processes are still poorly understood and could serve as potential ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160034

    authors: Klug D,Mair GR,Frischknecht F,Douglas RG

    更新日期:2016-04-01 00:00:00

  • Long non-coding RNA LINC00467 regulates hepatocellular carcinoma progression by modulating miR-9-5p/PPARA expression.

    abstract::The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190074

    authors: Cai K,Li T,Guo L,Guo H,Zhu W,Yan L,Li F

    更新日期:2019-09-27 00:00:00

  • Rheb and mammalian target of rapamycin in mitochondrial homoeostasis.

    abstract::Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy production and for the supply of metabolic intermediates necessary to su...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.130185

    authors: Groenewoud MJ,Zwartkruis FJ

    更新日期:2013-12-18 00:00:00

  • Linear ubiquitin chains: enzymes, mechanisms and biology.

    abstract::Ubiquitination is a versatile post-translational modification that regulates a multitude of cellular processes. Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. Linear ubiq...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170026

    authors: Rittinger K,Ikeda F

    更新日期:2017-04-01 00:00:00