Epichromatin and chromomeres: a 'fuzzy' perspective.

abstract：:Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the morphogenesis and body patterning during the development of metazoan species. In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal ...

journal_title：Open biology

authors： He CW,Liao CP,Pan CL

更新日期：2018-10-03 00:00:00

abstract：:The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial function and insulin secretion in β-cells, and the reported association of PD...

journal_title：Open biology

authors： Deas E,Piipari K,Machhada A,Li A,Gutierrez-del-Arroyo A,Withers DJ,Wood NW,Abramov AY

更新日期：2014-05-07 00:00:00

abstract：:Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing ...

journal_title：Open biology

authors： Markiewicz E,Barnard S,Haines J,Coster M,van Geel O,Wu W,Richards S,Ainsbury E,Rothkamm K,Bouffler S,Quinlan RA

更新日期：2015-04-01 00:00:00

abstract：:Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin com...

journal_title：Open biology

authors： Liu W,Wang Z,Yang J,Wang Y,Li K,Huang B,Yan B,Wang T,Li M,Zou Z,Yang J,Xiao G,Cui ZK,Liu A,Bai X

更新日期：2019-05-31 00:00:00

abstract：:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, ...

journal_title：Open biology

authors： Sun X,Zhu MJ

更新日期：2017-08-01 00:00:00

abstract：:Redox conditions change in events such as immune and platelet activation, and during viral infection, but the biochemical consequences are not well characterized. There is evidence that some disulfide bonds in membrane proteins are labile while others that are probably structurally important are not exposed at the pro...

journal_title：Open biology

authors： Metcalfe C,Cresswell P,Ciaccia L,Thomas B,Barclay AN

更新日期：2011-11-01 00:00:00

abstract：:Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...

journal_title：Open biology

authors： Cabruja M,Mondino S,Tsai YT,Lara J,Gramajo H,Gago G

更新日期：2017-02-01 00:00:00

abstract：:Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...

journal_title：Open biology

authors： Wang N,Zhou Z,Wu T,Liu W,Yin P,Pan C,Yu X

更新日期：2016-03-01 00:00:00

abstract：:Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...

journal_title：Open biology

authors： Schulte T,Liu L,Panas MD,Thaa B,Dickson N,Götte B,Achour A,McInerney GM

更新日期：2016-07-01 00:00:00

abstract：:Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report that tumour cells ...

journal_title：Open biology

authors： Uriostegui-Arcos M,Aguayo-Ortiz R,Valencia-Morales MDP,Melchy-Pérez E,Rosenstein Y,Dominguez L,Zurita M

更新日期：2020-06-01 00:00:00

abstract：:The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...

journal_title：Open biology

authors： Espinosa-Medina I,Garcia-Marques J,Cepko C,Lee T

更新日期：2019-12-01 00:00:00

abstract：:Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms under...

journal_title：Open biology

authors： Wu YY,Chiu FL,Yeh CS,Kuo HC

更新日期：2019-01-31 00:00:00

abstract：:In most animals, the bulk of sperm DNA is packaged with sperm nuclear basic proteins (SNBPs), a diverse group of highly basic chromosomal proteins notably comprising mammalian protamines. The replacement of histones with SNBPs during spermiogenesis allows sperm DNA to reach an extreme level of compaction, but little i...

journal_title：Open biology

authors： Kimura S,Loppin B

更新日期：2016-11-01 00:00:00

abstract：:Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This quest...

journal_title：Open biology

authors： Gopinath K,Venclovas C,Ioerger TR,Sacchettini JC,McKinney JD,Mizrahi V,Warner DF

更新日期：2013-02-13 00:00:00

abstract：:The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS). This interaction controls the localization and movement of these signalling proteins, but whether such control depends on ...

journal_title：Open biology

authors： Sun C,Marcello M,Li Y,Mason D,Lévy R,Fernig DG

更新日期：2016-03-01 00:00:00

abstract：:Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones. There are numerous homologues and isoforms of Hsp70 that participate in a wide variety of cellular functions. This diversity can facilitate adaption or specialization base...

journal_title：Open biology

authors： Larburu N,Adams CJ,Chen CS,Nowak PR,Ali MMU

更新日期：2020-08-01 00:00:00

abstract：:RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to knock down a targeted gene's expression. However, in other species,...

journal_title：Open biology

authors： Tayler A,Heschuk D,Giesbrecht D,Park JY,Whyard S

更新日期：2019-12-01 00:00:00

abstract：:With the widespread use of avermectins (AVMs) for managing parasitic and agricultural pests, the resistance of worms and insects to AVMs has emerged as a serious threat to human health and agriculture worldwide. The reduced penetration of AVMs is one of the main reasons for the development of the resistance to the che...

journal_title：Open biology

authors： Chen LP,Wang P,Sun YJ,Wu YJ

更新日期：2016-04-01 00:00:00

abstract：:Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...

journal_title：Open biology

authors： Yan B,Hu Y,Ma T,Wang Y

更新日期：2018-10-10 00:00:00

abstract：:AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...

journal_title：Open biology

authors： Burla R,Carcuro M,Torre ML,Fratini F,Crescenzi M,D'Apice MR,Spitalieri P,Raffa GD,Astrologo L,Lattanzi G,Cundari E,Raimondo D,Biroccio A,Gatti M,Saggio I

更新日期：2016-08-01 00:00:00

abstract：:Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...

journal_title：Open biology

authors： Granadillo Rodríguez M,Flath B,Chelico L

更新日期：2020-12-01 00:00:00

abstract：:RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. While RANKL and its membrane bound receptor RANK (TNFRSF11A) are expressed in the adult central nervous system and have been implicat...

journal_title：Open biology

authors： Gutierrez H,Kisiswa L,O'Keeffe GW,Smithen MJ,Wyatt S,Davies AM

更新日期：2013-01-08 00:00:00

abstract：:TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here, we demonstrate the expression of TRPA1 in rodent somatosensory ...

journal_title：Open biology

authors： Kheradpezhouh E,Choy JMC,Daria VR,Arabzadeh E

更新日期：2017-04-01 00:00:00

abstract：:Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of fusion. This enables rapid and efficient neurotransmitter secretion during presynaptic depolarization by an action potential. Extensive research has revealed that...

journal_title：Open biology

authors： Held RG,Kaeser PS

更新日期：2018-02-01 00:00:00

abstract：:Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy production and for the supply of metabolic intermediates necessary to su...

journal_title：Open biology

authors： Groenewoud MJ,Zwartkruis FJ

更新日期：2013-12-18 00:00:00

abstract：:With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology. As such, they provide a promising system for examining developmental and molecular processes underlying limb morphol...

journal_title：Open biology

authors： Melville J,Hunjan S,McLean F,Mantziou G,Boysen K,Parry LJ

更新日期：2016-10-01 00:00:00

abstract：:Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors. They interact with nuclear receptors using short linear motifs (SLiMs) termed co-repressor for nuclear receptor (CoRNR) boxes. Here, we identify ...

journal_title：Open biology

authors： Short S,Peterkin T,Guille M,Patient R,Sharpe C

更新日期：2015-08-01 00:00:00

abstract：:Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and function. These centrioles originate from the zygote, but because the oocyte does not provide any centrioles, it is surprising that the zygotes of many animals are thou...

journal_title：Open biology

authors： Fishman EL,Jo K,Ha A,Royfman R,Zinn A,Krishnamurthy M,Avidor-Reiss T

更新日期：2017-03-01 00:00:00

abstract：:Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the...

journal_title：Open biology

authors： Pachis ST,Kops GJPL

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...

journal_title：Open biology

authors： Cai K,Li T,Guo L,Guo H,Zhu W,Yan L,Li F

更新日期：2019-09-27 00:00:00